Sentence-Level Movements in Parkinson's Disease: Loud, Clear, and Slow Speech

2017 ◽  
Vol 60 (12) ◽  
pp. 3426-3440 ◽  
Author(s):  
Elaine Kearney ◽  
Renuka Giles ◽  
Brandon Haworth ◽  
Petros Faloutsos ◽  
Melanie Baljko ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Speech Intelligibility ◽  
Treatment Strategies ◽  
Principal Component ◽  
Sentence Production ◽  
Normal Movement ◽  
Articulatory Movements ◽  
Sentence Level ◽  
Slow Speech

Purpose To further understand the effect of Parkinson's disease (PD) on articulatory movements in speech and to expand our knowledge of therapeutic treatment strategies, this study examined movements of the jaw, tongue blade, and tongue dorsum during sentence production with respect to speech intelligibility and compared the effect of varying speaking styles on these articulatory movements. Method Twenty-one speakers with PD and 20 healthy controls produced 3 sentences under normal, loud, clear, and slow speaking conditions. Speech intelligibility was rated for each speaker. A 3-dimensional electromagnetic articulograph tracked movements of the articulators. Measures included articulatory working spaces, ranges along the first principal component, average speeds, and sentence durations. Results Speakers with PD demonstrated significantly smaller jaw movements as well as shorter than normal sentence durations. Between-speaker variation in movement size of the jaw, tongue blade, and tongue dorsum was associated with speech intelligibility. Analysis of speaking conditions revealed similar patterns of change in movement measures across groups and articulators: larger than normal movement sizes and faster speeds for loud speech, increased movement sizes for clear speech, and larger than normal movement sizes and slower speeds for slow speech. Conclusions Sentence-level measures of articulatory movements are sensitive to both disease-related changes in PD and speaking-style manipulations.

Game-Based Augmented Visual Feedback for Enlarging Speech Movements in Parkinson's Disease

2017 ◽  
Vol 60 (6S) ◽  
pp. 1818-1825 ◽  
Author(s):  
Yana Yunusova ◽  
Elaine Kearney ◽  
Madhura Kulkarni ◽  
Brandon Haworth ◽  
Melanie Baljko ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Visual Feedback ◽  
Speech Intelligibility ◽  
Training Session ◽  
Working Space ◽  
Retention Session ◽  
Tongue Movements ◽  
Impaired Speech ◽  
And Training

Purpose The purpose of this pilot study was to demonstrate the effect of augmented visual feedback on acquisition and short-term retention of a relatively simple instruction to increase movement amplitude during speaking tasks in patients with dysarthria due to Parkinson's disease (PD). Method Nine patients diagnosed with PD, hypokinetic dysarthria, and impaired speech intelligibility participated in a training program aimed at increasing the size of their articulatory (tongue) movements during sentences. Two sessions were conducted: a baseline and training session, followed by a retention session 48 hr later. At baseline, sentences were produced at normal, loud, and clear speaking conditions. Game-based visual feedback regarding the size of the articulatory working space (AWS) was presented during training. Results Eight of nine participants benefited from training, increasing their sentence AWS to a greater degree following feedback as compared with the baseline loud and clear conditions. The majority of participants were able to demonstrate the learned skill at the retention session. Conclusions This study demonstrated the feasibility of augmented visual feedback via articulatory kinematics for training movement enlargement in patients with hypokinesia due to PD. Supplemental Materials https://doi.org/10.23641/asha.5116840

scholarly journals Neuropsychiatric symptoms in Parkinson's disease: aetiology, diagnosis and treatment

2020 ◽  
Vol 26 (6) ◽  
pp. 333-342 ◽  
Author(s):  
Shoned Jones ◽  
Kelli M. Torsney ◽  
Lily Scourfield ◽  
Katie Berryman ◽  
Emily J. Henderson
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Neuropsychiatric Symptoms ◽  
Treatment Strategies ◽  
Current Treatment ◽  
Motor Disorder ◽  
Dopamine Dysregulation Syndrome ◽  
Disease Aetiology ◽  
Neuropsychiatric Manifestations ◽  
Assessment Scales

SUMMARYHistorically, Parkinson's disease was viewed as a motor disorder and it is only in recent years that the spectrum of non-motor disorders associated with the condition has been fully recognised. There is a broad scope of neuropsychiatric manifestations, including depression, anxiety, apathy, psychosis and cognitive impairment. Patients are more predisposed to delirium, and Parkinson's disease treatments give rise to specific syndromes, including impulse control disorders, dopamine agonist withdrawal syndrome and dopamine dysregulation syndrome. This article gives a broad overview of the spectrum of these conditions, describes the association with severity of Parkinson's disease and the degree to which dopaminergic degeneration and/or treatment influence symptoms. We highlight useful assessment scales that inform diagnosis and current treatment strategies to ameliorate these troublesome symptoms, which frequently negatively affect quality of life.

