Calcium signals in prostate cancer cells: specific activation by bone-matrix proteins

Cell Calcium ◽  
2000 ◽  
Vol 27 (1) ◽  
pp. 35-42 ◽  
Author(s):  
V Lecrone ◽  
W Li ◽  
R.E Devoll ◽  
C Logothetis ◽  
M.C Farach-Carson
Keyword(s):  
Prostate Cancer ◽  
Cancer Cells ◽  
Bone Matrix ◽  
Matrix Proteins ◽  
Prostate Cancer Cells ◽  
Calcium Signals ◽  
Bone Matrix Proteins

Osteopontin Modulates Prostate Carcinoma Invasive Capacity through RGD-Dependent Upregulation of Plasminogen Activators

2002 ◽  
Vol 383 (1) ◽  
pp. 229-234 ◽  
Author(s):  
Adriano Angelucci ◽  
Claudio Festuccia ◽  
Gabriele DAndrea ◽  
Anna Teti ◽  
Mauro Bologna
Keyword(s):  
Prostate Cancer ◽  
Cancer Cells ◽  
Cancer Progression ◽  
Matrix Protein ◽  
Bone Matrix ◽  
Cell Movement ◽  
Plasminogen Activators ◽  
Αvβ3 Integrin ◽  
Prostate Cancer Cells ◽  
Invasive Capacity

Abstract Osteopontin, a noncollageneous bone matrix protein, is produced in several human tumors but its role in cancer progression has been only partially elucidated. In this study we investigated the potential role of osteopontin in the malignancy of prostate cancer cells. Chemotaxis and chemoinvasion analyses revealed a dosedependent increase in PC3 cell movement induced by osteopontin and a strict dependence of cell invasion on αvβ3 integrin function. The pattern of protease expression was modified by osteopontin and was characterized by an upregulation of plasminogen activators. Our findings suggest that osteopontin may confer selective malignant potential to prostate cancer cells through the enhancement of their invasive and proteolytic capability.

Cathepsin K in the bone microenvironment: link between obesity and prostate cancer?

2007 ◽  
Vol 35 (4) ◽  
pp. 701-703 ◽  
Author(s):  
I. Podgorski ◽  
B.E. Linebaugh ◽  
B.F. Sloane
Keyword(s):  
Prostate Cancer ◽  
Cancer Cells ◽  
Advanced Prostate Cancer ◽  
Bone Matrix ◽  
Cathepsin K ◽  
Collagen I ◽  
Skeletal Metastases ◽  
Bone Microenvironment ◽  
Prostate Cancer Cells ◽  
Common Site

The skeleton is the most common site of metastasis in patients with advanced prostate cancer. Despite many advances in targeting skeletal metastases, the mechanisms behind the attraction of prostate cancer cells to the bone are not known. Osteoclast cathepsin K, due to its ability to effectively degrade bone matrix collagen I, has been implicated in colonization and growth of prostate tumours in the bone. Identification of new cathepsin K substrates in the bone microenvironment and the recent findings demonstrating its involvement in obesity and inflammation suggest additional roles for this enzyme in skeletal metastases of prostate cancer.

279: Inhibition of Cyclooxygenase-2 Pathway Overcomes the Heat-Resistance in Prostate Cancer Cells

2007 ◽  
Vol 177 (4S) ◽  
pp. 93-93
Author(s):  
Makoto Sumitomo ◽  
Kenji Kuroda ◽  
Takako Asano ◽  
Akio Horiguchi ◽  
Keiichi Ito ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Heat Resistance ◽  
Cancer Cells ◽  
Cyclooxygenase 2 ◽  
Prostate Cancer Cells

609: Effects of Sirna and Phytoestrogen Treatments on the Expression of Genes Regulated through the Androgen Receptor of Lncap Prostate Cancer Cells

2004 ◽  
Vol 171 (4S) ◽  
pp. 162-162
Author(s):  
Paul Thelen ◽  
Michal Grzmil ◽  
Iris E. Eder ◽  
Barbara Spengler ◽  
Peter Burfeind ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Androgen Receptor ◽  
Cancer Cells ◽  
Prostate Cancer Cells ◽  
Expression Of Genes
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