Double-Blind Comparison of Minoxidil and Hydrallazine in Severe Hypertension

1976 ◽  
Vol 51 (s3) ◽  
pp. 593s-595s ◽  
Author(s):  
G. Connor ◽  
R. L. Wilburn ◽  
C. M. Bennett

1. Thirty moderately severely hypertensive patients were studied in a double-blind comparison of minoxidil and hydrallazine in combination with frusemide and propranolol. 2. Blood pressure control in both groups of patients was satisfactory but long-term control appeared to be better in the minoxidil group. 3. Renal function was well preserved in both groups. Evidence of cardiac hypertrophy was slow to resolve despite good control of blood pressure. Side effects were negligible, and patient acceptance and rehabilitation was excellent.

1976 ◽  
Vol 51 (s3) ◽  
pp. 513s-515s
Author(s):  
L. Hansson ◽  
B. E. Karlberg ◽  
H. Åberg ◽  
A. Westerlund ◽  
N. C. Henningsen ◽  
...  

1. Atenolol (ICI 66.082, Tenormin) is a new β-adrenoreceptor-blocking agent, devoid of intrinsic sympathomimetic and membrane-stabilizing properties. It does not cross the blood—brain barrier. 2. Atenolol given to hypertensive patients in initial open trials reduced arterial blood pressure significantly. 3. A double-blind comparison between atenolol and placebo in forty-five patients with essential hypertension demonstrated that atenolol gave a statistically significant reduction of blood pressure (Δ 28/15 mmHg, P < 0·005). 4. The optimum anti-hypertensive dose of atenolol in patients with mild to moderately severe essential hypertension was 200 mg daily. 5. Atenolol was compared with propranolol in thirty patients with essential hypertension. No statistically significant differences of anti-hypertensive effect were observed between the two drugs. 6. Long-term results (up to 2 years) in 117 hypertensive patients indicate that drug tolerance is good. No serious toxic effects were observed. 7. In four of twelve hypertensive patients with obstructive airways disease atenolol had to be withdrawn owing to deterioration of ventilatory function.


2020 ◽  
Vol 35 (Supplement_3) ◽  
Author(s):  
Jiwon Jung ◽  
Joo Hoon Lee ◽  
Kun suk Kim ◽  
Young Seo Park

Abstract Background and Aims Renovascular disease is rare but important treatable cause of secondary hypertension in children. We aimed to evaluate the clinical presentations and long-term outcomes of pediatric patients with renovascular hypertension (RVH). Method We retrospectively reviewed medical records of patients with renovascular disease at our center between 1994 and 2019. Clinical courses including status of hypertension control with preservation of renal function during follow up were evaluated. Results 20 patients were diagnosed with RVH. 50 % (n = 10) were male, and median age at diagnosis was 10.1 (range 1.3 – 17.2) years, and median follow up period was 8.7 (range 0.1 – 24.6) years. 50 % (n = 10) presented with incidently detected high blood pressure (8 patients without symptoms, one with headache, and the other one with proteinuria), 25 % (n = 5) first admitted due to heart failure symptoms, and the rest (25 %, n = 5) presented with neurologic symptoms including seizure or paraplegia. Majority had no underlying disease except for 3 patients with Moyamoya disease. 80 % (n = 16) had unilateral renovascular stenosis. All patients showed elevated basal random renin activity (median 20.0, range 2.5 – 62.1 ng/ml/hr), and 45 % (n = 9) patients showed elevated basal random aldosterone level (median 822, range 266 – 2440 pg/ml). All patients needed antihypertensive medications for blood pressure control; 35 % (n = 7) of patients gained good control of blood pressure only with antihypertensive agents including angiotensin converting enzyme inhibitor/angiotensin receptor blocker (ACEI/ARB), 40 % (n = 8) of patients who underwent percutaneous transluminal angioplasty all still needed antihypertensive agents including ACEI for blood pressure control. 20 % (n = 4) of the patients initially showed profoundly low relative function of involved kidney on diuretic scan, leading to nephrectomy. Three of these patients with nephrectomy successfully discontinued all antihypertensive agent gaining good control of blood pressure. The remaining one patient showed progressive deterioration of relative function on the involved side of kidney during 13 years, ended up with nephrectomy, but couldn’t discontinue ACEI. Glomerular filtration rate (GFR) was within normal range for all patients at diagnosis. For patients without nephrectomy, mean relative function of the involved kidney on diuretic scan was 33.5 ± 11.4 % at diagnosis. There was no significant change or deterioration of relative renal function during a mean follow up period of 10 ± 8 (median 11.5, range 0 – 19.5) years, although they all used ACEI/ARB. All patients including patients with nephrectomy showed normal GFR with a mean of 114.1 ± 19.5 ml/min/1.73 m2 at the last follow up. Conclusion Antihypertensive medications including ACEI and ARB were safely used with no further deterioration of the renal function of the involved side with or without angioplasty. Pediatric RVH is well managed with preserved renal function in long-term follow up.


