Environment Friendly and Recyclable CuCl2-mediated C-S Bond Coupling Strategy Using DMEDA as Ligand, Base and Solvent
Simple reaction conditions and recyclable reagents are an irreplaceable advantage for environmentally friendly industrial applications. An environment friendly, recyclable and economic strategy was developed to synthesize diaryl chalcogenides by the CuCl2 catalyzed C-S bond formation reaction via iodobenzenes and benzenethiols/1,2-diphenyldisulfanes using N,N’-dimethylethane-1,2-diamine (DMEDA) as ligand, base and solvent. For these reactions, especially the reactions of diiodobenzenes and aminobenzenethiols/disulfanediyldianilines, a range of substrates is compatible to give the corresponding products in good to excellent yields. Both the reaction reagents of the catalytic system (CuCl2/DMEDA) are inexpensive, conveniently separable and recyclable for more than 5 cycles.