Metalloregulatory proteins and nitric oxide signalling in bacteria

2008 ◽  
Vol 36 (6) ◽  
pp. 1160-1164 ◽  
Author(s):  
Stephen Spiro
Keyword(s):  
Nitric Oxide ◽  
Transition Metal ◽  
Present Article ◽  
Binding Sites ◽  
Bacterial Gene ◽  
Recent Developments ◽  
Metalloregulatory Proteins ◽  
Metal Cofactors ◽  
Small Ligands

Bacterial gene regulators containing transition metal cofactors that function as binding sites for small ligands were first described in the 1990s. Since then, numerous metal-containing regulators have been discovered, and our knowledge of the diversity of proteins, their cofactors and the signals that they sense has greatly increased. The present article reviews recent developments, with a particular focus on bacterial sensors of nitric oxide.

scholarly journals Metallochaperones and metalloregulation in bacteria

2017 ◽  
Vol 61 (2) ◽  
pp. 177-200 ◽  
Author(s):  
Daiana A. Capdevila ◽  
Katherine A. Edmonds ◽  
David P. Giedroc
Keyword(s):  
Transition Metal ◽  
Active Site ◽  
Adaptive Response ◽  
Bacterial Infections ◽  
Transcriptional Regulators ◽  
Essential Metals ◽  
Metalloregulatory Proteins ◽  
Metal Cofactors ◽  
Structural Mechanisms ◽  
Metal Sensing

Bacterial transition metal homoeostasis or simply ‘metallostasis’ describes the process by which cells control the intracellular availability of functionally required metal cofactors, from manganese (Mn) to zinc (Zn), avoiding both metal deprivation and toxicity. Metallostasis is an emerging aspect of the vertebrate host–pathogen interface that is defined by a ‘tug-of-war’ for biologically essential metals and provides the motivation for much recent work in this area. The host employs a number of strategies to starve the microbial pathogen of essential metals, while for others attempts to limit bacterial infections by leveraging highly competitive metals. Bacteria must be capable of adapting to these efforts to remodel the transition metal landscape and employ highly specialized metal sensing transcriptional regulators, termed metalloregulatory proteins,and metallochaperones, that allocate metals to specific destinations, to mediate this adaptive response. In this essay, we discuss recent progress in our understanding of the structural mechanisms and metal specificity of this adaptive response, focusing on energy-requiring metallochaperones that play roles in the metallocofactor active site assembly in metalloenzymes and metallosensors, which govern the systems-level response to metal limitation and intoxication.

Reactions of secondary propargylamines with heteroallenes for the synthesis of diverse heterocycles

2018 ◽  
Vol 47 (11) ◽  
pp. 3861-3898 ◽  
Author(s):  
Vsevolod A. Peshkov ◽  
Olga P. Pereshivko ◽  
Anton A. Nechaev ◽  
Anatoly A. Peshkov ◽  
Erik V. Van der Eycken
Keyword(s):  
Transition Metal ◽  
Recent Developments ◽  
Transition Metal Catalyzed ◽  
Metal Catalyzed

This focused review aims to summarize recent developments in the processes involving additions of secondary propargylamines to various heteroallenes and subsequent transition metal-catalyzed or electrophile-mediated cyclizations.

scholarly journals Recent Developments in Polyene Cyclizations and Their Applications in Natural Product Synthesis

Synthesis ◽  
2018 ◽  
Vol 51 (01) ◽  
pp. 67-82 ◽  
Author(s):  
Anthony Barrett ◽  
Tsz-Kan Ma ◽  
Thomas Mies
Keyword(s):  
Transition Metal ◽  
Natural Product ◽  
Lewis Acid ◽  
Multiple Bond ◽  
Natural Product Synthesis ◽  
Cyclization Reactions ◽  
Cascade Cyclizations ◽  
Highly Efficient ◽  
Recent Developments ◽  
Radical Cascade

