scholarly journals Evaluation of Incisional Diabetic Wound Healing Activity of Ethanolic Leave Extract of Mimosa pudica L. in Rats

2017 ◽  
Vol 9 (08) ◽  
Author(s):  
R. Santosh Kumar ◽  
K. Rajkiran ◽  
Sunil Kumar Patnaik
Keyword(s):  
Wound Healing ◽  
Breaking Strength ◽  
Foot Ulcer ◽  
Limb Amputation ◽  
Control Group ◽  
Diabetic Wound ◽  
Mimosa Pudica ◽  
Herbal Products ◽  
Diabetic Wound Healing ◽  
Wound Healing Activity

Diabetes mellitus (DM) is a fast growing epidemic throughout the world. India is going to become the capital of DM. DM patients are at greater risk of serious infective foot ulcer or wound. The diabetic wound may be associated with late healing and septic manifestation and finally reach to limb amputation which is an overpriced incident. The herbal products are more precious in both prophylaxis as well as curative in delayed diabetic wound healing activity when compare to synthetic drugs. The present study was carried out to evaluate the diabetic incisional wound healing activity of ethanolic leave extract of Mimosa pudica L. (EMP) in Streptozotocin (55 mg/kg, i.p.) induced diabetic rats. A wound of 1cm incision was made on ventral side of diabetic male albino wistar rats. The two different doses (2.5% and 5%) of EMP are applied on wound b.i.d for 11 days. The initial and final fasting serum glucose levels were estimated to confirm the disease state. The breaking strength and histopathological studies of incisional healed skin was estimated. The EMP 2.5 % and EMP 5% have shown significant (p>0.01) increase in wound breaking strength as well as well epithelialization compared to diabetic control group.

scholarly journals Antihyperglycemic and diabetic wound healing activity of smallanthus sonchifolius leaves extract

2018 ◽  
Vol 197 ◽  
pp. 07001
Author(s):  
Rina Herowati ◽  
Alip D.S. Saputri ◽  
Tri Wijayanti ◽  
Gunawan P. Widodo
Keyword(s):  
Wound Healing ◽  
Foot Ulcer ◽  
Diabetic Foot Ulcer ◽  
Topical Administration ◽  
Serum Glucose ◽  
Diabetic Wound ◽  
Smallanthus Sonchifolius ◽  
Biopsy Punch ◽  
Diabetic Wound Healing ◽  
Wound Healing Activity

Diabetic patient tend to suffer from lower extremity complication that contribute to the occurence of diabetic foot ulcer. Smallanthus sonchifolius or yacon leaves extract has been used as an alternative medicine for diabetes and also showed antibacterial activity. This research aims to obtain the antihyperglycemic and diabetic wound healing activity of yacon leaves extract. Diabetic condition of rat was induced by streptozotocin (45 mg/kg bw) and nicotinamide (110 mg/kg bw). Rats were then allowed to develop diabetes for 21 days. A biopsy punch then was used to create a wound. Yacon leaves extract were administered by oral and topical for 14 day. The serum glucose level and diameter of the wound were measured every week, and histopatology study of the skin was conducted at the end of the study. Oral administration of yacon leaves extract (150 mg/kg bw) together with topical administration showed antihyperglycemic as well as diabetic wound healing activities comparable to the reference drugs (glibenclamide oral and nebacetin cream).

scholarly journals Nanoparticle-Based Therapeutic Approach for Diabetic Wound Healing

Nanomaterials ◽  
2020 ◽  
Vol 10 (6) ◽  
pp. 1234 ◽  
Author(s):  
Hariharan Ezhilarasu ◽  
Dinesh Vishalli ◽  
S. Thameem Dheen ◽  
Boon-Huat Bay ◽  
Dinesh Kumar Srinivasan
Keyword(s):  
Wound Healing ◽  
High Surface ◽  
Treatment Strategies ◽  
Foot Ulcer ◽  
Volume Ratio ◽  
Therapeutic Drug ◽  
Target Tissue ◽  
Diabetic Wound ◽  
Impaired Wound Healing ◽  
Diabetic Wound Healing

