scholarly journals Inhibitory effects of Spirulina in zymosan-induced arthritis in mice

2002 ◽  
Vol 11 (2) ◽  
pp. 75-79 ◽  
Author(s):  
Diadelis Remirez ◽  
Ricardo González ◽  
Nelson Merino ◽  
Sandra Rodriguez ◽  
Odelsa Ancheta
Keyword(s):  
Endoplasmic Reticulum ◽  
Synovial Fluid ◽  
Knee Joint ◽  
Experimental Model ◽  
Inflammatory Reaction ◽  
Inhibitory Effects ◽  
Ultrastructural Studies ◽  
Anti Inflammatory ◽  
Histopathological Studies ◽  
Inflammatory Effect

The anti-inflammatory effect of microalgae Spirulina was studied in zymosan-induced arthritis in mice. Four days after the intra-articular injection of zymosan (15 mg/ml), Spirulina (100 and 400 mg/kg per-orally) was administered to animals for 8 days. The mice were than killed and β-glucuronidase was measured in the synovial fluid. Each knee joint was totally removed for histopathological studies. Spirulina significantly reduced the levels of β-glucuronidase that had been increased by zymosan. Histopathological and ultrastructural studies showed inhibition of the inflammatory reaction, whereas no destruction of cartilage, well-preserved chondrocytes, and normal rough endoplasmic reticulum and mitochondria were seen. The anti-arthritic effect exerted by Spirulina as shown in this model may be at least partly due to the previously reported anti-inflammatory and antioxidative properties of its constituent, phycocyanin. To our knowledge, this is the first report on the anti-inflammatory effect of Spirulina in an experimental model of arthritis.

Anti-inflammatory effect of Uncaria tomentosa in an experimental model of cyclophosphamide-induced hemorrhagic cystitis

Planta Medica ◽  
2012 ◽  
Vol 78 (11) ◽  
Author(s):  
IST Figueiredo ◽  
FT Benevides ◽  
NMS Queiroz ◽  
LM Marques ◽  
TFG Souza ◽  
...  
Keyword(s):  
Experimental Model ◽  
Hemorrhagic Cystitis ◽  
Uncaria Tomentosa ◽  
Anti Inflammatory ◽  
Inflammatory Effect

scholarly journals Therapeutic Effects of Sodium Hyaluronate and Diclofenac Sodium in Chronic Arthritis

2019 ◽  
Vol 7 (4) ◽  
pp. 17-33
Author(s):  
Alsadek H Bogzil ◽  
Gamal Shams ◽  
Sohair Abd El-Latif
Keyword(s):  
Experimental Model ◽  
Diclofenac Sodium ◽  
Sodium Hyaluronate ◽  
Chronic Arthritis ◽  
Albino Rats ◽  
Therapeutic Effects ◽  
Monosodium Iodoacetate ◽  
Anti Inflammatory ◽  
Inflammatory Effect

The present study was designed to compare the anti-inflammatory effect of sodium hyaluronate, which is similar to the lubricant fluid that found naturally in the capsule of the healthy joint with diclofenac sodium, a member of NSAIDs commonly used in treatment of Osteoarthritis (OA), separately and in combination on an experimental model of osteoarthritis in rats induced by monosodium-iodoacetate (MIA). Twenty-five male albino rats weighing at the beginning of the experiment 160± 20 gm were used in this study. Rats were housed in cages at 25± 0.5°C. The rats were divided into 5 main groups.  

scholarly journals Experimental assessment of inflammatory effect of hypoxen

2015 ◽  
Vol 13 (3) ◽  
pp. 35-38
Author(s):  
Ludmila Konstantinovna Khnychenko ◽  
Irina Viktorovna Okunevich
Keyword(s):  
Experimental Model ◽  
Inflammatory Reaction ◽  
Cotton Wool ◽  
Experimental Assessment ◽  
Chronic Model ◽  
Inflammatory Effect ◽  
Inflammatory Tissue

