Titanium: A Unique Metal for Radical Dehydroxylative Functionalization of Alcohols

Synlett ◽  
2021 ◽  
Author(s):  
Xiaobo Pang ◽  
Xing-Zhong shu
Keyword(s):  
Homolytic Cleavage ◽  
Recent Developments ◽  
Carbon Radicals ◽  
Low Valent

The dehydroxylative functionalization of alcohols is synthetic appealing, but it remains a long-term challenge in the synthetic community. Low-valent titanium has shown the power to produce carbon radicals from alcohols via homolytic cleavage of the C−OH bonds and thus offers the potential to overcome this problem. In this perspective manuscript, we summarized the recent advance on radical dehydroxylative transformation of alcohols either promoted or catalyzed by titanium. The limitation and outlook of the studies in this field are also provided. 1 Introduction 2 Recent Developments in Dehydroxylative Functionalization of Alcohols 3 Summary and Outlook

Review of Recent Developments in Surface Nanocrystallization of Metallic Biomaterials

Nanoscale ◽  
2021 ◽  
Author(s):  
Srijan Acharya ◽  
Satyam Suwas ◽  
Kaushik Chatterjee
Keyword(s):  
Human Body ◽  
Surface Characteristics ◽  
Metallic Materials ◽  
Short Term ◽  
Surface Nanocrystallization ◽  
Metallic Biomaterials ◽  
Recent Developments

Metallic materials are widely used to prepare implants for both short-term and long-term use in the human body. The performance of these implants is greatly influenced by their surface characteristics,...

scholarly journals The evolving definition of salivary gland stem cells

2021 ◽  
Vol 6 (1) ◽  
Author(s):  
Cecilia Rocchi ◽  
Lara Barazzuol ◽  
Rob P. Coppes
Keyword(s):  
Stem Cells ◽  
Salivary Gland ◽  
Adult Stem Cell ◽  
Cell Types ◽  
Research Field ◽  
New Therapeutic Approaches ◽  
Recent Developments ◽  
Radiation Induced ◽  
Definition Of

AbstractDysfunction of the salivary gland and irreversible hyposalivation are the main side effects of radiotherapy treatment for head and neck cancer leading to a drastic decrease of the quality of life of the patients. Approaches aimed at regenerating damaged salivary glands have been proposed as means to provide long-term restoration of tissue function in the affected patients. In studies to elucidate salivary gland regenerative mechanisms, more and more evidence suggests that salivary gland stem/progenitor cell behavior, like many other adult tissues, does not follow that of the hard-wired professional stem cells of the hematopoietic system. In this review, we provide evidence showing that several cell types within the salivary gland epithelium can serve as stem/progenitor-like cells. While these cell populations seem to function mostly as lineage-restricted progenitors during homeostasis, we indicate that upon damage specific plasticity mechanisms might be activated to take part in regeneration of the tissue. In light of these insights, we provide an overview of how recent developments in the adult stem cell research field are changing our thinking of the definition of salivary gland stem cells and their potential plasticity upon damage. These new perspectives may have important implications on the development of new therapeutic approaches to rescue radiation-induced hyposalivation.

Developments in Cyclic Analysis and High Temperature Design

2005 ◽  
Author(s):  
Peter Carter ◽  
Douglas L. Marriott
Keyword(s):  
High Temperature ◽  
Power Systems ◽  
Creep Damage ◽  
Limit Load ◽  
Cyclic Stress ◽  
Research Literature ◽  
Stress Classification ◽  
Analysis Technique ◽  
Recent Developments

Design for cyclic loading is emerging as a key question for next generation power systems. Recent developments in techniques for cyclic stress analysis have significant implications for high temperature design. In the same way that limit load analysis is now being used to overcome the difficulties and guesswork of stress classification for steady primary loads, so shakedown and ratcheting analysis can eliminate the more difficult problems of stress classification for cyclic loads. The paper shows how reference stresses defined for shakedown and ratcheting provide rapid and conservative information for design against rupture and creep damage, deformation and strain accumulation, and ratcheting. These techniques will provide additional insights to designers and are likely to augment rather than replace, existing options. These ideas have existed in the research literature for some time, but have now become more accessible by the general industry with a new analysis technique in a commercial finite element code. Examples are given which demonstrate the methodology for nozzles having non-thermal secondary stresses, and prediction of long-term distortion in thermal shock problems.

