In-vivo antidiabetic effect of Cistus laurifolius L. leaves

Planta Medica ◽  
2009 ◽  
Vol 75 (09) ◽  
Author(s):  
M Aslan ◽  
N Orhan ◽  
E Sezik
Keyword(s):  
Antidiabetic Effect

scholarly journals In Vivo Subacute Toxicity and Antidiabetic Effect of Aqueous Extract of Nigella sativa

2017 ◽  
Vol 2017 ◽  
pp. 1-13 ◽  
Author(s):  
Karima Bensiameur-Touati ◽  
Ghouti Kacimi ◽  
El-Mehdi Haffaf ◽  
Sihem Berdja ◽  
Souhila Aouichat-Bouguerra
Keyword(s):  
Aqueous Extract ◽  
Nigella Sativa ◽  
Histological Study ◽  
Diabetic Rats ◽  
Antidiabetic Effect ◽  
Subacute Toxicity ◽  
Wide Range ◽  
Liver And Pancreas ◽  
Liver Tbars

Context. Nigella sativa seeds are usually used as traditional medicine for a wide range of therapeutic purposes. Objective. To investigate the subacute toxicity of NS aqueous extract and select its lowest dose to study its antidiabetic effect. Methods. 5 AqE.NS doses (2, 6.4, 21, 33, and 60 g/Kg) were daily administered to mice by gavage. Biochemical parameters measurements and histological study of the liver and the kidney were performed after 6 weeks of supplementation. Thereafter, and after inducing diabetes by alloxan, rats were treated by 2 g/Kg of AqE.NS during 8 weeks. Metabolic parameters were measured on sera. A horizontal electrophoresis of plasmatic lipoprotein was conducted. Glycogen, total lipids, and triglycerides were measured in the liver. TBARS were evaluated on adipose tissue, liver, and pancreas. Results. AqE.NS showed no variation in urea and albumin at the 5 doses, but hepatotoxicity from 21 g/Kg was confirmed by histopathological observations of the liver. In diabetic rats, AqE.NS significantly decreased glycemia, TG, T-cholesterol, LDL-c, and TBARS and showed a restored insulinemia and a significant increase in HDL-c. Results on the liver indicated a decrease in lipids and a possible glycogenogenesis. Conclusion. AqE.NS showed its safety at low doses and its evident antihyperglycemic, antihyperlipidemic, and antioxidant effect.

Prunus amygdalus extract exert antidiabetic effect via inhibition of DPP-IV: in-silico and in-vivo approaches

2020 ◽  
pp. 1-15
Author(s):  
Vikas Kumar ◽  
Richa Sachan ◽  
Mahfoozur Rahman ◽  
Kalicharan Sharma ◽  
Fahad A. Al-Abbasi ◽  
...  
Keyword(s):  
In Silico ◽  
Prunus Amygdalus ◽  
Antidiabetic Effect ◽  
Dpp Iv

scholarly journals In vitro and in vivo antidiabetic effect of extracts of Melia azedarach, Zanthoxylum alatum , and Tanacetum nubigenum

2018 ◽  
Vol 7 (2) ◽  
pp. 176-183 ◽  
Author(s):  
Mohammad Faheem Khan ◽  
Arun Kumar Rawat ◽  
Shahnaaz Khatoon ◽  
Mohd Kamil Hussain ◽  
Arvind Mishra ◽  
...  
Keyword(s):  
Melia Azedarach ◽  
Antidiabetic Effect

scholarly journals Antidiabetic Effect of Noodles Containing Fermented Lettuce Extracts

Metabolites ◽  
2021 ◽  
Vol 11 (8) ◽  
pp. 520
Author(s):  
Soon Yeon Jeong ◽  
Eunjin Kim ◽  
Ming Zhang ◽  
Yun-Seong Lee ◽  
Byeongjun Ji ◽  
...  
Keyword(s):  
Blood Glucose ◽  
Fasting Blood Glucose ◽  
Diabetic Mouse ◽  
Antidiabetic Activity ◽  
Oral Glucose ◽  
Antidiabetic Effect ◽  
In Vivo Experiments ◽  
Gaba Content ◽  
Tof Ms

The aim of the current study was to examine the antidiabetic effect of noodle containing fermented lettuce extract (FLE) on diabetic mice as a pre-clinical study. The γ-aminobutyric acid (GABA) content, antioxidant capacity, and total polyphenol content of the FLE noodles were analyzed and compared with those of standard noodles. In addition, oral glucose and sucrose tolerance, and fasting blood glucose tests were performed using a high-fat diet/streptozotocin-mediated diabetic mouse model. Serum metabolite profiling of mice feed standard or FLE noodles was performed using gas chromatography–time-of-flight mass spectrometry (GC–TOF-MS) to understand the mechanism changes induced by the FLE noodles. The GABA content, total polyphenols, and antioxidant activity were high in FLE noodles compared with those in the standard noodles. In vivo experiments also showed that mice fed FLE noodles had lower blood glucose levels and insulin resistance than those fed standard noodles. Moreover, glycolysis, purine metabolism, and amino acid metabolism were altered by FLE as determined by GC–TOF-MS-based metabolomics. These results demonstrate that FLE noodles possess significant antidiabetic activity, suggesting the applicability of fermented lettuce extract as a potential food additive for diabetic food products.

