Perfusion Imaging in the Soft Tissues in Patients with Diabetic Foot Syndrome (DFS) – Preliminary Results

Author(s):  
S Weber ◽  
B Röhrl ◽  
C Espinola-Klein ◽  
LM Schreiber ◽  
KF Kreitner
2021 ◽  
Vol 14 (3) ◽  
pp. 210-215
Author(s):  
Anton Petrovich Ostroushko ◽  
Alexander Alekseevich Andreev ◽  
Alexander Alexandrovich Shmarin ◽  
Vladislav Valeryevich Novomlinsky ◽  
Anastasia Yurievna Laptiyova ◽  
...  

Diabetes mellitus (DM) is the most common and socially significant endocrine disease that leads to early disability and is the most common cause of mortality in patients after cancer and cardiovascular pathology. The cost of managing patients with diabetes can reach 30% of the country's health budget, 90% of which is spent on the treatment of its complications. Diabetic foot syndrome (DFS) is developed in 20-80% of patients and is one of the most dangerous late complications. In clinical practice, various approaches to its treatment are used, but the number of high amputation and mortality rate in this group of patients remains significant. The aim of the study was to improve the results of treatment of patients with diabetic foot syndrome (DFS) by including the bubbling treatment method in the program of therapeutic measures. Forty-eight patients with neuropathic and neuroischemic forms of DFS were treated. The control group consisted of 23 patients receiving conventional treatment, the main group included 26 patients, who were applied bubbling treatment option locally. The analysis of groups of patients showed no significant differences by gender, age, stages of diabetic foot syndrome, depth of necrotic defect, complications and concomitant diseases. The use of the bubbling treatment method in the complex treatment of patients with DFS allowed more effectively arresting symptoms of local (edema, hyperemia, wound exudate, necrolysis) and general inflammation, anemia and intoxication syndromes, contributed to the activation of regeneration processes in soft tissues, which, combined with complex FDS treatment, together, reduced the number of amputations by 18.7%.


2019 ◽  
Vol 18 (3) ◽  
pp. 100-104
Author(s):  
V. P. Polyovyy ◽  
Khorshani Bilel ◽  
I. Yo. Sydorchuk ◽  
R. I. Sydorchuk ◽  
Yu. M. Mishkovsky ◽  
...  

2016 ◽  
Vol 175 (5) ◽  
pp. 63-68 ◽  
Author(s):  
M. A. Binienko ◽  
A. A. Kotslova ◽  
V. V. Davydenko ◽  
T. D. Vlasov

Diabetic foot syndrome (DFS) is one of the severe and more frequent complications of diabetes. It is characterized by occurrence of chronic purulent necrotic processes (trophic ulcers) on the foot with damage of skin, soft tissues and osteoarticular system due to pathological changes in the peripheral nervous system (diabetic neuropathy) and vascular system (diabetic angiopathy). This study aimed to evaluate the possibility of accelerating of wound healing in DFS by using the dermal equivalent (graftskin) and determine the safety of the method, factors and indications for its application. The research included 60 patients with DFS who were cured at the period from 2013 to 2016 in departments of purulent surgery of Hospital of war veterans and Municipal hospital № 14 of Saint-Petersburg. The patients were divided into 2 groups by random sampling of two comparable groups in age and sex. The patients of main group were treated by standard method and using application of dermal equivalent (DE) on the area of trophic ulcers. The patients of control group had only standard treatment. The DE showed a high efficacy in the main group of patients. The application of DE in complex treatment of patients with DFS stimulated processes of healing and accelerated the rate of epithelization. The application of DE was the most effective in patients with neuropathic form of DFS.


2017 ◽  
Vol 25 (2) ◽  
pp. 140-147
Author(s):  
S.G. Belov ◽  
◽  
O.V. Danilova ◽  
I.A. Taraban ◽  
D.I. Galata ◽  
...  

2018 ◽  
Vol 85 (6) ◽  
pp. 40-43
Author(s):  
S. M. Didenko

Objective. To improve the results of treatment of the ulcer-necrotic affections of the foot soft tissues in patients, suffering an ischemic form of diabetic foot syndrome (DFS). Маterials and methods. The investigated group have consisted of 48 patients, to whom necrectomy was performed, because a tendency for the wounds healing under the influence of standard methods of treatment through two weeks was absent. Results. After application of the tactics elaborated a complete healing of the wounds was registered in 89.6%, and a partial one - in 10.4% patients. Of 38 patients of a control group, to whom a standard treatment was conducted, the wounds have healed completely in 11 (28.9%), and partially - in 12 (31.6%) patients. Conclusion. Plastic coverage of the foot wounds after necrectomy and early performed revascularization operation for the ischemic form of DFS is indicated to patients, in whom the wounds are lacking a tendency towards healing under the influence of standard methods of treatment through two weeks.


