Total Synthesis of Citreochlorol Monochloro Analogs via a Catalytically Enantioselective Carbonyl Allylation
Keyword(s):
An efficient synthetic route to citreochlorol analogs, halogenated polyketide secondary metabolites, is described. The key features are Krische's enantioselective carbonyl allylation, IBr-promoted cyclization, and regioselective epoxide opening. The importance of the route lies in the access of the versatile epoxy ether 14, which opens access to the citreochlorol monochloro derivatives 5 and 6.
2013 ◽
Vol 9
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pp. 2028-2032
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2019 ◽
Vol 58
(50)
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pp. 18040-18045
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2019 ◽
Vol 58
(31)
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pp. 10718-10722
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2008 ◽
Vol 80
(5)
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pp. 1063-1069
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