Recent advancements in brain tumor targeting using magnetic nanoparticles

2020 ◽  
Vol 11 (2) ◽  
pp. 97-112 ◽  
Author(s):  
Himanshu Gandhi ◽  
Abhishek Kumar Sharma ◽  
Shikha Mahant ◽  
Deepak N Kapoor
Keyword(s):  
Gene Therapy ◽  
Brain Tumor ◽  
Magnetic Nanoparticles ◽  
Biomedical Applications ◽  
Tumor Targeting ◽  
Chemotherapeutic Agents ◽  
Diagnostic Systems ◽  
Hyperthermia Treatment ◽  
Recent Developments ◽  
The Brain

Transport of drugs through the blood–brain barrier to the brain and the toxic effects of drugs on the healthy cells can limit the effectiveness of chemotherapeutic agents. In recent years, magnetic nanoparticles (MNPs) have received much attention as targeted therapeutic and diagnostic systems due to their simplicity, ease of preparation and ability to tailor their properties such as their composition, size, surface morphology, etc. for biomedical applications. MNPs are utilized in drug delivery, radio therapeutics, hyperthermia treatment, gene therapy, biotherapeutics and diagnostic imaging. The present review will address the challenges in brain tumor targeting and discuss the application and recent developments in brain tumor targeting using MNPs.

scholarly journals Shape Anisotropic Iron Oxide-Based Magnetic Nanoparticles: Synthesis and Biomedical Applications

2020 ◽  
Vol 21 (7) ◽  
pp. 2455 ◽  
Author(s):  
Raquel G. D. Andrade ◽  
Sérgio R. S. Veloso ◽  
Elisabete M. S. Castanheira
Keyword(s):  
Iron Oxide ◽  
Magnetic Nanoparticles ◽  
Biomedical Applications ◽  
Finite Size ◽  
Spherical Shape ◽  
Magnetic Behavior ◽  
Ferrite Nanoparticles ◽  
Magnetic Drug Delivery ◽  
Recent Developments ◽  
Synthetic Routes

Research on iron oxide-based magnetic nanoparticles and their clinical use has been, so far, mainly focused on the spherical shape. However, efforts have been made to develop synthetic routes that produce different anisotropic shapes not only in magnetite nanoparticles, but also in other ferrites, as their magnetic behavior and biological activity can be improved by controlling the shape. Ferrite nanoparticles show several properties that arise from finite-size and surface effects, like high magnetization and superparamagnetism, which make them interesting for use in nanomedicine. Herein, we show recent developments on the synthesis of anisotropic ferrite nanoparticles and the importance of shape-dependent properties for biomedical applications, such as magnetic drug delivery, magnetic hyperthermia and magnetic resonance imaging. A brief discussion on toxicity of iron oxide nanoparticles is also included.

Magnetic Nanoparticles: Current Trends and Future Aspects in Diagnostics and Nanomedicine

2019 ◽  
Vol 20 (6) ◽  
pp. 457-472 ◽  
Author(s):  
Naga Veera Srikanth Vallabani ◽  
Sanjay Singh ◽  
Ajay Singh Karakoti
Keyword(s):  
Magnetic Nanoparticles ◽  
Biomedical Applications ◽  
Antimicrobial Agents ◽  
Superparamagnetic Iron Oxide ◽  
Disease Diagnosis ◽  
Imaging Modalities ◽  
Clinical Settings ◽  
Current Trends ◽  
Recent Developments ◽  
Near Future

Background: Biomedical applications of Magnetic Nanoparticles (MNPs) are creating a major impact on disease diagnosis and nanomedicine or a combined platform called theranostics. A significant progress has been made to engineer novel and hybrid MNPs for their multifunctional modalities such as imaging, biosensors, chemotherapeutic or photothermal and antimicrobial agents. MNPs are successfully applied in biomedical applications due to their unique and tunable properties such as superparamagnetism, stability, and biocompatibility. Approval of ferumoxytol (feraheme) for MRI and the fact that several Superparamagnetic Iron Oxide Nanoparticles (SPIONs) are currently undergoing clinical trials have paved a path for future MNPs formulations. Intensive research is being carried out in designing and developing novel nanohybrids for multiple applications in nanomedicine. Objective: The objective of the present review is to summarize recent developments of MNPs in imaging modalities like MRI, CT, PET and PA, biosensors and nanomedicine including their role in targeting and drug delivery. Relevant theory and examples of the use of MNPs in these applications have been cited and discussed to create a thorough understanding of the developments in this field. Conclusion: MNPs have found widespread use as contrast agents in imaging modalities, as tools for bio-sensing, and as therapeutic and theranostics agents. Multiple formulations of MNPs are in clinical testing and may be accepted in clinical settings in near future.