The experimental model of acute carrageenan-induced inflammation and chronic model of the “cotton wool`s granuloma” in mice and rats were used in the experinent. The changes in the volume of damaged limb with oedema and granuloma mass in groups of animals were registered. The effect of hypoxen (polydihydroxyphenylenthiosulfonate sodium) and comparative drugs simvastatin and ibuprophen on the inflammatory reaction was studied. Ibuprophen and simvastatin were shown to reduce the development of inflammatory reaction. The administration of hypoxen in dose of 50 mg/kg has got the significant efficiency in lowering of oedema degree and significant decreasing of inflammatory tissue assessed by granuloma mass.

scholarly journals The Effects of Moxibustion on PD-1/PD-L1-Related Molecular Expression and Inflammatory Cytokine Levels in RA Rats

2021 ◽  
Vol 2021 ◽  
pp. 1-10
Author(s):  
Yumei Zhong ◽  
Deli Lai ◽  
Linlin Zhang ◽  
Wenting Lu ◽  
Yanan Shang ◽  
...  
Keyword(s):  
Cell Death ◽  
Programmed Cell Death ◽  
Inflammatory Reaction ◽  
Moxibustion Therapy ◽  
Adenovirus Vector ◽  
Complementary Therapy ◽  
Cytokine Levels ◽  
Chronic Inflammatory Reaction ◽  
Anti Inflammatory ◽  
Inflammatory Effect

Objective. Rheumatoid arthritis (RA) is an autoimmune disease that starts with inflammation of the synovium. The pain and joint dysfunction caused by RA urgently need an effective treatment to alleviate the inflammatory reaction and delay the progression of the disease. The pathological damage of RA is proposed to associate with the dysfunction of the programmed cell death 1/programmed cell death ligand 1 (PD-1/PD-L1) pathway. Moxibustion, as a main complementary therapy of traditional Chinese medicine (TCM), has been proved effective to reduce chronic inflammatory reaction on RA, but whether the anti-inflammatory effects are mediated by PD-1/PD-L1 pathway is still unclear. Therefore, moxibustion was conducted in the rats with RA to investigate its effect on PD-1/PD-L1. Methods. The rats' right hind paws were injected with Freundʼs complete adjuvant (FCA) to establish the model of RA. Seven days after the injection of FCA, moxibustion therapy was performed on the acupoints of Shenshu (BL23) and Zusanli (ST36) once a day for three weeks. Then, ELISA and immunohistochemical methods were used to analyze the influence of moxibustion on the expression of PD-1/PD-L1. If the moxibustion had an effect on the expression of PD-1/PD-L1-related molecules, we would knock down PD-1 with adenovirus vector. After moxibustion therapy, ELISA and histological analysis were performed to observe the anti-inflammatory effect of moxibustion. Results. The results demonstrated that moxibustion had an effect on the expression of PD-1-related molecules. The results of ELISA manifested that moxibustion decreased the level of IFN-γ and increased the level of IL-4 and IL-10. HE staining revealed that moxibustion alleviated the proliferation of synovial tissue. However, the anti-inflammatory effect and pathological improvement were weakened when PD-1 was blocked. Conclusions. The results indicate that moxibustion affected the expression of PD-1/PD-L1-related molecules and can effectively treat RA damage. The anti-inflammatory effect of moxibustion was weakened when PD-1 was knocked down.

scholarly journals PPARαmediates the anti-inflammatory effect of simvastatin in an experimental model of zymosan-induced multiple organ failure

2011 ◽  
Vol 163 (3) ◽  
pp. 609-623 ◽  
Author(s):  
Barbara Rinaldi ◽  
Maria Donniacuo ◽  
Emanuela Esposito ◽  
Annalisa Capuano ◽  
Loredana Sodano ◽  
...  
Keyword(s):  
Multiple Organ Failure ◽  
Organ Failure ◽  
Experimental Model ◽  
Multiple Organ ◽  
Anti Inflammatory ◽  
Inflammatory Effect
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