New polyketides from the endophytic fungus Pestalotiopsis sp. isolated from the Chinese mangrove plant Rhizophora mucronata

Planta Medica ◽  
2009 ◽  
Vol 75 (09) ◽  
Author(s):  
J Xu ◽  
J Kjer ◽  
J Sendker ◽  
V Wray ◽  
H Guan ◽  
...  
2009 ◽  
Vol 17 (20) ◽  
pp. 7362-7367 ◽  
Author(s):  
Jing Xu ◽  
Julia Kjer ◽  
Jandirk Sendker ◽  
Victor Wray ◽  
Huashi Guan ◽  
...  

2021 ◽  
Vol 7 (1) ◽  
Author(s):  
P. Resmi ◽  
G. Jitha ◽  
Vishnu Murali ◽  
Anu Gopinath

Abstract Background Medicinal importance of mangrove plant Rhizophora mucronata, a red mangrove species found in the Asian countries, has long been recognised in traditional systems of medicine. The identification of its phytoconstituents can be a starting point for the drug development. The aim of the work was to extend the current knowledge of phytoconstituents from R. mucronata and to explore its pharmacological importance in the treatment of diabetes mellitus. In the present study, we analysed the chloroform extract from the bark of the mangrove plant R. mucronata for nitrogen-containing constituents using UHPLC QTOF MS profiling, and α-amylase inhibition assay was carried out. Results Four nitrogen-containing compounds were identified from the chloroform extract of the bark of R. mucronata using UHPLC QTOF MS profiling. The compounds identified were N,N′-dicyclohexyl urea, a cryptolepine derivative (C17H15N3O), an aliphatic cyclic compound with hydroxyl and amino groups (C22H43NO), and C16H19NO2 (m/z 258.1495). The anti-amylase activity, an in vitro antidiabetic bioassay, of chloroform extract showed an IC50 value of 220.09 μg/ml. Conclusions This is the first report on the identification of nitrogen-containing compounds from the chloroform extract of the bark of the R. Mucronata. One of the compounds identified was a novel cryptolepine derivative (C16H13N3O), and it falls under the rare category indoloquinoline alkaloid. The chloroform extract also showed significant activity towards α-amylase inhibition assay. Thus, the study has gone some way towards our understanding of the efficacy of bark of the R. mucronata for the treatment of diabetes mellitus and is open for further research.


2013 ◽  
Vol 54 (25) ◽  
pp. 3256-3259 ◽  
Author(s):  
David Rönsberg ◽  
Abdessamad Debbab ◽  
Attila Mándi ◽  
Victor Wray ◽  
Haofu Dai ◽  
...  

2015 ◽  
Vol 10 (10) ◽  
pp. 1934578X1501001 ◽  
Author(s):  
Fang Lv ◽  
Georgios Daletos ◽  
Wenhan Lin ◽  
Peter Proksch

Two new cyclic depsipeptides, W493 C (1) and D (2), along with two known derivatives W493 A (3) and B (4) were obtained from the endophytic fungus Fusarium sp. isolated from the Mangrove plant Ceriops tagal. The structures of the new compounds were determined on the basis of one- and two dimensional NMR and high-resolution mass spectroscopic data. The absolute configurations of the amino acid residues of 1 and 2 were confirmed by application of Marfey's method. W493 A (3) and B (4) exhibited moderate activity against the fungus Cladosporium cladosporiodes and weak antitumor activity against the human ovarian cancer cell line A2780.


2016 ◽  
Vol 27 (6) ◽  
pp. 957-960 ◽  
Author(s):  
Min Zhang ◽  
Ji-Mei Liu ◽  
Jin-Lian Zhao ◽  
Ning Li ◽  
Ri-Dao Chen ◽  
...  

2020 ◽  
Vol 26 (8) ◽  
pp. 1609-1622
Author(s):  
Kodikara Arachchilage Sunanda Kodikara ◽  
Ranasinghe Pathmasiri ◽  
Aziz Irfan ◽  
Jayatissa Loku Pullukuttige ◽  
Sanduni Kanishka Madarasinghe ◽  
...  

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