Human Erythrocyte Glutathione Reductase and Glucose 6-Phosphate Dehydrogenase Activities in Normal Subjects and in Persons Exposed to Lead

1. Blood lead and erythrocyte glutathione reductase (GSSG-R) and glucose 6-phosphate dehydrogenase (G6P-D) activities were measured in normal subjects and in those with occupational exposure to lead. 2. With increasing blood lead concentration, GSSG-R activity increases and that of G6P-D decreases. 3. It is suggested that these changes represent part of a compensatory mechanism to overcome the reduction of sulphydryl groups by lead ions.

Download Full-text

Purification of human erythrocyte glucose 6-phosphate dehydrogenase and glutathione reductase enzymes using 2′,5′-ADP Sepharose 4B affinity column material in single chromatographic step

Protein Expression and Purification ◽

10.1016/j.pep.2003.11.017 ◽

2004 ◽

Vol 34 (2) ◽

pp. 257-260 ◽

Cited By ~ 7

Author(s):

Mustafa Erat

Keyword(s):

Glutathione Reductase ◽

Human Erythrocyte ◽

Affinity Column ◽

Column Material ◽

Glucose 6 Phosphate Dehydrogenase ◽

Sepharose 4B

Download Full-text

Relationship between Blood Lead Concentration and Neurobehavioral Function of Children

Korean Journal of Occupational and Environmental Medicine ◽

10.35371/kjoem.2009.21.2.131 ◽

2009 ◽

Vol 21 (2) ◽

pp. 131

Author(s):

Kwang Seub Park ◽

Jae Yong Park ◽

Joon Sakong

Keyword(s):

Lead Concentration ◽

Blood Lead ◽

Blood Lead Concentration ◽

Neurobehavioral Function

Download Full-text

Response to comments on “What is the meaning of non-linear dose-response relationships between blood lead concentration and IQ?”

NeuroToxicology ◽

10.1016/j.neuro.2006.09.008 ◽

2006 ◽

Vol 27 (6) ◽

pp. 1123 ◽

Cited By ~ 1

Author(s):

Teresa S. Bowers ◽

Barbara D. Beck

Keyword(s):

Dose Response ◽

Lead Concentration ◽

Blood Lead ◽

Blood Lead Concentration ◽

Linear Dose ◽

Non Linear

Download Full-text

Study of the Heavy Metals in Fume of Buckshot, Blood Lead Concentration and Self-Rated Health Status of National Clay Shooting Athletes

The Korean Journal of Sports Medicine ◽

10.5763/kjsm.2018.36.2.84 ◽

2018 ◽

Vol 36 (2) ◽

pp. 84 ◽

Cited By ~ 1

Author(s):

Hong-Jae Chun ◽

Sang-Min Nam ◽

In-Ho Cho

Keyword(s):

Heavy Metals ◽

Health Status ◽

Lead Concentration ◽

Blood Lead ◽

Blood Lead Concentration ◽

Self Rated Health

Download Full-text

The effect of copper on human erythrocyte glutathione reductase

International Journal of Biochemistry ◽

10.1016/0020-711x(74)90029-9 ◽

1974 ◽

Vol 5 (7-8) ◽

pp. 649-653 ◽

Cited By ~ 5

Author(s):

J.P. Flikweert ◽

R.K.J. Hoorn ◽

G.E.J. Staal

Keyword(s):

Glutathione Reductase ◽

Human Erythrocyte ◽

Effect Of Copper

Download Full-text

Screening for Lead Poisoning: Measurements and Methodology

PEDIATRICS ◽

10.1542/peds.52.2.303 ◽

1973 ◽

Vol 52 (2) ◽

pp. 303-304

Author(s):

Gordon D. McLaren ◽

William F. Barthel ◽

Philip Landrigan

Keyword(s):

Lead Poisoning ◽

Lead Concentration ◽

Blood Lead ◽

Blood Lead Concentration ◽

Extensive Experience

Piomelli et al.1 have presented an extensive experience in comparison of free erythrocyte porphyrin (FEP) levels with blood lead concentrations. Their finding that an FEP ≥ 250µg/100 ml RBC was invariably associated with a blood lead concentration ≥ 6Oµg/100 ml is consistent with data obtained in our laboratory2 using a somewhat different microfluorometric method for FEP determination.3 We must, however, take issue with the conclusion of Piomelli et al.1 that only FEP levels above 250µg/100 ml RBC should be considered "positive."

