Anti-inflammatory effect of enzymatic hydrolysate of corn gluten in an experimental model of colitis

The present study was designed to compare the anti-inflammatory effect of sodium hyaluronate, which is similar to the lubricant fluid that found naturally in the capsule of the healthy joint with diclofenac sodium, a member of NSAIDs commonly used in treatment of Osteoarthritis (OA), separately and in combination on an experimental model of osteoarthritis in rats induced by monosodium-iodoacetate (MIA). Twenty-five male albino rats weighing at the beginning of the experiment 160± 20 gm were used in this study. Rats were housed in cages at 25± 0.5°C. The rats were divided into 5 main groups.

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Inhibitory effects of Spirulina in zymosan-induced arthritis in mice

Mediators of Inflammation ◽

10.1080/09629350220131917 ◽

2002 ◽

Vol 11 (2) ◽

pp. 75-79 ◽

Cited By ~ 41

Author(s):

Diadelis Remirez ◽

Ricardo González ◽

Nelson Merino ◽

Sandra Rodriguez ◽

Odelsa Ancheta

Keyword(s):

Endoplasmic Reticulum ◽

Synovial Fluid ◽

Knee Joint ◽

Experimental Model ◽

Inflammatory Reaction ◽

Inhibitory Effects ◽

Ultrastructural Studies ◽

Anti Inflammatory ◽

Histopathological Studies ◽

Inflammatory Effect

The anti-inflammatory effect of microalgae Spirulina was studied in zymosan-induced arthritis in mice. Four days after the intra-articular injection of zymosan (15 mg/ml), Spirulina (100 and 400 mg/kg per-orally) was administered to animals for 8 days. The mice were than killed and β-glucuronidase was measured in the synovial fluid. Each knee joint was totally removed for histopathological studies. Spirulina significantly reduced the levels of β-glucuronidase that had been increased by zymosan. Histopathological and ultrastructural studies showed inhibition of the inflammatory reaction, whereas no destruction of cartilage, well-preserved chondrocytes, and normal rough endoplasmic reticulum and mitochondria were seen. The anti-arthritic effect exerted by Spirulina as shown in this model may be at least partly due to the previously reported anti-inflammatory and antioxidative properties of its constituent, phycocyanin. To our knowledge, this is the first report on the anti-inflammatory effect of Spirulina in an experimental model of arthritis.

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Anti-inflammatory effect of a PAF receptor antagonist and a new molecule with antiproteinase activity in an experimental model of acute urate crystal arthritis

Journal of Lipid Mediators and Cell Signalling ◽

10.1016/0929-7855(95)00043-7 ◽

1996 ◽

Vol 13 (1) ◽

pp. 35-49 ◽

Cited By ~ 13

Author(s):

Roberto Miguélez ◽

Itziar Palacios ◽

Francisco Navarro ◽

Sylvia Gutierrez ◽

Olga Sanchez-Pernaute ◽

...

Keyword(s):

Receptor Antagonist ◽

Experimental Model ◽

Crystal Arthritis ◽

Urate Crystal ◽

Paf Receptor ◽

Anti Inflammatory ◽

Inflammatory Effect ◽

Paf Receptor Antagonist

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Correction: The anti-inflammatory effect of a glycosylation product derived from the high hydrostatic pressure enzymatic hydrolysate of a flatfish byproduct

Food & Function ◽

10.1039/c6fo90026g ◽

2016 ◽

Vol 7 (8) ◽

pp. 3637-3637

Author(s):

In-Hu Choe ◽

Hyeon Jin Jeon ◽

Sung-Hwan Eom ◽

Young-Ki Han ◽

Yoon Sook Kim ◽

...

Keyword(s):

Hydrostatic Pressure ◽

High Hydrostatic Pressure ◽

Enzymatic Hydrolysate ◽

Anti Inflammatory ◽

Inflammatory Effect

Correction for ‘The anti-inflammatory effect of a glycosylation product derived from the high hydrostatic pressure enzymatic hydrolysate of a flatfish byproduct’ by In-Hu Choe, et al., Food Funct., 2016, 7, 2557–2565.

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