The Role of Human-Derived Fibrin Sealant in the Reduction of Postoperative Flexor Tendon Adhesion Formation in Rabbits

2002 ◽  
Vol 27 (3) ◽  
pp. 278-282 ◽  
Author(s):  
M. E. JONES ◽  
S. BURNETT ◽  
A. SOUTHGATE ◽  
P. SIBBONS ◽  
A. O. GROBBELAAR ◽  
...  
Keyword(s):  
Fibrin Sealant ◽  
Flexor Tendon ◽  
Adhesion Formation ◽  
Active Movement ◽  
Post Injury ◽  
Significant Difference ◽  
Tendon Surgery ◽  
Injury Treatment ◽  
The Right

This study assessed the role of a novel fibrin sealant (Vivostat®) in adhesion reduction after flexor tendon surgery. The deep flexor tendons of the 2nd and 4th digits of the left paw of 20 rabbits were exposed and a standard partial injury was performed on each. The rabbits were randomized to either immediate post-injury treatment with Vivostat® or no treatment. In each case active movement of the 2nd digit was prevented while the 4th digit was allowed to move normally. The two groups were assessed at 14 days for adhesion formation with a tensiometer. The right paw acted as the unoperated control. Results showed that there was no significant difference in the force needed to remove the tendon from its sheath when comparing the two Vivostat®-treated groups to the unoperated controls. There was, however, a highly significant difference in this force between the non-Vivostat®-treated groups and the unoperated controls. This suggests a beneficial effect of Vivostat® in reducing post surgical tendon adhesion formation.

ROLE OF THE HYALURONAN-PRODUCING TENOSYNOVIUM IN PREVENTING ADHESION FORMATION DURING HEALING OF FLEXOR TENDON INJURIES

Hand Surgery ◽  
2012 ◽  
Vol 17 (01) ◽  
pp. 13-17 ◽  
Author(s):  
Masaharu Yagi ◽  
Yasuhiro Mitsui ◽  
Masafumi Gotoh ◽  
Naoto Sato ◽  
Kenji Yoshida ◽  
...  
Keyword(s):  
Flexor Tendon ◽  
Adhesion Formation ◽  
Immunohistochemical Analysis ◽  
Tendon Injuries ◽  
White Leghorn ◽  
Group I ◽  
Flexor Tendon Injuries ◽  
The Right ◽  
Hematoxylin Eosin

Flexor tendons of white Leghorn chickens (n = 25) were used for this study. One chicken was used as a normal control (no surgery), and the remaining 24 were used for experiments. After partial tendon-severing in both legs of 24 chickens, the right and the left leg were treated differently, thereby creating two groups: Group I, in which the tenosynovium was preserved, and Group II, in which the tenosynovium was removed. Hematoxylin-eosin staining was performed to observe adhesions; immunohistochemical analysis was used to localize HA. HA production was noted in granulation tissue invading between the tendon stumps in both groups; however, HA expression in the tenosynovium was observed only in Group I where adhesion formation was minimal. The HA-producing tenosynovium plays a crucial role in preventing adhesion formation in this model of flexor tendon injuries.

scholarly journals Behavior of Cellulose Biosynthetic Membrane as a Peritendinous Implant in Foals

2019 ◽  
Vol 47 (1) ◽  
Author(s):  
Jackson Schade ◽  
Maria Eduarda Gomes das Neves Oliveira ◽  
Renato Silva de Souza ◽  
Ivan Deconto ◽  
William Timboni Teixeira ◽  
...  
Keyword(s):  
Inflammatory Infiltrate ◽  
Histopathological Examination ◽  
Adhesion Formation ◽  
Tendon Injuries ◽  
Cellulose Membrane ◽  
Superficial Digital Flexor Tendon ◽  
Significant Difference ◽  
The Right ◽  
And Control ◽  
Surgically Induced