Cascade polyene cyclization reactions are highly efficient and elegant bioinspired transformations that involve simultaneous multiple bond constructions to rapidly generate complex polycyclic molecules. This review summarizes the most prominent work on a variety of cationic and radical cascade cyclizations and their applications in natural product synthesis published between 2014 and 2018.1 Introduction2 Cationic Polyene Cyclizations2.1 Lewis Acid Mediated Polyene Cyclizations2.2 Brønsted Acid Mediated Polyene Cyclizations2.3 Halogen Electrophile Initiated Polyene Cyclizations2.4 Sulfur Electrophile Initiated Polyene Cyclizations2.5 Transition-Metal-Mediated Cationic Polyene Cyclizations3 Radical Polyene Cyclizations3.1 Transition-Metal-Mediated Radical Polyene Cyclizations3.2 Photocatalyst-Mediated Polyene Cyclizations4 Origin of Stereocontrol in Polyene Cyclizations5 Conclusion

Recent developments in the chemistry of low-coordinated organophosphorus compounds

2005 ◽  
Vol 77 (12) ◽  
pp. 2011-2020 ◽  
Author(s):  
Masaaki Yoshifuji
Keyword(s):  
Transition Metal ◽  
Coordination Number ◽  
Organophosphorus Compounds ◽  
Metal Catalysts ◽  
Transition Metal Catalysts ◽  
Coupling Reactions ◽  
Recent Developments

Sterically protected organophosphorus compounds are described, involving diphosphenes, phosphaethenes, diphosphinidenecyclobutenes (DPCBs), phosphaalkynes, phosphaquinones, diphosphathienoquinones, and so on of coordination number 2 or 1. Application of the DPCBs as well as phosphinophosphaethenes as a ligand of transition-metal catalysts for several organic coupling reactions has been investigated.

Calcium-Binding Sites of Calmodulin and Electron Transfer by Inducible Nitric Oxide Synthase†

Biochemistry ◽  
2005 ◽  
Vol 44 (20) ◽  
pp. 7593-7601 ◽  
Author(s):  
Irena Gribovskaja ◽  
Kaleb C. Brownlow ◽  
Sam J. Dennis ◽  
Andrew J. Rosko ◽  
Michael A. Marletta ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Electron Transfer ◽  
Nitric Oxide Synthase ◽  
Inducible Nitric Oxide Synthase ◽  
Binding Sites ◽  
Calcium Binding ◽  
Calcium Binding Sites ◽  
Oxide Synthase ◽  
Inducible Nitric Oxide

scholarly journals Fabrication of Transition-metal (Zn, Mn, Cu)-based MOFs as Efficient Sensor Materials for Detection of H2 Gas by Clad Modified Fiber Optic Gas Sensor Technique

2021 ◽  
Author(s):  
M Nagoor Meeran ◽  
S.P. Saravanan ◽  
H.H Hegazy
Keyword(s):  
Transition Metal ◽  
Fiber Optic ◽  
Gas Sensing ◽  
High Sensitivity ◽  
Long Term Stability ◽  
Sensing Material ◽  
Sensor Technique ◽  
Recent Developments ◽  
Metal Organic ◽  
Elevated Surface

Abstract Recent research demonstrate that promising gas sensing materials are called metal-organic structures (MOFs) and their products due to their tunable form, elevated surface area, and extremely porous structure and physisorption towards gases with relatively low temperature.In this report, recent developments in transition-metal (Zn, Mn, Cu)-based MOFs and their derivatives are synthesized as sensing materials. The sensors samples were analyzed by XRD, SEM, TEM, BET and XPS in order to know the textural, structural and electronic state of the samples. Fiber optic clad modified sensors were fabricated and tested gas sensing properties towards H2 gas with various concentrations (0-1000 ppm). Among the three sensing material, Zn doped MOFs sensor showed outstanding selectivity with high sensitivity (115 counts/kpa) towards H2 gas. Moreover, it has shown high response (20 s) and recovery time (27 s) as well as long term stability. The designed sensors may be required to apply to the production of an outstanding sensor for H2 for commercial uses.

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