scholarly journals Early Changes in Peripheral Blood T Cell Subsets Induced by Antiretroviral Treatment of Human Immunodeficiency Virus-1 Positive Individuals

2000 ◽  
Vol 51 (2) ◽  
pp. 195-201 ◽  
Author(s):  
Dyrhol-Riise ◽  
Brantsaeter ◽  
Dunlop ◽  
Baklien ◽  
Skar ◽  
...  
Keyword(s):  
Human Immunodeficiency Virus ◽  
T Cell ◽  
Peripheral Blood ◽  
Antiretroviral Treatment ◽  
T Cell Subsets ◽  
Immunodeficiency Virus ◽  
Human Immunodeficiency Virus 1

scholarly journals Blood and Lymph Node Dissemination of Clonal Genome-Intact Human Immunodeficiency Virus 1 DNA Sequences During Suppressive Antiretroviral Therapy

2020 ◽  
Vol 222 (4) ◽  
pp. 655-660
Author(s):  
Hsiao-Hsuan Kuo ◽  
Riddhima Banga ◽  
Guinevere Q Lee ◽  
Ce Gao ◽  
Matthias Cavassini ◽  
...  
Keyword(s):  
Human Immunodeficiency Virus ◽  
Lymph Node ◽  
T Cell ◽  
Dna Sequences ◽  
T Cell Subsets ◽  
Cd4 T Cell ◽  
Viral Reservoir ◽  
Lymphoid Tissues ◽  
Immunodeficiency Virus ◽  
Human Immunodeficiency Virus 1

Abstract The majority of cells with latent human immunodeficiency virus 1 infection are located in lymphoid tissues that are difficult to access. In the current study, we used single-genome near-full-length proviral sequencing to evaluate intact and defective proviruses in blood and lymph node CD4 T cells enriched for specific functional polarizations. We observed minor variations between the frequencies of proviral sequences within individual CD4 T-cell subsets and across tissue compartments. However, we noted multiple clonal clusters of identical intact or defective proviral sequences from distinct compartments and CD4 T-cell subpopulations, suggesting frequent interchanges between viral reservoir cells in blood and tissues.

scholarly journals Reciprocal alterations of Th1/Th2 function in γδ T-cell subsets of human immunodeficiency virus-1-infected patients

2002 ◽  
Vol 118 (1) ◽  
pp. 282-288 ◽  
Author(s):  
Thomas S. Dobmeyer ◽  
Rita Dobmeyer ◽  
Daniela Wesch ◽  
Eilke B. Helm ◽  
Dieter Hoelzer ◽  
...  
Keyword(s):  
Human Immunodeficiency Virus ◽  
T Cell ◽  
T Cell Subsets ◽  
Γδ T Cell ◽  
Immunodeficiency Virus ◽  
Human Immunodeficiency Virus 1

scholarly journals Changes in the Composition of Circulating CD8+T Cell Subsets during Acute Epstein‐Barr and Human Immunodeficiency Virus Infections in Humans

2000 ◽  
Vol 182 (2) ◽  
pp. 451-458 ◽  
Author(s):  
Marijke Th. L. Roos ◽  
René A. W. van Lier ◽  
Dörte Hamann ◽  
Gerlinde J. Knol ◽  
Irma Verhoofstad ◽  
...  
Keyword(s):  
Human Immunodeficiency Virus ◽  
T Cell ◽  
Cd8 T Cell ◽  
T Cell Subsets ◽  
Virus Infections ◽  
Immunodeficiency Virus ◽  
Epstein Barr

scholarly journals Aviremia 10 Years Postdiscontinuation of Antiretroviral Therapy Initiated During Primary Human Immunodeficiency Virus-1 Infection and Association With Gag-Specific T-Cell Responses

2015 ◽  
Vol 2 (4) ◽  
Author(s):  
Sabine Kinloch-de Loes ◽  
Lucy Dorrell ◽  
Hongbing Yang ◽  
Gareth A. D. Hardy ◽  
Sabine Yerly ◽  
...  
Keyword(s):  
Human Immunodeficiency Virus ◽  
T Cell ◽  
Antiretroviral Therapy ◽  
Viral Reservoir ◽  
Cell Responses ◽  
Immunodeficiency Virus ◽  
Cellular Immune ◽  
Drug Free ◽  
Human Immunodeficiency Virus 1

Abstract Combination antiretroviral therapy during primary human immunodeficiency virus-1 infection may enable long-term drug-free virological control in rare individuals. We describe a female who maintained aviremia and a normal CD4+/CD8+ T cell ratio for 10 years after stopping therapy, despite a persistent viral reservoir. Cellular immune responses may have contributed to this outcome.

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