scholarly journals Application of magnetic nanoparticles in biomedicine

2008 ◽  
Vol 7 (2) ◽  
pp. 70-78
Author(s):  
A. G. Pershina ◽  
A. E. Sazonov ◽  
I. V. Milto
Keyword(s):  
Magnetic Resonance Imaging ◽  
Drug Delivery ◽  
Tissue Engineering ◽  
Gene Therapy ◽  
Magnetic Nanoparticles ◽  
Building Blocks ◽  
Resonance Imaging ◽  
Diagnostic Systems ◽  
Hyperthermic Treatment ◽  
Functional Diagnostic

The use of nanomaterials offers many advantages due to their unique properties. They can be used as building blocks for the fabrication of various functional diagnostic systems and agents of therapy. This article focuses on the application of magnetic nanoparticles in biomedicine such as magnetic separation, biosensor, contrast agents for MRI (magnetic resonance imaging), local operated hyperthermic treatment of tumors, drug delivery, gene therapy, tissue engineering.

Magnetic Nanocomplexes for Gene Delivery Applications

2021 ◽  
Author(s):  
Rih-Yang Huang ◽  
Zhuo-Hao Liu ◽  
Wei-Han Weng ◽  
Chien-Wen Chang
Keyword(s):  
Gene Therapy ◽  
Stem Cell ◽  
Magnetic Nanoparticles ◽  
Gene Delivery ◽  
Biomedical Applications ◽  
Gene Editing ◽  
Cell Engineering ◽  
Stem Cell Engineering ◽  
P Gene

Gene delivery is an indispensable technique for various biomedical applications such as gene therapy, stem cell engineering, and gene editing. Recently, magnetic nanoparticles (MNP) have received increasing attention for their...

Lipid Based Nanoparticles: Current Strategies for Brain Tumor Targeting

2019 ◽  
Vol 4 (2) ◽  
pp. 84-100 ◽  
Author(s):  
Bibhash C. Mohanta ◽  
Narahari N. Palei ◽  
Vijayaraj Surendran ◽  
Subas C. Dinda ◽  
Jayaraman Rajangam ◽  
...  
Keyword(s):  
Surface Modification ◽  
Brain Tumor ◽  
Tumor Cells ◽  
Early Stage ◽  
Chemotherapeutic Agents ◽  
Imaging Agent ◽  
Nanostructured Lipid Carrier ◽  
Diagnosis And Therapy ◽  
Tissue Cells ◽  
The Brain

Brain tumors arise from an uncontrolled proliferation of neural tissue cells or supportive glial tissue cells within the brain. The diagnosis and therapy of brain tumor is an extremely challenging task. Moreover, absence of early stage symptoms and consequently delays in diagnosis and therapy worsen its severity. Though in the present days, chemotherapeutic approach is the most common therapeutic approach; still it is linked with several precincts. The blood-brain barrier (BBB) is the main hurdle in delivering most of the chemotherapeutic agents as well as imaging agent that leads to insufficient accumulation of therapeutic / imaging agents at tumor site, and prevents adequate destruction of malignant cells. Recently, lipid based nanoparticles are gaining much more interest and are preferred over polymeric nanoparticles owing to their biodegradability, non-toxicity, excellent tumortargeting ability and ease of surface modification. Certain receptors are over expressed in brain tumor cells which confer an opportunity to the researchers for delivering the chemotherapeutic as well as imaging agent particularly to the tumor cells through the surface modification approach of nanoparticles. Ligands like proteins/peptides, carbohydrates, aptamers, antibodies, and antibody fragments are generally conjugated to the surface of the nanoparticles that bind specifically to an over expressed target on the brain tumor cell surface. In the present review, we discuss the diagnostic and therapeutic application of various types of lipid based nanoparticles such as liposomes, niosomes, solid lipid nanoparticles, nanostructured lipid carrier, lipid nanocapsule, and lipid polymer hybrid nanocarriers along with their various surface modified forms for targeting brain tumor.

Promising approaches in using magnetic nanoparticles in oncology

2011 ◽  
Vol 392 (11) ◽  
Author(s):  
Georgy Mikhaylov ◽  
Olga Vasiljeva
Keyword(s):  
Magnetic Resonance Imaging ◽  
Drug Delivery ◽  
Magnetic Nanoparticles ◽  
Drug Targeting ◽  
Biomedical Applications ◽  
Drug Delivery Systems ◽  
Magnetic Field Gradient ◽  
Chemotherapeutic Agents ◽  
Magnetic Drug Targeting ◽  
Resonance Imaging

Abstract The development of new and effective drug delivery systems for cancer treatment represents one of the significant challenges facing biomedical technology in the last decade. Among the different methods of drug delivery, magnetic drug targeting, by enabling specific delivery of chemotherapeutic agents through the use of magnetic nanoparticles and magnetic field gradient, could be a promising approach. Recently, magnetic nanoparticles have attracted additional attention because of their potential as contrast agents for magnetic resonance imaging and heat mediators for cancer therapy. This review summarizes these approaches in the use of magnetic nanoparticles in biomedical applications and novel methods for their optimization.

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