scholarly journals Zebrafish models for functional and toxicological screening of nanoscale drug delivery systems: promoting preclinical applications

2017 ◽  
Vol 37 (3) ◽  
Author(s):  
Keon Yong Lee ◽  
Gun Hyuk Jang ◽  
Cho Hyun Byun ◽  
Minhong Jeun ◽  
Peter C. Searson ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Animal Models ◽  
Drug Delivery Systems ◽  
Small Animal ◽  
Initial Step ◽  
Delivery Systems ◽  
Large Sample Size ◽  
Preclinical Studies ◽  
Organ Specific ◽  
Preclinical Trials

Preclinical screening with animal models is an important initial step in clinical translation of new drug delivery systems. However, establishing efficacy, biodistribution, and biotoxicity of complex, multicomponent systems in small animal models can be expensive and time-consuming. Zebrafish models represent an alternative for preclinical studies for nanoscale drug delivery systems. These models allow easy optical imaging, large sample size, and organ-specific studies, and hence an increasing number of preclinical studies are employing zebrafish models. In this review, we introduce various models and discuss recent studies of nanoscale drug delivery systems in zebrafish models. Also in the end, we proposed a guideline for the preclinical trials to accelerate the progress in this field.

scholarly journals Nanotechnologies for Curcumin: An Ancient Puzzler Meets Modern Solutions

2011 ◽  
Vol 2011 ◽  
pp. 1-8 ◽  
Author(s):  
Shengpeng Wang ◽  
Miao Tan ◽  
Zhangfeng Zhong ◽  
Meiwan Chen ◽  
Yitao Wang
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Skin Diseases ◽  
Curcuma Longa ◽  
Solid Dispersions ◽  
Delivery Systems ◽  
Protective Agent ◽  
Natural Polyphenol ◽  
Preclinical Trials ◽  
High Doses

Curcumin, a low-molecular-weight natural polyphenol mainly found in the plantCurcuma longa(turmeric), is widely used as a food colorant and as a potential protective agent against several chronic diseases including cancer, HIV-infection, neurological, cardiovascular, and skin diseases. Moreover, evidences from long-term use process and preclinical trials have demonstrated low toxicity of curcumin, even at relatively high doses. However, it has been well known that the application of curcumin was limited owing to its water insolubility, instability, and poor bioavailability. For decades, many attempts have been made to compensate for these disadvantages, with the development of improved delivery platforms as the feasible approaches. The past ten years witnessed the encouraging progress in the use of nanoscale drug delivery systems on curcumin such as loading curcumin into liposomes or nanoparticles, forming self-microemulsifying drug delivery systems (SMEDDS), cyclodextrin inclusions, and solid dispersions, as well as the latest reported technologies such as nadodisks and nanotubes. This paper summarizes the recent works on the design and development of nanoscale delivery systems of curcumin, with the goal of harnessing the true difficulties of this multifunctional agent in the clinical arena.

scholarly journals Application of neurotoxin- and pesticide-induced animal models of Parkinson’s disease in the evaluation of new drug delivery systems

2021 ◽  
Vol 72 (1) ◽  
pp. 35-58
Author(s):  
Yaquelyn Casanova ◽  
Sofia Negro ◽  
Emilia Barcia
Keyword(s):  
Parkinson’S Disease ◽  
Drug Delivery ◽  
Parkinson's Disease ◽  
Animal Models ◽  
Drug Delivery Systems ◽  
Unmet Need ◽  
Delivery Systems ◽  
New Drug ◽  
6 Hydroxydopamine ◽  
New Treatments

Abstract Parkinson’s disease (PD) is the second most prevalent neuro-degenerative disease after Alzheimer´s disease. It is characterized by motor symptoms such as akinesia, bradykinesia, tremor, rigidity, and postural abnormalities, due to the loss of nigral dopaminergic neurons and a decrease in the dopa-mine contents of the caudate-putamen structures. To this date, there is no cure for the disease and available treatments are aimed at controlling the symptoms. Therefore, there is an unmet need for new treatments for PD. In the past decades, animal models of PD have been proven to be valuable tools in elucidating the nature of the pathogenic processes involved in the disease, and in designing new pharmacological approaches. Here, we review the use of neurotoxin-induced and pesticide-induced animal models of PD, specifically those induced by rotenone, paraquat, maneb, MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) and 6-OHDA (6-hydroxydopamine), and their application in the development of new drug delivery systems for PD.

Techniques For The Preparation of Tissue Samples Containing Injectable Polymer Microcapsules

1985 ◽  
Vol 43 ◽  
pp. 710-711
Author(s):  
G.E. Visscher ◽  
R. L. Robison ◽  
G. J. Argentieri
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Gastrocnemius Muscle ◽  
Degradation Process ◽  
Delivery Systems ◽  
Tissue Reaction ◽  
Electron Microscopic ◽  
Tissue Samples ◽  
Injectable Polymer ◽  
Microscopic Techniques

The use of various bioerodable polymers as drug delivery systems has gained considerable interest in recent years. Among some of the shapes used as delivery systems are films, rods and microcapsules. The work presented here will deal with the techniques we have utilized for the analysis of the tissue reaction to and actual biodegradation of injectable microcapsules. This work has utilized light microscopic (LM), transmission (TEM) and scanning (SEM) electron microscopic techniques. The design of our studies has utilized methodology that would; 1. best characterize the actual degradation process without artifacts introduced by fixation procedures and 2. allow for reproducible results.In our studies, the gastrocnemius muscle of the rat was chosen as the injection site. Prior to the injection of microcapsules the skin above the sites was shaved and tattooed for later recognition and recovery. 1.0 cc syringes were loaded with the desired quantity of microcapsules and the vehicle (0.5% hydroxypropylmethycellulose) drawn up. The syringes were agitated to suspend the microcapsules in the injection vehicle.

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