Download Full-text

Isoniazid acetylating phenotype in patients with paracoccidioidomycosis and its relationship with serum sulfadoxin levels, glucose-6-phosphate dehydrogenase and glutathione reductase activities

Revista da Sociedade Brasileira de Medicina Tropical ◽

10.1590/s0037-86821991000200008 ◽

1991 ◽

Vol 24 (2) ◽

pp. 111-114 ◽

Cited By ~ 1

Author(s):

Benedito Barraviera ◽

Paulo Câmara Marques Pereira ◽

Jussara Marcondes Machado ◽

Maria Julia de Souza ◽

Carlos Roberto G. Lima ◽

...

Keyword(s):

Glutathione Reductase ◽

Reductase Activity ◽

Serum Levels ◽

Slow Acetylators ◽

Slow Acetylator ◽

A Value ◽

Acti Vity ◽

Glutathione Reductase Activity ◽

Glutathione Reductase Deficiency ◽

Glucose 6 Phosphate Dehydrogenase

The authors evaluated the isoniazid acetylating phenotype and measured hematocrit, hemoglobin, glucose-6-phosphate dehydrogenase and glutathione reductase activities plus serum sulfadoxin levels in 39 patients with paracoccidioidomycosis (33 males and 6 females) aged 17 to 58 years. Twenty one (53.84%) of the patients presented a slow acetylatingphenotype and 18(46.16%) a fast acetylating phenotype. Glucose-6-phosphate- dehydrogenase (G6PD) acti vity was decreased in 5(23.80%) slow acetylators and in 4(22.22%) fast acetylators. Glutathione reductase activity was decreased in 14 (66.66%) slow acetylators and in 12 (66.66%) fast acetylators. Serum levels of free and total sulfadoxin Were higher in slow acetylator (p < 0.02). Analysis of the resultspermitted us to conclude that serum sulfadoxin levels are related to the acetylatorphenotype. Furthermore, sulfadoxin levels were always above 50 µg/ml, a value considered therapeutic. Glutathione reductase deficiency observed in 66% of patients may be related to the intestinal malabsorption of nutrients, among them riboflavin, a FAD precursor vitamin, inpatients with paracoceidioidomycosis.

Download Full-text

Part III. The Respiratory Regulation in Psychotic Subjects

Journal of Mental Science ◽

10.1192/bjp.74.306.443 ◽

1928 ◽

Vol 74 (306) ◽

pp. 443-453 ◽

Cited By ~ 18

Author(s):

F. Golla ◽

S. A. Mann ◽

F. Golla ◽

R. G. B. Marsh

Keyword(s):

Organic Acid ◽

Acid Production ◽

Normal Subjects ◽

Compensatory Mechanism ◽

Acid Base ◽

Organic Acid Production ◽

Respiratory Regulation ◽

Acid Base Equilibrium ◽

Buffering Power ◽

Respiratory Centre

The preceding studies on the acid-base equilibrium in psychotics have made it evident that the failure to adjust must be attributed in the first instance to an inadequacy of the respiratory compensatory mechanism, and can be in no sense attributable to either a deficiency in the buffering power of the blood itself or to an increased organic acid production (acidosis). We have endeavoured to determine the excitability of the respiratory centre to the stimulus created by CO2. For this purpose a number of psychotic patients were tested as to the excitability of the respiratory centre to air containing 2% CO2 and the reaction compared with that obtaining in a number of normal subjects.

Download Full-text