Incorporating covalent and allosteric effects into rate equations: the case of muscle glycogen synthase

2014 ◽  
Vol 462 (3) ◽  
pp. 525-537 ◽  
Author(s):  
Daniel C. Palm ◽  
Johann M. Rohwer ◽  
Jan-Hendrik S. Hofmeyr
Keyword(s):  
Kinetic Parameters ◽  
Equilibrium Constant ◽  
Muscle Glycogen ◽  
Glycogen Synthase ◽  
Covalent Modification ◽  
Rate Equations ◽  
Phosphorylation State ◽  
Kinetics Of

The kinetics of muscle glycogen synthase in different phosphorylation states can be described with the same set of kinetic parameters by an adapted Monod–Wyman–Changeux equation in which covalent modification alters the T/R (taut/relaxed) equilibrium constant, L0. Only L0 depends on the phosphorylation state.

Isolation and characterization of the human muscle glycogen synthase gene

Diabetes ◽  
1995 ◽  
Vol 44 (9) ◽  
pp. 1099-1105 ◽  
Author(s):  
M. Orho ◽  
P. Nikula-Ijas ◽  
C. Schalin-Jantti ◽  
M. A. Permutt ◽  
L. C. Groop
Keyword(s):  
Muscle Glycogen ◽  
Glycogen Synthase ◽  
Human Muscle ◽  
Isolation And Characterization

Influence of medium on alkaline hydrolysis of succinic acid monomethyl and monopropyl esters

1980 ◽  
Vol 45 (11) ◽  
pp. 2873-2882
Author(s):  
Vladislav Holba ◽  
Ján Benko
Keyword(s):  
Succinic Acid ◽  
Kinetic Parameters ◽  
Alkaline Hydrolysis ◽  
Specific Interactions ◽  
Nonaqueous Media ◽  
The Media ◽  
Kinetics Of ◽  
Hydrolysis Of

The kinetics of alkaline hydrolysis of succinic acid monomethyl and monopropyl esters were studied in mixed aqueous-nonaqueous media at various temperatures and ionic strengths. The results of measurements are discussed in terms of electrostatic and specific interactions between the reactants and other components of the reaction mixture. The kinetic parameters in the media under study are related to the influence of the cosolvent on the solvation sphere of the reactants.

Kinetics of temperature-programmed reactivation of a hydrodesulphurization catalyst

1983 ◽  
Vol 48 (12) ◽  
pp. 3340-3355 ◽  
Author(s):  
Pavel Fott ◽  
Pavel Šebesta
Keyword(s):  
Carbon Dioxide ◽  
Thermal Analysis ◽  
Differential Thermal Analysis ◽  
Thin Layer ◽  
Kinetic Parameters ◽  
Diffusion Region ◽  
Reaction Heat ◽  
Gaseous Products ◽  
Temperature Programmed ◽  
Kinetics Of

The kinetic parameters of reactivation of a carbonized hydrodesulphurization (HDS) catalyst by air were evaluated from combined thermogravimetric (TG) and differential thermal analysis (DTA) data. In addition, the gaseous products leaving a temperature-programmed reactor with a thin layer of catalyst were analyzed chromatographically. Two exothermic processes were found to take part in the reactivation, and their kinetics were described by 1st order equations. In the first process (180-400 °C), sulphur in Co and Mo sulphides is oxidized to sulphur dioxide; in the second process (300-540 °C), in which the essential portion of heat is produced, the deposited carbon is oxidized to give predominantly carbon dioxide. If the reaction heat is not removed efficiently enough, ignition of the catalyst takes place, which is associated with a transition to the diffusion region. The application of the obtained kinetic parameters to modelling a temperature-programmed reactivation is illustrated on the case of a single particle.

scholarly journals Kinetic studies on muscle glycogen synthase.

1975 ◽  
Vol 250 (9) ◽  
pp. 3471-3475
Author(s):  
E Salsas ◽  
J Larner
Keyword(s):  
Muscle Glycogen ◽  
Glycogen Synthase ◽  
Kinetic Studies
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