Methanolic Extract of Piper nigrum Fruits Improves Memory Impairment by Decreasing Brain Oxidative Stress in Amyloid Beta(1–42) Rat Model of Alzheimer’s Disease

2014 ◽  
Vol 34 (3) ◽  
pp. 437-449 ◽  
Author(s):  
Lucian Hritcu ◽  
Jaurès A. Noumedem ◽  
Oana Cioanca ◽  
Monica Hancianu ◽  
Victor Kuete ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Amyloid Beta ◽  
Rat Model ◽  
Memory Impairment ◽  
Methanolic Extract ◽  
Piper Nigrum ◽  
Model Of Alzheimer’S Disease ◽  
Brain Oxidative Stress

Impact of Cerebral Radiofrequency Exposures on Oxidative Stress and Corticosterone in a Rat Model of Alzheimer’s Disease

2020 ◽  
Vol 73 (2) ◽  
pp. 467-476 ◽  
Author(s):  
Marc Bouji ◽  
Anthony Lecomte ◽  
Christelle Gamez ◽  
Kelly Blazy ◽  
Anne-Sophie Villégier
Keyword(s):  
Oxidative Stress ◽  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Rat Model ◽  
Model Of Alzheimer’S Disease

Effects of levothyroxine on lung inflammation, oxidative stress and pathology in a rat model of Alzheimer’s disease

2020 ◽  
Vol 277 ◽  
pp. 103437
Author(s):  
Kowsar Bavarsad ◽  
Saeideh Saadat ◽  
Nema Mohammadian Roshan ◽  
Mousa-Al-Reza Hadjzadeh ◽  
Mohammad Hossein Boskabady
Keyword(s):  
Oxidative Stress ◽  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Rat Model ◽  
Lung Inflammation ◽  
Model Of Alzheimer’S Disease

Protective Effect of Kaempferol on the Transgenic Drosophila Model of Alzheimer’s Disease

2018 ◽  
Vol 17 (6) ◽  
pp. 421-429 ◽  
Author(s):  
Tanveer Beg ◽  
Smita Jyoti ◽  
Falaq Naz ◽  
Rahul ◽  
Fahad Ali ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Amyloid Beta ◽  
Neuronal Damage ◽  
Natural Antioxidants ◽  
Acetylcholinesterase Activity ◽  
Model Of Alzheimer’S Disease ◽  
Climbing Ability ◽  
Transgenic Drosophila

Background: Alzheimer’s disease (AD) is characterized by the accumulation and deposition of β-amyloid peptides leading to a progressive neuronal damage and cell loss. Besides several hypotheses for explaining the neurodegenerative mechanisms, oxidative stress has been considered to be one of them. Till date, there is no cure for AD, but the pathogenesis of the disease could be delayed by the use of natural antioxidants. In this context, we decided to study the effect of kaempferol against the transgenic Drosophila expressing human amyloid beta-42. Method: The AD flies were allowed to feed on the diet having 10, 20, 30 and 40µM of kaempferol for 30 days. After 30 days of exposure, the amyloid beta flies were studied for their climbing ability and Aversive Phototaxis Suppression assay. Amyloid beta flies head homogenate was prepared for estimating the oxidative stress markers, Caspase and acetylcholinesterase activity. Results: The results of the present study reveal that the exposure of AD flies to kaempferol delayed the loss of climbing ability, memory, reduced the oxidative stress and acetylcholinesterase activity. Conclusion: Kaempferol could be used as a possible therapeutic agent against the progression of the Alzheimer’s disease.

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