Interstitial Keratitis with Lipid Keratopathy Mimicking Corneal Opacity Induced by Brimonidine Tartrate Eye Drops

2020 ◽  
Vol 237 (12) ◽  
pp. 1466-1467
Author(s):  
Yuka Kasuya ◽  
Ichiya Sano ◽  
Shinji Makino
Keyword(s):  
Corneal Opacity ◽  
Eye Drops ◽  
Interstitial Keratitis ◽  
Brimonidine Tartrate

scholarly journals Corneal Opacity Induced by Antiglaucoma Agents Other Than Brimonidine Tartrate

2020 ◽  
Vol 2020 ◽  
pp. 1-4
Author(s):  
Yuka Kasuya ◽  
Ichiya Sano ◽  
Shinji Makino ◽  
Hidetoshi Kawashima
Keyword(s):  
Anterior Segment ◽  
Corneal Stroma ◽  
Corneal Opacity ◽  
Eye Drops ◽  
Timolol Maleate ◽  
Normal Range ◽  
Topical Drugs ◽  
Antiglaucoma Agents ◽  
Brimonidine Tartrate

The aim of this study is to report a patient with corneal opacity that developed after the use of topical antiglaucoma medications other than brimonidine tartrate (BT). An 85-year-old woman presented with corneal opacity and neovascularization in both eyes. A diagnosis of glaucoma was made 20 years previously, and antiglaucoma agents were prescribed (latanoprost, tafluprost, timolol maleate, travoprost, bimatoprost, ripasudil hydrochloride hydrate, and brinzolamide/timolol maleate) for both eyes. Ocular examination revealed semicircular fan-shaped corneal sterile infiltration with neovascularization. Anterior-segment optical coherence tomography (OCT) showed marked corneal opacity and thickened corneal stroma. The topical drugs were discontinued and replaced with 0.1% betamethasone eye drops. Two weeks after topical drugs were discontinued and replaced with betamethasone, the corneal sterile infiltration markedly improved, although the corneal opacity remained across the stromal layer. In addition, corneal opacity, intermixed with separate transparent sections, was observed as a striped shape. OCT showed an improvement of the thickened corneal stroma. Six weeks after the initial visit, the remaining corneal opacity could be seen as a mixture of opaque and nonopaque areas in stripes. The corneal stromal thickness decreased almost back to the normal range, while the area of the corneal opacity remained unchanged. In vivo laser confocal microscopy showed hyperreflective materials with needle-like structures in the corneal stroma. The corneal opacity showed several similarities to the previous reports of the cases treated with BT. Therefore, clinicians should be mindful of a possible development of corneal opacity in patients treated with antiglaucoma medications other than BT.

scholarly journals DEVELOPMENT AND CHARACTERIZATION OF IN SITU GEL OF XANTHAN GUM FOR OPHTHALMIC FORMULATION CONTAINING BRIMONIDINE TARTRATE

2018 ◽  
Vol 11 (7) ◽  
pp. 277 ◽  
Author(s):  
Vazir Ashfaq Ahmed ◽  
Divakar Goli
Keyword(s):  
Drug Release ◽  
Xanthan Gum ◽  
Gelation Time ◽  
Gel Strength ◽  
Eye Drops ◽  
In Situ Gel ◽  
23 Factorial Design ◽  
Brimonidine Tartrate

Objective: The goal of this study was to develop and characterize an ion-activated in situ gel-forming brimonidine tartrate, solution eye drops containing xanthan gum as a mucoadhesive polymer.Method: Sol-gel formulation was prepared using gellan gum as an ion-activated gel-forming polymer, xanthan gum as mucoadhesive agent, and hydroxypropyl methyl cellulose (HPMC E50LV) as release retardant polymer. Phenylethyl alcohol is used as preservatives in borate buffer. The 23 factorial design was employed to optimize the formulation considering the concentration of gelrite, xanthan gum and HPMC as independent variables, gelation time, gel strength, and mucoadhesive force (N). Gelation time , gel strength, mucoadhesive force (N), viscosity (cP) and in vitro percentage drug release were chosen as dependent variables. The formulation was characteristics for pH, clarity, isotonicity, sterility, rheological behavior, and in vitro drug release, ocular irritation, and ocular visualization.Result: Based on desirability index of responses, the formulation containing a concentration of gelrite (0.4%), xanthan gum (0.21%), and HPMC (HPMC E50 (0.24%) was found to be the optimized formulation concentration developed by 23 factorial design. The solution eye drops resulted in an in situ phase change to gel-state when mixed with simulated tear fluid. The gel formation was also confirmed by viscoelastic measurements. Drug release from the gel followed non-fickian mechanism with 88% of drug released in 10 h, thus increased the residence time of the drug.Conclusion: An in situ gelling system is a valuable alternative to the conventional system with added benefits of sustained drug release which may ultimately result in improved patient compliance.

