Infectivity of blood from PCR-positive, HBsAg-negative, anti-HBs-positive cases of resolved hepatitis B infection

Transfusion ◽  
2001 ◽  
Vol 41 (3) ◽  
pp. 329-332 ◽  
Author(s):  
Alfred M. Prince ◽  
Dong-Hun Lee ◽  
Betsy Brotman
Keyword(s):  
Hepatitis B ◽  
Hepatitis B Infection ◽  
Positive Hbsag

scholarly journals HBsAg in Cord Blood Qf Newborns of HBsAg-Positive Mothers

2018 ◽  
Vol 34 (5-6) ◽  
pp. 125-8
Author(s):  
Adnan S. Wiharta ◽  
Evi Setiadi ◽  
H. M. Sjaifullah Noer ◽  
Triyatmo Rachimhadhi ◽  
Asri Rasad
Keyword(s):  
Hepatitis B ◽  
Cord Blood ◽  
Vertical Transmission ◽  
Placental Tissue ◽  
Intrauterine Infection ◽  
Hepatitis B Infection ◽  
Fetal Circulation ◽  
Positive Hbsag ◽  
Infancy And Early Childhood ◽  
Pregnant Mothers

Vertical transmission of hepatitis B infection that may occur during pregnancy at delivery-, in infancy, and early childhood has an important role in the development of chronic hepatitis B. Intrauterine infection is suspected to occur when hepatitis B viruses cross the placenta into fetal circulation due to failure of placental tissue function. In Cipto Mangunkusumo Hospital, Jakarta, 98 (6.4%) of 1536 pregnant mothers obseiVed during 3 years (1987 -1990) showed positive HBsAg. Six (8.3%) of 60 babies of born to HBsAg positive mothers showed positive HBsAg in their cord blood, but this disappeared after one month. All babies born to HBsAg positive mothers were vaccinated on months 0, 1, 2, and 12. HBsAg in cord blood might not play an important role in vertical transmission.

Update in management of hepatitis B in pregnancy and prevention of mother to child hepatitis B transmission

2018 ◽  
Vol 1 (3) ◽  
pp. 1-8
Author(s):  
Naichaya Chamroonkul
Keyword(s):  
Chronic Hepatitis ◽  
Viral Load ◽  
Hepatitis B ◽  
Chronic Hepatitis B ◽  
High Viral Load ◽  
World Population ◽  
Hepatitis B Infection ◽  
Mother To Child Transmission ◽  
Child Transmission ◽  
Mother To Child

Even with two decades of widespread using hepatitis B vaccination, chronic hepatitis B remains a major global health problem. In Thailand, the prevalence of chronic hepatitis B infection was down from 8 - 10% in last decade to 5% recently. Failure to control mother to child transmission is one of the important barriers to the total elimination of hepatitis B infection from world population. In the majority, vertical transmission can be prevented with a universal screening program, immunoprophylaxis by administration of hepatitis B vaccine and hepatitis B immunoglobulin (HBIg) for babies born to mothers with HBV. However, in mothers with a high viral load, the chance of immunoprophylaxis failure remains high. To date, there are standard recommendations by all international liver societies including AASLD, EASL and APASL suggest introducing an antiviral agent during the third trimester to CHB pregnant women with a high viral load. Previous US FDA pregnancy category B agents such as Tenofovir and Telbivudine are allowed through all trimesters of pregnancy and are effective for prevention of mother to child transmission. Breastfeeding for patients who receive antiviral agents can be allowed after a risk-benefit discussion with the patient and family.

Nucleic acid-based antiviral and gene therapy of chronic hepatitis B infection

1997 ◽  
Vol 12 (9-10) ◽  
pp. S354-S369 ◽  
Author(s):  
JR WANDS ◽  
M GEISSLER ◽  
JZU PUTLITZ ◽  
H BLUM ◽  
F WEIZSÄCKER ◽  
...  
Keyword(s):  
Gene Therapy ◽  
Chronic Hepatitis ◽  
Nucleic Acid ◽  
Hepatitis B ◽  
Chronic Hepatitis B ◽  
Hepatitis B Infection ◽  
Chronic Hepatitis B Infection
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