pH-responsive polymeric nanoparticles with tunable sizes for targeted drug delivery

Novel nanoparticles for efficient drug delivery were designed and constructed using polymeric 2,3-dialdehyde cellulose (DAC). The drug DOX was encapsulated into nanoparticles and underwent thoroughly controlled release in acidic tumor microenvironments.

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TEMPERATURE AND PH RESPONSIVE POLYMERIC NANOPARTICLES FOR TARGETED OXALIPLATIN DELIVERY

INDIAN DRUGS ◽

10.53879/id.55.11.10978 ◽

2018 ◽

Vol 55 (11) ◽

pp. 74-77

Author(s):

A. S Patil ◽

◽

A. P. Gadad

Keyword(s):

Drug Delivery ◽

Side Effects ◽

Targeted Drug Delivery ◽

Polymeric Nanoparticles ◽

Ph Responsive ◽

In Vitro Drug Release ◽

Dual Responsive ◽

Targeted Drug ◽

Targeted Drug Delivery System

In the present study temperature and pH responsive co-polymer chitosan-g-poly(N-isopropylacrylamide) (CS-g-PNIPAAm) was synthesized, characterized and efficiently loaded with oxaliplatin. Nanoparticles were evaluated for their physicochemical properties. The drug loaded nanoparticles showed smooth and spherical morphology with loading efficiency and drug content of about 80.7% and 48.7%, respectively. The in vitro drug release was significantly higher at tumor extracellular pH and temperature when compared to physiological pH and temperature. In conclusion, the developed nanoparticulate system is an effective dual responsive targeted drug delivery system for oxaliplatin with low toxic side effects.

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Hyaluronic acid-conjugated apoferritin nanocages for lung cancer targeted drug delivery

Biomaterials Science ◽

10.1039/c5bm00067j ◽

2015 ◽

Vol 3 (10) ◽

pp. 1386-1394 ◽

Cited By ~ 34

Author(s):

Yanan Luo ◽

Xuenv Wang ◽

Dan Du ◽

Yuehe Lin

Keyword(s):

Lung Cancer ◽

Drug Delivery ◽

Hyaluronic Acid ◽

Controlled Release ◽

Delivery System ◽

Targeted Drug Delivery ◽

Ph Responsive ◽

Protein Cage ◽

Targeted Drug

In this paper, we proposed a naturally derived protein cage based pH-responsive delivery system for intracellular prodrug controlled release.

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Conjugation of a smart polymer to doxorubicin through a pH-responsive bond for targeted drug delivery and improving drug loading on graphene oxide

RSC Advances ◽

10.1039/d1ra02361f ◽

2021 ◽

Vol 11 (31) ◽

pp. 18809-18817

Author(s):

Ali Bina ◽

Heidar Raissi ◽

Hassan Hashemzadeh ◽

Farzaneh Farzad

Keyword(s):

Drug Delivery ◽

Graphene Oxide ◽

Anticancer Drug ◽

Targeted Drug Delivery ◽

Polymeric Nanoparticles ◽

Drug Loading ◽

Ph Responsive ◽

Smart Polymer ◽

Anticancer Drug Delivery ◽

Targeted Drug

Polymeric nanoparticles have emerged as efficient carriers for anticancer drug delivery because they can improve the solubility of hydrophobic drugs and also can increase the bio-distribution of drugs throughout the bloodstream.

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AS1411 Aptamer and Folic Acid Functionalized pH-Responsive ATRP Fabricated pPEGMA–PCL–pPEGMA Polymeric Nanoparticles for Targeted Drug Delivery in Cancer Therapy

Biomacromolecules ◽

10.1021/bm5001263 ◽

2014 ◽

Vol 15 (5) ◽

pp. 1737-1752 ◽

Cited By ~ 77

Author(s):

Shantanu V. Lale ◽

Aswathy R. G. ◽

Athulya Aravind ◽

D. Sakthi Kumar ◽

Veena Koul

Keyword(s):

Drug Delivery ◽

Folic Acid ◽

Cancer Therapy ◽

Targeted Drug Delivery ◽

Polymeric Nanoparticles ◽

Ph Responsive ◽

Targeted Drug ◽

As1411 Aptamer

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Folic Acid-Terminated Poly(2-Diethyl Amino Ethyl Methacrylate) Brush-Gated Magnetic Mesoporous Nanoparticles as a Smart Drug Delivery System

Polymers ◽

10.3390/polym13010059 ◽

2020 ◽

Vol 13 (1) ◽

pp. 59

Author(s):

Abeer M. Beagan ◽

Ahlam A. Alghamdi ◽

Shatha S. Lahmadi ◽

Majed A. Halwani ◽

Mohammed S. Almeataq ◽

...

