p53 Polymorphism (codon-72) has no correlation with the development and the clinical features of cervical cancer

2000 ◽  
Vol 10 (5) ◽  
pp. 402-407 ◽  
Author(s):  
A. Nishikawa ◽  
T. Fujimoto ◽  
N. Akutagawa ◽  
M. Iwasaki ◽  
M. Takeuchi ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Clinical Features ◽  
Codon 72 ◽  
P53 Polymorphism

scholarly journals p53 polymorphism in codon 72 and risk of human papillomavirus-induced cervical cancer: effect of inter-laboratory variation

2000 ◽  
Vol 87 (4) ◽  
pp. 528-533 ◽  
Author(s):  
Hela Makni ◽  
Eduardo L. Franco ◽  
Jane Kaiano ◽  
Luisa L. Villa ◽  
Sylvie Labrecque ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Human Papillomavirus ◽  
Codon 72 ◽  
P53 Polymorphism

Codon 72 polymorphism of p53 in Israeli Jewish cervical cancer patients and healthy women

2002 ◽  
Vol 12 (6) ◽  
pp. 741-744 ◽  
Author(s):  
S. Arbel-Alon ◽  
J. Menczer ◽  
N. Feldman ◽  
M. Glezerman ◽  
L. Yeremin ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Cancer Patients ◽  
Population Sample ◽  
Significant Risk ◽  
Significant Risk Factor ◽  
Jewish Women ◽  
North African ◽  
Frequency Pattern ◽  
Codon 72 ◽  
P53 Polymorphism

Recently it has been found that the presence of homozygous arginine polymorphism at codon 72 of p53, represents a significant risk factor in the development of HPV-associated cervical cancer. The incidence of cervical carcinoma is persistently very low in Israeli Jewish women for unknown reasons. The incidence among those of North African origin is relatively higher. The aim of the present study was to assess the frequency distribution of the p53 homozygous arginine polymorphism in cervical cancer patients and in a population sample of healthy Israeli Jewish women in order to determine whether the incidence pattern among them is genetically based. The cases consisted of 23 Israeli Jewish patients with histologically confirmed squamous cell carcinoma of the cervix. A group of 162 randomly chosen Israeli Jewish healthy participants, considered to represent the general population, comprised the controls. The germline p53 polymorphism at codon 72 was determined by PCR in DNA obtained from a blood sample taken from each subject. Homozygous arginine was found in 34.8% of cases and in only 14.8% of controls. This difference was statistically significant (P = 0.01). The frequency of homozygous arginine polymorphism in controls was lower than in any other population hitherto reported. It was significantly more common among those of North African than among those of other origin (30.3% vs. 10.8%; P < 0.01). It may be assumed that the low incidence of cervical cancer in Israeli Jewish women and the differences between the ethnic groups may be related to the frequency pattern of the homozygous arginine p53 polymorphism

Association of TP53 codon 72 polymorphism with cervical cancer risk in Chinese women

2010 ◽  
Vol 197 (2) ◽  
pp. 174-178 ◽  
Author(s):  
Pei Jiang ◽  
Jianxin Liu ◽  
Xiaoxi Zeng ◽  
Wen Li ◽  
Jianxin Tang
Keyword(s):  
Cervical Cancer ◽  
Cancer Risk ◽  
Chinese Women ◽  
Codon 72 ◽  
Cervical Cancer Risk ◽  
Codon 72 Polymorphism ◽  
Tp53 Codon 72 Polymorphism

MTHFR/p53 Polymorphisms as Genetic Factors for Cervical Intraepithelial Neoplasia and Cervical Cancer in HPV-infected Mexican Women

2014 ◽  
Vol 29 (2) ◽  
pp. 142-149 ◽  
Author(s):  
Lizbeth González-Herrera ◽  
Patricia Rodríguez-Morales ◽  
María del Refugio González-Losa ◽  
Gerardo Pérez-Mendoza ◽  
Jaqueline Canul-Canché ◽  
...  
Keyword(s):  
Risk Factors ◽  
Cervical Cancer ◽  
Cervical Intraepithelial Neoplasia ◽  
Genetic Risk ◽  
Intraepithelial Neoplasia ◽  
Genetic Risk Factors ◽  
Mthfr Polymorphism ◽  
Hpv Test ◽  
P53 Polymorphism ◽  
P53 Polymorphisms

