scholarly journals Neuroplasticity in Aphasia: A Proposed Framework of Language Recovery

2019 ◽  
Vol 62 (11) ◽  
pp. 3973-3985 ◽  
Author(s):  
Swathi Kiran ◽  
Erin L. Meier ◽  
Jeffrey P. Johnson
Keyword(s):  
Left Hemisphere ◽  
Network Topology ◽  
Right Hemisphere ◽  
Current Knowledge ◽  
Mechanistic Model ◽  
Treatment Options ◽  
Brain Regions ◽  
Language Recovery ◽  
Behavior Network ◽  
The Right

Purpose Despite a tremendous amount of research in this topic, the precise neural mechanisms underlying language recovery remain unclear. Much of the evidence suggests that activation of remaining left-hemisphere tissue, including perilesional areas, is linked to the best treatment outcomes, yet recruitment of the right hemisphere for various language tasks has also been linked to favorable behavioral outcomes. In this review article, we propose a framework of language recovery that incorporates a network-based view of the brain regions involved in recovery. Method We review evidence from the extant literature and work from our own laboratory to identify findings consistent with our proposed framework and identify gaps in our current knowledge. Results Expanding on Heiss and Thiel's (2006) hierarchy of language recovery, we identify 4 emerging themes: (a) Several bilateral regions constitute a network engaged in language recovery; (b) spared left-hemisphere regions are important components of the network engaged in language recovery; (c) as damage increases in the left hemisphere, activation expands to the right hemisphere and domain-general regions; and (d) patients with efficient, control-like network topology show greater improvement than patients with abnormal topology. We propose a mechanistic model of language recovery that accounts for individual differences in behavior, network topology, and treatment responsiveness. Conclusion Continued work in this topic will lead us to a better understanding of the mechanisms underlying language recovery, biomarkers that influence recovery, and, consequently, more personalized treatment options for individual patients. Presentation Video https://doi.org/10.23641/asha.10257590

scholarly journals Overlapping but Language-Specific Mechanisms in Morphosyntactic Processing in Highly Competent L2 Acquired at School Entry: fMRI Evidence From an Alternating Language Switching Task

2021 ◽  
Vol 15 ◽  
Author(s):  
Azam Meykadeh ◽  
Arsalan Golfam ◽  
Seyed Amir Hossein Batouli ◽  
Werner Sommer
Keyword(s):  
Left Hemisphere ◽  
Right Hemisphere ◽  
Region Of Interest ◽  
Brain Regions ◽  
School Entry ◽  
Planum Temporale ◽  
Language Switching ◽  
Pars Opercularis ◽  
The Right ◽  
L1 And L2

Many bilingual individuals acquire their second language when entering primary school; however, very few studies have investigated morphosyntax processing in this population. Combining a whole-brain and region of interest (ROI)-based approach, we studied event-related fMRI during morphosyntactic processing, specifically person-number phi-features, in Turkish (L1) and Persian (L2) by highly proficient bilinguals who learned Persian at school entry. In a design with alternating language switching and pseudorandomized grammaticality conditions, two left-lateralized syntax-specific ROIs and 11 bilateral ROIs involved in executive functions (EF) were analyzed for the intensity of activation relative to a resting baseline. Our findings indicate a strong overlap of neural networks for L1 and L2, suggesting structural similarities of neuroanatomical organization. In all ROIs morphosyntactic processing invoked stronger activation in L1 than in L2. This may be a consequence of symmetrical switch costs in the alternating design used here, where the need for suppressing the non-required language is stronger for the dominant L1 when it is non-required as compared to the non-dominant L2, leading to a stronger rebound for L1 than L2 when the language is required. Both L1 and L2 revealed significant activation in syntax-specific areas in left hemisphere clusters and increased activation in EF-specific areas in right-hemisphere than left-hemisphere clusters, confirming syntax-specific functions of the left hemisphere, whereas the right hemisphere appears to subserve control functions required for switching languages. While previous reports indicate a leftward bias in planum temporale activation during auditory and linguistic processing, the present study shows the activation of the right planum temporale indicating its involvement in auditory attention. More pronounced grammaticality effect in left pars opercularis for L1 and in left pSTG for L2 indicate differences in the processing of morphosyntactic information in these brain regions. Nevertheless, the activation of pars opercularis and pSTG emphasize the centrality of these regions in the processing of person-number phi-features. Taken together, the present results confirm that morphosyntactic processing in bilinguals relates to composite, syntax-sensitive and EF-sensitive mechanisms in which some nodes of the language network are differentially involved.

scholarly journals Functional Neuroanatomy of the Cognitive Process of Mapping During Discourse Comprehension

