Neuartige Piperidin- und Dihydropyrrol-Alkaloide aus Lindenblüten (Tiliae flos) mit spasmogener Wirkung auf die Trachealmuskulatur der Maus

2021 ◽  
Vol 42 (05) ◽  
pp. 225-232
Author(s):  
Nico Symma ◽  
Alexander Hake ◽  
Martina Düfer ◽  
Andreas Hensel
Keyword(s):  
Tilia Cordata

ZusammenfassungLindenblüten (Tiliae flos) werden aus den getrockneten Blütenständen von Tilia cordata (Winterlinde), T. platyphyllos (Sommerlinde) und deren Hybride T.×vulgaris (Holländische Linde) gewonnen. Traditionell werden Extrakte aus Lindenblüten gegen Symptome von Erkältungskrankheiten sowie bei mentalem Stress eingesetzt. Die Droge ist durch einen hohen Gerbstoffanteil, größere Mengen an Schleimstoffen sowie durch ein komplexes Flavonoidmuster gekennzeichnet. Im Rahmen weiterführender phytochemischer Untersuchungen wurden erstmalig bisher noch nicht beschriebene Alkaloide aus Lindenblüten isoliert und strukturell charakterisiert. Bei diesen bisher noch unbekannten Naturstoffen handelt es sich um zwei diastereomere Dihydropyrrolalkaloide (Tiliin A/B), zwei Piperidin-alkaloide (Tiliamin A/B) sowie zwei acetylierte Piperidinalkaloide (Tilacetin A/B). Die Alkaloide werden bevorzugt mit hydroalkoholischen Solventien extrahiert (Alkaloidgehalt ca. 2 mg/g Trockenextrakt), noch besser mit Aceton-Wasser-Gemisch (ca. 5 mg/g), finden sich aber auch in klassischen Teezubereitungen (Infus, 1,3 mg/g), was bei Zugrundelegung der empfohlenen Tagesdosis von Lindenblüten (3–6 g Droge) zu einer Alkaloidaufnahme von 1–2 mg pro Tag führt.Pharmakologische Untersuchungen an aus C57BL/6N-Mäusen präparierten Tracheen im Organbad zeigten, dass eine Alkaloid-angereicherte Fraktion die durch Acetylcholin ausgelöste Muskelkontraktionen steigerte (ca.+30%). Eine weiteraufgereinigte Alkaloid-Fraktion (0,1 mg/ml) zeigte vergleichbare Effekte, die sich mittels Atropin (1 µM) aufheben ließen und denen von Galantamin (0,5 µM) glichen. Diese Beobachtungen führten zur Schlussfolgerung, dass die Lindenalkaloide cholinerge Effekte über muskarinerge M3-Rezeptoren vermitteln. Im zellfreien Enzymassay konnten die Lindenalkaloide als Acetylcholinesterase-Inhibitoren charakterisiert werden. Die in der Originalpublikation beschriebenen Interaktionen der Lindenalkaloiden mit dem cholinergen System könnten neue Ansatzpunkte in der rationalen Phytotherapie darstellen.

Species specificity of woody trees adaptation at technogenically transformed urbanhabitats of the Kyiv megalopolisis

2014 ◽  
Vol 26 (3-4) ◽  
pp. 42-61
Author(s):  
O. G. Lucyshyn ◽  
I. K. Teslenko
Keyword(s):  
Woody Plants ◽  
Sugar Maple ◽  
Horse Chestnut ◽  
Tilia Cordata ◽  
Technogenic Pollution ◽  
Acer Platanoides ◽  
Norway Maple ◽  
Na Ions ◽  
High Concentrations ◽  
Lombardy Poplar