scholarly journals Listener Perception of Monopitch, Naturalness, and Intelligibility for Speakers With Parkinson's Disease

2015 ◽  
Vol 58 (4) ◽  
pp. 1134-1144 ◽  
Author(s):  
Supraja Anand ◽  
Cara E. Stepp
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Speech Intelligibility ◽  
Potential Significance ◽  
Rehabilitation Outcomes ◽  
Rate Method ◽  
Highly Correlated ◽  
Short Utterances ◽  
Speech Naturalness

PurposeGiven the potential significance of speech naturalness to functional and social rehabilitation outcomes, the objective of this study was to examine the effect of listener perceptions of monopitch on speech naturalness and intelligibility in individuals with Parkinson's disease (PD).MethodTwo short utterances were extracted from monologue samples of 16 speakers with PD and 5 age-matched adults without PD. Sixteen listeners evaluated these stimuli for monopitch, speech naturalness and intelligibility using the visual sort and rate method.ResultsNaïve listeners can reliably judge monopitch, speech naturalness, and intelligibility with minimal familiarization. While monopitch and speech intelligibility were only moderately correlated, monopitch and speech naturalness were highly correlated.ConclusionsA great deal of attention is currently being paid to improvement of vocal loudness and thus speech intelligibility in PD. Our findings suggest that prosodic characteristics such as monopitch should be explored as adjuncts to this treatment of dysarthria in PD. Development of such prosodic treatments may enhance speech naturalness and thus improve quality of life.

Sentence production in Parkinson’s disease

2018 ◽  
Vol 32 (9) ◽  
pp. 804-822 ◽  
Author(s):  
Jessica Dick ◽  
Jennifer Fredrick ◽  
Grace Man ◽  
Jessica E. Huber ◽  
Jiyeon Lee
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Sentence Production

Selected natural and synthetic agents effective against Parkinson’s disease with diverse mechanisms

2021 ◽  
Vol 21 ◽  
Author(s):  
Hayrettin Ozan Gulcan
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Treatment Options ◽  
Treatment Strategies ◽  
Current Treatment ◽  
Dopamine Metabolism ◽  
Dopaminergic Agonists ◽  
Alternative Drug ◽  
Synthetic Agents ◽  
Disease Modifying

: Similar to other neurodegenerative diseases, Parkinson’s disease (PD) has been extensively investigated with respect to its neuropathological background and possible treatment options. Since the symptomatic outcomes are generally related to dopamine deficiency, the current treatment strategies towards PD mainly employ dopaminergic agonists as well as the compounds acting on dopamine metabolism. These drugs do not provide disease modifying properties; therefore alternative drug discovery studies focus on targets involved in the progressive neurodegenerative character of PD. This study has aimed to present the pathophysiology of PD concomitant to the representation of drugs and promising molecules displaying activity against the validated and non-validated targets of PD.

scholarly journals Exploring MicroRNA Biomarkers for Parkinson’s Disease from mRNA Expression Profiles

Cells ◽  
2018 ◽  
Vol 7 (12) ◽  
pp. 245 ◽  
Author(s):  
Y-h. Taguchi ◽  
Hsiuying Wang
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Expression Profiles ◽  
Gene Expression Profiles ◽  
Principal Component ◽  
Signs And Symptoms ◽  
Microarray Gene Expression ◽  
Kegg Pathways ◽  
Healthy Control ◽  
Physical Examinations

Parkinson’s disease (PD) is a chronic, progressive neurodegenerative disease characterized by both motor and nonmotor features. The diagnose of PD is based on a review of patients’ signs and symptoms, and neurological and physical examinations. So far, no tests have been devised that can conclusively diagnose PD. In this study, we explore both microRNA and gene biomarkers for PD. Microarray gene expression profiles for PD patients and healthy control are analyzed using a principal component analysis (PCA)-based unsupervised feature extraction (FE). 244 genes are selected to be potential gene biomarkers for PD. In addition, we implement these genes into Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways, and find that the 15 microRNAs (miRNAs), hsa-miR-92a-3p, 16-5p, 615-3p, 877-3p, 100-5p, 320a, 877-5p, 23a-3p, 484, 23b-3p, 15a-5p, 324-3p, 19b-3p, 7b-5p and 505-3p, significantly target these 244 genes. These miRNAs are shown to be significantly related to PD. This reveals that both selected genes and miRNAs are potential biomarkers for PD.

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