2000 ◽  
Vol 11 (3) ◽  
pp. 255-260 ◽  
Author(s):  
David A. Robertson ◽  
Morton Ann Gernsbacher ◽  
Seline J. Guidotti ◽  
Rachel R.W. Robertson ◽  
William Irwin ◽  
...  
Keyword(s):  
Frontal Lobe ◽  
Left Hemisphere ◽  
Cognitive Process ◽  
Right Hemisphere ◽  
Neural Substrates ◽  
Brain Regions ◽  
Functional Neuroanatomy ◽  
Discourse Comprehension ◽  
Discourse Coherence ◽  
The Right

We used functional magnetic resonance imaging (fMRI) to identify brain regions involved in the process of mapping coherent discourse onto a developing mental representation. We manipulated discourse coherence by presenting sentences with definite articles (which lead to more coherent discourse) or indefinite articles (which lead to less coherent discourse). Comprehending connected discourse, compared with reading unrelated sentences, produced more neural activity in the right than left hemisphere of the frontal lobe. Thus, the right hemisphere of the frontal lobe is involved in some of the processes underlying mapping. In contrast, left-hemisphere structures were associated with lower-level processes in reading (such as word recognition and syntactic processing). Our results demonstrate the utility of using fMRI to investigate the neural substrates of higher-level cognitive processes such as discourse comprehension.

scholarly journals A Review on Treatment-Related Brain Changes in Aphasia

2020 ◽  
Vol 1 (4) ◽  
pp. 402-433
Author(s):  
Klara Schevenels ◽  
Cathy J. Price ◽  
Inge Zink ◽  
Bert De Smedt ◽  
Maaike Vandermosten
Keyword(s):  
Language Processing ◽  
Large Scale ◽  
Right Hemisphere ◽  
Brain Plasticity ◽  
Integrated Approach ◽  
Brain Regions ◽  
Specific Information ◽  
Language Recovery ◽  
Brain Changes ◽  
The Right

Numerous studies have investigated brain changes associated with interventions targeting a range of language problems in patients with aphasia. We strive to integrate the results of these studies to examine (1) whether the focus of the intervention (i.e., phonology, semantics, orthography, syntax, or rhythmic-melodic) determines in which brain regions changes occur; and (2a) whether the most consistent changes occur within the language network or outside, and (2b) whether these are related to individual differences in language outcomes. The results of 32 studies with 204 unique patients were considered. Concerning (1), the location of treatment-related changes does not clearly depend on the type of language processing targeted. However, there is some support that rhythmic-melodic training has more impact on the right hemisphere than linguistic training. Concerning (2), we observed that language recovery is not only associated with changes in traditional language-related structures in the left hemisphere and homolog regions in the right hemisphere, but also with more medial and subcortical changes (e.g., precuneus and basal ganglia). Although it is difficult to draw strong conclusions, because there is a lack of systematic large-scale studies on this topic, this review highlights the need for an integrated approach to investigate how language interventions impact on the brain. Future studies need to focus on larger samples preserving subject-specific information (e.g., lesion effects) to cope with the inherent heterogeneity of stroke-induced aphasia. In addition, recovery-related changes in whole-brain connectivity patterns need more investigation to provide a comprehensive neural account of treatment-related brain plasticity and language recovery.

scholarly journals Volumetric MRI Analysis of Brain Structures in Patients with History of First and Repeated Suicide Attempts: A Cross Sectional Study

Diagnostics ◽  
2021 ◽  
Vol 11 (3) ◽  
pp. 488
Author(s):  
Milda Sarkinaite ◽  
Rymante Gleizniene ◽  
Virginija Adomaitiene ◽  
Kristina Dambrauskiene ◽  
Nijole Raskauskiene ◽  
...  
Keyword(s):  
Suicide Attempt ◽  
Left Hemisphere ◽  
Cortical Thickness ◽  
Suicide Attempts ◽  
Right Hemisphere ◽  
Temporal Cortex ◽  
Brain Regions ◽  
Cross Sectional ◽  
Suicide Attempters ◽  
The Right

Structural brain changes are found in suicide attempters and in patients with mental disorders. It remains unclear whether the suicidal behaviors are related to atrophy of brain regions and how the morphology of specific brain areas is changing with each suicide attempt. The sample consisted of 56 patients hospitalized after first suicide attempt (first SA) (n = 29), more than one suicide attempt (SA > 1) (n = 27) and 54 healthy controls (HC). Brain volume was measured using FreeSurfer 6.0 automatic segmentation technique. In comparison to HC, patients with first SA had significantly lower cortical thickness of the superior and rostral middle frontal areas, the inferior, middle and superior temporal areas of the left hemisphere and superior frontal area of the right hemisphere. In comparison to HC, patients after SA > 1 had a significantly lower cortical thickness in ten areas of frontal cortex of the left hemisphere and seven areas of the right hemisphere. The comparison of hippocampus volume showed a significantly lower mean volume of left and right parts in patients with SA > 1, but not in patients with first SA. The atrophy of frontal, temporal cortex and hippocampus parts was significantly higher in repeated suicide attempters than in patients with first suicide attempt.

