scholarly journals Quality comparison between two different types of platelet-rich plasma for knee osteoarthritis

2020 ◽  
Vol 8 ◽  
pp. 3
Author(s):  
Takanori Wakayama ◽  
Yoshitomo Saita ◽  
Yohei Kobayashi ◽  
Hirofumi Nishio ◽  
Sayuri Uchino ◽  
...  
Keyword(s):  
Observational Study ◽  
Knee Osteoarthritis ◽  
Platelet Rich Plasma ◽  
Therapeutic Option ◽  
Interleukin 1 ◽  
Retrospective Observational Study ◽  
Health Concern ◽  
Preparation Methods ◽  
Different Types ◽  
Soluble Tnf Receptor

Introduction: Knee osteoarthritis (KOA), the most common form of osteoarthritis (OA) is a considerable health concern worldwide. Platelet-rich plasma (PRP) is a common therapeutic option for KOA. Different types of PRPs have varying efficacies. However, a comparative analysis of the qualities of these PRPs is lacking. Methods: Two types of PRPs, including autologous protein solution (APS), and leukocyte-poor PRP (LP-PRP) along with whole blood (WB) and platelet-poor plasma (PPP) were characterized for platelet content, leukocyte content, and composition in 10 healthy volunteers (HV) (the controlled laboratory study) and 16 KOA patients (a retrospective observational study). Additionally, the levels of the platelet-derived growth factor (PDGF)-BB, and different cytokines were estimated in HV. Results: In HV, the concentrations of platelets and leukocytes, levels of different cytokines, including interleukin 1 receptor antagonist (IL-1Ra), soluble TNF receptor type II (sTNF-RII), and IL-1β, and the ratio of IL-1Ra/IL-1β were significantly higher in APS, whereas the PDGF-BB was higher in LP-PRP than APS. In KOA patients, a higher concentration of platelets was observed in LP-PRP, and a higher concentration of leukocytes was observed in APS than LP-PRP. Following the PAW classification system, LP-PRP was classified as P2-B type in HV (51.3 × 104/μl) and KOA (53.4 × 104/μl), whereas APS was classified as P3-A type in HV (110.1 × 104/μl) and P2-A type in KOA (29.0 × 104/μl). In a retrospective observational study, the KOA patients who underwent APS injection had a higher incidence of arthralgia, and this arthralgia lasted for a longer time than LP-PRP injection in the same individual. Discussion: The quality of the two PRPs differed distinctively depending on their preparation methods, which might affect their clinical efficacies and adverse events. Therefore, the characterization of these parameters should be prioritized while choosing PRP.

scholarly journals Percutaneous Vertebroplasty Combined with Percutaneous Pediculoplasty for Lytic Vertebral Body and Pedicle Lesions of Metastatic Tumors

2015 ◽  
Vol 3;18 (3;5) ◽  
pp. E347-E353
Author(s):  
Zhong-Liang Deng
Keyword(s):  
Observational Study ◽  
Vertebral Body ◽  
Percutaneous Vertebroplasty ◽  
Management Practice ◽  
Medical Center ◽  
Therapeutic Option ◽  
Retrospective Observational Study ◽  
Symptom Duration ◽  
Single Center ◽  
Metastatic Tumors

Background: Percutaneous pediculoplasty (PP) consists of the injection of Poly(methyl methacrylate) (PMMA) into the fractured pedicle or lytic vertebral pedicle lesions, as a technique derived from vertebroplasty. Objectives: To evaluate the short-term analgesic effect of percutaneous vertebroplasty (PV) and percutaneous pediculoplasty (PP) in patients with lytic vertebral body and pedicle lesions of metastatic tumors. Study Design: Single-center retrospective observational study. Setting: An interventional pain management practice, a medical center, major metropolitan city, China. Methods: Single-center retrospective observational study of all patients managed with PV and PP for painful vertebral body and pedicle metastatic tumors between 2007 and 2013. For each patient, symptom duration and pain intensity were recorded. PP was performed under local analgesia, in the prone position, with C-arm fluoroscopy guidance. The mixture of PMMA and Doxorubicin was delivered into the vertebral body with a non-beveled needle for the initial treatment followed by the mixture delivery into the lytic pedicle during needle withdrawal. Results: Nine patients (5 women, 4 men) were enrolled in the study with a mean age of 65.9 years (range 57 – 75). Technical success was defined as the ability to access the lesion using the approach. A positive clinical response for pain relief was achieved in these patients in whom vertebroplasty and pediculoplasty had been performed. Pain level was not significantly reduced in 3 patients in whom just vertebroplasty has been performed because the medial wall of the pedicle was destroyed by the metastatic lesion. Limitations: This study is limited by its sample size. Conclusions: PV and PP via the transpedicular approach for infiltrated vertebral bodies and infiltrated pedicles of metastatic tumors may be considered a valid therapeutic option. Key words: Percutaneous pediculoplasty, percutaneous vertebroplasty, lytic pedicular lesions, bone cement

