Seasonal Variations in Serum Levels of 25-Hydroxyvitamin D and Parathyroid Hormone but no Detectable Change in Femoral Neck Bone Density in an Older Population with Regular Outdoor Exposure

2001 ◽  
Vol 49 (9) ◽  
pp. 1190-1196 ◽  
Author(s):  
Annalisa Melin ◽  
Jan Wilske ◽  
Hans Ringertz ◽  
Maric Sääf
Keyword(s):  
Parathyroid Hormone ◽  
Bone Density ◽  
Femoral Neck ◽  
Seasonal Variations ◽  
Serum Levels ◽  
Outdoor Exposure ◽  
Detectable Change ◽  
Older Population ◽  
Hydroxyvitamin D ◽  
25 Hydroxyvitamin D

Are there any seasonal variations in 25-hydroxyvitamin D and parathyroid hormone serum levels in children and adolescents with severe obesity?

2020 ◽  
Author(s):  
Teodoro Durá-Travé ◽  
Fidel Gallinas-Victoriano ◽  
María Malumbres-Chacon ◽  
Lotfi Ahmed-Mohamed ◽  
María Jesús Chueca-Guindulain ◽  
...  
Keyword(s):  
Parathyroid Hormone ◽  
Children And Adolescents ◽  
Seasonal Variations ◽  
Severe Obesity ◽  
Serum Levels ◽  
Hydroxyvitamin D ◽  
25 Hydroxyvitamin D

Seasonal variations of 25 hydroxyvitamin D and parathyroid hormone in Ushuaia (Argentina), the southernmost city of the world

1993 ◽  
Vol 20 (1) ◽  
pp. 99-108 ◽  
Author(s):  
M.B. Oliveri ◽  
M. Ladizesky ◽  
C.A. Mautalen ◽  
A. Alonso ◽  
L. Martinez
Keyword(s):  
Parathyroid Hormone ◽  
Seasonal Variations ◽  
Hydroxyvitamin D ◽  
The World ◽  
25 Hydroxyvitamin D

Vitamin D and Calcitonin Treatment in Patients with Femoral Neck Fracture: A Prospective Controlled Clinical Study

1989 ◽  
Vol 17 (3) ◽  
pp. 226-242 ◽  
Author(s):  
E. Harju ◽  
R. Punnonen ◽  
R. Tuimala ◽  
J. Salmi ◽  
I. Paronen
Keyword(s):  
Vitamin D ◽  
Parathyroid Hormone ◽  
Serum Levels ◽  
Serum Calcitonin ◽  
Hydroxyvitamin D ◽  
Dihydroxyvitamin D ◽  
1,25 Dihydroxyvitamin D ◽  
Age Related ◽  
Neck Fracture ◽  
25 Hydroxyvitamin D

The effects on general and bone metabolism of femoral neck fracture patients of 0.25 μg α-calcoid given orally twice daily ( n=9) and 25 μg calcitonin given subcutaneously 30 times ( n=10) in 10 weeks were studied against a control ( n=ll). Bone histology and histomorphometry showed non-age related osteoporosis in 30% and osteomalacia in 22% of the patients studied. Impaired serum vitamin D status was found in 47 – 88% of patients, secondary hyperparathyroidism and increased serum parathyroid hormone in 59% and decreased serum calcitonin levels in 69%. On histology, normal findings and non-age related osteoporosis on histology were associated with low serum levels of 25-hydroxyvitamin D3,1,25- and 24,25-dihydroxy vitamin D3. Very high serum levels of 1,25-dihydroxyvitamin D3 and low levels of 25-hydroxyvitamin D3 occurred in fracture patients with osteomalacia. Calcitonin improved calcium balance, reduced osteoporosis and increased the serum 1,25- and 24,25-dihydroxyvitamin D3 levels but had no effect on osteomalacia. Vitamin D reduced osteomalacia, slightly increased the serum 1,25-dihydroxyvitamin D3 concentration and decreased serum levels of parathyroid hormone. Both treatments gave a similar slight decrease in serum calcitonin concentrations. A mechanism of action for the treatments is suggested.

Aging Adjusted Serum Levels of Parathyroid Hormone and 25-Hydroxyvitamin D in Outpatients of a Tertiary Care Center using Generalized Additive Models for Location, Scale, and Shape

2020 ◽  
Vol 04 (06) ◽  
Author(s):  
Tatiana Munhoz da Rocha Lemos Costa ◽  
Salomão Cury Riechi ◽  
Ricardo Rasmussen Petterle ◽  
Kátia Cristina Boritza ◽  
Carolina Aguiar Moreira ◽  
...  
Keyword(s):  
Parathyroid Hormone ◽  
Care Center ◽  
Generalized Additive Models ◽  
Tertiary Care ◽  
Serum Levels ◽  
Additive Models ◽  
Tertiary Care Center ◽  
Hydroxyvitamin D ◽  
25 Hydroxyvitamin D

scholarly journals Bone density parathyroid hormone and 25-hydroxyvitamin D concentrations in middle aged women.

BMJ ◽  
1992 ◽  
Vol 305 (6848) ◽  
pp. 273-277 ◽  
Author(s):  
K. T. Khaw ◽  
M. J. Sneyd ◽  
J. Compston
Keyword(s):  
Parathyroid Hormone ◽  
Bone Density ◽  
Middle Aged ◽  
Hydroxyvitamin D ◽  
25 Hydroxyvitamin D

scholarly journals Older Age Is Associated with Decreased Levels of VDR, CYP27B1, and CYP24A1 and Increased Levels of PTH in Human Parathyroid Glands

2020 ◽  
Vol 2020 ◽  
pp. 1-6
Author(s):  
Yi Jiang ◽  
Liyan Liao ◽  
Jina Li ◽  
Larry Wang ◽  
Zhongjian Xie
Keyword(s):  
Parathyroid Hormone ◽  
Inverse Correlation ◽  
Serum Levels ◽  
Older Age ◽  
Parathyroid Glands ◽  
Expression Levels ◽  
Hydroxyvitamin D ◽  
Dihydroxyvitamin D ◽  
1,25 Dihydroxyvitamin D ◽  
25 Hydroxyvitamin D

Parathyroid glands contain the vitamin D receptor (VDR) and 25-hydroxyvitamin D-1α-hydroxylase (CYP27B1) and 24-hydroxylase (CYP24A1), which catalyze the production and degradation of 1,25-dihydroxyvitamin D [1,25(OH)2D], respectively. Previous studies have shown that the serum level of intact parathyroid hormone (iPTH) increases with age. We hypothesized that the expression of CYP27B1 or VDR in parathyroid glands decreases with age, which might account for the increased serum levels of iPTH due to decreased suppression of parathyroid hormone (PTH) secretion by 1,25(OH)2D in older people. To test this hypothesis, we examined relative expression levels of VDR, CYP27B1, CYP24A1, and PTH in specimens from parathyroid glands unintentionally removed during thyroidectomy for 70 patients varying in age from 10 to 70 years. The results showed that there was an inverse correlation between age and VDR, CYP27B1, and CYP24A1 expression (p<0.05). A significant positive correlation between PTH expression levels and age was also observed (p<0.05). These data indicate that older age is associated with decreased levels of VDR, CYP27B1, and CYP24A1 and increased levels of PTH in human parathyroid glands.

Sign in / Sign up

Export Citation Format

Share Document