Background: Tendon injuries are common in horses and are commonly associated with lameness and athletic career disruption. Adhesions formed between the tendons and the surrounding tissues compromise the sliding and movement of the structures, compromising their functionality. Therefore, the control of adhesion formation is critical to restore the structural integrity of the tendon, as well as its biomechanical function. The aim of this study was to evaluate the behavior of the biosynthetic cellulose membrane implanted in foals with surgically induced tendinitis of the superficial digital flexor.Materials, Methods & Results: Six healthy foals were used, which underwent tendinitis induction in the superficial digital flexor of the right and left forelimbs. The lesions was induced by local ischemia by crushing the tendon with hemostatic forceps. The biosynthetic cellulose membranewas implanted only in the right forelimb, involving the superficial digital flexor tendon in the region of the ischemia and the left forelimb was used as control. After surgery, both forelimb were immobilized with synthetic plaster cast for 15 days. Ultrasonography was performed in six foals immediately before (M0), at 15° (M1) at and 30° (M2) day, and three were evaluate at 45° (M3) and 60° (M4) day after surgery. Incisional biopsies were performed in three animals on the 30° day and in three animals on the 60° day after surgery. Histopathological examination involved the analysis of tissue disorganization, presence and type of inflammatory infiltrate and neovascularization, according to the score of 0 to 3. Ultrasonography allowed visualization of the membrane, which was characterized as a continuous hyperechoic line at the edges of the tendon at 15 days (M1). In addition, at 30 and 45 days after surgery, interruption of the hyperechoic line and reduction of echogenicity were observed, and no echogenic lines were observed at 60 days after surgery. During the biopsies, the fragments obtained from the treated limb were presented with easily detachable layers and separate layers of tissue during histological cutting and the slides preparations. There was no significant difference in relation to the histopathological scores between the treated and control member. The inflammatory infiltrate was predominantly of mononuclear cells and fibroblasts, with identification of giant cell in a foal at 30 days. Neovascularization was observed in all limbs, treated and controls at 30 days and in two treated limbs and three control at 60 days. It was possible to identify the synthetic cellulose membrane by histopathology in only two limbs treated at 30 days and in no limb at 60 days.Discussion: The degree of tendonitis induced in the present study was considered mild according to ultrasonographic analysis at 15 days after surgery. This fact limited the evaluation of the biosynthetic cellulose membrane in the prevention of adhesions, since they were not observed in both groups. However, the ability of the membrane to minimize adhesion formation can be suggest by the macroscopically observed individualization of the tissue layers during histological sections and slides preparation. Ultrasonographic analysis allowed the visualization of the membrane, as well as its positioning and the absorption process. Therefore, ultrasonography can be used in post-implantation monitoring of the membrane. The comparison of the histopathological scores demonstrates the biocompatibility of the biosynthetic cellulose membrane when implanted in foals submitted to surgically induced tendinitis, since there was no difference when compared to treated and control limbs. Therefore, it can be used safely in the treatment of tendon injuries in horses.

scholarly journals The Effect of Teachers’ Work Ethic Practice: A Study at a Daily School in the Kubang Pasu District

2018 ◽  
pp. 353-356
Keyword(s):  
Ministry Of Education ◽  
Daily Lives ◽  
Work Ethics ◽  
Significant Difference ◽  
Post Test ◽  
Ethics Code ◽  
The Difference ◽  
The Right ◽  
Test Result

This study aims to identify the effect of Teachers’ Work Ethics (TWE) practice based on the teachers’ work ethics code outlined by the Ministry of Education (MOE). The research sample involved teachers who are teaching at one of the daily schools in the Kubang Pasu District whom were given intervention for a month. Questionnaire was used to seek the effect of intervention prescribed in the effort to develop TWE Model. The study employed inferential statistics of t-test paired sample to see the difference between pre test and post test result. The finding showed that there is an increase in ethics practice in terms of the right intention, good conduct, initiator of goodness, fulfilling promise and; disciplined and civilised. However, in the aspect of discipline and conduct, there is significant difference between pre and post test that is (p< 0.05). This difference shows that teachers focus more on practicing this particular aspect in their daily lives. Study findings give the implication that attitude, training and role of leaders are important in determining that this principle is implemented successfully.