scholarly journals Allogenic platelet-rich plasma in induced ulcers in rat’s cornea

2021 ◽  
Vol 73 (3) ◽  
pp. 613-621
Author(s):  
M.G. Gandolfi ◽  
C.V.S. Brandão ◽  
C.H. Pellizon ◽  
I.N. Hirota ◽  
R. Barros ◽  
...  
Keyword(s):  
Topical Treatment ◽  
Platelet Rich Plasma ◽  
Corneal Opacity ◽  
Repair Time ◽  
Control Group ◽  
Eye Drops ◽  
Elisa Method ◽  
Clinical Exam ◽  
Speed Up

ABSTRACT The objective in this study was to evaluate the clinic effect of applying allogenic platelet-rich plasma (PRP) heated or not, for treating cornea ulcers, including the dosage of PDGF-BB in the cornea. The ulcers were induced, standardizing the left eye from 81 rats (Ratus norvegicus, albinus variety), assigned randomly into three groups (N=27): control group (CG) which did not receive any topic treatment; heated PRP group (GA) and PRP group (GP), which received topical treatment every eight hours for five days. Each group underwent evaluation at 24 hours (M1), three days (M3) and five days (M5). The clinical exam evaluated the opacity, vascularization and corneal repair. The corneal PDGF-BB was dosed through the ELISA method. The corneal opacity was decreased in PRP-treated animals (GA and GP) and corneal repair time reduced when compared to CG at M1 and M5. Furthermore, GP showed greater vascularization at M3 compared to M1. Applied allogenic PRP eye drops, heated or not, speed up corneal healing, and reduce corneal repair time. However, the corneal PDGF concentration was not altered in any of the treatments.

scholarly journals Successful management of Keratoconjunctivitis in goats in Chennai

2018 ◽  
Vol 10 (4) ◽  
pp. 1196-1198
Author(s):  
G.R. Athira ◽  
D. Chandrasekaran ◽  
C.S. Arunaman ◽  
N.R. Senthil ◽  
S. Vaiaramuthu
Keyword(s):  
Tamil Nadu ◽  
Supportive Therapy ◽  
Antibiotic Sensitivity ◽  
College Teaching ◽  
Corneal Opacity ◽  
Purulent Discharge ◽  
Uneventful Recovery ◽  
Eye Drops ◽  
Biochemical Tests ◽  
Antibiotic Sensitivity Test

Present study was undertaken to study the management of keratoconjunctivitis in five non- descriptive female goats presented to Madras Veterinary College Teaching Hospital, Tamil Nadu with the history of gradual clouding of eyes and partial loss of vision after 15 days from kidding. On clinical examination, the present study observed purulent discharge from eyes and congested conjunctival mucous membrane of goats with other clinical parameters which were normal. Eye examination showed creamy white spot and opacity of corneal opacity with absence of reflexes such as menace, papillary light reflex (PLR) and with partial blindness. Hemato biochemical parameters showed normal values except neutrophilia. Sterile ocular swabs were collected and the organism was identified as Morexella bovis based on their colony morphology and biochemical tests. Based on the Antibiotic sensitivity test (ABST), the affected goats were treated with sensitive antibiotics, eye drops and supportive therapy and the affected goats showed clinical improvement followed by uneventful recovery after one week and prevent further complications such as corneal ulceration and blindness, which in turn affects the economy of the farmer.