scholarly journals Anterior Shoulder Dislocation

2009 ◽  
Vol 91 (1) ◽  
pp. 2-7 ◽  
Author(s):  
Steven Cutts ◽  
Mark Prempeh ◽  
Steven Drew
Keyword(s):  
Shoulder Dislocation ◽  
Graphical Representation ◽  
Significant Proportion ◽  
Anterior Dislocation ◽  
Anterior Shoulder Dislocation ◽  
Medline Search ◽  
Recent Developments ◽  
Shoulder Arthritis ◽  
Delays In Diagnosis

INTRODUCTION Anterior dislocation of the shoulder is commonly seen in accident and emergency (A&E) and trauma clinics. In this article, we review the existing literature on the injury and the recent trends in management. MATERIALS AND METHODS We have discussed this condition with our colleagues and performed a Medline search (‘anterior shoulder dislocation’) of the relevant papers. We also describe key historical publications and recent developments regarding immobilisation of the joint. RESULTS Management decisions regarding this condition continue to vary between units, especially for recurrent and posterior dislocation. This paper lays some emphasis on the choice of analgesic agent when attempting shoulder reduction in the A&E setting. A summary of the data from our own department has provided a graphical representation of the classical age and sex distribution for this condition. CONCLUSIONS Shoulder dislocation is a common injury. Delays in diagnosis remain the single biggest obstacle to optimum results in this group of patients. A significant proportion will require eventual surgery and up to a third of these patients will go on to develop long-term shoulder arthritis. Even patients who have experienced a single episode of dislocation may go on to develop long-term sequelae.

Strategic Ethnography and the Biography of Artefacts

2013 ◽  
pp. 347-376 ◽  
Author(s):  
Neil Pollock ◽  
Robin Williams
Keyword(s):  
Enterprise Resource Planning ◽  
Technology Implementation ◽  
Large Scale ◽  
Resource Planning ◽  
Work Organisation ◽  
Social Scientists ◽  
Knowledge Based ◽  
Enterprise Resource Planning Systems ◽  
Recent Developments

In health research and services, and in many other domains, the authors note the emergence of large-scale information systems intended for long-term use with multiple users and uses. These e-infrastructures are becoming more widespread and pervasive and, by enabling effective sharing of information and coordination of activities between diverse, dispersed groups, are expected to transform knowledge-based work. Social scientists have sought to analyse the significance of these systems and the processes by which they are created. Much current attention has been drawn to the often-problematic experience of those attempting to establish them. By contrast, this chapter is inspired by concerns about the theoretical and methodological weakness of many studies of technology and work organisation—particularly the dominance of relatively short-term, often single site studies of technology implementation. These weaknesses are particularly acute in relation to the analysis of infrastructural technologies. The authors explore the relevance to such analysis of recent developments in what they call the Biography of Artefacts (BoA) perspective—which emphasises the value of strategic ethnography: theoretically-informed, multi-site, and longitudinal studies. They seek to draw insights from a programme of empirical research into the long-term evolution of corporate e-infrastructures (reflected in current Enterprise Resource Planning systems) and review some new conceptual tools arising from recent research into e-Infrastructures (e-Is). These are particularly relevant to understanding the current and ongoing difficulties encountered in attempts to develop large-scale Health Infrastructures.

Solitary Confinement across Borders

2019 ◽  
pp. 59-76
Author(s):  
Sharon Shalev
Keyword(s):  
United States ◽  
New Zealand ◽  
The United States ◽  
Prison System ◽  
Solitary Confinement ◽  
Management Units ◽  
England And Wales ◽  
Close Supervision ◽  
Recent Developments

This chapter looks at the use of solitary confinement in three jurisdictions where the author has conducted research: England and Wales, New Zealand, and the United States. It asks when and why prisoners are placed in solitary confinement in these jurisdictions, and what are the conditions of their confinement. The chapter's main focus is on the long-term use of solitary confinement as a tool for managing individuals classified and labeled as the most dangerous or troublesome in the prison system, including in New Zealand's Management Units and England and Wales’s Close Supervision Centres. Finally, it examines recent developments and asks what learning there might be for other jurisdictions.