scholarly journals Radiofrequency Denervation of Genicular Nerves for Advanced Knee Osteoarthritis Pain: A retrospective Observational Study

2021 ◽  
Vol 3 (3) ◽  
pp. 1576-1583
Author(s):  
Sandeep Khuba ◽  
Sanjay Kumar ◽  
Sujeet Gautam ◽  
Anil Agarwal ◽  
Chetna Shamshery ◽  
...  
Keyword(s):  
Observational Study ◽  
Knee Osteoarthritis ◽  
Retrospective Observational Study ◽  
Osteoarthritis Pain ◽  
Radiofrequency Denervation

scholarly journals Treating Severe Knee Osteoarthritis with Combination of Intra-Osseous and Intra-Articular Infiltrations of Platelet-Rich Plasma: An Observational Study

Cartilage ◽  
2018 ◽  
Vol 10 (2) ◽  
pp. 245-253 ◽  
Author(s):  
Mikel Sánchez ◽  
Diego Delgado ◽  
Orlando Pompei ◽  
Juan Carlos Pérez ◽  
Pello Sánchez ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Observational Study ◽  
Knee Osteoarthritis ◽  
Knee Injury ◽  
Platelet Rich Plasma ◽  
Control Group ◽  
Therapeutic Effects ◽  
Radiographic Severity ◽  
Important Improvement ◽  
Minimal Clinically Important Improvement

Objective Assessing the therapeutic effects of a combination of intra-articular and intra-osseous infiltrations of platelet-rich plasma (PRP) to treat severe knee osteoarthritis (KOA) using intra-articular injections of PRP as the control group. Design In this observational study, 60 patients suffering from severe KOA were treated with intra-articular infiltrations of PRP (IA group) or with a combination of intra-osseous and intra-articular infiltrations of PRP (IO group). Both groups were matched for sex, age, body mass index, and radiographic severity (III and IV degree according to Ahlbäck scale). Clinical outcome was evaluated at 2, 6, and 12 months, using the Knee injury and Osteoarthritis Outcome Score (KOOS) and Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) questionnaires. Results At 2, 6 and 12 months after treatment, IO group had a significant improvement in all KOOS and WOMAC subscales ( P < 0.05). On the contrary, patients of the IA group did not improve in any of the scores. Sixteen out of 30 IO group patients showed minimal clinically important improvement (MCII) whereas 8 out of 30 IA group patients showed this response at 6 months (26.7%; 95% CI −0.4 to 49.9; P = 0.037). At 12 months, 14 patients of IO group and 5 patients of the IA group showed MCII (30%; 95% CI 4.3 to 51.9; P = 0.013). No differences between groups were observed at 2 months. Conclusions PRP intra-articular injections in severe KOA were not effective and did not provide any benefit. Combination of intra-articular and intra-osseous infiltrations of PRP was not clinically superior at 2 months, but it showed superior clinical outcomes at 6 and 12 months when compared with intra-articular injections of PRP.

scholarly journals Perioperative concerns in pediatric patients undergoing different types of scoliosis correction surgery: A retrospective observational study

2013 ◽  
Vol 29 (3) ◽  
pp. 323
Author(s):  
Anjolie Chhabra ◽  
MaheshKumar Arora ◽  
DalimKumar Baidya ◽  
Praveen Talawar ◽  
PreetMohinder Singh ◽  
...  
Keyword(s):  
Observational Study ◽  
Pediatric Patients ◽  
Retrospective Observational Study ◽  
Scoliosis Correction ◽  
Different Types ◽  
Correction Surgery

