The antioxidants α-lipoic acid and N-acetylcysteine reverse memory impairment and brain oxidative stress in aged SAMP8 mice

Resveratrol (RVT) is a phytoalexin polyphenolic compound found in various plants, including grapes, berries and peanuts. Recently, studies have documented various health benefits of resveratrol including cardiovascular and cancer-chemopreventive properties. The aim of the present study was to demonstrate the effects of resveratrol on the learning and memory impairment. The senescence-accelerated mice (SAM) were introgastric gavage administrated resveratrol (25,100mg/(kg•bw)) for 60 days. The learning and memory behavior was assessed using open-field test while the parameters of oxidative stress assessed were malondialdehyde (MDA) and superoxide dismutases (SOD).The results showed that resveratrol significantly improved the learning and memory ability in open-field test. Further investigation showed that resveratrol restored SOD levels, but decreased MDA level in the mouce brain. These results indicated that the pharmacological action of RVT may offer a novel therapeutic strategy for the treatment of age-related conditions.

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Goat milk attenuates mimetic aging related memory impairment via suppressing brain oxidative stress, neurodegeneration and modulating neurotrophic factors in d-galactose-induced aging model

Biogerontology ◽

10.1007/s10522-019-09854-x ◽

2019 ◽

Vol 21 (2) ◽

pp. 203-216

Author(s):

Afifa Safdar ◽

Rahimah Zakaria ◽

Che Badariah Ab Aziz ◽

Usman Rashid ◽

Khairunnuur Fairuz Azman

Keyword(s):

Oxidative Stress ◽

Neurotrophic Factors ◽

Memory Impairment ◽

Goat Milk ◽

Aging Model ◽

Brain Oxidative Stress

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Methanolic Extract of Piper nigrum Fruits Improves Memory Impairment by Decreasing Brain Oxidative Stress in Amyloid Beta(1–42) Rat Model of Alzheimer’s Disease

Cellular and Molecular Neurobiology ◽

10.1007/s10571-014-0028-y ◽

2014 ◽

Vol 34 (3) ◽

pp. 437-449 ◽

Cited By ~ 48

Author(s):

Lucian Hritcu ◽

Jaurès A. Noumedem ◽

Oana Cioanca ◽

Monica Hancianu ◽

Victor Kuete ◽

...

Keyword(s):

Oxidative Stress ◽

Alzheimer’S Disease ◽

Alzheimer's Disease ◽

Amyloid Beta ◽

Rat Model ◽

Memory Impairment ◽

Methanolic Extract ◽

Piper Nigrum ◽

Model Of Alzheimer’S Disease ◽

Brain Oxidative Stress

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Co-administration of α-Lipoic Acid and Vitamin C Protects Liver and Brain Oxidative Stress in Mice Exposed to Arsenic Contaminated Water

Water Quality Exposure and Health ◽

10.1007/s12403-009-0013-8 ◽

2009 ◽

Vol 1 (3-4) ◽

pp. 135-144 ◽

Cited By ~ 12

Author(s):

Harshneet Kaur ◽

Deepshikha Mishra ◽

Pradeep Bhatnagar ◽

Pallavi Kaushik ◽

Swaran J. S. Flora

Keyword(s):

Oxidative Stress ◽

Vitamin C ◽

Lipoic Acid ◽

Contaminated Water ◽

Brain Oxidative Stress

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Agathisflavone isolated from Schinus polygamus (Cav.) Cabrera leaves prevents scopolamine-induced memory impairment and brain oxidative stress in zebrafish (Danio rerio)

Phytomedicine ◽

10.1016/j.phymed.2019.152889 ◽

2019 ◽

Vol 58 ◽

pp. 152889 ◽

Cited By ~ 10

Author(s):

Gabriela Dumitru ◽

Heba A.S. El-Nashar ◽

Nada M. Mostafa ◽

Omayma A. Eldahshan ◽

Razvan Stefan Boiangiu ◽

...

Keyword(s):

Oxidative Stress ◽

Danio Rerio ◽

Memory Impairment ◽

Brain Oxidative Stress

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EFFECT OF ECLIPTA ALBA ON SCOPOLAMINE INDUCED AMNESIA IN MICE

Journal of Drug Delivery and Therapeutics ◽

10.22270/jddt.v8i5-s.1926 ◽

2018 ◽

Vol 8 (5-s) ◽

pp. 162-168

Author(s):

Harmel Singh Chahal ◽

Shailendra Sharma

Keyword(s):

Oxidative Stress ◽

Learning And Memory ◽

Morris Water Maze ◽

Water Maze ◽

Memory Impairment ◽

Ache Activity ◽

Memory Deficits ◽

Eclipta Alba ◽

Brain Oxidative Stress ◽

Brain Ache Activity

The present study deals with the evaluation of potential effects of Eclipta alba (EA) in memory impairment of mice. Memory impairment was induced by scopolamine (3 mg/kg, i.p) in animals. To assess learning and memory in mice Morris water maze test was employed. The acetylcholinestrase enzyme (AChE) activity in brain was measured to evaluate the central cholinergic activity. The levels of thiobarbituric acid-reactive species (TBARS) and reduced glutathione (GSH)in brain were estimated to assess the degree of oxidative stress. Scopolamine treatment produces significant impairment of learning and memory in mice, as reflected by a significant decrease in MWM performance. Scopolamine also produced a significant enhancement of brain AChE activity and brain oxidative stress (increase in TBARS and decrease in GSH) levels. EA (300 and 600 mg/kg,oral) significantly prevented scopolamine-induced learning and memory deficits along with decrease of scopolamine-induced rise in brain AChE activity and brain oxidative stress levels. It may be concluded that Eclipta alba has significant protective action against scopolamine induced memory deficits in mice that can be attributed to its anti AChE and anti oxidant actions. Keywords: Alzheimer disease, Oxidative stress, Morris water Maze, Scopolamine

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Nicotine-induced memory impairment by increasing brain oxidative stress

Open Life Sciences ◽

10.2478/s11535-009-0029-x ◽

2009 ◽

Vol 4 (3) ◽

pp. 335-342 ◽

Cited By ~ 16

Author(s):

Lucian Hritcu ◽

Alin Ciobica ◽

Lucian Gorgan

Keyword(s):

Oxidative Stress ◽

Passive Avoidance ◽

Memory Impairment ◽

Short Term Memory ◽

Memory Performance ◽

Long Term Memory ◽

Avoidance Task ◽

Term Memory ◽

Y Maze ◽

Brain Oxidative Stress

AbstractMale Wistar rats were subjected to chronic nicotine treatment (0.3 mg/kg; 7 continuous days) and their memory performance was studied by means of Y-maze and multi-trial passive avoidance tasks. Nicotine significantly decreased spontaneous alternation in Y-maze task and step-through-latency in the multi-trial passive avoidance task, suggesting effects on both short-term memory and long-term memory, respectively. In addition, nicotine induced neuronal apoptosis, DNA fragmentation, reduced antioxidant enzymes activity, and increased production of lipid peroxidation and reactive oxygen species, suggesting pro-oxidant activity. Our results provide further support that nicotine-induced memory impairment is due to an increase in brain oxidative stress in rats.

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