SERUM LEVELS OF 25-HYDROXYVITAMIN D, 24,25-DIHYDROXYVITAMIN D AND PARATHYROID HORMONE IN PATIENTS WITH FEMORAL NECK FRACTURE IN SOUTHERN FINLAND

The effects on general and bone metabolism of femoral neck fracture patients of 0.25 μg α-calcoid given orally twice daily ( n=9) and 25 μg calcitonin given subcutaneously 30 times ( n=10) in 10 weeks were studied against a control ( n=ll). Bone histology and histomorphometry showed non-age related osteoporosis in 30% and osteomalacia in 22% of the patients studied. Impaired serum vitamin D status was found in 47 – 88% of patients, secondary hyperparathyroidism and increased serum parathyroid hormone in 59% and decreased serum calcitonin levels in 69%. On histology, normal findings and non-age related osteoporosis on histology were associated with low serum levels of 25-hydroxyvitamin D3,1,25- and 24,25-dihydroxy vitamin D3. Very high serum levels of 1,25-dihydroxyvitamin D3 and low levels of 25-hydroxyvitamin D3 occurred in fracture patients with osteomalacia. Calcitonin improved calcium balance, reduced osteoporosis and increased the serum 1,25- and 24,25-dihydroxyvitamin D3 levels but had no effect on osteomalacia. Vitamin D reduced osteomalacia, slightly increased the serum 1,25-dihydroxyvitamin D3 concentration and decreased serum levels of parathyroid hormone. Both treatments gave a similar slight decrease in serum calcitonin concentrations. A mechanism of action for the treatments is suggested.

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Serum 24,25-dihydroxyvitamin D and 25-hydroxyvitamin D concentrations in femoral neck fracture.

BMJ ◽

10.1136/bmj.2.6146.1196-a ◽

1978 ◽

Vol 2 (6146) ◽

pp. 1196-1197 ◽

Cited By ~ 32

Author(s):

Y Weisman ◽

R Salama ◽

A Harell ◽

S Edelstein

Keyword(s):

Femoral Neck ◽

Femoral Neck Fracture ◽

Hydroxyvitamin D ◽

Dihydroxyvitamin D ◽

Neck Fracture ◽

25 Hydroxyvitamin D

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Seasonal Variations in Serum Levels of 25-Hydroxyvitamin D and Parathyroid Hormone but no Detectable Change in Femoral Neck Bone Density in an Older Population with Regular Outdoor Exposure

Journal of the American Geriatrics Society ◽

10.1046/j.1532-5415.2001.49236.x ◽

2001 ◽

Vol 49 (9) ◽

pp. 1190-1196 ◽

Cited By ~ 44

Author(s):

Annalisa Melin ◽

Jan Wilske ◽

Hans Ringertz ◽

Maric SÃ¤Ã¤f

Keyword(s):

Parathyroid Hormone ◽

Bone Density ◽

Femoral Neck ◽

Seasonal Variations ◽

Serum Levels ◽

Outdoor Exposure ◽

Detectable Change ◽

Older Population ◽

Hydroxyvitamin D ◽

25 Hydroxyvitamin D

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Perioperative risk factors in patients with a femoral neck fracture – influence of 25-hydroxyvitamin D and C-reactive protein on postoperative medical complications and 1-year mortality

BMC Musculoskeletal Disorders ◽

10.1186/s12891-016-0906-1 ◽

2016 ◽

Vol 17 (1) ◽

Cited By ~ 10

Author(s):

Johannes KM Fakler ◽

Antonia Grafe ◽

Jamila Dinger ◽

Christoph Josten ◽

Gabriela Aust

Keyword(s):

Risk Factors ◽

Femoral Neck ◽

Femoral Neck Fracture ◽

Perioperative Risk ◽

Medical Complications ◽

C Reactive Protein ◽

Hydroxyvitamin D ◽

Reactive Protein ◽

Neck Fracture ◽

25 Hydroxyvitamin D

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Older Age Is Associated with Decreased Levels of VDR, CYP27B1, and CYP24A1 and Increased Levels of PTH in Human Parathyroid Glands

International Journal of Endocrinology ◽

10.1155/2020/7257913 ◽

2020 ◽

Vol 2020 ◽

pp. 1-6

Author(s):

