A universal mechanism for fumarate reduction

2002 ◽  
Vol 30 (3) ◽  
pp. A51-A51
Author(s):  
Graeme A. Reid ◽  
Christopher G. Mowat ◽  
Caroline S. Miles ◽  
Kate Pankhurst ◽  
Malcolm D. Walkinshaw ◽  
...  
Keyword(s):  
Fumarate Reduction ◽  
Universal Mechanism

DYNAMICS OF BARLEY FLAVONOID AND PRODUCTIVITY UNDER UF-A RADIATION

1970 ◽  
pp. 14-18
Author(s):  
L. I. Goncharova ◽  
P. N. Tsygvintsev ◽  
О. А. Guseva
Keyword(s):  
Grain Yield ◽  
Defense Mechanisms ◽  
Antioxidant Defense ◽  
Malonic Dialdehyde ◽  
Growth Period ◽  
Negative Effects ◽  
Uv Spectrum ◽  
Quantum Energy ◽  
Dry Soil ◽  
Universal Mechanism

The effect of increased UV-A radiation during the ontogeny of barley plants of the Vladimir variety in the vegetation experiment was studied. Changes in the content of malonic dialdehyde, flavonoids and grain yield were revealed. UV-A radiation as compared to UV-B radiation, has lower quantum energy and can have both positive and negative effects on plant regulatory and photosynthetic processes. One of the most damaging effects of increased levels of UV-A radiation is oxidative stress, which causes lipid peroxidation of biological membranes. The existence of a plant cell in such conditions is possible only thanks to a system of antioxidant defense mechanisms. The accumulation of phenolic compounds under the action of UV radiation is a universal mechanism of protection against photodamage, which was formed in the early stages of the evolution of photoautotrophic organisms. Flavonoids are localized in the epidermis of plant tissues and act as an internal filter. The content of flavonoids is determined by the genotype and due to ontogenetic patterns. Plants were grown in a greenhouse, in vessels containing 4.5 kg of air-dry soil. The repetition is threefold (3 vessels in each variant). Sowing density - 13 plants in each vessel. As a source of UV-A radiation used lamps Black Light BLUE company Philips. Plants were irradiated for 5 hours a day from 10 to 15 hours at 13, 25, 34, 43 and 52 stages of organogenesis. The magnitude of the daily biologically effective dose of UV-A radiation was 60.7 kJ / m2. The solar part of the UV spectrum in the vegetation experiment was absent in the greenhouse. The nature of changes in the content of flavonoids under the action of UV-A irradiation during the growing season of plants with the dynamics of the oxidative process has been established. The first maximum was observed during the vegetative growth period, the second - at the earing stage. The data obtained indicate that flavonoids have ontogenetic conditionality and perform photoprotective functions. The increase in their content under the action of UV-A radiation is accompanied by an increase in resistance to photodamage, which is confirmed by the formation of grain yield.

scholarly journals PARALLEL COMPUTATIONS AND CO-SIMULATION IN UNIVERSAL MECHANISM SOFTWARE. PART I: ALGORITHMS AND IMPLEMENTATION

2019 ◽  
Vol 14 (3) ◽  
pp. 163-175
Author(s):  
Dmitry POGORELOV ◽  
Alexander RODIKOV ◽  
Roman KOVALEV
Keyword(s):  
Parallel Computations ◽  
Universal Mechanism

scholarly journals “Regulatory Sandboxes” in Russia: New Horizons and Challenges

2020 ◽  
Vol 1 (2) ◽  
pp. 17-27
Author(s):  
Damir R. Salikhov
Keyword(s):  
Artificial Intelligence ◽  
Real Life ◽  
Federal Law ◽  
Digital Innovation ◽  
New Horizons ◽  
The Third ◽  
Special Mechanism ◽  
Life Model ◽  
The Government ◽  
Universal Mechanism