Antimicrobial Applications of Nanoparticles

2022 ◽  
pp. 269-288
Author(s):  
Ayesha Kanwal ◽  
Zeeshan Ahmad Bhutta ◽  
Ambreen Ashar ◽  
Ashar Mahfooz ◽  
Rizwan Ahmed ◽  
...  
Keyword(s):  
Antibacterial Activity ◽  
Side Effects ◽  
Antibacterial Agent ◽  
Antibacterial Agents ◽  
The Other ◽  
Drug Resistant ◽  
Short Term ◽  
Human Mortality ◽  
Recent Developments

Human mortality due to drug-resistant infections is becoming more prevalent in our society. Antibiotics are impotent due to abuse and/or misuse, leading to new, more expensive, and more effective medicines and treatments. Therefore, it causes many short-term and long-term side effects in the patient. On the other hand, nanoparticles have exhibited antibacterial activity against various pathogens due to their small size and ability to destroy cells by various mechanisms. Unlike antibiotics for the treatment of patients' diseases and infections, nanomaterials provide an exciting way to limit the growth of microorganisms due to infections in humans. This has led to the development of a number of nanoparticles as active antibacterial agents. Therefore, the authors have carefully reviewed the recent developments in the use of nanomaterials for antibacterial applications and the mechanisms that make them an effective alternate antibacterial agent.

Laboratory Investigations on the Effects of Bacteria on Fine-Grained Soils

2017 ◽  
Vol 21 ◽  
pp. 352-357 ◽  
Author(s):  
S. Sowmya ◽  
P.S. Meenu ◽  
R. Asha Latha ◽  
Devendra Narain Singh
Keyword(s):  
Preliminary Investigation ◽  
Biological Processes ◽  
Fine Grained ◽  
Recent Developments ◽  
Prospective Application ◽  
Laboratory Investigations ◽  
The Impact ◽  
Geotechnical Problems ◽  
Long Term Studies

Over the years, the field of geotechnical engineering focused on physical, chemical and mechanical aspects of the geomaterials. However, recent developments in environmental geotechnics have highlighted the impact of biological processes on geo-materials and their performance. Also, the present day geotechnical problems favour biological interventions to develop eco-friendly and sustainable technology. In view of this, the present study is a preliminary investigation on the impact of microbial loading on fine-grained soils. In addition, a protocol has been developed to establish ‘bio-geo interface’ between bacteria and the geo-material. However, long term studies are demanded in this direction for in-depth understanding of the mechanism for development of prospective application.

Liver: A Target of Late Diabetic Complications

2012 ◽  
Vol 120 (04) ◽  
pp. 202-204 ◽  
Author(s):  
S. Herzig
Keyword(s):  
Hepatic Dysfunction ◽  
Vascular Complications ◽  
Transcriptional Regulators ◽  
Causative Factor ◽  
Late Complications ◽  
The Metabolic Syndrome ◽  
Recent Developments ◽  
Diabetic Late Complications

AbstractWhereas many studies have implicated metabolic liver dysfunction as a causative factor for obesity-related type 2 diabetes and the Metabolic Syndrome, its role as a long-term complication of diabetic metabolism is still mostly unexplored.In contrast to the well-described late diabetic micro- and macro-vascular complications in response to hyperglycemic conditions such as nephro- and retinopathy as well as atherosclerosis, only recent studies have highlighted disturbances of liver function as a novel aspect of diabetic late complications that may substantially impact the overall disease outcome and determine mortality rates in diabetic subjects. Here we will discuss recent developments in this area, particularly focusing on transcriptional regulators of hepatic dysfunction as a long-term consequence of established diabetes.

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