A Prospective Longitudinal Study of Phonological Development in Late Talkers

2003 ◽  
Vol 34 (2) ◽  
pp. 138-153 ◽  
Author(s):  
A. Lynn Williams ◽  
Mary Elbert
Keyword(s):  
Late Onset ◽  
Free Play ◽  
Phonological Development ◽  
Prospective Longitudinal Study ◽  
Error Patterns ◽  
Late Talkers ◽  
Qualitative Variables ◽  
The Individual ◽  
Prospective Longitudinal

Purpose: This study involved prospective longitudinal data on 5 late talkers to provide information about the course of phonological development in order to identify possible predictors of delayed versus deviant development. Method: Five children (3 boys, 2 girls) were identified as late talkers and divided into a younger group and an older group. Each child was followed monthly for 10 to 12 months (22–33 months for the younger group and 30–42 months for the older group). Two types of monthly language samples (free play and elicited) were obtained to describe the individual courses of phonological development for each child. Independent and relational analyses were completed at each age to describe word-initial and word-final phonetic inventories, syllable structure, syllable diversity, percentage of consonants correct (PCC), sound variability, and error patterns. Results: The results indicated that 3 of the children resolved their late onset of speech by 33 to 35 months of age. In addition to quantitative factors, (e.g., limited phonetic inventory, lower PCC, and more sound errors), qualitative variables (e.g., atypical error patterns, greater sound variability, and slower rate of resolution) also were identified as potential markers of long-term phonological delay. Clinical Implications: This study provides information to clinicians so they can identify those children who are less likely to resolve their late onset of phonological development without direct intervention. Procedures are described for assessing early linguistic behaviors that incorporate independent and relational analyses on more extensive speech samples (elicited and free play). From these analyses, clinicians can examine quantitative and qualitative variables to differentiate phonological delay from deviance.

A Prospective Longitudinal Study of Language Development in Late Talkers

1994 ◽  
Vol 37 (4) ◽  
pp. 852-867 ◽  
Author(s):  
Susan Ellis Weismer ◽  
Jamie Murray-Branch ◽  
Jon F. Miller
Keyword(s):  
Language Development ◽  
Late Onset ◽  
Expressive Language ◽  
Language Outcomes ◽  
Prospective Longitudinal Study ◽  
Late Talkers ◽  
Late Talker ◽  
Prospective Assessment ◽  
Language Assessments ◽  
Prospective Longitudinal

This longitudinal investigation charted the course of cognitive and language development from the prelinguistic period to multiword productions in 19 typically developing (TD) toddlers and 4 toddlers who were subsequently identified as having late onset of expressive language. Assessments were conducted at 3-month intervals over a 21-month period, with 12 months of prospective assessment data comparing the TD and late talker (LT) subjects (mean CA: 13 to 25 months) and 9 months of follow-up data (mean CA: 25–34 months) on the 4 subjects who were identified as late talkers at age 2. Three different developmental profiles were identified, and predictors of expressive language outcomes for the LT subjects were evaluated.

scholarly journals Chikungunya Virus-associated Long-term Arthralgia: A 36-month Prospective Longitudinal Study

2013 ◽  
Vol 7 (3) ◽  
pp. e2137 ◽  
Author(s):  
Clémentine Schilte ◽  
Frédérik Staikovsky ◽  
Thérèse Couderc ◽  
Yoann Madec ◽  
Florence Carpentier ◽  
...  
Keyword(s):  
Longitudinal Study ◽  
Chikungunya Virus ◽  
Prospective Longitudinal Study ◽  
Prospective Longitudinal

scholarly journals MON-307 Prospective, Longitudinal Study of Glucose-Suppressed GH Levels in 87 Acromegaly Patients with IGF-1 Normalization After Surgical Therapy: Prognostic Value of Nadir GH Levels for Long-Term Remission or Recurrence

