Allogeneic Red Blood Cell Transfusion Is an Independent Risk Factor for the Development of Postoperative Bacterial Infection

Objective This study aimed to examine the clinical value of a decrease in hemoglobin concentration (HC) after the onset of sepsis for predicting occurrence of necrotizing enterocolitis (NEC) in preterm infants with late-onset sepsis. Methods We performed a retrospective cohort study between January 2015 and January 2020. Premature neonates (gestational age <37 weeks) with late-onset sepsis (age >3 days) were enrolled. According to the degree of reduction in HC, neonates were divided into the non-decrease group, mild decrease group, and severe decrease group. Demographic data, perinatal conditions, blood cell count analysis, blood culture, and treatment measures were compared. Results Eighty premature infants with sepsis were studied. The mortality rate and incidence of NEC were significantly higher in the severe decrease group than in the non-decrease and mild decrease groups. Significant differences were observed in the decrease in HC, red blood cell transfusion, and ventilator application between the NEC and non-NEC groups. A significant decrease in HC was an independent risk factor for NEC in preterm infants with sepsis. Conclusion A significant decrease in HC is an independent risk factor for NEC and may predict the occurrence of NEC in preterm infants with sepsis.

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Red Blood Cell Transfusions Following Resection of Skull Base Meningiomas: Risk Factors and Clinical Outcomes

Journal of Neurological Surgery Part B Skull Base ◽

10.1055/s-0038-1651502 ◽

2018 ◽

Vol 79 (06) ◽

pp. 599-605

Author(s):

Carlito Lagman ◽

John Sheppard ◽

Joel Beckett ◽

Alexander Tucker ◽

Daniel Nagasawa ◽

...

Keyword(s):

Risk Factors ◽

Risk Factor ◽

Blood Cell ◽

Skull Base ◽

Red Blood Cell ◽

Independent Risk Factor ◽

Operative Time ◽

Discharge Disposition ◽

Skull Base Meningiomas ◽

Rbc Transfusion

Objective This article identifies risk factors for and investigates clinical outcomes of postoperative red blood cell transfusion in patients with skull base meningiomas. Design Retrospective cohort study. Setting Single academic medical center. Participants The transfusion group included patients who had skull base meningiomas and who received packed red blood cell (RBC) transfusion within 7 days of surgery. The no transfusion group included patients who had skull base meningiomas but who did not have RBCs transfused within 7 days of surgery. Main Outcome Measures In-hospital complication rate, length of stay (LOS), and discharge disposition. Results One hundred and ninety-six patients had a craniotomy for resection of a meningioma at our institution from March 2013 to January 2017. Seven patients had skull base meningiomas and received RBC transfusion within 7 days of surgery (the transfusion group). The skull base was an independent risk factor for transfusion after we controlled for the effect of meningioma size (OR 3.89, 95% CI 1.34, 11.25). Operative time greater than 10 hours was an independent risk factor for prolonged hospital stay (OR 8.84, 95% CI 1.08, 72.10) once we controlled for the effect of transfusion. In contrast, transfusion did not independently impact LOS or discharge disposition once we controlled for the effect of operative time. Conclusions The skull base is an independent predictor of RBC transfusion. However, RBC transfusion alone cannot predict LOS or discharge disposition in patients who undergo surgical resection of a skull base meningioma.

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Female sex of older patients is an independent risk factor for red blood cell alloimmunization after transfusion

Transfusion ◽

10.1111/trf.13111 ◽

2015 ◽

Vol 55 (6pt2) ◽

pp. 1478-1485 ◽

Cited By ~ 15

Author(s):

Esther P. Verduin ◽

Anneke Brand ◽

Rutger A. Middelburg ◽

Henk Schonewille

Keyword(s):

Risk Factor ◽

Blood Cell ◽

Red Blood Cell ◽

Older Patients ◽

Independent Risk Factor ◽

Female Sex

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Non-red blood cell transfusion as a risk factor for mortality following percutaneous coronary intervention

International Journal of Cardiology ◽

10.1016/j.ijcard.2010.12.013 ◽

2012 ◽

Vol 157 (2) ◽

pp. 169-173 ◽

Cited By ~ 4

Author(s):

Simon D. Robinson ◽

Christian Janssen ◽

Eric B. Fretz ◽

Alex J. Chase ◽

Anthony Della Siega ◽

...

Keyword(s):

Percutaneous Coronary Intervention ◽

Risk Factor ◽

Blood Cell ◽

Red Blood Cell ◽

Coronary Intervention ◽

Red Blood Cell Transfusion ◽

Percutaneous Coronary

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Erythrocytosis and Performance of HbA1c in Detecting Diabetes on an Oxygen-Deficient Plateau: A Population-based Study

The Journal of Clinical Endocrinology & Metabolism ◽

10.1210/clinem/dgaa001 ◽

2020 ◽

Vol 105 (4) ◽

pp. e1612-e1620

Author(s):

Qian Ren ◽

Xuemei Lv ◽

Lihui Yang ◽

Jun Yue ◽

Yingying Luo ◽

...

Keyword(s):

Risk Factor ◽

Blood Cell ◽

Cell Count ◽

Red Blood Cell ◽

Independent Risk Factor ◽

Hemoglobin A1c ◽

Population Based ◽

Serum Glucose ◽

Diabetes Screening ◽

Blood Cell Count

Abstract Context The hemoglobin A1c (HbA1c) test is a standard test for diabetes screening and diagnosis. Objective To evaluate A1c performance for diabetes screening in high-altitude polycythemia compared to a population with a high proportion of people living in an oxygen-deficient environment. Design A population-based epidemiological survey was conducted. Setting The cities Lhasa and Shigatse were selected. Volunteers were recruited through educational advertisements about diabetes. Participants A total of 1401 Tibetan adults without known diabetes. Interventions Oral glucose tolerance test (OGTT), HbA1c, and complete blood cell count were performed. Hemoglobin A1c was evaluated using high-performance liquid chromatography, and serum glucose level, using the hexokinase method. Main Outcome Measures World Health Organization criteria were used to define diabetes and prediabetes. Hemoglobin A1c test performance was evaluated using receiver operating characteristic analysis. Results The participants’ mean age was 44.3 ± 15.0 years; 33.3% of the participants were men and 38.6% lived in urban areas. The prediabetes and diabetes prevalence rates were 7.5% and 3.6%, respectively. The optimal HbA1c cutoff for detecting diabetes was 46 mmol/mol (6.4%), with a sensitivity and specificity of 60.8% and 93.6%, respectively. The cutoff for detecting diabetes was 6.7% (50 mmol/mol) in subjects with high-altitude polycythemia (HAPC). The relationship between red blood cell (RBC) counts and HbA1c was significant (P < 0.001), while there was no correlation between hemoglobin (Hb) and HbA1c (P = 0.085). Multiple linear regression analysis showed that after adjusting for age and fasting serum glucose or 2-hour OGTT (OGTT2h) serum glucose, RBC count and not Hb level was an independent risk factor for HbA1c (β = 0.140, P < 0.001). Conclusions The optimal HbA1c cutoff for detecting diabetes was 46 mmol/mol (6.4%) in Tibet. Red blood cell count was an independent risk factor for elevated HbA1c, and HAPC may affect the predictive ability of HbA1c.

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