Does Surgical Glove Powder Increase Adhesions in Flexor Tendon Surgery?

1985 ◽  
Vol 10 (1) ◽  
pp. 65-66 ◽  
Author(s):  
D. JAFFRAY ◽  
A. MA ◽  
C. IRVING
Keyword(s):  
Flexor Tendon ◽  
Adhesion Formation ◽  
Surgical Glove ◽  
Flexor Tendons ◽  
Tendon Surgery

The effects of surgical glove powder on adhesion formation after surgery on the flexor tendons in the chicken was analysed biomechanically. Surgical glove powder did not increase adhesion formation in flexor tendon surgery.

scholarly journals Processing of Words and Faces by Patients with Left and Right Temporal Lobe Epilepsy

1991 ◽  
Vol 4 (2) ◽  
pp. 121-128 ◽  
Author(s):  
Andrew W. Ellis ◽  
Jonathan C. Hillam ◽  
Alistair Cardno ◽  
Janice Kay
Keyword(s):  
Temporal Lobe ◽  
Face Processing ◽  
Reading Tests ◽  
Temporal Lobes ◽  
Control Subjects ◽  
Significant Difference ◽  
Left And Right ◽  
Right Temporal Lobe Epilepsy ◽  
The Right

Tests of word and face processing were given to patients with complex partial epilepsy focussed on the left or right temporal lobe, and to non-epileptic control subjects. The left TLE group showed the greatest impairment on object naming and on reading tests, but the right TLE group also showed a lesser impairment relative to the normal control subjects on both tests. The right TLE group was selectively impaired on distinguishing famous from non-famous faces while the left TLE group was impaired at naming famous faces they had successfully recognized as familiar. There was no significant difference between the three groups on recognition memory for words. The implications of the results for theories of the role of the temporal lobes in word and face processing, and the possible neural mechanisms responsible for the deficits in TLE patients, are discussed.

scholarly journals Extensive reading in primary school EFL

2018 ◽  
Vol 12 (2) ◽  
pp. 9 ◽  
Author(s):  
Anna Birketveit ◽  
Hege Emma Rimmereide ◽  
Monika Bader ◽  
Linda Fisher
Keyword(s):  
Gender Differences ◽  
Primary School ◽  
Extensive Reading ◽  
Writing Project ◽  
Reading Material ◽  
Significant Difference ◽  
Reading Culture ◽  
The Right ◽  
Primary School Pupils