scholarly journals MSCs helped reduce scarring in the cornea after fungal infection when combined with anti-fungal treatment

2019 ◽  
Author(s):  
Yue Zhou ◽  
Yuqing Chen ◽  
Suiyue Wang ◽  
Fangyuan Qin ◽  
Wang liya
Keyword(s):  
Fungal Infection ◽  
Second Harmonic ◽  
Corneal Thickness ◽  
Corneal Opacity ◽  
Scar Formation ◽  
Control Group ◽  
Eye Drops ◽  
Corneal Tissue ◽  
Related Factors ◽  
Corneal Scar

Abstract Background Fungal Keratitis (FK) is an infective keratopathy with extremely high blindness rate. The damaging effect of this disease is not only the destruction of corneal tissue during fungal infection, but also the cornea scar formed during the healing period after infection control, which can also seriously affect a patient's vision. The purpose of the study was to observe the effect of umbilical cord mesenchymal stem cells (uMSCs) on corneal scar formation in FK. Methods The FK mouse model was made according to a previously reported method. Natamycin eye drops were used for antifungal treatment 24 hours after modeling. There are four groups involved in the study, including control group, FK group, vehicleinj FK group and uMSCsinj FK group. Mice in uMSCsinj FK group received repeated subconjunctival injections of uMSCs for 3 times at the 1d, 4d and 7d after FK modeling. At 14d, 21d and 28d after trauma, clinical observation, histological examination, second harmonic generation and molecular assays were performed. Results The uMSCs topical administration reduced corneal scar formation area and corneal opacity, accompanying with decreased corneal thickness and inflammatory cell infiltration, following down-regulated fibrotic-related factors α-SMA, TGFβ1, CTGF, and COLI and finally inhibited phosphorylation of TGFβ1/Smad2 signaling pathway during FK corneal fibrosis. Conclusion The results confirmed that uMSCs can improve corneal opacity during the scar formation stage of FK, and exert anti-inflammatory and anti-fibrotic effects..

scholarly journals Comparative efficacy study of brimonidine tartrate 0.15% and timolol maleate 0.5% ophthalmic solution (benzalkonium chloride free) versus Brimolol® (with benzalkonium chloride) following single ocular instillation in New Zealand white rabbits

2020 ◽  
Vol 9 (7) ◽  
pp. 1050
Author(s):  
Amit Thavkar ◽  
Sateesh Kumar Chauhan ◽  
Subhas Bhowmick ◽  
Vinod Burade
Keyword(s):  
Intraocular Pressure ◽  
New Zealand ◽  
Repeated Measures ◽  
Benzalkonium Chloride ◽  
Ophthalmic Solution ◽  
Eye Drops ◽  
Timolol Maleate ◽  
Repeated Measures Analysis ◽  
Brimonidine Tartrate ◽  
Ophthalmic Solutions

Background: Benzalkonium chloride (BKC) is the most used preservative in topical eye drops but it causes effects such as dry eye and trabecular meshwork degeneration. Polyhexamethylene biguanide (PHMB) is a polymeric biguanide is a less harmful preservative used in ophthalmic solutions. The objective of this study to com-pare the efficacy of PHMB preserved versus BKC preserved ophthalmic solutions containing brimonidine tartrate and timolol maleate on intraocular pressure (IOP) following single ocular instillation in New Zealand white (NZW) rabbits.Methods: This study was conducted on 12 normotensive male NZW rabbits (2.9-3.6 kg) between 6-9 months of age. Animals received single ocular instillation of 35 µl ophthalmic solution containing brimonidine tartrate 0.15 %w/v and timolol maleate 0.5% w/v with PHMB as preservative (n=6, test) or BKC as preservative (n=6, reference) as per the randomization. Intraocular pressure (IOP) was measured before and 2, 4, 6, 8 and 24 hours after instillation using a pneumatonometer. Percentage change in IOP from pre-instillation values were calculated. Changes in IOP were analysed using the repeated-measures analysis of variance followed by Bonferroni post-test.Results: Single ocular instillation of PHMB and BKC formulations show significant IOP reduction up to 6 hours as compared with baseline (p<0.05). Reduction in IOP was 35.8% and 32.0% at 2 hours with PHMB and BKC formulations respectively. No differences were observed between the test and reference groups for change in IOP from baseline.Conclusions: PHMB preserved brimonidine tartrate 0.15% w/v and timolol maleate 0.5% w/v ophthalmic solution was comparable to BKC preserved solution in normotensive NZW rabbits.

