Epicardial or intramyocardial bioartificial tissue transplantation: Does the surgical implantation technique influence cell survival?

2013 ◽  
Vol 61 (S 01) ◽  
Author(s):  
H Baraki ◽  
G Kensah ◽  
S Asch ◽  
SV Rojas ◽  
A Martens ◽  
...  
Author(s):  
Humberto Dória Silva ◽  
Rostan Silvestre da Silva ◽  
Eduardo Dória Silva ◽  
Maria Tamires Dória Silva ◽  
Cristiana Pereira Dória ◽  
...  

Neurophysiological anatomy of natural binocular vision shows the need to focus with both eyes to jointly produce the two corneas accommodation, correcting, in a compensatory way, the divergences inherent in the two different images, of the same visual field projected in the two distinct spaces, the two retinas. Corneal accommodation is part of the forced convection mechanism for the transfer of mobile mass in the cornea, trabecular meshwork and retina, to inhibit the accumulation of dehydrated intraocular metabolic residue, which can cause refractive errors in the cornea, obstruction of the trabecular meshwork and reduction of the amplitude of the signals produced by the phototransducers and sent to the brain. The IOL monovision surgical implantation technique differs from the physiology of natural binocular vision, which can cause after surgery disorders, described in this chapter, in that it imposes a different adaptation from the neurophysiological anatomy of human vision in addition to favoring the continuous progression of residue accumulation dehydrated intraocular metabolic and stimulate ocular.


2016 ◽  
Vol 45 (1) ◽  
pp. 71-78 ◽  
Author(s):  
Valentine Martlé ◽  
Luc M. L. Van Ham ◽  
Paul Boon ◽  
Jacques Caemaert ◽  
Mulenda Tshamala ◽  
...  

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Maria Xeroudaki ◽  
Muthukumar Thangavelu ◽  
Anton Lennikov ◽  
Anjula Ratnayake ◽  
Jovana Bisevac ◽  
...  

Abstract Biomaterials designed to replace the diseased cornea could be used to treat corneal blindness where human donor tissue is in short supply, but challenges are the integration of biomaterials with host tissue and cells, avoiding a rapid material degradation and maintaining corneal transparency. Additionally, implantation surgery often triggers an aggressive wound healing response that can lead to corneal thinning and opacity. Here, we report a collagen-based hydrogel with transparency and mechanical properties suitable for replacing a substantial portion of a damaged or diseased corneal stroma. The porous hydrogel permitted migration and population by host cells while maintaining transparency and thickness six months after surgical implantation in an in vivo model of human corneal surgery. With a novel hybrid surgical implantation technique inspired by LASIK refractive surgery, rapid wound healing occurred around implants to maintain biomaterial integrity, transparency and function. Host stromal cell repopulation and regeneration of host epithelium and nerves were observed, as necessary steps towards corneal regeneration. Finally, as a proof-of-principle, the hydrogel loaded with a neuroregenerative drug achieved sustained slow-release drug delivery in vitro. The proposed hydrogel and novel implantation technique together represent a therapeutic approach with translational potential for replacing and regenerating diseased corneal stromal tissue.


Author(s):  
D.E. Philpott ◽  
W. Sapp ◽  
C. Williams ◽  
J. Stevenson ◽  
S. Black ◽  
...  

Spermatogonial stem-cell survival after irradiation injury has been studied in rodents by histological counts of surviving cells. Many studies, including previous work from our laboratory, show that the spermatogonial population demonstrates a heterogeneous response to irradiation. The spermatogonia increase in radio-sensitivity as differentiation proceeds through the sequence As - Apr - A1 - A2 - A3 - A4 - In - B. The stem (As) cell is the most resistant and the B cell is the most sensitive. The purpose of this work is to investigate the response of spermatogonial cell to low doses (less than 10 0 rads) of helium particle irradiation.


2007 ◽  
Vol 177 (4S) ◽  
pp. 62-63
Author(s):  
Oleg Sukonko ◽  
Sergey Krasny ◽  
Sergey Polaykov ◽  
Alexandr Rolevich ◽  
Carsten H. Ohlmann ◽  
...  

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