Usefulness of a brief assessment battery for early detection of Charcot foot deformity in patients with diabetes

2004 ◽  
Vol 43 (2) ◽  
pp. 87-92 ◽  
Author(s):  
Kelley D Foltz ◽  
Lawrence M Fallat ◽  
Steven Schwartz
Keyword(s):  
Early Detection ◽  
Charcot Foot ◽  
Foot Deformity ◽  
Assessment Battery ◽  
Brief Assessment ◽  
Patients With Diabetes

Diagnostic efficacy of serum and urinary netrin-1 in the early detection of diabetic nephropathy

2021 ◽  
pp. jim-2021-001785
Author(s):  
Rasha A Elkholy ◽  
Reham L Younis ◽  
Alzahraa A Allam ◽  
Rasha Youssef Hagag ◽  
Muhammad Tarek Abdel Ghafar
Keyword(s):  
Diabetic Nephropathy ◽  
Early Detection ◽  
Characteristic Curve ◽  
Fasting Blood Glucose ◽  
Area Under The Curve ◽  
Diagnostic Value ◽  
Control Group ◽  
Diagnostic Efficacy ◽  
Significant Difference ◽  
Patients With Diabetes

This study aimed to assess the diagnostic value of serum and urinary netrin-1 in patients with type 2 diabetes mellitus (T2DM) at different stages of diabetic nephropathy (DN) and to compare its efficacy of estimation in serum with that in the urine. This study was carried out on 135 patients with T2DM and 45 healthy subjects. The patients with diabetes were divided according to urinary albumin creatinine ratio (UACR) into: T2DM with normoalbuminuria, incipient DN with microalbuminuria, and overt DN with macroalbuminuria groups. Serum and urinary levels of netrin-1 were measured by ELISA. The mean levels of serum and urinary netrin-1 were significantly higher in the microalbuminuric and macroalbuminuric patients with DN than those in the normoalbuminuric patients with T2DM, with the highest values detected in macroalbuminuric patients with DN. Urinary netrin-1 level was significantly higher in the normoalbuminuric T2DM group than control group, whereas no significant difference existed regarding serum netrin-1 level. In T2DM groups, the urinary and serum netrin-1 correlated with each other and were independently related to fasting blood glucose, UACR, and estimated glomerular filtration rate. Receiver operating characteristic curve analysis showed that the area under the curve of urinary netrin-1 was 0.916 which is significantly higher than that of serum netrin-1 (0.812) for the detection of incipient DN and reached 0.938 on coestimation of both urinary and serum netrin-1. In conclusion, netrin-1 is a potential diagnostic marker for early detection of DN with its estimation in urine has higher accuracy than that of serum.

scholarly journals An unusual presentation of acute onset Charcot arthropathy

2020 ◽  
Vol 2020 (5) ◽  
Author(s):  
Ammar Al-Najjar ◽  
Julien Al Shakarchi ◽  
Melwyn Pereira ◽  
Richard Downing
Keyword(s):  
Rare Complication ◽  
Major Amputation ◽  
Acute Onset ◽  
Lower Limbs ◽  
Charcot Foot ◽  
Charcot Arthropathy ◽  
Plantar Aspect ◽  
Patients With Diabetes ◽  
Fracture Dislocations ◽  
High Index Of Suspicion

Abstract Charcot arthropathy is a progressive condition primarily affecting the lower limbs in patients with diabetes mellitus. It is a rare complication of diabetic neuropathy and if left untreated can lead to severe limb destruction necessitating major amputation. Here, we report the case of a 41-year-old female who presented with rapidly progressive Charcot foot over a 10-day period, necessitating open reduction and internal fixation of Lisfranc-type fracture dislocations. Her presentation with a rapidly progressing red, swollen foot with a blister on the plantar aspect prompted initial treatment on the basis of a diabetic foot infection. The report will therefore serve as a useful reminder to maintain a high index of suspicion for Charcot foot, which may present in an atypical manner.

scholarly journals A Generic Study on Diabetic Retinopathy Detection

2021 ◽  
Vol 12 (3) ◽  
pp. 4274-4783
Author(s):  
Akash Bhakat Et.al
Keyword(s):  
Diabetic Retinopathy ◽  
Early Detection ◽  
Automated Detection ◽  
Fundus Image ◽  
Patients With Diabetes ◽  
Color Fundus Image ◽  
Flow Through ◽  
Sugar Levels ◽  
Very High ◽  
Growing Population

Diabetic Retinopathy is one of a major cause of visual defects in the growing population which affects the light perception part of the retina. It affects both types of diabetes mellitus. It occurs when high blood sugar levels damage the blood vessels in retina causing them to swell and leak or stop blood flow through them. It starts with no or mild vision problems and can eventually cause blindness if not treated.With the advancements in technology, automated detection and analysis of the stage of Diabetic Retinopathy will help in early detection and treatment. Almost 75% of the patients with diabetes have the risk of being affected by this disease. With early detection this disease can be prevented. Currently DR detection is a traditional and manual, time-consuming process. It requires a trained technician to analyze the color fundus image of retina.With the ever growing population, DR detection is very high in demand to prevent blindness. In this paper we aim to review the existing methodologies and techniques for detection. Also a system for the detection of the 4 stages of DR is proposed.

