scholarly journals Subcutaneous Panniculitis-Like T-Cell Lymphoma Presenting as a Local Inflammation of a Thigh in an 8-Month-Old Child

2017 ◽  
Vol 05 (01) ◽  
pp. e68-e70 ◽  
Author(s):  
Kaja Gizewska-Kacprzak ◽  
Katarzyna Karpinska-Kaczmarczyk ◽  
Tomasz Ociepa
Keyword(s):  
T Cell ◽  
Cell Lymphoma ◽  
Histopathological Examination ◽  
Skin Inflammation ◽  
T Cell Lymphoma ◽  
Pediatric Care ◽  
Cytotoxic T Cell ◽  
Local Inflammation ◽  
Surgical Biopsy ◽  
History Of

AbstractDuring infancy, skin inflammation is usually treated in basic pediatric care. In this study, we present a case of an 8-month-old girl with a 2-month history of an inflammation of the thigh treated locally by ointments and oral antibiotics in basic and dermatological care. The patient had a history of fever, sweating, and failure to thrive. The lactate dehydrogenase was elevated up to 869 U/L with low C-reactive protein (1.04 mg/L). Magnetic resonance imaging of the thigh reassured the diagnosis of local inflammation. Intravenous antibiotic caused mild local improvement, but the episodes of high fever sustained. The patient was transferred to our pediatric surgery department for treatment and surgical biopsy of the lesion. Histopathological examination confirmed a subcutaneous panniculitis-like T-cell lymphoma, which is a rare cytotoxic T-cell lymphoma representing less than 1% of non-Hodgkin lymphomas, uncommon in children. The patient was introduced to a chemotherapy protocol EURO-LB 2002 with good response. In a skin lesion that is associated with systemic symptoms and responding untypically to antibiotic treatment malignancy should be considered and biopsy not be postponed.

scholarly journals A case of canine renal lymphoma of granular lymphocytes with severe polycythemia

2021 ◽  
Vol 17 (1) ◽  
Author(s):  
Sara Kotb ◽  
Carolina Allende ◽  
T. William O’Neill ◽  
Krista Bruckner ◽  
Helio DeMorais ◽  
...  
Keyword(s):  
T Cell ◽  
Cell Lymphoma ◽  
Left Kidney ◽  
Abdominal Ultrasound ◽  
The Body ◽  
T Cell Lymphoma ◽  
Cytotoxic T Cell ◽  
Renal Lymphoma ◽  
History Of ◽  
Granular Lymphocytes

Abstract Background Renal lymphoma in dogs is rare and has a poor prognosis. Granular lymphocyte morphology is rarely reported in canine renal lymphoma. Mild to moderate polycythemia is reported in a number of canine renal lymphoma cases. Case presentation A 10-year-old Labrador retriever presented to a university veterinary teaching hospital after a 1-month history of polyuria, polydipsia, and pollakiuria and a 2-week history of abdominal distention, lethargy, and increased respiratory effort. Abdominal ultrasound showed a wedge-shaped to rounded, heterogeneously hypoechoic mass lesion in the left kidney. Cytologic analysis of a percutaneous aspirate of the mass was consistent with lymphoma of granular lymphocytes. Severe polycythemia (hematocrit 0.871) was noted on a complete blood cell count. Clonality analysis identified a clonally rearranged T-cell receptor (TCR) gene and immunohistochemical staining was CD3+, CD79a- and CD11d+, supporting cytotoxic T-cell lymphoma. Conclusions To our knowledge, this is the first report of renal cytotoxic T-cell lymphoma with severe polycythemia in a dog. Severe polycythemia and renal cytotoxic T-cell lymphoma are both rare in dogs; this report adds to the body of knowledge on these conditions.

scholarly journals Hemophagocytic Lymphohistiocytosis as the Initial Presentation of Subcutaneous Panniculitis-Like T-Cell Lymphoma: A Rare Case Responding to Cyclosporine A and Steroids

2020 ◽  
Vol 8 ◽  
pp. 232470962098153
Author(s):  
Caitlin Sullivan ◽  
Arya Loghmani ◽  
Katharine Thomas ◽  
Rachna Jetly-Shridhar ◽  
Rajasree Pia Chowdry
Keyword(s):  
T Cell ◽  
Cyclosporine A ◽  
Hemophagocytic Lymphohistiocytosis ◽  
Cell Lymphoma ◽  
Skin Lesions ◽  
T Cell Lymphoma ◽  
Cytotoxic T Cell ◽  
Life Threatening ◽  
History Of ◽  
Rare Malignancy

Subcutaneous panniculitis-like T-cell lymphoma (SPTCL) is a rare peripheral cytotoxic T-cell lymphoma, clinically resembling panniculitis. Hemophagocytic lymphohistiocytosis (HLH) is a life-threatening syndrome of immune overactivation, triggered by underlying conditions. SPTCL presenting with HLH may represent a severe and rapidly progressive disease course. Currently, there is no standardized approach to treatment of HLH secondary to underlying SPTCL. A 34-year-old Asian male presented with a several months history of high fevers, weight loss, and nonpruritic purple discoloration of the skin. He had a skin biopsy showing atypical lymphohistiocytic panniculitis with dermal mucinosis and erythrophagocytosis consistent with SPTCL. The patient was initiated on treatment with dexamethasone and cyclosporine A. Almost immediate improvement of his skin lesions was noted and laboratory abnormalities trended toward baseline within 2 weeks. He noted complete symptom resolution after 3 months on therapy. SPTCL may be treated effectively with cyclosporine A and steroids to achieve rapid clinical and symptom management of this rare malignancy.