scholarly journals A Case of Atypical Mucin Balls Wearing Extended Wear of Silicone Hydrogel Lens for Therapeutic Use

2013 ◽  
Vol 2013 ◽  
pp. 1-3
Author(s):  
Yusuke Matsuzaki ◽  
Hiroshi Toshida ◽  
Toshihiko Ohta ◽  
Akira Murakami
Keyword(s):  
Visual Acuity ◽  
Ethylenediaminetetraacetic Acid ◽  
Ophthalmic Solution ◽  
Physiological Saline ◽  
Major Axis ◽  
Corneal Opacity ◽  
Therapeutic Use ◽  
Eye Drops ◽  
Snellen Chart ◽  
Rose Bengal Dye

A 25-year-old man visited our hospital showing atopic conjunctivitis and corneal shield ulcer on his left eye. Although eye drops of 0.1% of betamethasone sodium phosphate and 0.1% of hyaluronic acid ophthalmic solution were prescribed, calcific corneal opacities developed. The corrected visual acuity decreased to 6/20 in Snellen chart. After corneal epithelial exfoliation, removal of calcific corneal opacity was scrubbed with MQA soaked in 0.05 M of ethylenediaminetetraacetic acid (EDTA). After washing the eye with 200 mL of physiological saline, a silicon hydrogel lens, PureVision (balafilcon A), was inserted to obtain pain relief for the therapeutic use. At postoperative day 11, mucin balls were found between cornea and contact lens and stained by rose bengal dye. One of them was atypically larger than usual, and the major axis was approximately 1.5 mm. Wearing lens was stopped, and all of mucin balls and corneal staining were disappeared at postoperative day. Little corneal opacity remained, and visual acuity after surgery recovered to 14/20 at five months.

scholarly journals MSCs helped reduce scarring in the cornea after fungal infection when combined with anti-fungal treatment

2019 ◽  
Author(s):  
Yue Zhou ◽  
Yuqing Chen ◽  
Suiyue Wang ◽  
Fangyuan Qin ◽  
Wang liya
Keyword(s):  
Fungal Infection ◽  
Second Harmonic ◽  
Corneal Thickness ◽  
Corneal Opacity ◽  
Scar Formation ◽  
Control Group ◽  
Eye Drops ◽  
Corneal Tissue ◽  
Related Factors ◽  
Corneal Scar

Abstract Background Fungal Keratitis (FK) is an infective keratopathy with extremely high blindness rate. The damaging effect of this disease is not only the destruction of corneal tissue during fungal infection, but also the cornea scar formed during the healing period after infection control, which can also seriously affect a patient's vision. The purpose of the study was to observe the effect of umbilical cord mesenchymal stem cells (uMSCs) on corneal scar formation in FK. Methods The FK mouse model was made according to a previously reported method. Natamycin eye drops were used for antifungal treatment 24 hours after modeling. There are four groups involved in the study, including control group, FK group, vehicleinj FK group and uMSCsinj FK group. Mice in uMSCsinj FK group received repeated subconjunctival injections of uMSCs for 3 times at the 1d, 4d and 7d after FK modeling. At 14d, 21d and 28d after trauma, clinical observation, histological examination, second harmonic generation and molecular assays were performed. Results The uMSCs topical administration reduced corneal scar formation area and corneal opacity, accompanying with decreased corneal thickness and inflammatory cell infiltration, following down-regulated fibrotic-related factors α-SMA, TGFβ1, CTGF, and COLI and finally inhibited phosphorylation of TGFβ1/Smad2 signaling pathway during FK corneal fibrosis. Conclusion The results confirmed that uMSCs can improve corneal opacity during the scar formation stage of FK, and exert anti-inflammatory and anti-fibrotic effects.

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