scholarly journals Antihyperglycemic and diabetic wound healing activity of smallanthus sonchifolius leaves extract

2018 ◽  
Vol 197 ◽  
pp. 07001
Author(s):  
Rina Herowati ◽  
Alip D.S. Saputri ◽  
Tri Wijayanti ◽  
Gunawan P. Widodo
Keyword(s):  
Wound Healing ◽  
Foot Ulcer ◽  
Diabetic Foot Ulcer ◽  
Topical Administration ◽  
Serum Glucose ◽  
Diabetic Wound ◽  
Smallanthus Sonchifolius ◽  
Biopsy Punch ◽  
Diabetic Wound Healing ◽  
Wound Healing Activity

Diabetic patient tend to suffer from lower extremity complication that contribute to the occurence of diabetic foot ulcer. Smallanthus sonchifolius or yacon leaves extract has been used as an alternative medicine for diabetes and also showed antibacterial activity. This research aims to obtain the antihyperglycemic and diabetic wound healing activity of yacon leaves extract. Diabetic condition of rat was induced by streptozotocin (45 mg/kg bw) and nicotinamide (110 mg/kg bw). Rats were then allowed to develop diabetes for 21 days. A biopsy punch then was used to create a wound. Yacon leaves extract were administered by oral and topical for 14 day. The serum glucose level and diameter of the wound were measured every week, and histopatology study of the skin was conducted at the end of the study. Oral administration of yacon leaves extract (150 mg/kg bw) together with topical administration showed antihyperglycemic as well as diabetic wound healing activities comparable to the reference drugs (glibenclamide oral and nebacetin cream).

scholarly journals Evaluation of Incisional Diabetic Wound Healing Activity of Ethanolic Leave Extract of Mimosa pudica L. in Rats

2017 ◽  
Vol 9 (08) ◽  
Author(s):  
R. Santosh Kumar ◽  
K. Rajkiran ◽  
Sunil Kumar Patnaik
Keyword(s):  
Wound Healing ◽  
Breaking Strength ◽  
Foot Ulcer ◽  
Limb Amputation ◽  
Control Group ◽  
Diabetic Wound ◽  
Mimosa Pudica ◽  
Herbal Products ◽  
Diabetic Wound Healing ◽  
Wound Healing Activity

Diabetes mellitus (DM) is a fast growing epidemic throughout the world. India is going to become the capital of DM. DM patients are at greater risk of serious infective foot ulcer or wound. The diabetic wound may be associated with late healing and septic manifestation and finally reach to limb amputation which is an overpriced incident. The herbal products are more precious in both prophylaxis as well as curative in delayed diabetic wound healing activity when compare to synthetic drugs. The present study was carried out to evaluate the diabetic incisional wound healing activity of ethanolic leave extract of Mimosa pudica L. (EMP) in Streptozotocin (55 mg/kg, i.p.) induced diabetic rats. A wound of 1cm incision was made on ventral side of diabetic male albino wistar rats. The two different doses (2.5% and 5%) of EMP are applied on wound b.i.d for 11 days. The initial and final fasting serum glucose levels were estimated to confirm the disease state. The breaking strength and histopathological studies of incisional healed skin was estimated. The EMP 2.5 % and EMP 5% have shown significant (p>0.01) increase in wound breaking strength as well as well epithelialization compared to diabetic control group.

scholarly journals Nanoparticle-Based Therapeutic Approach for Diabetic Wound Healing

Nanomaterials ◽  
2020 ◽  
Vol 10 (6) ◽  
pp. 1234 ◽  
Author(s):  
Hariharan Ezhilarasu ◽  
Dinesh Vishalli ◽  
S. Thameem Dheen ◽  
Boon-Huat Bay ◽  
Dinesh Kumar Srinivasan
Keyword(s):  
Wound Healing ◽  
High Surface ◽  
Treatment Strategies ◽  
Foot Ulcer ◽  
Volume Ratio ◽  
Therapeutic Drug ◽  
Target Tissue ◽  
Diabetic Wound ◽  
Impaired Wound Healing ◽  
Diabetic Wound Healing

