Bone Mineral Content of the Lumbar Spine in Normal and Osteoporotic Women: Cross-Sectional and Longitudinal Studies

1. Bone mineral content of the second, third and fourth lumbar vertebrae was determined in normal women and women with clinical osteoporosis by using dual-photon (153Gd) absorptiometry. 2. A cross-sectional study of 70 normal women (aged 19–88 years) showed a bone loss of 44% from the age of around 34 years throughout life. 3. Longitudinal data from 59 normal women confirmed that the vertebral bone loss started before the menopause. An accelerated bone loss amounting to nearly 6% per year was seen immediately after the menopause. The bone loss of older women was slower. 4. Mean lumbar bone mineral content of 36 women (aged 48–93 years) with recent fractures of their femoral neck after minor trauma equalled that of age-matched normal women. Lumbar bone mineral content of the women with intratrochanteric femoral neck fractures was lower than that of the women with medial femoral neck fractures. 5. Mean lumbar bone mineral content of 72 women (aged 58–89 years) with primary osteoporosis was 41% lower than that of normal premenopausal women and 18% lower than that of age-matched controls. A weak inverse relationship between lumbar bone mineral content and the number of compression fractures was found. A weak inverse relationship between lumbar bone mineral content and the number of compression fractures was found. 6. Women with lumbar bone mineral content values below the 95% confidence limits for normal premenopausal women are at risk of future vertebral compression fractures, the fracture risk being inversely related to lumbar bone mineral content.

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Physical Exercise as Prophylaxis against Involutional Vertebral Bone Loss: A Controlled Trial

Clinical Science ◽

10.1042/cs0640541 ◽

1983 ◽

Vol 64 (5) ◽

pp. 541-546 ◽

Cited By ~ 292

Author(s):

Bjørn Krølner ◽

Birte Toft ◽

Stig Pors Nielsen ◽

Erik Tøndevold

Keyword(s):

Lumbar Spine ◽

Bone Loss ◽

Physical Exercise ◽

Bone Mineral Content ◽

Bone Mineral ◽

Mineral Content ◽

Controlled Trial ◽

Exercise Group ◽

Control Group ◽

Normal Women

1. The skeletal effects of physical training were studied in a controlled trial involving 31 healthy women (aged 50–73 years) with previous Colles' fracture of the forearm. The bone mineral content of the lumbar spine and both distal forearms was measured by dual-photon (153Gd) absorptiometry. 2. The participants were allocated to either a physical exercise group or a control group. The former group followed a standardized exercise programme, exercising for 1 h twice weekly during 8 months. 3. Twenty-seven women completed the study. Lumbar spine bone mineral content of the exercise group increased by 3.5%, whereas that of the control group decreased by 2.7%. The rate of bone loss in the control group equalled that of age-matched normal women. 4. The changes in forearm bone mineral content appeared to be independent of the exercise. The bone mineral content of the previously fractured forearm remained nearly unchanged. The bone mineral content of the uninjured forearm decreased on average by 3.5%. 5. The data suggest that physical exercise can inhibit or reverse the involutional bone loss from the lumbar vertebrae in normal women. Physical exercise may prevent spinal osteoporosis.

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Bone mineral content and fixation strength of femoral neck fractures: A cadaver study

Acta Orthopaedica Scandinavica ◽

10.3109/17453679408995426 ◽

1994 ◽

Vol 65 (2) ◽

pp. 161-165 ◽

Cited By ~ 30

Author(s):

Åke Sjöstedt ◽

Carl Zetterberg ◽

Tommy Hansson ◽

Erik Hult ◽

Lars Ekström

Keyword(s):

Femoral Neck ◽

Bone Mineral Content ◽

Bone Mineral ◽

Mineral Content ◽

Cadaver Study ◽

Femoral Neck Fractures ◽

Fixation Strength

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Association of HIVEP3 Gene and Lnc RNA with Femoral Neck Bone Mineral Content and Hip Geometry by Genome-Wide Association Analysis in Chinese People

International Journal of Endocrinology ◽

10.1155/2020/6929073 ◽

2020 ◽

Vol 2020 ◽

pp. 1-8

Author(s):

Weiwei Hu ◽

Jinwei He ◽

Luyue Qi ◽

Chun Wang ◽

Hua Yue ◽

...