Diabetes mellitus (DM) is a common endocrine disease characterized by a state of hyperglycemia (higher level of glucose in the blood than usual). DM and its complications can lead to diabetic foot ulcer (DFU). DFU is associated with impaired wound healing, due to inappropriate cellular and cytokines response, infection, poor vascularization, and neuropathy. Effective therapeutic strategies for the management of impaired wound could be attained through a better insight of molecular mechanism and pathophysiology of diabetic wound healing. Nanotherapeutics-based agents engineered within 1–100 nm levels, which include nanoparticles and nanoscaffolds, are recent promising treatment strategies for accelerating diabetic wound healing. Nanoparticles are smaller in size and have high surface area to volume ratio that increases the likelihood of biological interaction and penetration at wound site. They are ideal for topical delivery of drugs in a sustained manner, eliciting cell-to-cell interactions, cell proliferation, vascularization, cell signaling, and elaboration of biomolecules necessary for effective wound healing. Furthermore, nanoparticles have the ability to deliver one or more therapeutic drug molecules, such as growth factors, nucleic acids, antibiotics, and antioxidants, which can be released in a sustained manner within the target tissue. This review focuses on recent approaches in the development of nanoparticle-based therapeutics for enhancing diabetic wound healing.

scholarly journals Effect of Ficus hispida L. on normal and dexamethasone suppressed wound healing

2011 ◽  
Vol 47 (4) ◽  
pp. 855-860 ◽  
Author(s):  
Krishna Murti ◽  
Vijay Lambole ◽  
Mayank Panchal
Keyword(s):  
Wound Healing ◽  
Dead Space ◽  
Breaking Strength ◽  
Ethanolic Extract ◽  
Control Group ◽  
Albino Rats ◽  
Root Extract ◽  
Control Groups ◽  
Ficus Hispida ◽  
Wound Healing Activity

Ethanolic extract of roots of Ficus hispida was investigated in normal and dexamethasone depressed healing conditions, using incision, excision and dead space wound models in albino rats. The root extract of Ficus hispida has shown the maximum breaking strength compared to control group. The rate of epithelialization and wound contraction in excision model was better as compared to control groups. There was significant increase in granulation tissue weight and hydroxyproline content in dead space model compared to control group. The antihealing effect of dexamethasone was also reverted by the administration of ethanolic extract of Ficus hispida in all the wound models .The results indicated that the root extract of Ficus hispida has a significant wound healing activity and also promotes healing in dexamethasone depressed healing conditions.

scholarly journals Insulin-Containing Wound Dressing Promotes Diabetic Wound Healing Through Stabilizing HIF-1α

2020 ◽  
Vol 8 ◽  
Author(s):  
Peilang Yang ◽  
Di Wang ◽  
Yan Shi ◽  
Mingzhong Li ◽  
Min Gao ◽  
...  
Keyword(s):  
Extracellular Matrix ◽  
Wound Healing ◽  
Wound Dressing ◽  
Control Group ◽  
Unstable State ◽  
Diabetic Wound ◽  
Diabetic State ◽  
Matrix Deposition ◽  
Diabetic Wound Healing

HIF-1α is seen as a major regulator during wound healing and controls many wound healing processes, such as angiogenesis, extracellular deposition, and reepithelialization. A diabetic state plays a vicious effect on wound healing, and the destabilization of HIF-1α is a non-negligible factor. Insulin-loaded silk fibroin microparticles were prepared to release insulin by covering the wounds, and this material was proven to promote wound healing in both in vitro and in vivo studies. In this work, we found that this insulin-containing wound dressing could accelerate diabetic wound healing by promoting reepithelialization, angiogenesis, and extracellular matrix, especially collagen deposition. Meanwhile, HIF-1α was stable and accumulated in insulin-containing dressing to group wound cells, which was significantly unstable in the control group. In further studies, we showed that methylglyoxal (MGO), the main form of advanced glycation end products (AGEs), accumulated significantly and caused the destabilization of HIF-1α in the diabetic state. Insulin could alleviate the MGO-induced HIF-1α unstable state and promote HIF-1α target gene expression and its downstream biological effect such as angiogenesis and wound extracellular matrix deposition.

Pengaruh Frekuensi Vibrasi terhadap Penyembuhan Luka Diabetes

1970 ◽  
Vol 4 (2) ◽  
Author(s):  
Yunita Sari ◽  
Eman Sutrisna ◽  
Hartono H
Keyword(s):  
Wound Healing ◽  
Vibration Frequency ◽  
Wound Care ◽  
Control Group ◽  
Diabetic Wound ◽  
Vibration Therapy ◽  
White Rats ◽  
Diabetic Wound Healing ◽  
Alloxan Monohydrate ◽  
40 Hz