scholarly journals Clinical and functional status of the peripheral nervous system in patients with diabetic polyneuropathy

2015 ◽  
pp. 13-17
Author(s):  
N.K. Svyrydova ◽  
Y.V. Ponomarenko ◽  
N.V. Terentyeva
Keyword(s):  
Type 2 Diabetes ◽  
Nervous System ◽  
Early Detection ◽  
Functional Status ◽  
Peripheral Nervous System ◽  
Diabetic Polyneuropathy ◽  
Patients With Diabetes ◽  
Clinical And Functional Status ◽  
The Moment

It seems impossible at the moment to stem the incidence of diabetes despite the enormous efforts to address this global problem. We have examined 30 patients with type 2 diabetes to study the clinical and functional status of the peripheral nervous system in patients with diabetic distal polyneuropathy. Our works showed the importance of both clinical and electroneuroneuromiographic examination of patients with diabetes who have or do not have objective manifestations of polyneuropathy. This allows for early detection of the initial effects of polyneuropathy. In patients with symptomatic stage of diabetic polyneuropathy, this method allows to establish the pattern, nature, and severity of lesions of fibers of peripheral nerve trunks.

Neuropathic ulcerations plantar to the lateral column in patients with charcot foot deformity: A flexible approach to limb salvage

1997 ◽  
Vol 36 (5) ◽  
pp. 360-363 ◽  
Author(s):  
Barry I. Rosenblum ◽  
John M. Giurini ◽  
Leonard B. Miller ◽  
James S. Chrzan ◽  
Geoffrey M. Habershaw
Keyword(s):  
Limb Salvage ◽  
Charcot Foot ◽  
Foot Deformity ◽  
Flexible Approach ◽  
Lateral Column

The Development of a Neuropathic Ankle following Successful Correction of Non-Plantigrade Charcot Foot Deformity

2012 ◽  
Vol 33 (8) ◽  
pp. 644-646 ◽  
Author(s):  
Michael S. Pinzur
Keyword(s):  
External Fixator ◽  
Weight Bearing ◽  
Case Series ◽  
Disease Process ◽  
Circular Ring ◽  
Surgical Correction ◽  
Charcot Foot ◽  
Foot Deformity ◽  
Retrospective Case ◽  
Level Of Evidence

Background: The treatment of Charcot foot arthropathy has traditionally involved immobilization during the acute phase followed by longitudinal management with accommodative bracing. In response to the perceived poor outcomes associated with nonoperative accommodative treatment, many experts now advise surgical correction of the deformity, especially when the affected foot is not clinically plantigrade. The significant rate of surgical and medical-associated morbidity accompanying this form of treatment has led surgeons to look for improved methods of surgical stabilization, including the use of the circular ring external fixation. Methods: Over a 7-year period, a single surgeon performed surgical correction of non-plantigrade Charcot foot deformity on 171 feet in 164 patients with a statically applied circular external fixator. Following successful correction, five patients developed a neuropathic deformity of the ipsilateral ankle after removal of the external fixator and subsequent weight bearing total contact cast. Results: Three of the five patients progressed to successful healing of the neuropathic (Charcot) ankle arthropathy following treatment with a series of weightbearing total contact casts. Two underwent successful ankle fusion with retrograde locked intramedullary nailing. Discussion: This unusual clinical scenario likely represents either a progression of the disease process in the foot or a complication associated with surgical correction of the original neuropathic foot deformity. A better understanding of this observation will likely become apparent as we acquire more experience with this disorder. Level of Evidence: IV, Retrospective Case Series

Start treatment early to avoid Charcot foot deformity

BMJ ◽  
2012 ◽  
Vol 344 (may01 2) ◽  
pp. e2765-e2765 ◽  
Author(s):  
E. A. Chantelau
Keyword(s):  
Charcot Foot ◽  
Foot Deformity

scholarly journals Self-monitoring of blood glucose in patients with diabetes and cardiac pathology with the Meter Contour TS use

2014 ◽  
Vol 5 (3-4) ◽  
pp. 14-19
Author(s):  
I. I Kochergina
Keyword(s):  
Blood Glucose ◽  
Early Detection ◽  
Cardiovascular Complications ◽  
Self Monitoring ◽  
Cardiac Pathology ◽  
Complications Of Diabetes ◽  
Acute Complications ◽  
Patients With Diabetes

The article presents data on the prevalence of diabetes, the role of hyper - and hypoglycemia in the development of cardiovascular complications, the importance of self-monitoring for early detection of acute complications of diabetes and compensation, as well as the use of Contour TS meter for this purpose.

scholarly journals How Common Is the Rare Charcot Foot in Patients With Diabetes?

Diabetes Care ◽  
2021 ◽  
pp. dc202590
Author(s):  
Ole Lander Svendsen ◽  
Oliver Christian Rabe ◽  
Matilde Winther-Jensen ◽  
Kristine Højgaard Allin
Keyword(s):  
Charcot Foot ◽  
Patients With Diabetes
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