Lack of association between miR-218 rs11134527 A>G and Kawasaki disease susceptibility

Kawasaki disease (KD) is a type of disease that includes the development of a fever that lasts at least 5 days and involves the clinical manifestation of multicellular vasculitis. KD has become one of the most common pediatric cardiovascular diseases. Previous studies have reported that miR-218 rs11134527 A>G is associated with susceptibility to various cancer risks. However, there is a lack of evidence regarding the relationship between this polymorphism and KD risk. The present study explored the correlation between the miR-218 rs11134527 A>G polymorphism and the risk of KD. We recruited 532 patients with KD and 623 controls to genotype the miR-218 rs11134527 A>G polymorphism with a TaqMan allelic discrimination assay. Our results illustrated that the miR-218 rs11134527 A>G polymorphism was not associated with KD risk. In an analysis stratified by age, sex, and coronary artery lesions, we found only that the risk of KD was significantly decreased for children older than 5 years (GG vs. AA/AG: adjusted OR = 0.26, 95% CI = 0.07–0.94, P=0.041). The present study demonstrated that the miR-218 rs1113452 A>G polymorphism may have an age-related relationship with KD susceptibility that has not previously been revealed.

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The miRNA-608 rs4919510 G>C polymorphism confers reduce coronary injury of Kawasaki disease in a Southern Chinese population

Bioscience Reports ◽

10.1042/bsr20181660 ◽

2019 ◽

Vol 39 (5) ◽

Author(s):

Yanfei Wang ◽

Zhaoliang Lu ◽

Lanyan Fu ◽

Yaqian Tan ◽

Di Che ◽

...

Keyword(s):

Kawasaki Disease ◽

Systemic Vasculitis ◽

Mucocutaneous Lymph Node Syndrome ◽

Allelic Discrimination Assay ◽

Allelic Discrimination ◽

Taqman Allelic Discrimination ◽

Southern Chinese ◽

Immune Mediated ◽

Single Locus Analysis ◽

The Relationship

Abstract Kawasaki disease (KD) is also called mucocutaneous lymph node syndrome and is an acute febrile pediatric disease characterized by systemic vasculitis. KD typically occurs in children 5 years old or younger and occurs more often in males than in females. miRNA-608 has been reported to interact with interleukin-6 and affect innate immunity. The immune-mediated inflammation could induce the occurrence of KD; however, there is no previous research focused on the relationship between miRNA-608 polymorphism and the KD risk. The present study explored the correlation between the miRNA-608 rs4919510 G>C polymorphism and the risk for KD. We recruited 532 patients with KD and 623 controls to genotype the miRNA-608 rs4919510 G>C polymorphism with a TaqMan allelic discrimination assay. Single-locus analysis showed no significant association between miRNA rs4919510 G>C polymorphism and KD susceptibility. However in an analysis stratified by age, gender, and coronary artery lesion (CAL), we found a relationship between the miRNA-608 rs4919510 G>C polymorphism and KD susceptibility. When KD patients were stratified by coronary injury, the CG/CC genotypes of the miRNA-608 rs4919510 G>C polymorphism contributed to a higher occurrence of KD than that was found in the GG genotype patients (adjusted odds ratio = 0.74, 95% CI = 0.56–0.98, P = 0.033). The present study demonstrated that the miRNA-608 rs4919510 G>C polymorphism may have a CAL-related relationship with KD susceptibility that has not been previously revealed.

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Comparison of High-Resolution Melting Analysis, TaqMan Allelic Discrimination Assay, and Sanger Sequencing for Clopidogrel Efficacy Genotyping in Routine Molecular Diagnostics

Journal of Molecular Diagnostics ◽

10.1016/j.jmoldx.2013.04.005 ◽

2013 ◽

Vol 15 (5) ◽

pp. 600-606 ◽

Cited By ~ 11

Author(s):

Lina Zhang ◽

Guanglin Cui ◽

Zongzhe Li ◽

Haoran Wang ◽

Hu Ding ◽

...

