Decreased serum copper level in developmental stutterers

2000 ◽  
Vol 7 (6) ◽  
pp. 748-748 ◽  
Author(s):  
J. Pešák ◽  
J. Opavský
Keyword(s):  
Serum Copper ◽  
Copper Level ◽  
Serum Copper Level

Serum Copper Level and Polycystic Ovarian Syndrome: A Meta-Analysis

2021 ◽  
pp. 1-8
Author(s):  
Qingtao Jiang ◽  
Feng Zhang ◽  
Lei Han ◽  
Baoli Zhu ◽  
Xin Liu
Keyword(s):  
Large Scale ◽  
Polycystic Ovarian Syndrome ◽  
Meta Analysis ◽  
Serum Copper ◽  
Copper Level ◽  
Serum Copper Level ◽  
Copper Status ◽  
Plasma Copper ◽  
Mean Differences ◽  
Ovarian Syndrome

<b><i>Introduction:</i></b> The association of serum copper with polycystic ovarian syndrome (PCOS) has been studied for years, but no definite conclusion is drawn. Therefore, we conducted a meta-analysis to investigate serum copper concentrations in PCOS subjects compared with healthy controls. <b><i>Methods:</i></b> Electronic search was performed in PubMed, Google Scholar, and Scopus up to June 30, 2020, without any restriction. Standardized mean differences (SMDs) with corresponding 95% CIs in serum copper levels were employed with random-effects model. <i>I</i><sup>2</sup> was applied to evaluate heterogeneity among studies. <b><i>Results:</i></b> Nine studies, measuring plasma copper levels in 1,168 PCOS patients and 1,106 controls, were included. Pooled effect size suggested serum copper level was significantly higher in women with PCOS (SMD = 0.51 μg/mL, 95% CI = [0.30, 0.72], <i>p</i> &#x3c; 0.0001). The overall heterogeneity was not connected with subgroups of the country, but derived from the opposite result of 1 study. <b><i>Conclusion:</i></b> Our research generally indicated circulating copper level in PCOS sufferers was significantly higher than normal controls. Large-scale studies are still needed to elucidate the clear relation between copper status and etiology of PCOS.

scholarly journals Serum Copper with Coronary Artery Disease in Male and its Relation with Lipid Profile

1970 ◽  
pp. 7-9
Author(s):  
Sifat Jubaira ◽  
Forhadul Haque Mollah ◽  
Tahrim Mehdi ◽  
M Iqbal Arslan
Keyword(s):  
Myocardial Infarction ◽  
Coronary Artery Disease ◽  
Acute Myocardial Infarction ◽  
Coronary Artery ◽  
Lipid Profile ◽  
Density Lipoprotein ◽  
Serum Copper ◽  
Copper Level ◽  
Serum Copper Level ◽  
Artery Disease

The study was designed to explore serum copper as a risk factor for coronary artery disease (CAD). In this case-control study 30 healthy controls and 60 diagnosed cases of acute myocardial infarction (AMI) were enrolled. Serum copper concentration and serum lipid profile were measured in all study subjects. Serum copper level was significantly higher in AMI as compared to controls. The concentrations of serum TC, TG, LDL-C level were found to be significantly higher in cases as compared to controls. The concentration serum HDL-C was found to be significantly lower in cases as compared to controls. CAD leads to raised serum copper level and it has positive correlation with TC, TG and LDL-C but negative correlation with HDL-C in males.Keywords: Coronary artery disease; serum copper; acute myocardial infarction; total cholesterol; triglyceride; low density lipoprotein cholesterol. DOI: 10.3329/bjpp.v24i1.5730Bangladesh J Physiol Pharmacol 2008; 24(1&2) : 7-9

Low serum copper level and neural tube defect: A case control study

2007 ◽  
Vol 24 (1) ◽  
pp. 68
Author(s):  
Abbas Ali Keshtkar ◽  
Mohammad Jafar Golalipoor ◽  
Azad Reza Mansourian
Keyword(s):  
Neural Tube ◽  
Neural Tube Defect ◽  
Case Control Study ◽  
Case Control ◽  
Serum Copper ◽  
Copper Level ◽  
Serum Copper Level ◽  
Control Study ◽  
Low Serum

scholarly journals Establishment and Validation of Prognostic Nomograms Based on Serum Copper Level for Patients With Early-Stage Triple-Negative Breast Cancer

2021 ◽  
Vol 9 ◽  
Author(s):  
Fangfang Duan ◽  
Jianpei Li ◽  
Jiajia Huang ◽  
Xin Hua ◽  
Chenge Song ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Regression Analysis ◽  
Triple Negative ◽  
Cox Regression ◽  
Early Stage ◽  
Serum Copper ◽  
Copper Level ◽  
Serum Copper Level ◽  
Training Cohort ◽  
Cox Regression Analysis

