Effect of interleukin-4 on pro-inflammatory cytokine production and the acute phase response in healthy individuals and in patients with cancer or multiple organ failure

1998 ◽  
Vol 95 (3) ◽  
pp. 347 ◽  
Author(s):  
Stephen J. WIGMORE ◽  
Jean P. MAINGAY ◽  
Kenneth C.H. FEARON ◽  
Michael G. O’RIORDAIN ◽  
James A. ROSS
Keyword(s):  
Multiple Organ Failure ◽  
Organ Failure ◽  
Acute Phase Response ◽  
Inflammatory Cytokine ◽  
Cytokine Production ◽  
Multiple Organ ◽  
Interleukin 4 ◽  
Healthy Individuals ◽  
Inflammatory Cytokine Production ◽  
Patients With Cancer

Effect of interleukin-4 on pro-inflammatory cytokine production and the acute phase response in healthy individuals and in patients with cancer or multiple organ failure

1998 ◽  
Vol 95 (3) ◽  
pp. 347-354 ◽  
Author(s):  
Stephen J. WIGMORE ◽  
Jean P. MAINGAY ◽  
Kenneth C. H. FEARON ◽  
Michael G. O'RIORDAIN ◽  
James A. ROSS
Keyword(s):  
Acute Phase ◽  
Acute Phase Response ◽  
Inflammatory Cytokine ◽  
Cytokine Production ◽  
Acute Phase Proteins ◽  
Disease Model ◽  
Multiple Organ ◽  
Interleukin 4 ◽  
Healthy Individuals ◽  
Inflammatory Cytokine Production

1.This study investigates whether previously documented effects of interleukin-4 in down-regulating pro-inflammatory cytokine production by peripheral blood mononuclear cells (PBMCs) from healthy individuals would be reproducible in PBMCs isolated from patients with multiple organ failure (acute disease model) and gastrointestinal cancer (chronic disease model). The effects of interleukin-4 on the ability of PBMC supernatants to elicit an acute phase protein response from isolated human hepatocytes were also studied. 2.Incubation of PBMCs with interleukin-4 significantly reduced both spontaneous and lipopolysaccharide-induced production of tumour necrosis factor and lipopolysaccharide-induced interleukin-6 production, demonstrating that the PBMCs from patients with acute and chronic disease are not refractory to the effects of interleukin-4. The effects of interleukin-4 on the ability of PBMCs from the groups studied to elicit an acute phase response were complex and varied both between patient groups and individual acute phase proteins. Overall, interleukin-4 reduced the potential of PBMCs to stimulate production of the positive acute phase proteins C-reactive protein, α1-antichymotrypsin and α1-acid glycoprotein. 3.This work emphasizes the pleiotropic nature of cytokines and the complex regulatory mechanisms which exist. The study illustrates the difficulties in devising in vivo intervention strategies using cytokines such as interleukin-4.

Oncologists’ and Intensivists’ Attitudes Toward the Care of Critically Ill Patients with Cancer

2017 ◽  
Vol 34 (10) ◽  
pp. 811-817 ◽  
Author(s):  
Antonio Paulo Nassar ◽  
Aldo Lourenço Abadde Dettino ◽  
Cristina Prata Amendola ◽  
Rodrigo Alves dos Santos ◽  
Daniel Neves Forte ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Pancreatic Cancer ◽  
Multiple Organ Failure ◽  
Organ Failure ◽  
Critically Ill ◽  
Critically Ill Patients ◽  
Life Support ◽  
Multiple Organ ◽  
Patients With Cancer ◽  
Support Measures