Keyword(s):

High Resolution ◽

Molecular Diagnostics ◽

Sanger Sequencing ◽

High Resolution Melting ◽

High Resolution Melting Analysis ◽

Allelic Discrimination Assay ◽

Allelic Discrimination ◽

Taqman Allelic Discrimination Assay ◽

Taqman Allelic Discrimination ◽

Melting Analysis

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Development of a TaqMan allelic discrimination assay for the distinction of two major subtypes of the grapevine yellows phytoplasma Bois noir

European Journal of Plant Pathology ◽

10.1007/s10658-008-9424-9 ◽

2009 ◽

Vol 124 (3) ◽

pp. 521-526 ◽

Cited By ~ 12

Author(s):

Jennifer Berger ◽

Josef Dalla Via ◽

Sanja Baric

Keyword(s):

Allelic Discrimination Assay ◽

Allelic Discrimination ◽

Bois Noir ◽

Taqman Allelic Discrimination Assay ◽

Taqman Allelic Discrimination ◽

Grapevine Yellows

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Specific TaqMan allelic discrimination assay for rs1477196 and rs9939609 single nucleotide polymorphisms of FTO gene demonstrated that there is no association between these SNPs and risk of breast cancer in Iranian women

Advanced Biomedical Research ◽

10.4103/2277-9175.161532 ◽

2015 ◽

Vol 4 (1) ◽

pp. 136 ◽

Cited By ~ 5

Author(s):

Mansoor Salehi ◽

Mahboobeh Mojaver ◽

Fariborz Mokarian ◽

Mohammad Kazemi

Keyword(s):

Breast Cancer ◽

Single Nucleotide Polymorphisms ◽

Nucleotide Polymorphisms ◽

Iranian Women ◽

Fto Gene ◽

Allelic Discrimination Assay ◽

Allelic Discrimination ◽

Single Nucleotide ◽

Taqman Allelic Discrimination Assay ◽

Taqman Allelic Discrimination

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Association between rs4149056 variant in SLCO1B1 and early discontinuation of statin after acute myocardial infarction

Pharmacogenomics ◽

10.2217/pgs-2019-0109 ◽

2020 ◽

Vol 21 (3) ◽

pp. 163-172

Author(s):

Abdallah Al-Salameh ◽

Nicolas Danchin ◽

Céline Verstuyft ◽

Salma Kotti ◽

Etienne Puymirat ◽

...

Keyword(s):

Myocardial Infarction ◽

Acute Myocardial Infarction ◽

Wild Type Allele ◽

Wild Type ◽

Early Discontinuation ◽

Allelic Discrimination Assay ◽

Allelic Discrimination ◽

Taqman Allelic Discrimination Assay ◽

Taqman Allelic Discrimination ◽

Increased Risk

Data from two French surveys were used to analyze the association between in-hospital statin discontinuation and SLCO1B1 polymorphism (rs4149056) in patients with acute myocardial infarction. Using TaqMan allelic discrimination assay, 1674 and 1708 patients were genotyped for SLCO1B1 in 2005 and 2010, respectively. The association with in-hospital statin discontinuation was assessed after adjusting for confounding factors. In 2005, homozygosity for the reduced-function allele was associated with an increased risk of in-hospital statin discontinuation (OR: 3.68; p = 0.004) compared with the wild-type allele but this association disappeared in 2010. However, statin type and intensity-dose differed significantly between the surveys. SLCO1B1 polymorphism (rs4149056) does not seem to be a major determinant of early ‘in-hospital’ statin discontinuation after acute myocardial infarction.

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Development of a TaqMan Allelic Discrimination Assay for detection of Single Nucleotides Polymorphisms associated with anti-malarial drug resistance

Malaria Journal ◽

10.1186/1475-2875-11-23 ◽

2012 ◽

Vol 11 (1) ◽

Cited By ~ 13

Author(s):

Edwin Kamau ◽

Saba Alemayehu ◽

Karla C Feghali ◽

LaDonna S Tolbert ◽

Bernard Ogutu ◽

...

Keyword(s):

Drug Resistance ◽

Allelic Discrimination Assay ◽

Allelic Discrimination ◽

Taqman Allelic Discrimination Assay ◽

Taqman Allelic Discrimination

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The rs9932581 and rs1049255 Polymorphisms in CYBA is not Associated with Preeclampsia in Chinese Han Women

Cellular Physiology and Biochemistry ◽

10.1159/000447850 ◽

2016 ◽

Vol 39 (4) ◽

pp. 1471-1478 ◽

Cited By ~ 3

Author(s):

Shiguo Liu ◽

Xueying Li ◽

Jingli Wang ◽

Jing Ji ◽

Jingjing Liu ◽

...