AbstractReading in the English subject in both primary and secondary school often involves studying course book texts in detail. Therefore, pupils are rarely exposed to longer texts which require reading for meaning, a skill needed in higher education and working life. With the right reading material, extensive reading (ER) should start already in primary school. This article reports on a study of primary school pupils from three different schools and their perceptions of an extensive reading and writing project, as well as their responses to the reading material offered. The study was designed to address the following research questions:1. Which types of reading material appeal to the pupils in the study?2. What is the role of gender in the pupils’ evaluation of the reading material?3. Are there differences between the pupils’ evaluation of the reading material offered, depending on their previous academic achievement?4. What are the pupils’ attitudes towards (extensive) reading?Two sets of questionnaire data were collected in the course of the project. First, during the reading, the learners were asked to answer a questionnaire about each book they had read or attempted to read. At the end of the project, the learners were asked to complete a questionnaire about their overall perception of the project. The study shows that there was a significant difference between the schools in the evaluation of the reading material, and there was also a significant difference between boys and girls in the perception of the reading material. More¬over, the study shows that the learners valued the chance to select the reading material themselves highly. When carrying out ER with pupils, it is essential to be aware of gender differences in reading preferences and ensure that there are enough books to cater for both boys’ and girls’ particular interests. Moreover, fostering a reading culture in both the Norwegian and English subjects is important.Keywords: extensive reading, gender differences, choice of books, the impor-tance of self-selection of books, motivation for readingEkstensiv lesing i engelsk som fremmedspråk i barneskolenSammendragLesing i skolefaget engelsk i både barne- og ungdomsskolen betyr ofte at elevene må gjøre rede for lærebokteksten på detaljnivå. Derfor møter elevene sjelden lengre tekster som krever forståelse av meningen med teksten, en ferdighet det forventes at de behersker i høyere utdannelse og i arbeidslivet. Med det rette utvalget av tekster burde elevene øve seg på ekstensiv lesing allerede i barneskolen. Denne artikkelen legger frem resultater fra en studie av elever fra tre forskjellige barneskoler og deres oppfatninger av et ekstensivt lese- og skrive-prosjekt i tillegg til deres respons på utvalget av tekster. Forskningsspørsmålene i studien er som følger:1. Hvilke typer lesestoff appellerer til elevene i studien?2. Hvilken betydning har kjønn i elevenes evaluering av lesestoffet?3. Har elevenes tidligere akademiske resultater betydning for deres evaluering av lesestoffet?4. Hvilke holdninger har elevene til ekstensiv lesing?To typer spørreskjema-data ble samlet inn i løpet av prosjektet. Først, i løpet av leseperiodene, ble elevene bedt om å svare på et spørreskjema om hver bok de hadde lest eller prøvd å lese. Når prosjektet var avsluttet, ble elevene bedt om å fylle ut et spørreskjema om deres totale opplevelse av prosjektet. Studien viser at det var en signifikant forskjell mellom skolene i elevenes vurdering av tekstene som ble tilbudt som lesestoff, og det var også en signifikant forskjell mellom gutter og jenter. Dessuten viser studien at elevene satte stor pris på muligheten til å velge lesestoff selv. Når man gjennomfører ekstensiv lesing med elever, er det viktig å være klar over kjønnsforskjeller i elevenes lesepreferanser og forsikre seg om at utvalget av bøker er stort nok til å ivareta både gutters og jenters spesielle interesser. Dessuten er det viktig å utvikle en kultur for lesing i både norskfaget og engelskfaget.Nøkkelord: ekstensiv lesing i engelsk, kjønnsforskjeller, elevers valg av bøker, betydningen av å velge bøker selv, motivasjon for lesing

scholarly journals Mandibular Canine Index: A Reliable Sex Determinant –Original Research

2018 ◽  
Author(s):  
Nikita Rathi ◽  
shweta bhat ◽  
Rajiv Desai
Keyword(s):  
Sex Determination ◽  
Forensic Odontology ◽  
Original Research ◽  
City Population ◽  
Significant Difference ◽  
Mandibular Canine ◽  
The Right ◽  
Mumbai City

Introduction: Forensic odontology is a unique discipline dealing with evidence related to dental and oral structures. Mandibular canines are considered to be an important aid for sex determination. The aim of this study was to analyse the role of mandibular canine index in sex determination of Mumbai city population. Materials and Methodology: This was a retrospective study done on the study models of 50 patients aged between 17 to 25 years old and equally distributed among both the sexes, whose treatment has been taken place in The Department of Orthodontics, Nair Hospital Dental College, Mumbai. Mesio-distal width of mandibular canines were measured using a digital Vernier calliper and mandibular canine index was calculated using standardized equation. Independent sample t-test was used and P < 0.05 was considered statistically significant. Results: There was a significant difference (P < 0.05) observed between right and left mandibular canine width and a significant difference between the right and left mandibular canine index between males and females. Conclusion: The present study verifies the fact that mandibular canine index can be used for sex determination in the population of Mumbai city and can form basis for forensic investigations. Key-words: Canine index, Sex determination, Forensic odontology

scholarly journals The Effect of Gelatin Molecular Weight on Tendon Lubrication Utilizing an Extrasynovialized Turkey Flexor Tendon Model