Background: Patients with cancer represent an important proportion of intensive care unit (ICU) admissions. Oncologists and intensivists have distinct knowledge backgrounds, and conflicts about the appropriate management of these patients may emerge. Methods: We surveyed oncologists and intensivists at 2 academic cancer centers regarding their management of 2 hypothetical patients with different cancer types (metastatic pancreatic cancer and metastatic breast cancer with positive receptors for estrogen, progesterone, and HER-2) who develop septic shock and multiple organ failure. Results: Sixty intensivists and 46 oncologists responded to the survey. Oncologists and intensivists similarly favored withdrawal of life support measures for the patient with pancreatic cancer (33/46 [72%] vs 48/60 [80%], P = .45). On the other hand, intensivists favored more withdrawal of life support measures for the patient with breast cancer compared to oncologists (32/59 [54%] vs 9/44 [21%], P < .001). In the multinomial logistic regression, the oncology specialists were more likely to advocate for a full-code status for the patient with breast cancer (OR = 5.931; CI 95%, 1.762-19.956; P = .004). Conclusions: Oncologists and intensivists share different views regarding life support measures in critically ill patients with cancer. Oncologists tend to focus on the cancer characteristics, whereas intensivists focus on multiple organ failure when weighing in on the same decisions. Regular meetings between oncologists and intensivists may reduce possible conflicts regarding the critical care of patients with cancer.

Early Cytokine Production Risk Stratifies Trauma Patients for Multiple Organ Failure

2009 ◽  
Vol 209 (3) ◽  
pp. 320-331 ◽  
Author(s):  
Kenneth M. Jastrow ◽  
Ernest A. Gonzalez ◽  
Mary F. McGuire ◽  
James W. Suliburk ◽  
Rosemary A. Kozar ◽  
...  
Keyword(s):  
Multiple Organ Failure ◽  
Organ Failure ◽  
Cytokine Production ◽  
Multiple Organ ◽  
Trauma Patients ◽  
Production Risk

Hemoperfusion plus continuous veno-venous hemofiltration in the treatment of patients with multiple organ failure after wasp stings

2019 ◽  
Vol 43 (3) ◽  
pp. 143-149
Author(s):  
Li Li ◽  
Wang Bo ◽  
Huang Chen ◽  
Liu XiaoWei ◽  
Liu Hongbao ◽  
...  
Keyword(s):  
Multiple Organ Failure ◽  
Organ Failure ◽  
Interleukin 10 ◽  
Simplified Acute Physiology Score ◽  
Multiple Organ ◽  
Interleukin 4 ◽  
Clinical Effects ◽  
Wasp Sting ◽  
Hemodynamic Variables ◽  
Wasp Stings

Purpose: This study aimed to evaluate the clinical effects of hemoperfusion plus continuous veno-venous hemofiltration in the treatment of patients with multiple organ failure after wasp stings and investigate its impacts on cytokines. Methods: A total of 12 patients with multiple organ failure after wasp stings admitted to Xijing Hospital were included in the present study between January 2017 and January 2019. All patients received hemoperfusion plus continuous veno-venous hemofiltration treatment in addition to conventional treatment after admission. Procedure of treatment was conducted as the following: hemoperfusion (2 h/day) and followed by continuous veno-venous hemofiltration (22 h/day) for at least 5 days. Patients’ clinical features, serum laboratory tests, and hemodynamic variables were monitored. The blood samples were taken to measure the changes of plasma cytokines. Results: All 12 patients survived in the observation period. After hemoperfusion plus continuous veno-venous hemofiltration treatment, there were significant improvements in indicators of liver function, renal function, state of consciousness, and mediators in blood circulation, including alanine transaminase, aspartate transaminase, creatine kinase, blood urea nitrogen, serum creatinine, myoglobin, C-reactive protein, and so on. In these patients, acid–base metabolism returned to normal levels; Acute Physiology and Chronic Health Evaluation II score, Simplified Acute Physiology Score II score, and Sequential Organ Failure Assessment score lowered markedly. Furthermore, the plasma levels of interleukin 1β, interleukin 4, interleukin 6, interleukin 8, and interleukin 10 in these patients were significantly decreased; no significant change was shown in the level of tumor necrosis factor α. Conclusion: Our results revealed that hemoperfusion plus continuous veno-venous hemofiltration was effective in the management of patients with multiple organ failure after wasp sting via the non-specific removal of the wasp venom and inflammatory cytokines.

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