2012 ◽  
Vol 93 (2) ◽  
pp. 298-301
Author(s):  
I V Klyushkin ◽  
R I Fatykhov

Presented was the comparative characteristic of modern methods of diagnosing tissue viability in the diabetic foot syndrome with the assessment of their advantages and disadvantages. An analysis of articles was conducted devoted to diagnostic methods that are used in diabetic foot syndrome. Doppler ultrasound investigation of lower extremity arteries makes it possible to determine the level of trophic disturbances, the degree of stenosis, the type of blood flow, however the informativeness of the method decreases during distal forms of lesions, mismatch of indicators of regional ischemia and hemodynamic severity with the clinical picture is possible. Duplex scanning makes it possible to evaluate the hemodynamics, the condition of the arterial wall, the presence of atherosclerotic plaques, gives an idea about the state of small vessels including collaterals, but does not always provide an opportunity to solve the problem of topical diagnosis. The method of radiopaque angiography and duplex scanning with contrast is not suitable for routine control of the vascular bed condition because of the invasiveness, toxicity of contrast agents and radiation exposure to the patient. In assessing the speed and volume of the out-flowing peripheral lymph and blood using rheolymphovasography the volume of the limbs and the development of subcutaneous fat, the ambient temperature, the psycho-emotional condition of the patient - all have a significant impact on the result. Impedance measurement can clearly identify the trophic disorders in the soft tissues, but can not be used to evaluate the bones. Thermal imaging study is characterized by its rapidness and objectivity, however, makes it impossible to determine the boundaries of trophic disorders. The state of the peripheral innervation can be assessed by electromyography, and chronaxiemetry electro-diagnosis. The first method is not widely used due to high equipment cost, complexity and lack of selectivity, the second one is still poorly understood. Laser Doppler flowmetry makes it possible to evaluate the level of macro- and microcirculation, even in preclinical stages, but it requires specially trained personnel. Biopsy of soft tissues with histological, histochemical, ultrastructural studies make is possible to assess the latent forms of diabetic foot syndrome; limitations are due to the invasiveness of the methods. In order to improve the quality of diagnosis of the diabetic foot syndrome is necessary to develop new methods of medical imaging, which should have the advantages superior to those of the traditional methods and have a minimum of contraindications.


Author(s):  
V. M. Bensman ◽  
A. G. Baryshev ◽  
S. N. Pyatakov ◽  
K. G. Triandafilov ◽  
V. N. Ponomarev ◽  
...  

Despite the success in treatment, currently 30.0% of patients with diabetic foot syndrome (DFS) still undergo high amputations with a mortality rate of up to 54.0–68.0 %. The causes of high low limb amputations in 28.0 % of patients are infection, and in 46.0 % – arterial insufficiency in the stage of critical limb ischemia.Objective: to improve the results of patients treatment by reducing the number of high amputations of the lower extremities, reducing the occurrence of complications and deaths of the disease.Materials and methods. To study the results of treatment of patients with DFS, they were divided into two comparison groups and two main groups. From 1982 to 2019, the frequency of amputations, mainly at the hip level, was 71.0 % (177 amputations in 248 patients). These patients formed the first comparison group of observations. The second comparison group (1988–1994) included 58.3 % of patients in whom amputations were performed according to more stringent indications (157 amputations in 269 patients). The first main group of observations (1995–2013) included 9.9 % of patients with DFS who were amputated only for wet gangrene, incurable critical limb ischemia, and infection with a systemic inflammatory response (130 amputations out of 1312 patients). In ischemia with preserved blood flow through the deep artery of the thigh, amputation of the lower leg was performed in a sequential-two-flap method with removal of the soleus muscle. Amputations were completed with the imposition of drainage removable muscle-fascial sutures. The second main group (2014) consisted of 11.4 % of patients who underwent amputations only for sepsis or wet gangrene (124 amputations in 1083 patients). The difference between the second main group and the first was the division of the high amputation intervention into 2 stages.Results. Comparison of the treatment results in the main groups and in the comparison groups revealed a 6-fold decrease in the number of high amputations (from 64.6 to 10.69 %) and a significant improvement in the main quality indicators. This concerns a 6-fold decrease in mortality, which was a consequence of the introduction of a two-stage tactic for high amputation treatment of the most severe patients and the limitation of indications for amputation of the hip. Using of removable drainage muscle-fascial sutures decreased postoperative wound complications from 51.9 to 13.0 %, and the number of re-amputations decreased in 17th times.Conclusion. Amputation of the lower extremities for irreversible critical limb ischemia can be performed with a decrease in TcP02 of the stitched stump tissues to no more than 30 mm Hg. Preserving the knee joint improves the possibilities of prosthetics, which allows older diabetics to lead an active life. Methods of performing parallel- or sequential-two-flap high amputation improve the conditions for cutting out racquet-shaped wound flaps, which provides free displacement of the soft tissues of the stump connected by removable drainage sutures.


2014 ◽  
Vol 17 (3) ◽  
pp. 113-121
Author(s):  
Ekaterina Leonidovna Zaytseva ◽  
Ludmila Petrovna Doronina ◽  
Roman Vakhtangovich Molchkov ◽  
Iya Alexandrovna Voronkova ◽  
Valeriy Afanasievich Mitish ◽  
...  

Aim. To evaluate the efficiency of topical negative pressure wound therapy (NPWT) compared with standard therapy for the regeneration of the soft tissues of the lower extremities in patients with diabetic foot syndrome. Materials and Methods. The effects of negative pressure therapy on the clinical (size, tissue oxygenation), histological (light microscopy) and immunohistochemical (CD68, MMP-9, TIMP-1) aspects of repair of the soft tissue of the lower extremities in patients with diabetes mellitus were compared with those of standard treatment. Thirty-one patients with diabetic foot ulcers were included in the study from the moment of debridement until the plastic closure of the wound. During the perioperative period, 13 patients received NPWT (-90 to -120 mmHg) and 18 patients received standard therapy. Results. A reduction of the wound area (26.6%?17.2%) and the depth of the defects (40.5%?25.6%) were achieved with negative pressure therapy compared with baseline data. In the control group, the corresponding values were 25.3%?19.4% and 21.8%?21.6%, respectively. The results of transcutaneous oximetry showed a greater increase in the level of local hemodynamics in the study group (p


Planta Medica ◽  
2013 ◽  
Vol 79 (13) ◽  
Author(s):  
TS Kustova ◽  
LK Mamonov ◽  
CL Cantrell ◽  
SA Ross

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