Keyword(s):

Genetic Variants ◽

Late Onset ◽

Case Control ◽

Control Model ◽

Chinese Han ◽

Allelic Discrimination ◽

Taqman Allelic Discrimination ◽

Significant Difference ◽

The Relationship ◽

Lines Of Evidence

Background/Aims: Several lines of evidence have been reported that oxidative stress plays an important role in the pathogenesis of Preeclampsia (PE). Therefore, this research is aimed to investigate whether polymorphisms of CYBA are related to susceptibility to PE in Chinese Han women. Methods: We studied the genetic frequency of the rs9932581 and 1049255 polymorphisms in CYBA in 1029 PE patients and 1400 controls of later pregnant women by the TaqMan allelic discrimination real-time PCR and a case-control model. Results: Our research indicated that no significant differences were found for the genotypic or allelic frequencies at the two polymorphic sites in CYBA between PE patients and controls. To further study the relationship between the polymorphic sites and PE, we also found that there is no significant difference in the genetic distributions identified between the mild or severe PE and early or the late-onset PE and controls. Conclusion: The study demonstrated that the genetic variants of rs9932581 and rs1049255 in CYBA might not be associated with PE. However, investigations of genetic variability that influence on the disease outcome are needed in other large prospective populations or regions, so the complicated interconnection of genetic and environmental elements can be emulated for better understanding.

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Association of PECAM-1 Gene Polymorphisms with Kawasaki Disease in Chinese Children

Disease Markers ◽

10.1155/2017/2960502 ◽

2017 ◽

Vol 2017 ◽

pp. 1-6 ◽

Cited By ~ 4

Author(s):

Zhuoying Li ◽

Dong Han ◽

Jie Jiang ◽

Jia Chen ◽

Lang Tian ◽

...

Keyword(s):

Coronary Artery Disease ◽

Coronary Artery ◽

Kawasaki Disease ◽

Gene Polymorphisms ◽

Cell Adhesion Molecule ◽

Systemic Vasculitis ◽

Healthy Children ◽

Coronary Artery Lesions ◽

Artery Disease ◽

The Relationship

Kawasaki disease (KD) is an acute systemic vasculitis complicated by development of coronary artery lesions. PECAM-1 is a kind of cell adhesion molecule, which plays an important role in coronary artery disease. The relationship between PECAM-1 gene polymorphisms and their susceptibility to Kawasaki diseases (KD) is still unclear. In our study, we examined the PECAM-1 gene polymorphisms in 44 KD patients and 59 healthy children and revealed the correlation of PECAM-1 gene polymorphisms in KD children with and without coronary artery lesions (CAL).

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CD40Gene Polymorphisms Associated with Susceptibility and Coronary Artery Lesions of Kawasaki Disease in the Taiwanese Population

The Scientific World JOURNAL ◽

10.1100/2012/520865 ◽

2012 ◽

Vol 2012 ◽

pp. 1-5 ◽

Cited By ~ 20

Author(s):

Ho-Chang Kuo ◽

Mei-Chyn Chao ◽

Yu-Wen Hsu ◽

Ying-Chi Lin ◽

Ying-Hsien Huang ◽

...

Keyword(s):

Coronary Artery ◽

Kawasaki Disease ◽

Systemic Vasculitis ◽

Recessive Model ◽

Unknown Etiology ◽

Nucleotide Polymorphisms ◽

Taiwanese Population ◽

Allelic Discrimination Assay ◽

Allelic Discrimination ◽

First Time

Background. Kawasaki disease (KD) is characterized by systemic vasculitis of unknown etiology. Our previous studies showed expression ofCD40ligand on CD4+ T cells correlated to the coronary artery lesion (CAL) and disease progress in KD. Other studies from Japan suggested the role ofCD40Lin the pathogenesis of CAL, and this might help explain the excessive number of males affected with KD but cannot be reproduced by Taiwanese population. This study was conducted to investigate theCD40polymorphism in KD and CAL formation.Methods. A total of 950 subjects (381 KD patients and 569 controls) were investigated to identify 2 tagging single-nucleotide polymorphisms (tSNPs) ofCD40(rs4810485 and rs1535045) by using the TaqMan allelic discrimination assay.Results. A significant association was noted with regards toCD40tSNPs (rs1535045) between controls and KD patients (P=0.0405, dominant model). In KD patients, polymorphisms ofCD40(rs4810485) showed significant association with CAL formation (P=0.0436, recessive model). Haplotype analysis did not yield more significant results between polymorphisms ofCD40and susceptibility/disease activity of KD.Conclusions. This study showed for the first time that polymorphisms ofCD40are associated with susceptibility to KD and CAL formation, in the Taiwanese population.

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