Medicine ◽  
2016 ◽  
Vol 95 (20) ◽  
pp. e3572 ◽  
Author(s):  
Yu Ting Li ◽  
Harry H.X. Wang ◽  
Kirin Q.L. Liu ◽  
Gabrielle K.Y. Lee ◽  
Wai Man Chan ◽  
...  

2019 ◽  
Vol 21 (8) ◽  
pp. 1124-1131 ◽  
Author(s):  
Maria E. Marketou ◽  
Spyros Maragkoudakis ◽  
Kostantinos Fragiadakis ◽  
John Konstantinou ◽  
Alexandros Patrianakos ◽  
...  

Hypertension ◽  
2015 ◽  
Vol 66 (1) ◽  
pp. 37-43 ◽  
Author(s):  
Linsay McCallum ◽  
Jeemon Panniyammakal ◽  
Claire E. Hastie ◽  
Jonathan Hewitt ◽  
Rajan Patel ◽  
...  

2013 ◽  
pp. 19-26
Author(s):  
S. Lenti ◽  
G. Nuzzi ◽  
A. Urselli ◽  
P. Corradini ◽  
R. Bagnardi ◽  
...  

AIM OF THE STUDY The EDAPA Project (Education of self-measurement of blood pressure) was conceived to train hypertensive patients in self blood pressure monitoring (SBPM) and to survey their feedback, including patient’ assessment, by recording their related cardiovascular diseases (CVD risks factors) and lifestyle habits. METHODS The project was conducted during the year 2006. Initially we met Grottaglie’s citizens and illustrated to participants the importance of SBPM at home in the overall management of hypertension, that might lead to a better control of BP and cardiovascular outcomes. After explaining the correct technique for SBPM, we distributed semiautomatic devices (OMRON M6) and asked the participants to fill in the Hypertension Questionnaire Form and to record their own blood pressure values in a diary. RESULTS Among almost 3,000 citizens interviewed, 370 (198 M, 172 F; mean age: 60 years) agreed to take part in our study. They were hypertensive for almost 10 years, but waited 3 years before beginning therapy. They measured BP 4 times a month and, in the same sitting, 66% of them carried out only 1 measurement, 29% of them 2 measurements and only 2.5% carried out 3 measurements. Taking as reference BP value of 135/85 mmHg, we registered 28% of the population as normotensive and the remaining 72% as hypertensive. Among the hypertensives, 30% showed a good control, 55% showed a bad one and the remaining 15% was not aware of being hypertensive. Adding non-treated hypertensives to those treated but not controlled, we noticed that 70% of the participants was not properly controlled. Regarding risk factors, almost 64% showed hypercholesterolemia; 18% were smokers; 35% of males and 28% of females showed hyperglicemia and 63% of the latter had a waist line > 88 cm; 32% used to consume alcohol (46% males and 15% females); 26% had a metabolic syndrome; 13% was affected by vascular brain injuries, 30% by peripheral artheriopaty, 35% had heart diseases, 10% was nephropatic and 13% diabetic. CONCLUSIONS By this project we evidenced that, with simple devices and low costs, it is possible to make people understand the importance of self-measurement for a more practical management of the illness, for the follow-up of the BP values and to verify the efficiency of the treatment. A more active and direct role of hypertensive patients in their own medical care could reasonably bring a reduction of expenses in long-term management of the disease, a reduction of inappropriate shifts of therapy and, as seen, an increased reliability of the self-measured pressure values.


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