“Regulatory sandboxes” are regarded as a special mechanism for setting up experimental regulation in the area of digital innovation (especially in financial technologies), creating a special regime for a limited number of participants and for a limited time.Russiahas its own method of experimental regulation, which is not typical but may be helpful for other jurisdictions. There are three approaches to legal experiments (including digital innovations) inRussia. The first approach is accepting special regulation on different issues. There are recent examples of special laws (e.g. Federal Law on the experiment with artificial intelligence technologies inMoscow). An alternative to this option is establishing experimental regulation by an act of the Government if legislation does not prohibit it (e.g. labeling with means of identification). The second approach deals only with Fintech innovations and provides a special mechanism to pilot models of innovative financial technologies. The participants of such a “sandbox” may create a close-to-life model in order to estimate the effects and risks. If the model works fine, the regulation may be amended. The third approach works with creating a universal mechanism of real-life experiments in the sphere of digital innovations based on the special Federal Law and the specific decision of the Government of theRussian Federationor the Bank of Russia in the financial sphere. The author compares the three approaches and their implementation within the framework of Russian legislation and practice and concludes that this experience may be used by developing countries with inflexible regulation, in order to facilitate the development of digital innovations.

Malate Metabolism by Desulfovibrio gigas and its Link to Sulfate and Fumarate Reduction: Purification of the Malic Enzyme and Detection of NAD(P)+ Transhydrogenase Activity

Anaerobe ◽  
1995 ◽  
Vol 1 (4) ◽  
pp. 227-235 ◽  
Author(s):  
Liang Chen ◽  
Jean LeGall ◽  
Paula Fareleira ◽  
Helena Santos ◽  
António V. Xavier
Keyword(s):  
Malic Enzyme ◽  
Desulfovibrio Gigas ◽  
Fumarate Reduction ◽  
Malate Metabolism

scholarly journals Selective protein unfolding: a universal mechanism of action for the development of irreversible inhibitors

2018 ◽  
Vol 54 (14) ◽  
pp. 1738-1741 ◽  
Author(s):  
Samuel Askin ◽  
Thomas E. H. Bond ◽  
Alanna E. Sorenson ◽  
Morgane J. J. Moreau ◽  
Helma Antony ◽  
...  
Keyword(s):  
High Throughput ◽  
Mechanism Of Action ◽  
Protein Unfolding ◽  
Enzyme Inhibitors ◽  
Irreversible Inhibitors ◽  
Differential Scanning Fluorimetry ◽  
Universal Mechanism

Selective protein unfolding was combined with high-throughput differential scanning fluorimetry of GFP-tagged proteins for the identification of irreversible enzyme inhibitors.

Molecule which changed the view on skin treatment

2021 ◽  
pp. 44-55
Author(s):  
L.Ya. Fedorich
Keyword(s):  
Retinoic Acid ◽  
Nuclear Receptors ◽  
Mechanism Of Action ◽  
Molecular Mechanisms ◽  
Local Treatment ◽  
Mechanisms Of Action ◽  
Clinical Effects ◽  
Topical Retinoids ◽  
Acne Therapy ◽  
Universal Mechanism

Objective — to study the modern classification, mechanisms of action and clinical effects of vitamin A derivatives, to analyze retinoid for local treatment of various dermatoses with a universal mechanism of action at the epidermis and dermis levels. Materials and methods. A review of the literature and an analysis of the results of international clinical trials of drugs based on the natural retinoid of the first generation — tretinoin (retinoic acid) is presented. The works of dozens of authors since 1980s to the present day are analyzed. Most sources provide detailed information on the results of topical retinoids in acne therapy, which are the base of clinical guidelines. Long-term (6 months or more) studies of retinoic acid-based preparations carried out in recent decades have discovered the unique clinical effects of tretinoin in the treatment of skin photoaging, actinic keratosis, etc. They are achieved due to the effect of tretinoid on the nuclear receptors of keratinocytes and fibroblasts. Results and discussion. The molecular mechanisms of action of retinoic acid, realizing the cellular and tissue effects of the most studied retinoid, are systematized and grouped in a single review. It has been proven that a unique feature of tretinin is its ability to activate directly all subtypes of RARs- and, indirectly, RARs-nuclear receptors of skin cells. A new modern drug for external use is presented — AltrenoТМ lotion containing micronized 0.05 % tretinoin in combination with sodium hyaluronate, soluble collagen and glycerin. This combination exhibits the expected clinical efficacy in acne therapy and prevents side effects such as dryness, redness and exfoliation. AltrenoТМ is approved for use in children of 9 years of age and older. Conclusions. Tretinoin (retinoic acid) is a modern powerful retinoid with a universal mechanism of action, recommended for the treatment of acne.

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