Perineuronal nets ensheath fast spiking, parvalbumin-immunoreactive neurons in the medial septum/diagonal band complex

2000 ◽  
Vol 12 (3) ◽  
pp. 828-838 ◽  
Author(s):  
Neil P. Morris ◽  
Zaineb Henderson
Keyword(s):  
Medial Septum ◽  
Perineuronal Nets ◽  
Diagonal Band ◽  
Fast Spiking

scholarly journals Septohippocampal transmission from parvalbumin-positive neurons features rapid recovery from synaptic depression

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Feng Yi ◽  
Tavita Garrett ◽  
Karl Deisseroth ◽  
Heikki Haario ◽  
Emily Stone ◽  
...  
Keyword(s):  
Pyramidal Neurons ◽  
Synaptic Depression ◽  
Medial Septum ◽  
Membrane Properties ◽  
Projection Neurons ◽  
Calcium Dependent ◽  
Light Pulses ◽  
Diagonal Band ◽  
Initial Release ◽  
Intrinsic Membrane Properties

AbstractParvalbumin-containing projection neurons of the medial-septum-diagonal band of Broca ($$\hbox {PV}_{\text{MS-DBB}}$$ PV MS-DBB ) are essential for hippocampal rhythms and learning operations yet are poorly understood at cellular and synaptic levels. We combined electrophysiological, optogenetic, and modeling approaches to investigate $$\hbox {PV}_{\text{MS-DBB}}$$ PV MS-DBB neuronal properties. $$\hbox {PV}_{\text{MS-DBB}}$$ PV MS-DBB neurons had intrinsic membrane properties distinct from acetylcholine- and somatostatin-containing MS-DBB subtypes. Viral expression of the fast-kinetic channelrhodopsin ChETA-YFP elicited action potentials to brief (1–2 ms) 470 nm light pulses. To investigate $$\hbox {PV}_{\text{MS-DBB}}$$ PV MS-DBB transmission, light pulses at 5–50 Hz frequencies generated trains of inhibitory postsynaptic currents (IPSCs) in CA1 stratum oriens interneurons. Using a similar approach, optogenetic activation of local hippocampal PV ($$\hbox {PV}_{\text{HC}}$$ PV HC ) neurons generated trains of $$\hbox {PV}_{\text{HC}}$$ PV HC -mediated IPSCs in CA1 pyramidal neurons. Both synapse types exhibited short-term depression (STD) of IPSCs. However, relative to $$\hbox {PV}_{\text{HC}}$$ PV HC synapses, $$\hbox {PV}_{\text{MS-DBB}}$$ PV MS-DBB synapses possessed lower initial release probability, transiently resisted STD at gamma (20–50 Hz) frequencies, and recovered more rapidly from synaptic depression. Experimentally-constrained mathematical synapse models explored mechanistic differences. Relative to the $$\hbox {PV}_{\text{HC}}$$ PV HC model, the $$\hbox {PV}_{\text{MS-DBB}}$$ PV MS-DBB model exhibited higher sensitivity to calcium accumulation, permitting a faster rate of calcium-dependent recovery from STD. In conclusion, resistance of $$\hbox {PV}_{\text{MS-DBB}}$$ PV MS-DBB synapses to STD during short gamma bursts enables robust long-range GABAergic transmission from MS-DBB to hippocampus.

scholarly journals Perineuronal nets decrease membrane capacitance of peritumoral fast spiking interneurons in a model of epilepsy

2018 ◽  
Vol 9 (1) ◽  
Author(s):  
Bhanu P. Tewari ◽  
Lata Chaunsali ◽  
Susan L. Campbell ◽  
Dipan C. Patel ◽  
Adam E. Goode ◽  
...  
Keyword(s):  
Membrane Capacitance ◽  
Perineuronal Nets ◽  
Fast Spiking

0355 Neurobiological Correlates of Sleepiness in Middle Aged and Older Adults: A FDG-PET Study

SLEEP ◽  
2020 ◽  
Vol 43 (Supplement_1) ◽  
pp. A134-A136
Author(s):  
D Z Carvalho ◽  
E K St. Louis ◽  
C G Schwarz ◽  
B F Bradley ◽  
V J Lowe ◽  
...  
Keyword(s):  
Older Adults ◽  
Sex Education ◽  
Fdg Pet ◽  
Linear Models ◽  
Medial Septum ◽  
Nucleus Basalis ◽  
Middle Aged ◽  
Sleep Patterns ◽  
Cross Sectional ◽  
Diagonal Band