The recent ecological situation of Kyiv megalopolis has a special specific of environment technogenic pollution as a chemical features and content of polluting phytotoxicants. During 2007–2012, our observation revealed what the most dangerous factors which have harm impact on the street woody plants are the huge concentration of phytotoxic elements (Na+, Cl-, Pb2+, Cd2+). Nowadays, the technogenic impact on the megalopolyisis surrounding comes to the dangerous, even, catastrophic level. The main reason of total and chloral necrose of leaves, the summer defoliation of crown and major tree's death is the over pollution of the soil and plant's phytomass by phytotoxic elements, the concentration of which by standards evaluation and by trees reactions are critical and exists at the level of adaptation possibility and survival. The main sources of Pb2+ and Cd2+ ions are transport outcomes (> 90 % of total technogenic pollution). The increasing of Pb2+ and Cd2+ in the soil is depended from intensivity of transport outcomes, using of ethylated petrol, and location of trees along roads as well as from the trees species. Continuously increasing of number of cars at the city streets is accompanying with similar increasing of ions concentration. Thus, in the soil around root system of street woody plants, depending from their location along roads, the concentration of Pb2+ (moving form) is between 41,7 (I. Kudri str.) and 102,6 mg\kg of soil (Nauki avenue). It exceeds the maximum permissible concentration (MPC), which is 20,8–51,3 mg\kg of soil. Next, for Norway maple (Acer platanoides) the concentration of Pb2+ in the soil varies from 41,7 to 80,5 mg / kg of soil in the area of the root system and it is around 20,8–40,2 MPC. In the leaves of this tree it is 7,83–13,5 mg / kg of dry mass (MPC is 15,8–27,0). For the horse chestnut (Aedculus hippocastanum) at the Nauka avenue, the concentration of plumbum in the root is 13,4 mg / kg (MPC is 26,8), in the cortex – 17,7 mg / kg (MPC is 35,4), in leaves – 8,21 mg / kg (MPC is 16,4), which by the normative evaluation are the critical concentrations. The source of Na+ and Cl-, which is a new factor for Kyiv megalopolis, is irregular load of high concentrations of industrial salt NaCl into the environment, as a way against black ice in winter time, where the Na+ ions ( mobile form) is in the high concentrations in leaves (0,76 % for Norway maple (Acer platanoides) on the I. Kudri str., 1,28 % – small-leaved linden (Tilia cordata) at the 40-richya Zhovtnya ave, 2,0 % – horse chestnut (Aedculus hippocastanum) at the Nauki ave), those are exceeded the concentration of the element comparing to the control test object, respectively, in 10,6, 12,8 and 5,0 times. Na+ ions are an aggressive phytotoxins and the main factor of leaves necrose of tree crown (within 70–100 % necrosis leaves in the crown). Degradation and total reduction of the specific weight of plants in the megalopolis environment are decrease the cleaning role of the street tree plants, which are the main alive filters for soil and air cleaning, as well as the main bioaccumulators and detoxicants of harm substances of anthropogenic pollution. Species adaptive specificity is revealed at the bioaccumulation level and the selective locality of phytotoxic elements (Na+, Cl-, Pb2+, Cd2+, agile form) in technourbanhabitats-pic conditions, there dominated bioaccumulation and localization of Na+ ions by trees assimilative system is caused the adaptive orientation of endogenic and intraspecific variability of phytoindicative morphophysiologic features of plants functional condition under the stressing factors. This also is defined the sensitivity of small-leaved linden (Tilia cordata Mill.), norway maple (Acer platanoides L.) and horse chestnut (Aesculus hippocastanum L.) to the big concentration of potassium as the most danger one for the plant survival. The biggest accumulation of Na+ ions at the roots of Lombardy poplar (Populus pyramidalis Roz.), Bolle's poplar (Populus bolleana Lauche) and sugar maple (Acer saccharinum L.) is lead to a higher resistance of their assimilation system. At the technourbohabitate-pic conditions, the level of realization of ontogenetic and phylogenetic adaptive capacity of the sensitive species of trees is harmfully low (21,3–44,3 %). It is at the level of survival/death of plants. The street Lombardy poplar, Bolle's poplar and sugar maple, despite of more higher level of their adaptation (68,4–87,7 %), still also can't fully adapt to the critical levels of technogenic pollution of megalopolis environment. 

Изменчивость хлоропластной ДНК отражает историю Tilia cordata s. l. в восточной части ареала

2020 ◽  
Vol 56 (2) ◽  
pp. 188-200
Author(s):  
С. А. Семерикова ◽  
И. Ю. Исаков ◽  
В. Л. Семериков
Keyword(s):  
Tilia Cordata

scholarly journals The Wood Quality of Small-Leaved Lime (Tilia cordata Mill.) Trees in an Urban Area: A Pilot Study

Forests ◽  
2021 ◽  
Vol 12 (4) ◽  
pp. 420
Author(s):  
Benas Šilinskas ◽  
Aistė Povilaitienė ◽  
Gintautas Urbaitis ◽  
Marius Aleinikovas ◽  
Iveta Varnagirytė-Kabašinskienė
Keyword(s):  
Urban Area ◽  
Urban Areas ◽  
Wood Quality ◽  
Wood Products ◽  
Urban Trees ◽  
Measuring System ◽  
Forest Site ◽  
Tilia Cordata ◽  
Mean Values ◽  
Wood Development