Primary central nervous system gamma delta cytotoxic T-cell lymphoma

2016 ◽  
Vol 26 ◽  
pp. 138-140 ◽  
Author(s):  
Kelly L. Mooney ◽  
Winward Choy ◽  
Joslyn Woodard ◽  
Rena R. Xian ◽  
Taylor M. Deal ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
T Cell ◽  
Cell Lymphoma ◽  
T Cell Lymphoma ◽  
Cytotoxic T Cell ◽  
Gamma Delta ◽  
System Gamma

scholarly journals Enteropathy associated T-cell lymphoma

2007 ◽  
Vol 135 (1-2) ◽  
pp. 80-84
Author(s):  
Milena Bakrac ◽  
Branka Bonaci-Nikolic ◽  
Natasa Colovic ◽  
Sanja Simic-Ogrizovic ◽  
Miodrag Krstic ◽  
...  
Keyword(s):  
T Cell ◽  
Cell Lymphoma ◽  
Previous History ◽  
Lymph Node Biopsy ◽  
Intestinal Wall ◽  
T Cell Lymphoma ◽  
The Third ◽  
History Of ◽  
Small Intestinal ◽  
Mesenterial Lymph Node

Enteropathy associated T-cell lymphoma (EATCL) is a high grade, pleomorphic peripheral T-cell lymphoma with usually cytotoxic phenotype. This is a case report of three patients with EATCL. The first patient was 50 year-old woman with four year history of gluten sensitive enteropathy (GSE). Diagnosis of lymphoma was confirmed after the resection of the jejunum (small intestine obstruction). Pathohistological (PAS, Reticulin, Giemsa) and immunohistochemical (anti-LCA, anti-CD20, anti- CD45RO, anti-CD3) methods revealed the diagnosis of EATCL: CD45RO+, CD3+. After the third cycle of chemotherapy, the disease progressed with massive lung infiltration. Patient died due to complications of bone marrow aplasia. The second patient was 23 year-old woman with long earlier history of GSE. She presented with the acute renal failure. According to established diagnosis of tubulointerstitial nephritis, she was treated with pulse doses of steroid therapy. After temporary improvement, she had dissemination of the disease. On MRI, small intestinal wall was thickened, and abdominal lymph nodes were enlarged with extraluminal compression of common bile duct. Laparotomy with mesenterial lymph node biopsy and consecutive pathohistological and immunohistochemical analyses revealed the diagnosis of EATCL. The patient received chemotherapy, but she died with signs of pulmonary embolization. The third patient was 53 year-old woman without previous history of GSE. Diagnosis of EATCL was revealed after the resection of jejunum because of small intestinal obstruction. She received two cycles of chemotherapy, but she died with signs of disease progression. IgA antiendomysial antibodies were detected in the serum of all patients. The overall survival of patients was 7 months. The possibility of lymphoma rising in patients with clinical progression of GSE despite gluten free diet must be kept in mind.

scholarly journals T-cell Lymphoma in the Nasal Cavity in Goat

2021 ◽  
Vol 49 ◽  
Author(s):  
Millena Oliveira Firmino ◽  
Ismael Lira Borges ◽  
Gian Libânio Da Silveira ◽  
Mikael Leandro Duarte De Lima Tolentino ◽  
Erika de Lourdes Gomes Queiroz ◽  
...  
Keyword(s):  
T Cell ◽  
Nasal Cavity ◽  
Cell Lymphoma ◽  
Histopathological Examination ◽  
Clinical Signs ◽  
T Cell Lymphoma ◽  
Differential Diagnoses ◽  
Farm Animals ◽  
Ocular Involvement ◽  
The Right

