The Influences of Surface Charge on the Tumor Targeting of Fe3O4 Nanoparticles for MRI

2022 ◽  
Author(s):  
Saisai Yue ◽  
Xin Zhang ◽  
Yuping Xu ◽  
Lichong Zhu ◽  
Junwei Cheng ◽  
...  
Keyword(s):  
Surface Charge ◽  
Fe3o4 Nanoparticles ◽  
Tumor Targeting ◽  
Chemotherapeutic Agents ◽  
Targeting Therapy ◽  
Passive Targeting ◽  
Epr Effect ◽  
Promising Strategy

Nanomedicine based tumor targeting therapy has emerged as a promising strategy to overcome the lack of specificity of conventional chemotherapeutic agents. The “passive” targeting caused by tumor EPR effect and...

scholarly journals Efficacy of Tumor-Targeting Salmonella typhimurium A1-R against Malignancies in Patient-Derived Orthotopic Xenograft (PDOX) Murine Models

Cells ◽  
2019 ◽  
Vol 8 (6) ◽  
pp. 599 ◽  
Author(s):  
Takashi Murakami ◽  
Yukihiko Hiroshima ◽  
Kentaro Miyake ◽  
Tasuku Kiyuna ◽  
Itaru Endo ◽  
...  
Keyword(s):  
Salmonella Typhimurium ◽  
Tumor Targeting ◽  
Malignant Cell ◽  
Chemotherapeutic Agents ◽  
Molecular Targeting ◽  
Murine Models ◽  
Targeting Therapy ◽  
Orthotopic Xenograft ◽  
Molecular Targeting Agents

We developed tumor-targeting Salmonella typhimurium (S. typhimurium) A1-R, a facultative anaerobe that is an auxotroph of leucine and arginine. The tumor-targeting efficacy of S. typhimurium A1-R was demonstrated in vivo and vitro using several malignant cell lines including melanoma, sarcoma, glioma, breast, pancreatic, colon, cervical, prostate, and ovarian cancers. Our laboratory also developed a patient-derived orthotopic xenograft (PDOX) model by implanting patient-derived malignant tumor fragments into orthotopic sites in mice. We reviewed studies of S. typhimurium A1-R against recalcitrant cancers. S. typhimurium A1-R was effective against all PDOX tumor models tested and showed stronger efficacies than chemotherapy or molecular-targeting therapy against some tumors. Furthermore, the synergistic efficacy of S. typhimurium A1-R when combined with chemotherapeutic agents, molecular-targeting agents, or recombinant methioninase was also demonstrated. We suggest potential clinical uses of this S. typhimurium A1-R treatment.

scholarly journals A Glycyrrhetinic Acid-Modified Curcumin Supramolecular Hydrogel for liver tumor targeting therapy

2017 ◽  
Vol 7 (1) ◽  
Author(s):  
Guoqin Chen ◽  
Jinliang Li ◽  
Yanbin Cai ◽  
Jie Zhan ◽  
Jie Gao ◽  
...  
Keyword(s):  
Liver Tumor ◽  
Tumor Targeting ◽  
Glycyrrhetinic Acid ◽  
Supramolecular Hydrogel ◽  
Targeting Therapy

Tumor targeting therapy using peplomycin-conjugated ST433 monoclonal antibody in nude mice

1988 ◽  
Vol 10 ◽  
pp. 30
Author(s):  
K. Shibuya ◽  
T. Someno ◽  
F. Abe ◽  
T. Setoh ◽  
S. Fukushima ◽  
...  
Keyword(s):  
Monoclonal Antibody ◽  
Nude Mice ◽  
Tumor Targeting ◽  
Targeting Therapy

Influence of Dose on Neutrophil-Mediated Delivery of Nanoparticles for Tumor-Targeting Therapy Strategies

2021 ◽  
Vol 22 (3) ◽  
Author(s):  
Min Liu ◽  
Cong Li ◽  
NaYan ◽  
Dan Zhao ◽  
Hongxia Zhang ◽  
...  
Keyword(s):  
Tumor Targeting ◽  
Targeting Therapy ◽  
Therapy Strategies

pH Triggered Doxorubicin Delivery of PEGylated Glycolipid Conjugate Micelles for Tumor Targeting Therapy

2012 ◽  
Vol 9 (9) ◽  
pp. 2469-2478 ◽  
Author(s):  
Fu-Qiang Hu ◽  
Yin-Ying Zhang ◽  
Jian You ◽  
Hong Yuan ◽  
Yong-Zhong Du
Keyword(s):  
Tumor Targeting ◽  
Targeting Therapy ◽  
Doxorubicin Delivery

Recent advancements in brain tumor targeting using magnetic nanoparticles

2020 ◽  
Vol 11 (2) ◽  
pp. 97-112 ◽  
Author(s):  
Himanshu Gandhi ◽  
Abhishek Kumar Sharma ◽  
Shikha Mahant ◽  
Deepak N Kapoor
Keyword(s):  
Gene Therapy ◽  
Brain Tumor ◽  
Magnetic Nanoparticles ◽  
Biomedical Applications ◽  
Tumor Targeting ◽  
Chemotherapeutic Agents ◽  
Diagnostic Systems ◽  
Hyperthermia Treatment ◽  
Recent Developments ◽  
The Brain

Transport of drugs through the blood–brain barrier to the brain and the toxic effects of drugs on the healthy cells can limit the effectiveness of chemotherapeutic agents. In recent years, magnetic nanoparticles (MNPs) have received much attention as targeted therapeutic and diagnostic systems due to their simplicity, ease of preparation and ability to tailor their properties such as their composition, size, surface morphology, etc. for biomedical applications. MNPs are utilized in drug delivery, radio therapeutics, hyperthermia treatment, gene therapy, biotherapeutics and diagnostic imaging. The present review will address the challenges in brain tumor targeting and discuss the application and recent developments in brain tumor targeting using MNPs.

A self-delivery system based on an amphiphilic proapoptotic peptide for tumor targeting therapy

2019 ◽  
Vol 7 (5) ◽  
pp. 778-785 ◽  
Author(s):  
Si Chen ◽  
Jin-Xuan Fan ◽  
Xin-Hua Liu ◽  
Ming-Kang Zhang ◽  
Fan Liu ◽  
...  
Keyword(s):  
Delivery System ◽  
Therapeutic Efficacy ◽  
Tumor Targeting ◽  
Targeting Therapy

A self-delivery system KDH was constructed to realize tumor targeting therapy, and it possessed extraordinary therapeutic efficacy both in vitro and in vivo.

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