This study performed a pilot evaluation of the wood quality—defined by a single parameter: dynamic modulus of elasticity (MOEdyn, N mm−2)—of small-leaved lime (Tilia cordata Mill.) trees in urban areas. A search of the literature revealed few studies which examined the specifics of tree wood development in urban areas. Little is known about the potential of wood from urban trees wood of their suitability for the timber industry. In this study, an acoustic velocity measuring system was used for wood quality assessment of small-leaved lime trees. The MOEdyn parameter was evaluated for small-leaved lime trees growing in two urban locations (along the streets, and in an urban park), with an additional sample of forest sites taken as the control. MOEdyn was also assessed for small-leaved lime trees visually assigned to different health classes. The obtained mean values of MOEdyn of 90–120-year old small-leaved lime trees in urban areas ranged between 2492.2 and 2715.8 N mm−2. For younger trees, the values of MOEdyn were lower in the urban areas than in the forest site. Otherwise, the results of the study showed that the small-leaved lime wood samples were of relatively good quality, even if the tree was classified as moderately damaged (which could cause a potential risk to the community). Two alternatives for urban tree management can be envisaged: (1) old trees could be left to grow to maintain the sustainability of an urban area until their natural death, or (2) the wood from selected moderately damaged trees could be used to create wood products, ensuring long-term carbon retention.

scholarly journals Palaeoecology as a Tool for the Future Management of Forest Ecosystems in Hesse (Central Germany): Beech (Fagus sylvatica L.) versus Lime (Tilia cordata Mill.)

Forests ◽  
2021 ◽  
Vol 12 (7) ◽  
pp. 924
Author(s):  
Astrid Stobbe ◽  
Maren Gumnior
Keyword(s):  
Fagus Sylvatica ◽  
Tilia Cordata ◽  
Beech Forests ◽  
Mountain Ranges ◽  
The Future ◽  
Spruce Stands ◽  
Fagus Sylvatica L ◽  
Low Mountain Ranges ◽  
Intramontane Basins ◽  
Future Management

In the Central German Uplands, Fagus sylvatica and Picea abies have been particularly affected by climate change. With the establishment of beech forests about 3000 years ago and pure spruce stands 500 years ago, they might be regarded as ‘neophytes’ in the Hessian forests. Palaeoecological investigations at wetland sites in the low mountain ranges and intramontane basins point to an asynchronous vegetation evolution in a comparatively small but heterogenous region. On the other hand, palynological data prove that sustainably managed woodlands with high proportions of Tilia have been persisting for several millennia, before the spread of beech took place as a result of a cooler and wetter climate and changes in land management. In view of increasingly warmer and drier conditions, Tilia cordata appears especially qualified to be an important silvicultural constituent of the future, not only due to its tolerance towards drought, but also its resistance to browsing, and the ability to reproduce vegetatively. Forest managers should be encouraged to actively promote the return to more stress-tolerant lime-dominated woodlands, similar to those that existed in the Subboreal chronozone.

scholarly journals Communities of tree vegetation and wood-destroying fungi in parks of the Kyiv city, Ukraine

2016 ◽  
Vol 62 (2) ◽  
pp. 110-122 ◽  
Author(s):  
Olena Blinkova ◽  
Oleksandra Ivanenko
Keyword(s):  
Species Composition ◽  
Pinus Sylvestris ◽  
Age Structure ◽  
Woody Plants ◽  
Quercus Robur ◽  
Health Conditions ◽  
Tilia Cordata ◽  
Acer Platanoides ◽  
Sambucus Nigra ◽  
Xylotrophic Fungi

Abstract Selected forestry parameters were investigated in the system of tree vegetation and wood-destroying fungi in parks of the Kyiv city along a gradient of recreational transformation. We investigated vitality, age structure and health conditions of woody plants (Acer platanoides L., Aesculus hippocastanum L., Carpinus betulus L., Frangula alnus Mill., Pinus sylvestris L., Quercus robur L., Q. rubra L., Sambucus nigra L., Tilia cordata Mill.), and species, systematic, trophic and spatial compositions of xylotrophic fungi (27 species of xylotrophs representing 22 genera, 16 families, 6 orders of divisions Basidiomycota; class Agaricomycetes). The results showed that the communities of tree vegetation and xylotrophic fungi in parks depend on the degree of recreational transformation of the environment. Vitality, age structure and health conditions of trees altered species composition of xylotrophs.