Background: Lymphomas are considered uncommon in goats, being the multicentric form with the highest number of cases for the species. Primary intranasal lymphomas are often diagnosed in dogs, cats, and humans. In the literature, there is only a description of a multicentric case involving the frontal sinuses and mucosa of the nasal cavity in a goat; therefore, it is important to describe unusual cases of this disease for the inclusion of new clinical and pathological characteristics in the ruminant clinic medicine. The objective of this work is to describe a case of T-cell lymphoma in the nasal cavity of a young goat.Case: The animal had dyspnea and respiratory noise for 15 days. Clinical examination showed nodulation in the right nasal cavity associated with serosanguinous secretion. Tracheostomy was performed; however, after 30 days the animal was euthanized. A sagittal plane of the head showed a pinkish-gray mass in the right and left nasal cavity, with a smooth, multilobulated surface, smooth adhering to the rostral portion of the dorsal concha and occluding the dorsal nasal meatus. Submandibular lymph nodes were slightly enlarged. Histopathological examination of the nasal cavity revealed a non-encapsulated, poorly delimited and ulcerated tumor composed of round cells arranged in a mantle supported by a discrete fibrovascular stroma extending the mucosa and lamina propria. Cells were round with sparse, eosinophilic and poorly delimited cytoplasm. Nuclei varied from round to elongated with condensed chromatin and evident nucleoli. Occasionally, aberrant nuclei, reniform shape and multinucleated cells were seen. Pleomorphism was moderate characterized by anisocytosis and anisocariosis. Typical and atypical mitosis were frequent (0-4 per field of highest magnification [400x]). Amidst the neoplasm, there were multifocal areas of necrosis and hemorrhage associated with a mild lymphocytic inflammatory infiltrate. Immunohistochemistry showed positive immunostaining for Vimentin antibodies and CD3, and negative for pan CK and CD20.Discussion: The lymphomas immunophenotyping is little used when it comes to farm animals, and there are few studies that use this technique for the definitive diagnosis of these neoplasms for small ruminants. The use of this technique must be considered in each case, in order to determine the pathogenesis, the accurate diagnosis and the origin of the neoplastic lymphocytes. In goats, T-cell lymphomas are the most diagnosed, although cases of multicentric B-cell lymphomas with ocular involvement have been diagnosed. In view of the clinical picture of the case described, infectious rhinitis already described in goats, such as aspergillosis and protothecosis, should be included as differential diagnoses. However, the anatomopathological findings facilitate the direction of the diagnosis, since infectious rhinitis presents as nodules / ulcerated masses or focal areas of necrosis associated with purulent secretion and in the histopathological examination it is possible to observe the intralesional etiological agents. In addition, the enzootic ethmoidal tumor must be included, as it has similar clinical signs and affects young animals, but they are adenomas/adenocarcinomas that affect the ethmoidal nasal shells induced by a retrovirus. Lymphomas in the caprine species are rare in the Northeastern semi-arid, but that in the present diagnostic routine occasionally occurs, being important the first description of its nasal shape for its inclusion in the differential diagnoses of diseases that present with clinical obstruction and dyspnea for the species. Keywords: hematopoietic neoplasia, immunophenotyping, lymphocytes, dyspnea.Descritores: neoplasia hematopoietica, imunofenotipagem, linfócitos, dispneia.Título: Linfoma de células T na cavidade nasal de caprino. 

Subcutaneous panniculitis-like T cell lymphoma arising in association with chronic lymphocytic leukaemia

2021 ◽  
Vol 14 (9) ◽  
pp. e243490
Author(s):  
Lakshmi Shree Kulumani Mahadevan ◽  
Metin Ozdemirli
Keyword(s):  
Risk Factors ◽  
T Cell ◽  
Cell Lymphoma ◽  
Case Reports ◽  
Lymphocytic Leukemia ◽  
T Cell Lymphoma ◽  
Cytotoxic T Cell ◽  
Lupus Panniculitis ◽  
Autoimmune Conditions ◽  
Subcutaneous Adipose

Subcutaneous panniculitis-like T cell lymphoma (SPTCL) is a rare cutaneous T cell malignancy of cytotoxic T cell origin. It is frequently associated with autoimmune diseases. It is known to preferentially involve subcutaneous adipose tissue and histologically resembles lupus panniculitis. The aetiology and risk factors of SPTCL are unclear and there are limited studies available since this entity was initially described in 2001. There are even fewer case reports describing the association between SPTCL and chronic lymphocytic leukemia (CLL). In this article, we present a case of SPTCL arising during treatment for CLL. We conducted an extensive review of literature to delve into the possible risk factors for SPTCL development in association with CLL, including pre-existing haematological malignancies, autoimmune conditions, immunomodulation and immunosuppressive chemotherapy.

Primary cutaneous CD8 + cytotoxic T‐cell lymphoma of the face with intraoral involvement, presenting facial nerve palsy after chemotherapy

2022 ◽  
Author(s):  
Daphine Caxias Travassos ◽  
Heitor Albergoni Silveira ◽  
Evânio Vilela Silva ◽  
Beatriz Zamboni Martins Panucci ◽  
Nilson Coelho da Silva Filho ◽  
...  
Keyword(s):  
T Cell ◽  
Facial Nerve ◽  
Nerve Palsy ◽  
Facial Nerve Palsy ◽  
Cell Lymphoma ◽  
T Cell Lymphoma ◽  
Cytotoxic T Cell ◽  
The Face

Aggressive CD8+ epidermotropic cytotoxic T-cell lymphoma

2001 ◽  
pp. 46-47
Author(s):  
D. Massi ◽  
N. Pimpinelli ◽  
M. Santucci
Keyword(s):  
T Cell ◽  
Cell Lymphoma ◽  
T Cell Lymphoma ◽  
Cytotoxic T Cell
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