Penelitian menyatakan bahwa vibrasi 47 Hz dapat meningkatkan penyembuhan luka diabetes. Namun sampai saat ini belum diketahui apakah frekuensi dibawah dan diatas 47 Hz dapat meningkatkan penyembuhan luka diabetes. Oleh karena itu, tujuan dari penelitian ini adalah untuk mengetahui efek frekuensi vibrasi yang berbeda terhadap penyembuhan luka diabetes. Desain penelitian eksperimen ini melibatkan 5 kelompok tikus putih; kelompok yang mendapatkan vibrasi 40 Hz (frekuensi rendah), kelompok 106 Hz (frekuensi menengah), kelompok 200 Hz (frekuensi tinggi), kelompok 300 Hz (frekuensi sangat tinggi), dan kelompok kontrol (tanpa vibrasi). Induksi diabetes dilakukan dengan Alloxan Monohidrat. Vibrasi diberikan selama 10 menit. Status luka didasarkan pada jaringan nekrotik, ukuran luka, inflamasi, dan reepitelisasi. Analisis histologi dilakukan dengan pewarnaan Hematoksilin dan Eosin. Ukuran luka dianalisis dengan uji ANOVA, diikuti oleh tes Tukey. Hasil penelitian menunjukkan bahwa jaringan nekrotik dan intensitas inflamasi paling sedikit pada kelompok 40 Hz, dan paling banyak pada kelompok 300 Hz. Reepitelisasi paling baik pada kelompok 40 Hz, dan paling rusak pada 300 Hz. Ukuran luka di kelompok 40 Hz secara signifikan lebih kecil dibandingkan dengan kelompok lain (p <0.05). Hasil penelitian ini menunjukkan bahwa vibrasi frekuensi rendah dapat mempercepat penyembuhan luka diabetes, sebaliknya, vibrasi frekuensi tinggi dapat merusak atau memperparah jaringan luka.Kata kunci :Diabetes, penyembuhan, luka, terapi komplementer, vibrasi.The Provision of Different Vibration Frequency to Accelerate Diabetic Wound HealingAbstractStudies have revealed that diabetic wound healing can be accelerated using the vibration therapy of 47 Hz. However, no strong evidence compelled the use of different vibration rates. Thus, this experimental study aimed to examine the effect of different vibration frequencies towards diabetic wound healing. Five groups of white rats were injected using Alloxan Monohydrate within ten minutes before the vibration therapy. The dosage was given categorized as 40 Hz (low), 106 Hz (moderate), 200 Hz (high) and 300 Hz (very high). Control group was created without given vibration therapy. Wound status was evaluated using the presence of necrotic tissues, size, inflammation, and reepithelization where Hematoxicilin and Eosin color-based were used to analyse the histological presentation. Using ANOVA and Tukey test, it was found that the necrotic tissues and the intended inflammation have less developed among low vibration group compared to others. Reepithelization and wound size reduction most experienced by the lower group, but the worst damaged occupied by the highest vibration group. It is suggested that lower vibration frequency enabled to accelerate the wound care healing, but a high-frequency rate can disturb or damage the injured tissues. Keywords:Complementary therapy, diabetes mellitus, wound healing.

scholarly journals Inflammation and neuropeptides: the connection in diabetic wound healing

2009 ◽  
Vol 11 ◽  
Author(s):  
Leena Pradhan ◽  
Christoph Nabzdyk ◽  
Nicholas D. Andersen ◽  
Frank W. LoGerfo ◽  
Aristidis Veves
Keyword(s):  
Wound Healing ◽  
Wound Repair ◽  
Major Complication ◽  
Limb Amputation ◽  
Diabetic Patients ◽  
Diabetic Wound ◽  
Molecular Events ◽  
Diabetic Wound Healing

Abnormal wound healing is a major complication of both type 1 and type 2 diabetes, with nonhealing foot ulcerations leading in the worst cases to lower-limb amputation. Wound healing requires the integration of complex cellular and molecular events in successive phases of inflammation, cell proliferation, cell migration, angiogenesis and re-epithelialisation. A link between wound healing and the nervous system is clinically apparent as peripheral neuropathy is reported in 30–50% of diabetic patients and is the most common and sensitive predictor of foot ulceration. Indeed, a bidirectional connection between the nervous and the immune systems and its role in wound repair has emerged as one of the focal features of the wound-healing dogma. This review provides a broad overview of the mediators of this connection, which include neuropeptides and cytokines released from nerve fibres, immune cells and cutaneous cells. In-depth understanding of the signalling pathways in the neuroimmune axis in diabetic wound healing is vital to the development of successful wound-healing therapies.

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