scholarly journals Mapping a cognitive theory onto neurology

2021 ◽  
Author(s):  
Lorin Friesen
Keyword(s):  
Frontal Cortex ◽  
Left Hemisphere ◽  
Cognitive Theory ◽  
Right Hemisphere ◽  
Cognitive Styles ◽  
Brain Regions ◽  
The Other ◽  
Anterior Cingulate ◽  
The Right ◽  
The Brain

Neurological research has made amazing strides in recent years. Enough is now known about what specific brain areas do to make it possible to start examining how various parts of the brain interact. What is missing is a general theory of cognition to tie all of this information together. Back in the 1980s, a cognitive theory was developed that began with a system of cognitive styles and was expanded through an in-depth study of biographies. It was discovered at that time that this theory mapped in a general way onto the brain. This cognitive theory, known as the theory of mental symmetry, has recently been tested as a meta-theory by using it to analyze a number of fields and theories dealing with human thought and behavior. This paper shows that personality traits that were discovered by mental symmetry correspond in detail to the functioning of brain regions described in current neurological papers. In brief, the cognitive model suggests that there are seven cognitive styles: There are four simple styles, and there are three composite styles that combine the thinking of the simple styles. Two of the simple styles use emotions and emphasize a circuit composed of orbitofrontal cortex, inferior frontal cortex, temporal lobe, and amygdala, with one in the left hemisphere and the other in the right hemisphere. The other two simple styles use confidence and emphasize a circuit consisting of dorsolateral frontal cortex, frontopolar cortex, parietal cortex, and hippocampus, again with one in the left hemisphere and the other in the right hemisphere. The three composite styles form a processing chain. The first composite style combines the two simple emotional styles and emphasizes the ventral striatum, and dopamine. This leads to the second composite style, which combines the two simple confidence styles and emphasizes the anterior cingulate, the dorsal striatum, and serotonin. This is followed by the third composite style which balances the functioning of the mind and emphasizes the thalamus and noradrenaline.

Investigation of the Effect of Mode and Tempo on Emotional Responses to Music Using EEG Power Asymmetry

2013 ◽  
Vol 27 (3) ◽  
pp. 142-148 ◽  
Author(s):  
Konstantinos Trochidis ◽  
Emmanuel Bigand
Keyword(s):  
Left Hemisphere ◽  
Right Hemisphere ◽  
Emotional Responses ◽  
Interactive Effects ◽  
Eeg Activity ◽  
Musical Excerpt ◽  
Major Mode ◽  
Musical Modes ◽  
Slow Tempo ◽  
The Right

The combined interactions of mode and tempo on emotional responses to music were investigated using both self-reports and electroencephalogram (EEG) activity. A musical excerpt was performed in three different modes and tempi. Participants rated the emotional content of the resulting nine stimuli and their EEG activity was recorded. Musical modes influence the valence of emotion with major mode being evaluated happier and more serene, than minor and locrian modes. In EEG frontal activity, major mode was associated with an increased alpha activation in the left hemisphere compared to minor and locrian modes, which, in turn, induced increased activation in the right hemisphere. The tempo modulates the arousal value of emotion with faster tempi associated with stronger feeling of happiness and anger and this effect is associated in EEG with an increase of frontal activation in the left hemisphere. By contrast, slow tempo induced decreased frontal activation in the left hemisphere. Some interactive effects were found between mode and tempo: An increase of tempo modulated the emotion differently depending on the mode of the piece.

Dual Intentional Agency

2018 ◽  
Author(s):  
Elizabeth Schechter
Keyword(s):  
Left Hemisphere ◽  
Practical Reasoning ◽  
Right Hemisphere ◽  
Brain Surgery ◽  
Experimental Conditions ◽  
Split Brain ◽  
Intentional Agency ◽  
Intentional Agents ◽  
Experimental Findings ◽  
The Right

This chapter defends the 2-agents claim, according to which the two hemispheres of a split-brain subject are associated with distinct intentional agents. The empirical basis of this claim is that, while both hemispheres are the source or site of intentions, the capacity to integrate them in practical reasoning no longer operates interhemispherically after split-brain surgery. As a result, the right hemisphere-associated agent, R, and the left hemisphere-associated agent, L, enjoy intentional autonomy from each other. Although the positive case for the 2-agents claim is grounded mainly in experimental findings, the claim is not contradicted by what we know of split-brain subjects’ ordinary behavior, that is, the way they act outside of experimental conditions.