Diabetes mellitus (DM) is a common endocrine disease characterized by a state of hyperglycemia (higher level of glucose in the blood than usual). DM and its complications can lead to diabetic foot ulcer (DFU). DFU is associated with impaired wound healing, due to inappropriate cellular and cytokines response, infection, poor vascularization, and neuropathy. Effective therapeutic strategies for the management of impaired wound could be attained through a better insight of molecular mechanism and pathophysiology of diabetic wound healing. Nanotherapeutics-based agents engineered within 1–100 nm levels, which include nanoparticles and nanoscaffolds, are recent promising treatment strategies for accelerating diabetic wound healing. Nanoparticles are smaller in size and have high surface area to volume ratio that increases the likelihood of biological interaction and penetration at wound site. They are ideal for topical delivery of drugs in a sustained manner, eliciting cell-to-cell interactions, cell proliferation, vascularization, cell signaling, and elaboration of biomolecules necessary for effective wound healing. Furthermore, nanoparticles have the ability to deliver one or more therapeutic drug molecules, such as growth factors, nucleic acids, antibiotics, and antioxidants, which can be released in a sustained manner within the target tissue. This review focuses on recent approaches in the development of nanoparticle-based therapeutics for enhancing diabetic wound healing.

scholarly journals Rationale of Orthosiphon aristatus for Healing Diabetic Foot Ulcer

2020 ◽  
Vol 15 (9) ◽  
pp. 1934578X2095330
Author(s):  
Farah Izana Abdullah ◽  
Lee Suan Chua ◽  
Siti Pauliena Mohd Bohari ◽  
Eka Sari
Keyword(s):  
Wound Healing ◽  
Plant Extract ◽  
Diabetic Foot ◽  
Healing Process ◽  
Foot Ulcer ◽  
Diabetic Foot Ulcer ◽  
South East Asia ◽  
Diabetic Wound Healing ◽  
Preclinical And Clinical Studies ◽  
Significant Concentration

Orthosiphon aristatus (Blume) Miq. is traditionally used for wound healing in South East Asia and scientifically proven for its antidiabetic potential. Wounds due to diabetes, especially diabetic foot ulcer (DFU), always involve a complicated healing process. The present work aims to review the information on the rationale of the phytochemicals from O. aristatus in promoting DFU healing. The findings showed that the DFU healing potential of O. aristatus was characterized by a reduction in the blood glucose level, mainly attributed to the significant concentration of constituents such as caffeic acid, rosmarinic acid, and sinensetin in the plant extract. These phytochemicals possibly induce insulin secretion and sensitivity, improve the lipid profile, and stimulate glucose uptake. Furthermore, the healing effect may also be contributed to the antioxidant, anti-inflammatory, and antihyperglycemic properties of the plant. The roles of phytochemicals have been systematically postulated in the 4 phases of the healing process. Moreover, no adverse toxic sign or abnormality has been reported upon oral administration of the plant extract. This suggests that O. aristatus extract could be a potential diabetic wound healing phytomedicine for further preclinical and clinical studies.

scholarly journals Synthesis And Evaluation Of Wound Healing Properties of HyDrO-DiAb Hydrogel Loaded With Green-Synthetized AGNPS: In Vitro And In Ex Vivo Studies

2021 ◽  
Author(s):  
Mariarosa Ruffo ◽  
Ortensia Ilaria Parisi ◽  
Marco Dattilo ◽  
Francesco Patitucci ◽  
Rocco Malivindi ◽  
...  
Keyword(s):  
Wound Healing ◽  
Diabetic Foot ◽  
Ex Vivo ◽  
Foot Ulcer ◽  
Vascular Diseases ◽  
Diabetic Foot Ulcer ◽  
Wound Dressings ◽  
Diabetic Patients ◽  
Wound Healing Activity

Abstract In diabetic patients, the presence of neuropathy, peripheral vascular diseases and ischemia, leads to the formation of foot ulcerations with a higher risk of infection because the normal response to bacterial infection is missing. In the aim to control and treat Diabetic Foot Ulcerations (DFUs), wound dressings able to absorb exudate, to prevent infections and to promote wound healing, are needed. For this reason, the aim of the present research was to synthetize a biocompatible hydrogel composed by Carboxymethylcellulose (HyDrO-DiAb) loaded with Silver nanoparticles (AgNPs) for the treatment of diabetic foot ulcer. In this study, AgNPs were obtained by a green synthesis and, then, were dissolved in CMC hydrogel that, after freeze drying process become a flexible and porous structure. The in vitro and in ex-vivo wound healing activity of the obtained HyDrO-DiAb hydrogel was evaluated.

scholarly journals Acceleration of diabetic wound healing using a novel protease–anti-protease combination therapy

2015 ◽  
Vol 112 (49) ◽  
pp. 15226-15231 ◽  
Author(s):  
Ming Gao ◽  
Trung T. Nguyen ◽  
Mark A. Suckow ◽  
William R. Wolter ◽  
Major Gooyit ◽  
...  
Keyword(s):  
Wound Healing ◽  
Chronic Wounds ◽  
Pathological Condition ◽  
Topical Administration ◽  
The United States ◽  
Diabetic Wound ◽  
Diabetic Wound Healing ◽  
Diabetic Wounds ◽  
Pathological Consequence