Abstract Introduction Sleepiness has been associated with functional and cognitive decline, and may present with excessive daytime sleepiness (EDS) and/or increased sleep duration. We investigated whether sleepiness and changes in sleep patterns are associated with FDG-PET levels in wake-promoting regions. Methods From the Mayo Clinic Study of Aging cohort, we identified 373 cognitively-unimpaired middle-aged and older adults (mean +/- s.d. 66.1 +/- 13.2 yo) who underwent FDG-PET. EDS was defined as ESS score >=10. Changes in sleep patterns (sleeping more, less, or no change) were assessed using question #16 of the Beck Depression Inventory-2. We used probabilistic maps to create regions of interest (ROIs): the locus coeruleus (LC), posterior lateral hypothalamus (PLH), and the basal forebrain divided in 1) medial septum/diagonal band of Broca (MS/DB) and 2) nucleus basalis of Meynert (nbM). FDG-PET levels were referenced to the pons (SUVR). In this cross-sectional analysis, we fit linear models to assess the association between EDS and changes in sleeping patterns with FDG SUVR in in each ROI, while controlling for age, sex, education, BMI, witnessed apneas, and cardiovascular risk factors. Results 10.5% had EDS, 15% reported sleeping more and 21% reported sleeping less than usual. 30.7% of participants with EDS reported sleeping more, 25.6% less, and 43.5% the same. EDS was associated with an elevation in FDG-PET SUVR in the MS/DB region (.035 [95% CI .008; .063], p=.012), while sleeping more was associated with a decrease in FDG-PET SUVR in the same region (-.027 [95%CI -.052; -.002], p=.036). Sleeping less was associated with an increase in FDG-PET SUVR in the PLH (.021 [95% CI .005; .03], p=.019). No associations were found in other ROIs. Conclusion Our results suggest that sleepiness and changes in sleep patterns in cognitively-unimpaired middle-aged and older adults were associated with measurable metabolic changes in areas of the brain involved in sleep and wakefulness. Further research should clarify whether these findings could represent different phenotypes of sleepiness with potential diagnostic and prognostic implications. Support NIA/NIH

Lanthanum and zinc sensitivity of GABAA-activated currents in adult medial septum/diagonal band neurons from ethanol dependent rats

1996 ◽  
Vol 720 (1-2) ◽  
pp. 101-110 ◽  
Author(s):  
Gerald D. Frye ◽  
Annette S. Fincher ◽  
Cathy A. Grover ◽  
Sudheer Jayaprabhu
Keyword(s):  
Medial Septum ◽  
Diagonal Band

scholarly journals Co-activation of nAChR and mGluR induces γ oscillation in rat medial septum diagonal band of Broca slices

2014 ◽  
Vol 35 (2) ◽  
pp. 175-184
Author(s):  
Ya-li Wang ◽  
Jian-gang Wang ◽  
Gao-xiang Ou-yang ◽  
Xiao-li Li ◽  
Zaineb Henderson ◽  
...  
Keyword(s):  
Medial Septum ◽  
Diagonal Band ◽  
Co Activation ◽  
Diagonal Band Of Broca

Chemical microstimulation of the septal area lowers arterial pressure in the rat

1987 ◽  
Vol 252 (4) ◽  
pp. R760-R767 ◽  
Author(s):  
A. J. Gelsema ◽  
F. R. Calaresu
Keyword(s):  
Electrical Stimulation ◽  
Arterial Pressure ◽  
Cardiovascular Responses ◽  
Medial Septum ◽  
Septal Area ◽  
Lateral Septum ◽  
Bed Nucleus ◽  
Diagonal Band ◽  
Alpha Chloralose ◽  
Spontaneously Breathing

Electrical stimulation of the septal area has been previously reported to result in either an increase or a decrease in arterial pressure (AP) and heart rate (HR) depending on the site of stimulation within the septum or on the anesthetic. These conflicting results could be due to the different proportions of cell bodies and fibers activated by electrical stimulation at different sites and to the different anesthetics acting differently on cell bodies and fibers. To study the cardiovascular responses to activation of cell bodies, DL-homocysteate (20-50 nl) was injected into histologically verified sites in the lateral septum (LS), the medial septum (MS), the nucleus of the vertical limb of the diagonal band of Broca (NDBB), and in the bed nucleus of the stria terminalis (BST) in urethananesthetized, paralyzed, and artificially ventilated rats. Injections in the LS, MS, and NDBB elicited a decrease in AP [-12.6 +/- 0.9 (SE) mmHg, n = 111] accompanied by variable changes in HR. In a group of spontaneously breathing rats anesthetized with urethan, AP responses were not significantly different from those obtained in paralyzed animals. Finally, in a group of animals under alpha-chloralose, AP responses were not significantly different from those observed in animals under urethan. Homocysteate application in the BST resulted in either depressor [-10.8 +/- 0.9 (SE) mmHg, n = 20] or pressor responses [13.7 +/- 1.9 (SE) mmHg, n = 9].(ABSTRACT TRUNCATED AT 250 WORDS)

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