Keyword(s):

Femoral Neck ◽

Bone Mineral Content ◽

Bone Mineral ◽

Mineral Content ◽

Geometric Parameters ◽

Hip Geometry ◽

Cross Sectional ◽

Pathogenic Genes ◽

Genome Wide ◽

Enhancer Binding Protein

Purpose. GWAS has successfully located and analyzed the pathogenic genes of osteoporosis. Genetic studies have found that heritability of BMD is 50%–85% while the other half is caused by hip geometric parameters and tissue horizontal characteristics. This study was designed to study the GWAS of osteoporosis in Shanghai Han population. Methods. We collected 1224 unrelated healthy young men (20–40 years old), young women (20–40 years old), and postmenopausal women (over 50 years old) who lived in Shanghai. BMD and hip geometric parameters were measured by dual-energy X-ray absorptiometry. The genomic DNA of peripheral blood was extracted and analyzed by using Illumina Human Asian Screening Array-24 + v 1.0 (ASA) gene chip. Statistical analysis was carried out to evaluate the relationship between these SNPs and BMD and hip geometric parameters. Results. A total of 1155 subjects were included. We found that one SNP rs35282355 located in the human immunodeficiency virus type 1 enhancer-binding protein 3 gene (HIVEP3) and another 25 SNPs located in LINC RNA were significantly correlated with bone mineral content (BMC) in the femoral neck ( P = 2.30 × 10−9, P < 5 × 10−8). We also found that the correlation between SNP rs35282355 and cross-sectional area (CSA) of hip geometry was a significant marginal statistical difference ( P = 5.95 × 10−8). Conclusions. Through this study, we found that HIVEP3 gene and LINC RNA are potentially correlated with femoral neck BMC. These results provide important information for us to further understand the etiology and genetic pathogenesis of osteoporosis. In the future, we will expand the sample size to verify these loci and carry out molecular research.

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Cross Sectional and Longitudinal Study of Bone Mineral Content of the Distal Forearm in Adult Premenopausal Women

Hormone and Metabolic Research ◽

10.1055/s-2007-1003647 ◽

1991 ◽

Vol 23 (04) ◽

pp. 185-187 ◽

Cited By ~ 6

Author(s):

J. Wishart ◽

M. Horowitz ◽

M. Cochran ◽

A. Need ◽

B. Chatterton ◽

...

Keyword(s):

Longitudinal Study ◽

Bone Mineral Content ◽

Bone Mineral ◽

Mineral Content ◽

Premenopausal Women ◽

Distal Forearm ◽

Cross Sectional

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Longitudinal study of bone loss after thyroidectomy and suppressive thyroxine therapy in premenopausal women

Acta Endocrinologica ◽

10.1530/acta.0.1260238 ◽

1992 ◽

Vol 126 (3) ◽

pp. 238-242 ◽

Cited By ~ 45

Author(s):

Giulio Pioli ◽

Mario Pedrazzoni ◽

Ernesto Palummeri ◽

Mario Sianesi ◽

Roberto Del Frate ◽

...

Keyword(s):

Bone Loss ◽

Bone Mineral Content ◽

Bone Mineral ◽

Mineral Content ◽

Premenopausal Women ◽

Subtotal Thyroidectomy ◽

Suppressive Therapy ◽

Control Group ◽

Thyroxine Therapy ◽

Rate Of Bone Loss

The effects of suppressive doses of L-thyroxine on the appendicular and axial bone mineral content were followed for 12–36 months after total or subtotal thyroidectomy in 15 premenopausal women. Compared to age-matched controls, these patients had a more marked bone loss of the spinal bone mineral content (2.6±1.9% vs 0.2±1.2% per year). The changes in radial cortical bone density were not significantly different from the control group. We conclude that when a suppressive therapy with L-thyroxine is necessary the rate of bone loss should be monitored at regular intervals.