scholarly journals Using Picus® Sonic Tomograph to assess the health state of trees of monumental sizes

2017 ◽  
Vol 13 (2) ◽  
pp. 73-82
Author(s):  
Wojciech Durlak ◽  
Margot Dudkiewicz ◽  
Krystyna Pudelska ◽  
Marek Dąbski
Keyword(s):  
Cultural Landscape ◽  
Visual Assessment ◽  
Image Resolution ◽  
The Body ◽  
Actual State ◽  
Health State ◽  
Tilia Cordata ◽  
Sound Waves ◽  
Gingko Biloba ◽  
Ulmus Glabra

The aim of the study was to examine the usefulness of The Picus 3 Sonic Tomograph to assess the health state of trees of monumental sizes, which are an important part of the cultural landscape. In the study there were selected tree species Tilia cordata, Gingko biloba and Ulmus glabra growing in the vicinity of Lublin in different habitat conditions. Changes in the internal structure of the tree trunks were shown on the colour tomograms. Two tested specimens of Tilia cordata located in Radawiec Duży were intended to be cut down due to the construction of the ring road of Lublin. This made it possible to compare the obtained tomograms with the actual state of the inside of tree trunks after cutting down the examined trees. The results of Picus tomography Ulmus glabra and Gingko biloba growing in the historic park in Czesławice were confirmed by a visual assessment of trees. In each case the number of installed sensors influenced the image resolution and accuracy of the obtained tomograms. Diagnostics using sound waves is important in assessing the state of health of each tree, but it is especially recommended for testing of valuable trees. It allows for early diagnosis and selection of such protective actions to reduce to a minimum the destructive impact study on the body of the plant.

scholarly journals Optimization and Kinetic Modelling of Total Phenols and Flavonoids Extraction from Tilia cordata M. Flowers

2021 ◽  
Vol 75 ◽  
Author(s):  
Milan Mitic ◽  
Sonja Jankovic ◽  
Snezana Mitic ◽  
Gordana Kocic ◽  
Pavle Maskovic ◽  
...  
Keyword(s):  
Kinetic Modelling ◽  
Tilia Cordata ◽  
Total Phenols

scholarly journals Phytocenotic role of Tilia cordata on natural and urban territories

2006 ◽  
Vol 4 (4) ◽  
pp. 8-8
Author(s):  
E A Platonova ◽  
A S Lantratova ◽  
K Ju Golubin
Keyword(s):  
Tilia Cordata ◽  
Urban Territories

scholarly journals A contribution to the knowledge of biology and harmfulness of Deporaus betulae (L.) (Coleoptera, Attelabidae)

2012 ◽  
Vol 60 (6) ◽  
pp. 317-338 ◽  
Author(s):  
Jaroslav Urban
Keyword(s):  
Fagus Sylvatica ◽  
Betula Pendula ◽  
Leaf Blade ◽  
Alnus Glutinosa ◽  
Field Studies ◽  
Corylus Avellana ◽  
Quercus Petraea ◽  
Egg Laying ◽  
Tilia Cordata ◽  
Average Area

The paper deals with the occurrence, development and harmfulness of Deporaus betulae (L.). The majority of field studies was carried out at Training Forest Enterprise (TFE) Masaryk Forest in Křtiny (District Brno-venkov) in 2010 and 2011. In addition to this, the species was studied in detail also in a laboratory. It occurred mostly on Betula pendula and Carpinus betulus. Rarely, the species was found on Alnus glutinosa and Corylus avellana and only sporadically on Fagus sylvatica, Quercus petraea, Tilia cordata and T. platyphyllos. In the studied area, larvae and pupae hibernate. Beetles occur on trees from the end of April to the beginning of July, sporadically later. Females lay on average 2.5 (in the laboratory 4.4) eggs into rolls on B. pendula, on C. betulus 2.2 eggs. During two months, they damage on average 5.3 cm2 leaves creating 14 rolls and laying 35 eggs into the rolls. Larvae consume only 1.7 cm2 leaf blade. The development of the species takes three to four months from egg laying to the departure of larvae into soil. On leaves of B. pendula of an average area of 14.2 cm2, females roll up the same area (about 11.2 cm2) as on leaves of C. betulus of an area of 21.7 cm2. Into the rolls, they lay on average the same number of eggs. The average number of eggs in rolls increases with the increased area of B. pendula leaf blade. Trees partly compensate for the reduction of assimilatory area also by the growth of the area of neighbouring undamaged leaves (on average by 12.7 %).

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