The prediction of the conformation of membrane proteins from the sequence of amino acids
Keyword(s):
The methods of Chou & Fasman [Biochemistry (1974) 13, 211-222, 222-245] and of Lim [J. Mol. Biol. (1974)88, 857-872, 873-894] for predicting secondary structure from amino acid sequence have been applied to five predominantly helical membrane-associated peptides. The predictions from the method of Lim (1974a,b) are consistent with the experimental observations, whereas those from Chou & Fasman (1974a,b), although not inconsistent with α-helix, favour a β-structure for several very hydrophobic regions. The results may be rationalized in terms of the effect of the solvent on the conformation of a polypeptide.
1979 ◽
Vol 42
(05)
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pp. 1652-1660
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1964 ◽
Vol 42
(6)
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pp. 755-762
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1984 ◽
Vol 53
(11)
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pp. 4083-4090
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1987 ◽
Vol 105
(3)
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pp. 1183-1190
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1963 ◽
Vol 18
(12)
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pp. 1032-1049
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1990 ◽
Vol 55
(3)
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pp. 950-955
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2018 ◽
Vol 123
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pp. 112-118
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