Yi Jiang ◽

Liyan Liao ◽

Jina Li ◽

Larry Wang ◽

Zhongjian Xie

Keyword(s):

Parathyroid Hormone ◽

Inverse Correlation ◽

Serum Levels ◽

Older Age ◽

Parathyroid Glands ◽

Expression Levels ◽

Hydroxyvitamin D ◽

Dihydroxyvitamin D ◽

1,25 Dihydroxyvitamin D ◽

25 Hydroxyvitamin D

Parathyroid glands contain the vitamin D receptor (VDR) and 25-hydroxyvitamin D-1α-hydroxylase (CYP27B1) and 24-hydroxylase (CYP24A1), which catalyze the production and degradation of 1,25-dihydroxyvitamin D [1,25(OH)2D], respectively. Previous studies have shown that the serum level of intact parathyroid hormone (iPTH) increases with age. We hypothesized that the expression of CYP27B1 or VDR in parathyroid glands decreases with age, which might account for the increased serum levels of iPTH due to decreased suppression of parathyroid hormone (PTH) secretion by 1,25(OH)2D in older people. To test this hypothesis, we examined relative expression levels of VDR, CYP27B1, CYP24A1, and PTH in specimens from parathyroid glands unintentionally removed during thyroidectomy for 70 patients varying in age from 10 to 70 years. The results showed that there was an inverse correlation between age and VDR, CYP27B1, and CYP24A1 expression (p<0.05). A significant positive correlation between PTH expression levels and age was also observed (p<0.05). These data indicate that older age is associated with decreased levels of VDR, CYP27B1, and CYP24A1 and increased levels of PTH in human parathyroid glands.

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Preliminary study on serum levels of 1, 25-dihydroxyvitamin D and 25-hydroxyvitamin D in cadmium-induced renal tubular dysfunction

Toxicology Letters ◽

10.1016/0378-4274(91)90123-n ◽

1991 ◽

Vol 57 (1) ◽

pp. 91-99 ◽

Cited By ~ 14

Author(s):

A KEIKO ◽

K MINORU

Keyword(s):

Serum Levels ◽

Tubular Dysfunction ◽

Renal Tubular Dysfunction ◽

Hydroxyvitamin D ◽

Dihydroxyvitamin D ◽

25 Hydroxyvitamin D ◽

Preliminary Study ◽

Renal Tubular

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Lack of influence of the anabolic steroid nandrolondecanoate on bone metabolism

Acta Endocrinologica ◽

10.1530/acta.0.1010140 ◽

1982 ◽

Vol 101 (1) ◽

pp. 140-143 ◽

Cited By ~ 5

Author(s):

J. W. J. Bijlsma ◽

S. A. Duursma ◽

R. Bosch ◽

O. Huber

Keyword(s):

Bone Metabolism ◽

Anabolic Steroid ◽

Seasonal Fluctuation ◽

Serum Levels ◽

Term Treatment ◽

Gamma Glutamyl Transpeptidase ◽

Short Term Treatment ◽

Hydroxyvitamin D ◽

Dihydroxyvitamin D ◽

25 Hydroxyvitamin D

Abstract. Eleven male patients with rheumatoid arthritis were treated with the anabolic steroid nandrolondecanoate and parameters of calcium and bone metabolism were studied. No changes were found in the concentrations of calcium, phosphorus or hydroxyproline in serum and urine (corrected for the creaturia). A significant decrease (P < 0.01) was observed in the levels of alkaline phosphatase, but this was attributed to a change in liver enzymes, because the gamma glutamyl transpeptidase fell. Acid phosphatase levels showed an increase, possibly as a result of an effect of nandrolondecanoate on the prostate. No change was found during treatment in the serum levels of parathyroid hormone, calcitonin, 25 hydroxyvitamin D, 24,25 dihydroxyvitamin D and 1.25 dihydroxyvitamin D. A seasonal fluctuation was observed for 25 hydroxyvitamin D and 24,25 dihydroxyvitamin D, but not for 1,25 dihydroxyvitamin D. It was concluded that short-term treatment with the anabolic steroid nandrolondecanoate did not result in changes in parameters of calcium and bone metabolism.

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