Keyword(s):

Drug Delivery ◽

Drug Resistance ◽

Folic Acid ◽

Drug Delivery System ◽

Targeted Drug Delivery ◽

Ph Responsive ◽

Ethyl Methacrylate ◽

Mesoporous Nanoparticles ◽

Targeted Drug ◽

Mcf 7

Currently, chemotherapy is an important method for the treatment of various cancers. Nevertheless, it has many limitations, such as poor tumour selectivity and multi-drug resistance. It is necessary to improve this treatment method by incorporating a targeted drug delivery system aimed to reduce side effects and drug resistance. The present work aims to develop pH-sensitive nanocarriers containing magnetic mesoporous silica nanoparticles (MMSNs) coated with pH-responsive polymers for tumour-targeted drug delivery via the folate receptor. 2-Diethyl amino ethyl methacrylate (DEAEMA) was successfully grafted on MMSNs via surface initiated ARGET atom transfer radical polymerization (ATRP), with an average particle size of 180 nm. The end groups of poly (2-(diethylamino)ethyl methacrylate) (PDEAEMA) brushes were converted to amines, followed by a covalent bond with folic acid (FA) as a targeting agent. FA conjugated to the nanoparticle surface was confirmed by X-ray photoelectron spectroscopy (XPS). pH-Responsive behavior of PDEAEMA brushes was investigated by Dynamic Light Scattering (DLS). The nanoparticles average diameters ranged from ca. 350 nm in basic media to ca. 650 in acidic solution. Multifunctional pH-sensitive magnetic mesoporous nanoparticles were loaded with an anti-cancer drug (Doxorubicin) to investigate their capacity and long-circulation time. In a cumulative release pattern, doxorubicin (DOX) release from nano-systems was ca. 20% when the particle exposed to acidic media, compared to ca. 5% in basic media. The nano-systems have excellent biocompatibility and are minimally toxic when exposed to MCF-7, and -MCF-7 ADR cells.

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β‐Cyclodextrin‐Decorated Carbon Dots Serve as Nanocarriers for Targeted Drug Delivery and Controlled Release

ChemNanoMat ◽

10.1002/cnma.201800528 ◽

2019 ◽

Vol 5 (4) ◽

pp. 479-487 ◽

Cited By ~ 6

Author(s):

Ting Yang ◽

Jing‐Li Huang ◽

Yi‐Ting Wang ◽

An‐Qi Zheng ◽

Yang Shu ◽

...

Keyword(s):

Drug Delivery ◽

Controlled Release ◽

Targeted Drug Delivery ◽

Carbon Dots ◽

Targeted Drug

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Programmable shape-morphing microrobots for localized cancer cells treatment

10.21203/rs.3.rs-198740/v1 ◽

2021 ◽

Author(s):

Chen Xin ◽

Dongdong Jin ◽

Yanlei Hu ◽

Liang Yang ◽

Rui Li ◽

...

Keyword(s):

Drug Delivery ◽

Drug Release ◽

Targeted Drug Delivery ◽

Biological Applications ◽

Proof Of Concept ◽

Ph Responsive ◽

Solution Ph ◽

Shape Morphing ◽

On Demand ◽

Targeted Drug

Abstract Microrobots have attracted great attentions due to their wide applications in microobjects manipulation and targeted drug delivery. To realize more complex micro/nano cargos manipulation (e.g., encapsulation and release) in biological applications, endowing microrobots with shapes adaptability with the environment is highly desirable. Here, designable shape-morphing microrobots (SMMRs) have been developed by programmatically encoding different expansion rate in a pH-responsive hydrogel. Combined with magnetic propelling, the shape-morphing microcrab (SMMC) is capable of performing targeted microparticle delivery, including gripping, transporting, and releasing through claws morphing. As a proof-of-concept demonstration, the shape-morphing microfish (SMMF) is designed to encapsulate drug (doxorubicin (DOX)) by closing mouth in phosphate buffer saline (PBS, pH~7.4) and release them by opening mouth in slightly acid solution (pH<7), which realize localized Hela cells treatment in an artificial vascular network. These SMMRs with powerful shape morphing capabilities and remote motion controllability provide new platforms for complex microcargos operation and on-demand drug release.

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