2020 ◽  
Vol 4 (Supplement_1) ◽  
Author(s):  
Pamela Freda ◽  
Jeffrey N Bruce ◽  
Carlos Reyes-Vidal ◽  
Yessica De Leon ◽  
Zhezhen Jin ◽  
...  
Keyword(s):  
Healthy Subjects ◽  
Prognostic Value ◽  
Relevant Information ◽  
Oral Glucose ◽  
Surgical Removal ◽  
Prospective Longitudinal Study ◽  
Normal Ranges ◽  
Prospective Longitudinal

Abstract Surgical removal of the GH-secreting tumor is the initial treatment of choice for acromegaly. Outcome of surgery is assessed by measuring IGF-1 and glucose-suppressed GH levels. IGF-1 normalization is an essential biochemical criterion for remission. The cut-off for nadir GH after oral glucose that signifies remission, however, is debated. It also remains unclear whether GH levels provide additional prognostic or clinically relevant information when IGF-1 results are definitive. To address this question, we examined how initial postoperative glucose-suppressed GH levels change over time on serial testing in patients who achieve initial remission as defined by IGF-1 normalization. We studied 87 acromegaly patients (48M, 39F) who achieved a normal IGF-1 level after surgery alone longitudinally from 1996 to 2019. All had GH measured before and 60, 90 and 120 minutes after 75 or 100 mg oral glucose (OGTT) at ≥ 3 months after surgery and GH and IGF-1 repeated ≥ 1 year later. GH was by measured by sensitive, 22KDa GH specific assays, either a IRMA (DSL, International Reference Standard (IRS) 88/624) or a chemiluminescence immunoassay (IDS-iSYS, IRS 98/574). OGTT Nadir GH levels were also measured in healthy subjects; n=46 (26 M, 20 F, ages 19-71 yr.) by DSL and n=46 (29 M, 17 F; ages 20-66 yr.) by IDS-iSYS. Nadir GH levels in acromegaly patients were compared to the 95%CI of healthy subjects’ mean and categorized relative to healthy subjects’ 97.5 percentile, which was 0.14 µg/L for both assays. IGF-1 levels were compared to age and gender adjusted normal ranges. Subjects were grouped based on initial nadir GH ≤ or > 0.14 µg/L and the patterns of change in nadir GH and IGF-1 at last follow up or until IGF-1 became elevated (i.e. recurrence). Follow up durations are given as median(range). In follow up, 73 patients remained in remission (normal IGF-1) and 14 had a recurrence (elevated IGF-1). Of the 73 in remission, 55 had initial nadir GH ≤ 0.14 µg/L that persisted to 10 yr.(1-22yr.) of follow up, 5 had initial GH ≤ 0.14 µg/L that rose to > 0.14 µg/L by 9(3-21)yr., 10 had GH > 0.14 µg/L that persisted at 5.5(2-22)yr., and 3 had GH > 0.14 µg/L that fell to ≤ 0.14 µg/L at 5(4-7)yr. of follow up. Of the 14 that recurred, 11 had an initial and persistent GH > 0.14 µg/L and developed an elevated IGF-1 level after 6(1-23) yr.. The 3 other patients that recurred had an initial GH ≤ 0.14 µg/L that rose to > 0.14 µg/L by 1-6 years later and subsequently developed an elevated IGF-1 level by 14-16 years of follow up. In summary, we found that the pattern of normal IGF-1 along with nadir GH > 0.14 µg/L on initial testing or developing with time, was associated with recurrence in 14/32 patients. We also found that initial nadir GH ≤ 0.14 µg/L was highly predictive of long-term persistent remission: 60/63 such patients remained in remission. In conclusion, glucose-suppressed GH levels are of prognostic value in acromegaly patients with normal IGF-1 after surgery.