Nonhealing chronic wounds are major complications of diabetes resulting in >70,000 annual lower-limb amputations in the United States alone. The reasons the diabetic wound is recalcitrant to healing are not fully understood, and there are limited therapeutic agents that could accelerate or facilitate its repair. We previously identified two active forms of matrix metalloproteinases (MMPs), MMP-8 and MMP-9, in the wounds of db/db mice. We argued that the former might play a role in the body’s response to wound healing and that the latter is the pathological consequence of the disease with detrimental effects. Here we demonstrate that the use of compound ND-336, a novel highly selective inhibitor of gelatinases (MMP-2 and MMP-9) and MMP-14, accelerates diabetic wound healing by lowering inflammation and by enhancing angiogenesis and re-epithelialization of the wound, thereby reversing the pathological condition. The detrimental role of MMP-9 in the pathology of diabetic wounds was confirmed further by the study of diabetic MMP-9–knockout mice, which exhibited wounds more prone to healing. Furthermore, topical administration of active recombinant MMP-8 also accelerated diabetic wound healing as a consequence of complete re-epithelialization, diminished inflammation, and enhanced angiogenesis. The combined topical application of ND-336 (a small molecule) and the active recombinant MMP-8 (an enzyme) enhanced healing even more, in a strategy that holds considerable promise in healing of diabetic wounds.

scholarly journals Clinical effect of Apamarga Kshara Taila and adjuvant drugs in the management of Diabetic wound – A Case Report.

The Healer ◽  
2021 ◽  
Vol 2 (02) ◽  
pp. 106-110
Author(s):  
Hetal koriya ◽  
Manisha Kapadiya ◽  
Dr. Tukaram S. Dudhamal
Keyword(s):  
Wound Healing ◽  
Case Report ◽  
Single Case ◽  
Foot Ulcer ◽  
Diabetic Foot Ulcer ◽  
Healing Time ◽  
Diabetic Wound ◽  
Healing Ulcer ◽  
Single Case Report ◽  
Complete Wound Healing

Diabetic foot ulcer is a serious devastating complication of diabetes mellitus (DM) when it involves deep tissues and bone which may require amputations. In this case report a 70 year old male patient presented with non healing ulcer of sized (3.5 *3.2) cm2 at dorsum of the left foot since last 4 years. The ulcer was on the dorsum having most movable part in daily activity so it was reluctant to meal by all means of conventional management. So patient consultant to Ayurveda OPD and he was treated with local dressing of Apamarga Kshara Taila till wound healing for 50days. Along with local dressing patient prescribed with Haritaki Churna 5gm at night with luke warm water and Punarnavashtak Kwatha 40ml twice in a day on empty stomach for 50 days. Inj. wosulin 12 units thrice in day and Inj. basalog 14 units at nigh were continued simultaneously as prescribed by diabetologist during the treatment. Complete wound healing was achieved within 50days with unit healing time 4.46 day/cm2. This single case report showed wound healing potential of Ayurvedic medicine in diabetic wound.

scholarly journals A comparative study to assess the effectiveness of Topical Insulin Dressing vs Normal Saline Dressing on wound healing of Diabetic Foot Ulcer

2020 ◽  
Vol 11 (SPL4) ◽  
pp. 134-138
Author(s):  
Ruban David ◽  
Nandhini Rajkumar
Keyword(s):  
Wound Healing ◽  
Normal Saline ◽  
Diabetic Foot ◽  
Foot Ulcer ◽  
Diabetic Foot Ulcer ◽  
T Test ◽  
Diabetic Patients ◽  
Background Variable ◽  
Diabetic Wound ◽  
Paired T Test

Diabetic foot ulcer (diabetic foot ulcer) is an injury entering through the profound vascular and collagenous (dermis) layers of the skin in diabetic patients. Helpless information by walking care and helpless foot care rehearses were distinguish as significant danger factors for foot issues in diabetes. The principle target of the investigation was to survey the effectiveness of topical insulin dressing versus saline dressing and analyze the degree of diabetic injury healing. Quasi-experimental with comparative research design was embraced for the investigation. Convenience sampling technique was utilized to choose 60 examples. Structured interview was used to collect background variable and Wagner diabetic wound assessment scale for assessing diabetic wound. The diabetic wound was dressed with topical insulin dressing and normal saline dressing for 6 days. The calculated paired 't' test value of t = 15.703 was found to be statistically highly significant at p<0.001 level whereas the calculated paired 't' test value of t = 3.247 was found to be statistically highly significant at p<0.01 level. There was significant that the topical insulin dressing is the more effective and improving the level of wound healing than normal saline dressing.

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