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The Positive Relationship between Moderate-to-Vigorous Physical Activity and Bone Mineral Content Is Not Mediated by Free Leptin Index in Prepubertal Children: The PANIC Study

International Journal of Environmental Research and Public Health ◽

10.3390/ijerph18105365 ◽

2021 ◽

Vol 18 (10) ◽

pp. 5365

Author(s):

Annie M. Constable ◽

Josie E. Porter ◽

Danielle Benger ◽

Dimitris Vlachopoulos ◽

Alan R. Barker ◽

...

Keyword(s):

Physical Activity ◽

Bone Mineral Content ◽

Bone Mineral ◽

Mineral Content ◽

Vigorous Physical Activity ◽

Normal Weight ◽

Cross Sectional ◽

Prepubertal Children ◽

Total Body ◽

The Relationship

Purpose: Moderate-to-vigorous physical activity (MVPA) positively influences bone mineral content (BMC) in prepubertal children, but it is unknown whether this relationship is partially mediated by free leptin index. The aim of this study was to examine whether the relationship between MVPA and total body less head (TBLH) BMC is mediated or moderated by free leptin index in prepubertal children. Methods: We performed a cross-sectional analysis on 401 children (194 girls) from baseline examinations of the Physical Activity and Nutrition in Childhood Study. We applied the four-way decomposition mediation analysis method to assess whether free leptin index, measured from fasted blood samples, mediated the relationship between accelerometer-measured MVPA and TBLH BMC measured by dual-energy X-ray absorptiometry. Results: MVPA had a positive controlled direct effect on TBLH BMC in girls and boys (β = 0.010 to 0.011, p < 0.05). There was no mediation or interaction between MVPA, free leptin index and TBLH BMC in girls or boys (β = −0.000 to 0.001, p > 0.05). Conclusion: Our study indicates that MVPA positively influences TBLH BMC through pathways not related to free leptin index in predominantly normal-weight prepubertal children, likely primarily through mechanical loading. The relationships between MVPA, free leptin index and TBLH BMC may be influenced by other factors such as pubertal status and adiposity, so it is unknown whether these observations extend to overweight and obese children at different stages of puberty.

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Divergent Significance of Bone Mineral Density Changes in Aging Depending on Sites and Sex Revealed through Separate Analyses of Bone Mineral Content and Area

Journal of Osteoporosis ◽

10.1155/2012/642486 ◽

2012 ◽

Vol 2012 ◽

pp. 1-6 ◽

Cited By ~ 1

Author(s):

Yasumoto Matsui ◽

Marie Takemura ◽

Atsushi Harada ◽

Fujiko Ando ◽

Hiroshi Shimokata

Keyword(s):

Bone Mineral Density ◽

Lumbar Spine ◽

Femoral Neck ◽

Bone Mineral Content ◽

Bone Mineral ◽

Mineral Content ◽

Neck Region ◽

Community Dwelling ◽

Mineral Density ◽

Area Change

Bone mineral density (aBMD) is equivalent to bone mineral content (BMC) divided by area. We rechecked the significance of aBMD changes in aging by examining BMC and area separately. Subjects were 1167 community-dwelling Japanese men and women, aged 40–79 years. ABMDs of femoral neck and lumbar spine were assessed by DXA twice, at 6-year intervals. The change rates of BMC and area, as well as aBMD, were calculated and described separately by the age stratum and by sex. In the femoral neck region, aBMDs were significantly decreased in all age strata by an increase in area as well as BMC loss in the same pattern in both sexes. In the lumbar spine region, aBMDs decreased until the age of 60 in women, caused by the significant BMC decrease accompanying the small area change. Very differently in men, aBMDs increased after their 50s due to BMC increase, accompanied by an area increase. Separate analyses of BMC and area change revealed that the significance of aBMD changes in aging was very divergent among sites and between sexes. This may explain in part the dissociation of aBMD change and bone strength, suggesting that we should be more cautious when interpreting the meaning of aBMD change.

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