scholarly journals Human Adipose-Derived Mesenchymal Stem Cells Respond to Short-Term Hypoxia by Secreting Factors Beneficial for Human Islets in Vitro and Potentiate Antidiabetic Effect in Vivo

Cell Medicine ◽  
2017 ◽  
Vol 9 (3) ◽  
pp. 103-116 ◽  
Author(s):  
Simen W. Schive ◽  
Mohammad Reza Mirlashari ◽  
Grete Hasvold ◽  
Mengyu Wang ◽  
Dag Josefsen ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Human Islets ◽  
Insulin Content ◽  
Oral Glucose ◽  
Islet Function ◽  
Soluble Factors ◽  
Antidiabetic Effect

Adipose-derived mesenchymal stem cells (ASCs) release factors beneficial for islets in vitro and protect against hyperglycemia in rodent models of diabetes. Oxygen tension has been shown to induce metabolic changes and alter ASCs' release of soluble factors. The effects of hypoxia on the antidiabetic properties of ASCs have not been explored. To investigate this, we incubated human ASCs for 48 h in 21% (normoxia) or 1% O2 (hypoxia) and compared viability, cell growth, surface markers, differentiation capability, and soluble factors in the conditioned media (CM). Human islets were exposed to CM from ASCs incubated in either normoxia or hypoxia, and islet function and apoptosis after culture with or without proinflammatory cytokines were measured. To test hypoxic preconditioned ASCs' islet protective effects in vivo, ASCs were incubated for 48 h in normoxia or hypoxia before being injected into Balb/c Rag 1-/- immunodeficient mice with streptozotocin-induced insulitis. Progression of diabetes and insulin content of pancreas were measured. We found that incubation in hypoxia was well tolerated by ASCs and that levels of VEGF-A, FGF-2, and bNGF were elevated in CM from ASCs incubated in hypoxia compared to normoxia, while levels of HGF, IL-8, and CXCL1 were reduced. CM from ASCs incubated in hypoxia significantly improved human islet function and reduced apoptosis after culture, and reduced cytokine-induced apoptosis. In our mouse model, pancreas insulin content was higher in both groups receiving ASCs compared to control, but the mice receiving preconditioned ASCs had lower random and fasting blood glucose, as well as improved oral glucose tolerance compared to untreated mice. In conclusion, our in vitro results indicate that the islet protective potential of ASCs improves in hypoxia, and we give insight into factors involved in this. Finally we show that hypoxic preconditioning potentiates ASCs' antidiabetic effect in vivo.

scholarly journals Evaluation ofα-Glucosidase Inhibitory Effect of 50% Ethanolic Standardized Extract ofOrthosiphon stamineusBenth in Normal and Streptozotocin-Induced Diabetic Rats

2015 ◽  
Vol 2015 ◽  
pp. 1-6 ◽  
Author(s):  
Elsnoussi Ali Mohamed ◽  
Mariam Ahmad ◽  
Lee Fung Ang ◽  
Mohd. Zaini Asmawi ◽  
Mun Fei Yam
Keyword(s):  
Plasma Glucose ◽  
Inhibitory Activity ◽  
Ethanolic Extract ◽  
Inhibitory Effect ◽  
Diabetic Rats ◽  
Lower Plasma ◽  
Antidiabetic Effect ◽  
Glucose Levels ◽  
Lower Plasma Glucose

In the present study, a 50% ethanolic extract ofOrthosiphon stamineuswas tested for itsα-glucosidase inhibitory activity.In vivoassays of the extract (containing 1.02%, 3.76%, and 3.03% of 3′hydroxy-5,6,7,4′-tetramethoxyflavone, sinensetin, and eupatorin, resp.) showed that it possessed an inhibitory activity againstα-glucosidase in normal rats loaded with starch and sucrose. The results showed that 1000 mg/kg of the 50% ethanolic extract ofO. stamineussignificantly (P<0.05) decreased the plasma glucose levels of the experimental animals in a manner resembling the effect of acarbose. In streptozotocin-induced diabetic rats, only the group treated with 1000 mg/kg of the extract showed significantly (P<0.05) lower plasma glucose levels after starch loading. Hence,α-glucosidase inhibition might be one of the mechanisms by whichO. stamineusextract exerts its antidiabetic effect. Furthermore, our findings indicated that the 50% ethanolic extract ofO. stamineuscan be considered as a potential agent for the management of diabetes mellitus.

In vivo and in vitro antidiabetic effect of Cistus laurifolius L. and detection of major phenolic compounds by UPLC–TOF-MS analysis

2013 ◽  
Vol 146 (3) ◽  
pp. 859-865 ◽  
Author(s):  
Nilüfer Orhan ◽  
Mustafa Aslan ◽  
Murat Şüküroğlu ◽  
Didem Deliorman Orhan
Keyword(s):  
Phenolic Compounds ◽  
Antidiabetic Effect ◽  
Ms Analysis ◽  
Tof Ms
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