Background: Altered copper levels have been observed in several cancers, but studies on the relationship between serum copper and early-stage triple-negative breast cancer (TNBC) remain scare. We sought to establish a predictive model incorporating serum copper levels for individualized survival predictions.Methods: We retrospectively analyzed clinicopathological information and baseline peripheric blood samples of patients diagnosed with early-stage TNBC between September 2005 and October 2016 at Sun Yat-sen University Cancer Center. The optimal cut-off point of serum copper level was determined using maximally selected log-rank statistics. Kaplan-Meier curves were used to estimate survival probabilities. Independent prognostic indicators associated with survival were identified using multivariate Cox regression analysis, and subsequently, prognostic nomograms were established to predict individualized disease-free survival (DFS) and overall survival (OS). The nomograms were validated in a separate cohort of 86 patients from the original randomized clinical trial SYSUCC-001 (SYSUCC-001 cohort).Results: 350 patients were eligible in this study, including 264 in the training cohort and 86 in the SYSUCC-001 cohort. An optimal cut-off value of 21.3 μmol/L of serum copper was determined to maximally divide patients into low- and high-copper groups. After a median follow-up of 87.1 months, patients with high copper levels had significantly worse DFS (p = 0.002) and OS (p &lt; 0.001) than those with low copper levels in the training cohort. Multivariate Cox regression analysis revealed that serum copper level was an independent factor for DFS and OS. Further, prognostic models based on serum copper were established for individualized predictions. These models showed excellent discrimination [C-index for DFS: 0.689, 95% confidence interval (CI): 0.621–0.757; C-index for OS: 0.728, 95% CI: 0.654–0.802] and predictive calibration, and were validated in the SYSUCC-001 cohort.Conclusion: Serum copper level is a potential predictive biomarker for patients with early-stage TNBC. Predictive nomograms based on serum copper might be served as a practical tool for individualized prognostication.

scholarly journals The Effects of Antiepileptic Drugs (AED) on Serum Copper Level in Children with Epilepsy

2019 ◽  
pp. 1-7
Author(s):  
Shamim-Ara-Sarkar . ◽  
Habibur Rahman ◽  
Israt Jahan ◽  
Md. Ranzu Ahmed
Keyword(s):  
Antiepileptic Drugs ◽  
Serum Copper ◽  
Copper Level ◽  
Control Group ◽  
Case Group ◽  
Serum Copper Level ◽  
Unusual Behavior ◽  
Epileptic Child ◽  
Multiple Drugs

Background: Epilepsy is a central nervous system disorder in which brain activity becomes irregular, causing seizures or periods of unusual behavior, sensations, and sometimes loss of awareness. Serum copper level may change due to long term use of antiepileptic drugs. Objective: The purpose of the present study was to assess the serum copper level in childhood epilepsy treated with long-term Anti-Epileptic Drug (AED). Methodology: This cross-sectional study was carried out in the Department of Paediatric Neurology, Bangabandhu Sheikh Mujib Medical University (BSMMU) during March to August’ 2013. Sample size was one hundred, among these fifty were case (epileptic child who had received  anti-epileptic drugs (Carbamazepine and/or Valproic acid) for more than three months) and rest fifty were control (newly diagnosed epileptic child, who yet not received antiepileptic drug). Result: The mean copper level was 1.11±0.32 µg/ml in case group and 0.96±0.20 µg/ml in control group, which was statistically significant (p<0.05). Conclusion: The use of one drug or multiple drugs in the treatment of epileptic patients may play significant role in increasing copper serum level.

Factors Influencing Serum Copper and Ceruloplasmin Oxidative Activity in the Rat

1958 ◽  
Vol 194 (3) ◽  
pp. 581-584 ◽  
Author(s):  
B. J. Meyer ◽  
A. C. Meyer ◽  
M. K. Horwitt
Keyword(s):  
Oxidase Activity ◽  
Normal Subjects ◽  
Estradiol Benzoate ◽  
Serum Copper ◽  
Copper Level ◽  
Serum Copper Level ◽  
Albino Rat ◽  
Rat Serum ◽  
Normal Humans ◽  
Average Serum

The effect of turpentine, estradiol benzoate and epinephrine hydrochloride on the copper concentration and paraphenylenediamine oxidase activity of serum were studied in the male albino rat. All three of these substances raised the serum copper level and paraphenylenediamine oxidase activity in both ‘control’ and ‘adrenalectomized’ animals, turpentine being the most active. The average serum copper level is approximately the same for normal humans and rats, while the phenylenediamine oxidase activity of normal human serum is about 2–3 times as high as that of rat serum. The data are discussed with relation to the known facts about serum copper in normal subjects and mental patients.

A Study on Serum Copper Level in 20 Acute Schizophrenics

1959 ◽  
Vol 105 (439) ◽  
pp. 511-513 ◽  
Author(s):  
E. L. Edelstein ◽  
D. Krassilowsky ◽  
J. Gdalia
Keyword(s):  
Serum Copper ◽  
Copper Level ◽  
Serum Copper Level ◽  
Chronic Infections ◽  
In Pregnancy

Blood copper had been known to be increased in pregnancy, chronic infections and neoplasms. Since the publication of Ullrich in 1942 (9), who found an increased copper level in the blood of schizophrenics, the hypercupraemia has been recognized as possibly significant and pathognomonic in this disease. Therefore during the following years a few investigators studied this aspect and also tried to prove the implications of this fact.

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