The thick waxy coat of mycobacteria, a protective layer against antibiotics and the host's immune system
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Tuberculosis, caused by the pathogenic bacterium Mycobacterium tuberculosis (Mtb), is the leading cause of death from an infectious disease, with a mortality rate of over a million people per year. This pathogen's remarkable resilience and infectivity is largely due to its unique waxy cell envelope, 40% of which comprises complex lipids. Therefore, an understanding of the structure and function of the cell wall lipids is of huge indirect clinical significance. This review provides a synopsis of the cell envelope and the major lipids contained within, including structure, biosynthesis and roles in pathogenesis.
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1994 ◽
Vol 22
(2)
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pp. 374-378
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2004 ◽
Vol 55
(1)
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pp. 109-139
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1985 ◽
Vol 1985
(Supplement 2)
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pp. 105-127
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