We performed a case-control association study to evaluate the association between common polymorphisms in MTHFR (C677T and A1298C) and the Arg72Pro polymorphism in the p53 gene and the risk for cervical intraepithelial neoplasia (CIN) or invasive cervical cancer (ICC) in Mexican HPV-infected women. We included 131 women with diagnosis of CIN grade I-II and 78 with CIN III or ICC; as controls we also included 274 women with normal Pap smear and negative HPV test. Genotyping for MTHFR and p53 polymorphisms was performed by PCR-RFPLs. HPV was tested by Hybrid Capture II. Odds ratios and 95% confidence intervals were estimated. Genotype frequencies for the 3 studied polymorphisms were distributed according to the Hardy-Weinberg equilibrium. The A1298C-MTHFR polymorphism showed significant differences for the heterozygous AC genotype and the C allele, whereas the AA genotype and A allele resulted to be genetic risk factors for CIN or ICC (p<0.03). The Arg72Pro-p53 polymorphism showed for the genotypes Arg/Pro and Pro/Pro, and for the Pro allele, a significant association only to the risk for CIN (p<0.03). The MTHFR/p53 interaction showed that the genotype combinations AA/ArgArg and AA/ArgPro were associated, respectively, to the risk of ICC and CIN (p<0.05). This study suggests that the A1298C-MTHFR polymorphism contributes to the genetic risk for both CIN and ICC, whereas the Arg72Pro-p53 polymorphism only contributes to the risk for CIN. The MTHFR/p53 genetic combinations AA/ArgArg and AA/ArgPro are associated genetic risk factors for ICC and CIN in Mexican HPV-infected women.

Oncology

2020 ◽  
pp. 493-508
Author(s):  
Charlotte Frise ◽  
Sally Collins
Keyword(s):  
Cervical Cancer ◽  
Clinical Features ◽  
Late Effects ◽  
Acute Leukaemia ◽  
Hodgkin’S Lymphoma ◽  
Hodgkin's Lymphoma ◽  
Neutropenic Sepsis ◽  
Breast And Cervical Cancer

Principles of managing cancer during pregnancy are described in this chapter. Subsequently, the background, clinical features, and management of breast and cervical cancer, melanoma, Hodgkin’s lymphoma, and acute leukaemia are separately covered. Preserving fertility, late effects on treatment, and neutropenic sepsis are also described.

ECHOGRAPHIC AND CLINICAL FEATURES OF CERVICAL CANCER

2020 ◽  
Vol 93 (1) ◽  
pp. 46-48
Author(s):  
Dilfuzaxon Mamarasulova ◽  
◽  
Dilnoza Isakova ◽  
Habibaxon Negmatshayeva ◽  
Albina Validova ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Disease Progression ◽  
Clinical Features ◽  
Malignant Tumors ◽  
Cancer Center ◽  
Optimal Methods ◽  
Ultrasound Monitoring ◽  
Methods Of Treatment

This article discusses the clinical and echodopplerographic features of cervical cancer, which allows to improve the differential, topical and clarifying diagnosis of malignant tumors of the uterus. The material for the study included 115 patients with cervical cancer who applied to the Andijan branch of the cancer center. The revealed clinical and echodopplerographic features of СС made it possible to predict the course, outcome of the disease and to choose the optimal methods of treatment. Ultrasound monitoring of patients with СС, allows to assess the effectiveness of treatment and timely detect metastases and disease progression.

TP53 Codon 72 Polymorphism does not Affect Risk of Cervical Cancer in Patients from the Gambia

2003 ◽  
Vol 18 (4) ◽  
pp. 280-283 ◽  
Author(s):  
G. Tanara ◽  
C. Falugi ◽  
A. Cesario ◽  
S. Margaritora ◽  
P. Russo ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Geographical Area ◽  
Population Sample ◽  
Hpv Infection ◽  
The Gambia ◽  
Control Group ◽  
Genotype Distribution ◽  
Hpv 16 ◽  
Codon 72 ◽  
Tp53 Polymorphism

Aims A case-control study was performed to investigate the relationship between cervical cancer and TP53 polymorphism at codon 72 in young black African women from The Gambia. Materials and Methods The TP53 polymorphism at codon 72 was examined by PCR amplification and SSCP analysis in 40 patients with primary cervical cancer and in 20 healthy women of the same age and from the same geographical area. The occurrence of TP53 polymorphism in combination with the HPV-16 E6 genotype (assayed by PCR) was evaluated. Results The distribution of TP53 genotypes in cervical cancer patients and in the control group was not statistically different (p=0.45) and homozygosity for argine at residue 72 was not associated with cervical cancer (odds ratio: 1.24; 95% confidence interval 0.21-9.16). Similarly, a different genotype distribution, cervical cancer and presence of HPV-16 E6 were not observed. Conclusions These results cannot rule out an association between TP53 polymorphism at codon 72, HPV infection and the etiology of cervical cancer in this population sample.

Correlation between human papillomavirus-associated cervical cancer and p53 codon 72 arginine/proline polymorphism

1999 ◽  
Vol 105 (6) ◽  
pp. 564-566 ◽  
Author(s):  
R. Tachezy ◽  
I. Mikyšková ◽  
M. Saláková ◽  
M. Van Ranst
Keyword(s):  
Cervical Cancer ◽  
Human Papillomavirus ◽  
P53 Codon 72 ◽  
Codon 72
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