[4+n] Annulation Reactions Using ortho-Halomethyl Anilines as Aza-ortho-Quinone Methide Precursors
Keyword(s):
Aza-ortho-quinone methides are an important class of reactive intermediates, which have found broad applications in synthetic chemistry. Recently, 1,4-elimination of ortho-halomethyl aniline derivatives has emerged as a new powerful and convenient method for aza-ortho-quinone methide generation. This review will highlight their recent applications as aza-ortho-quinone methide precursors in annulation reactions to access various biologically important nitrogen-containing heterocycles. The general mechanisms are briefly discussed as well.
2001 ◽
Vol 73
(3)
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pp. 529-534
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2000 ◽
Vol 72
(12)
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pp. 2299-2308
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2009 ◽
Vol 131
(39)
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pp. 14125-14126
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2018 ◽
Vol 5
(23)
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pp. 3483-3487
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