scholarly journals Functional network topology of the right insula affects emotion dysregulation in hyperactive-impulsive attention-deficit/hyperactivity disorder

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Tammo Viering ◽  
Pieter J. Hoekstra ◽  
Alexandra Philipsen ◽  
Jilly Naaijen ◽  
Andrea Dietrich ◽  
...  
Keyword(s):  
Attention Deficit Hyperactivity Disorder ◽  
Network Topology ◽  
Resting State ◽  
Latent Variable ◽  
Emotion Dysregulation ◽  
Adult Adhd ◽  
Brain Regions ◽  
Graph Analysis ◽  
Hyperactivity Disorder ◽  
The Right

AbstractEmotion dysregulation is common in attention-deficit/hyperactivity disorder (ADHD). It is highly prevalent in young adult ADHD and related to reduced well-being and social impairments. Neuroimaging studies reported neural activity changes in ADHD in brain regions associated with emotion processing and regulation. It is however unknown whether deficits in emotion regulation relate to changes in functional brain network topology in these regions. We used a combination of graph analysis and structural equation modelling (SEM) to analyze resting-state functional connectivity in 147 well-characterized young adults with ADHD and age-matched healthy controls from the NeuroIMAGE database. Emotion dysregulation was gauged with four scales obtained from questionnaires and operationalized through a latent variable derived from SEM. Graph analysis was applied to resting-state data and network topology measures were entered into SEM models to identify brain regions whose local network integration and connectedness differed between subjects and was associated with emotion dysregulation. The latent variable of emotion dysregulation was characterized by scales gauging emotional distress, emotional symptoms, conduct symptoms, and emotional lability. In individuals with ADHD characterized by prominent hyperactivity-impulsivity, the latent emotion dysregulation variable was related to an increased clustering and local efficiency of the right insula. Thus, in the presence of hyperactivity-impulsivity, clustered network formation of the right insula may underpin emotion dysregulation in young adult ADHD.

scholarly journals Pulmonary Hypertension in Acute and Chronic High Altitude Maladaptation Disorders

2021 ◽  
Vol 18 (4) ◽  
pp. 1692
Author(s):  
Akylbek Sydykov ◽  
Argen Mamazhakypov ◽  
Abdirashit Maripov ◽  
Djuro Kosanovic ◽  
Norbert Weissmann ◽  
...  
Keyword(s):  
Pulmonary Hypertension ◽  
High Altitude ◽  
Clinical Experience ◽  
Current Knowledge ◽  
Hypoxic Pulmonary Vasoconstriction ◽  
Treatment Options ◽  
Right Heart Failure ◽  
Channel Blockers ◽  
The Right ◽  
Extensive Clinical Experience

Alveolar hypoxia is the most prominent feature of high altitude environment with well-known consequences for the cardio-pulmonary system, including development of pulmonary hypertension. Pulmonary hypertension due to an exaggerated hypoxic pulmonary vasoconstriction contributes to high altitude pulmonary edema (HAPE), a life-threatening disorder, occurring at high altitudes in non-acclimatized healthy individuals. Despite a strong physiologic rationale for using vasodilators for prevention and treatment of HAPE, no systematic studies of their efficacy have been conducted to date. Calcium-channel blockers are currently recommended for drug prophylaxis in high-risk individuals with a clear history of recurrent HAPE based on the extensive clinical experience with nifedipine in HAPE prevention in susceptible individuals. Chronic exposure to hypoxia induces pulmonary vascular remodeling and development of pulmonary hypertension, which places an increased pressure load on the right ventricle leading to right heart failure. Further, pulmonary hypertension along with excessive erythrocytosis may complicate chronic mountain sickness, another high altitude maladaptation disorder. Importantly, other causes than hypoxia may potentially underlie and/or contribute to pulmonary hypertension at high altitude, such as chronic heart and lung diseases, thrombotic or embolic diseases. Extensive clinical experience with drugs in patients with pulmonary arterial hypertension suggests their potential for treatment of high altitude pulmonary hypertension. Small studies have demonstrated their efficacy in reducing pulmonary artery pressure in high altitude residents. However, no drugs have been approved to date for the therapy of chronic high altitude pulmonary hypertension. This work provides a literature review on the role of pulmonary hypertension in the pathogenesis of acute and chronic high altitude maladaptation disorders and summarizes current knowledge regarding potential treatment options.

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