Homelessness and Immigrants: In Front of the Border Between Spain and France

2017 ◽  
Vol 41 (S1) ◽  
pp. S621-S621
Author(s):  
F. Calvo ◽  
C. Giralt ◽  
C. Xavier
Keyword(s):  
Total Population ◽  
Homeless People ◽  
Data Bases ◽  
Prospective Longitudinal Study ◽  
Qualitative Variables ◽  
Competing Interest ◽  
Autochthonous Population ◽  
Prospective Longitudinal ◽  
Official Records

IntroductionIn 2006, prior to the worldwide economic crisis which especially affected Western countries, Southern Spain was one of the illegal immigrant gateways from Africa into Europe. The aim of this study is to establish the rate of homeless immigrants in a cohort of 2006 and carry out a follow up until 2015 in order to explore the chronicity associated to the territory.MethodsSample: 949 persons experiencing homelessness in Girona, according to official records. Procedure: prospective longitudinal study of the total population of homeless people in Girona. In 2006, a list was made of all the homeless people detected by both specialised and nonspecialised teams, which have been followed until the present day. Instruments: data bases of different official teams. Statistical analysis: measures of central tendency and dispersion and contingency tables were used for the comparison of qualitative variables.ResultsOverall, 64.8% of the population of Girona are immigrants (n = 614), principally from the Maghreb, (χ2 = 36.9, df = 4, P < .001) and 333 (36.3%) are autochthonous. The percentage of homeless immigrants in relation to the total immigrant population was 4.4%. Comparing the homeless autochthonous population with the total of the autochthonous population, homelessness among autochthonous population was 0.4%.ConclusionsThe results suggest that homelessness was more incidental in the immigrant group than in the autochthonous group. The percentage of immigrants who still live in homeless conditions suggests that immigration is a risk factor in the chronicity of the problem.Disclosure of interestThe authors have not supplied their declaration of competing interest.

The Berkeley Girls with ADHD Longitudinal Study

2016 ◽  
Author(s):  
Elizabeth B. Owens ◽  
Christine A. Zalecki ◽  
Stephen P. Hinshaw
Keyword(s):  
Longitudinal Study ◽  
Recruitment Strategy ◽  
Term Outcome ◽  
Prospective Longitudinal Study ◽  
Long Term Outcome ◽  
Health Significance ◽  
Matched Comparison ◽  
Prospective Longitudinal ◽  
Girls With Adhd

We describe the initiation and evolution of the Berkeley Girls with ADHD Longitudinal Study, an ongoing prospective, longitudinal study of 140 girls diagnosed with ADHD when they were children during the late 1990s, as well as 88 matched comparison girls. Study rationale, design, procedures, recruitment strategy, and measures are described in detail. Primary psychosocial and neuropsychological findings during childhood, adolescence, and adulthood are summarized. Our initial findings regarding predictors of outcome are presented. Results are discussed in light of the existing literature regarding long-term outcome among children with ADHD. Overall, during childhood, adolescence, and young adulthood, in almost every psychosocial and neuropsychological domain we investigated, females with ADHD show sizable disadvantages and deficits relative to females without ADHD. Our findings affirm the public health significance of ADHD in girls, given the likelihood of persisting symptoms and (especially) impairment in crucial domains over the long-term.

Laparoscopic Versus Open Ileo-Colonic Resection in Crohn’s Disease: Short- and Long-Term Results from a Prospective Longitudinal Study

2007 ◽  
Vol 12 (6) ◽  
pp. 1094-1102 ◽  
Author(s):  
Giuseppe S. Sica ◽  
Edoardo Iaculli ◽  
Domenico Benavoli ◽  
Livia Biancone ◽  
Emma Calabrese ◽  
...  
Keyword(s):  
Crohn’S Disease ◽  
Longitudinal Study ◽  
Crohn's Disease ◽  
Colonic Resection ◽  
Long Term Results ◽  
Prospective Longitudinal Study ◽  
Short And Long Term ◽  
Prospective Longitudinal

M1589 Long Term Results of a Prospective Longitudinal Study Comparing Laparoscopic vs Open Gastrectomy for Advance Gastric Cancer

2009 ◽  
Vol 136 (5) ◽  
pp. A-902-A-903 ◽  
Author(s):  
Giuseppe S. Sica ◽  
Edoardo Iaculli ◽  
Paolo Gentileschi ◽  
Livia Biancone ◽  
Giovanna Del Vecchio Blanco ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Longitudinal Study ◽  
Open Gastrectomy ◽  
Long Term Results ◽  
Prospective Longitudinal Study ◽  
Prospective Longitudinal
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