2021 ◽  
Vol 186 (Supplement_1) ◽  
pp. 729-736
Author(s):  
Michael J Forthofer, BS ◽  
Katherine M Arnold, MS ◽  
Ramona L Reisdorf, BS ◽  
Peter C Amadio, MD ◽  
Chunfeng Zhao, MD
Keyword(s):  
Molecular Weight ◽  
Flexor Tendon ◽  
Adhesion Formation ◽  
Flexor Digitorum Profundus ◽  
Saline Control ◽  
Control Group ◽  
Saline Control Group ◽  
Military Population ◽  
Significant Difference ◽  
Flexor Digitorum

ABSTRACT Introduction Flexor tendon injuries are common hand injuries among the military population often resulting in functional impairment. Flexor tendon gliding friction has been linked to adhesion formation, especially with the use of extrasynovial grafts. Carbodiimide-derivatized hyaluronic acid with gelatin (cd-HA-gelatin) can reduce gliding friction of the tendon graft; however, the effects of gelatin molecular weight (MW) have not been studied. The turkey model has been shown to better match humans, but extrasynovial tendons are unavailable. The purpose of this study was to (1) manually roughen turkey flexor digitorum profundus (FDP) tendons to simulate extrasynovial tendons and (2) investigate the effects of gelatin MW on tendon friction. Materials and Methods The third digit of (n = 48) turkeys were dissected with the proximal pulley, and FDP tendon and the flexor superficialis tendon were preserved. Digits were randomly assigned into four groups: one saline control and three cd-HA-gelatin-treated groups of varying gelatin MW. Flexor digitorum profundus tendon friction was measured at its original condition, serving as a baseline. Tendons were roughened using a custom rig, and tendon friction was measured again. All four groups received treatment and gliding friction was measured every 100 cycles to a total of 1,000 cycles. Results Tendon friction significantly increased (P &lt; 0.05) after roughening. Friction in the saline control group increased steadily over repeated cycles, whereas friction of all gelatin-treated tendons decreased significantly compared with the saline control group (P &lt; 0.05), maintaining low friction to 1,000 cycles representing human tendons. There was no significant difference found between gelatin-treated groups. Conclusions We have developed a method to roughen synovial FDP tendons to create extrasynovial-like tendons for lubrication material evaluations. Cd-HA-gelatin effectively reduces tendon friction in this model. Our data suggest medium or low MW gelatin may provide a better reduction in friction compared with high MW gelatin.

scholarly journals P.130 The natural history of central cord syndrome and the role of surgical intervention: a retrospective review from 2005-2010

2016 ◽  
Vol 43 (S2) ◽  
pp. S50-S50
Author(s):  
A Dakson ◽  
BM David ◽  
G Thibault-Halman ◽  
S Christie
Keyword(s):  
Natural History ◽  
Retrospective Review ◽  
Surgical Intervention ◽  
Spinal Injury ◽  
Post Injury ◽  
Significant Difference ◽  
Central Cord Syndrome ◽  
History Of ◽  
The Mean

Background: The management of central cord syndrome (CCS) is controversial. There is a perception that CCS patients tend to improve without the need for surgical intervention. The purpose of this study was to compare the clinical improvements of patients with traumatic SCI, both with and without CCS. Methods: Nova Scotia Provincial Trauma Registry was retrospectively reviewed from 2005-2010. Improvement in the American Spinal Injury Association (ASIA) Impairment Scale (AIS) was determined after mean 5 months follow-up. Results: The study population comprised 96 cases with SCI, subdivided into cases with AIS grade A, non-CCS cases with AIS grades B-D and CCS cases. 88% of the non-CCS and 65% of the CCS patients underwent surgical decompression, with mean operative times being 71.6±137.8 and 102.9±144.6 post injury (p=0.45). The mean improvements in the mean ASIA motor scores for the three groups were 1.3±6.5 and 15.6±35.0 and 22.5±14.6 (p=0.004) respectively, with a statistically significant difference only between the CCS and AIS grade A groups (p<0.001). 20%, 54% and 10% of the patients respectively, underwent an improvement of ≥ one AIS grades (p=0.018, c2=8.0). Conclusions: This retrospective review investigates the natural history of CCS and explores the role of surgical intervention on optimizing patient outcome.

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