The use of platelet-rich plasma (PRP) in the treatment of gastrocnemius strains: a retrospective observational study

Platelets ◽  
2017 ◽  
Vol 29 (6) ◽  
pp. 596-601 ◽  
Author(s):  
Paolo Borrione ◽  
Chiara Fossati ◽  
Maria Teresa Pereira ◽  
Silvana Giannini ◽  
Marco Davico ◽  
...  
Keyword(s):  
Observational Study ◽  
Platelet Rich Plasma ◽  
Retrospective Observational Study

scholarly journals Effect of Intra-Articular Injection of Platelet-Rich Plasma on the Serum Levels of Osteoarthritic Biomarkers in Patients with Unilateral Knee Osteoarthritis

2021 ◽  
Vol 10 (24) ◽  
pp. 5801
Author(s):  
Marek Lacko ◽  
Denisa Harvanová ◽  
Lucia Slovinská ◽  
Martin Matuška ◽  
Marek Balog ◽  
...  
Keyword(s):  
Knee Joint ◽  
Knee Osteoarthritis ◽  
Collagen Type ◽  
Platelet Rich Plasma ◽  
Therapeutic Option ◽  
Clinical Status ◽  
Inflammatory Biomarkers ◽  
Anti Inflammatory

Background: The aim of this study is to determine the effect of three doses of intra-articular injection of platelet-rich plasma (PRP) into the osteoarthritic (OA) knee joint on the functional status and on the changes in the levels of specific OA biomarkers in blood serum. Methods: Forty patients with unilateral primary knee osteoarthritis were enrolled in this single center, prospective clinical trial. For each patient, three intra-articular PRP injections were administered one week apart. Clinical and laboratory assessment was performed before the first PRP injection (baseline), and 3 months after the third PRP application (3-month follow up). Pain in the affected knee joint was assessed with the Visual Analog Scale for Pain (VAS). Change in clinical status was evaluated with the Western Ontario and McMaster Universities Arthritis Index Questionnaire (WOMAC). Concentrations of 19 biomarkers (EGF, Eotaxin, FGF-2, GRO, IL-10, IL-1RA, IL-8, IP-10, MCP-1, PDGF-AB/BB, RANTES, MMP-3, MMP-13, Collagen type 2, BMP-2, TIMP-1, TIMP-2, TGF beta 1, and COMP) in the serum of studied patients were quantified. Results: At 3-month follow up, there was a significant decrease in the VAS score and significant improvement in the WOMAC score. There was a significant decrease in the levels of Eotaxin, MCP-1, MMP-1, IL-10, EGF, PDGF-AB/BB, TGF- β1 compared to baseline levels. A significant increase in markers BMP-2, COMP, Collagen type 2 and GRO was found at the same time point. There was no significant change in the concentrations of other biomarkers (FGF-2, IL-1RA, IL-8, IL-10, MMP-3, RANTES, TIMP-1, TIMP-3). Conclusions: We found an increase in specific pro-anabolic and anti-inflammatory biomarkers with a concomitant decrease in pro-inflammatory biomarkers at 3 months after three intra-articular applications of PRP. Significant improvement in VAS and WOMAC scores was observed. Treatment with PRP may be an effective therapeutic option with anti-inflammatory and regenerative potential in patients with primary knee OA.

scholarly journals Pulsed Radiofrequency for Lumbar Facet Joint Pain: A Viable Therapeutic Option? A Retrospective Observational Study

2020 ◽  
Vol 9 (2) ◽  
pp. 573-582
Author(s):  
Pasquale Sansone ◽  
Luca G. Giaccari ◽  
Antonietta Lippiello ◽  
Caterina Aurilio ◽  
Antonella Paladini ◽  
...  
Keyword(s):  
Observational Study ◽  
Joint Pain ◽  
Facet Joint ◽  
Therapeutic Option ◽  
Retrospective Observational Study ◽  
Pulsed Radiofrequency ◽  
Lumbar Facet Joint ◽  
Facet Joint Pain ◽  
Lumbar Facet
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