A case of canine renal lymphoma of granular lymphocytes with severe polycythemia

Abstract Background Renal lymphoma in dogs is rare and has a poor prognosis. Granular lymphocyte morphology is rarely reported in canine renal lymphoma. Mild to moderate polycythemia is reported in a number of canine renal lymphoma cases. Case presentation A 10-year-old Labrador retriever presented to a university veterinary teaching hospital after a 1-month history of polyuria, polydipsia, and pollakiuria and a 2-week history of abdominal distention, lethargy, and increased respiratory effort. Abdominal ultrasound showed a wedge-shaped to rounded, heterogeneously hypoechoic mass lesion in the left kidney. Cytologic analysis of a percutaneous aspirate of the mass was consistent with lymphoma of granular lymphocytes. Severe polycythemia (hematocrit 0.871) was noted on a complete blood cell count. Clonality analysis identified a clonally rearranged T-cell receptor (TCR) gene and immunohistochemical staining was CD3+, CD79a- and CD11d+, supporting cytotoxic T-cell lymphoma. Conclusions To our knowledge, this is the first report of renal cytotoxic T-cell lymphoma with severe polycythemia in a dog. Severe polycythemia and renal cytotoxic T-cell lymphoma are both rare in dogs; this report adds to the body of knowledge on these conditions.

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Subcutaneous Panniculitis-Like T-Cell Lymphoma Presenting as a Local Inflammation of a Thigh in an 8-Month-Old Child

European Journal of Pediatric Surgery Reports ◽

10.1055/s-0037-1607036 ◽

2017 ◽

Vol 05 (01) ◽

pp. e68-e70 ◽

Cited By ~ 1

Author(s):

Kaja Gizewska-Kacprzak ◽

Katarzyna Karpinska-Kaczmarczyk ◽

Tomasz Ociepa

Keyword(s):

T Cell ◽

Cell Lymphoma ◽

Histopathological Examination ◽

Skin Inflammation ◽

T Cell Lymphoma ◽

Pediatric Care ◽

Cytotoxic T Cell ◽

Local Inflammation ◽

Surgical Biopsy ◽

History Of

AbstractDuring infancy, skin inflammation is usually treated in basic pediatric care. In this study, we present a case of an 8-month-old girl with a 2-month history of an inflammation of the thigh treated locally by ointments and oral antibiotics in basic and dermatological care. The patient had a history of fever, sweating, and failure to thrive. The lactate dehydrogenase was elevated up to 869 U/L with low C-reactive protein (1.04 mg/L). Magnetic resonance imaging of the thigh reassured the diagnosis of local inflammation. Intravenous antibiotic caused mild local improvement, but the episodes of high fever sustained. The patient was transferred to our pediatric surgery department for treatment and surgical biopsy of the lesion. Histopathological examination confirmed a subcutaneous panniculitis-like T-cell lymphoma, which is a rare cytotoxic T-cell lymphoma representing less than 1% of non-Hodgkin lymphomas, uncommon in children. The patient was introduced to a chemotherapy protocol EURO-LB 2002 with good response. In a skin lesion that is associated with systemic symptoms and responding untypically to antibiotic treatment malignancy should be considered and biopsy not be postponed.

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Mediastinal T-cell lymphoma with presumed secondary monostotic long bone involvement in the absence of local recurrence

Veterinary Record Case Reports ◽

10.1136/vetreccr-2019-000904 ◽

2020 ◽

Vol 8 (1) ◽

pp. e000904

Author(s):

Andrea Mosca ◽

Oliver Greville-Heygate ◽

Fernando Constantino-Casas ◽

Antonio Giuliano ◽

Jane M Dobson

Keyword(s):

T Cell ◽

Cell Lymphoma ◽

Complete Response ◽

Distal Humerus ◽

The Body ◽

T Cell Lymphoma ◽

Exercise Intolerance ◽

Long Bone ◽

History Of ◽

Total Body

A 7-year-old male neutered cocker crossbreed was presented with a 1-month history of tachypnoea and exercise intolerance. Initial investigations confirmed a pleural effusion due to a mediastinal T-cell lymphoma. L-asparaginase and a 23-week lomustine, vincristine, prednisolone protocol were pursued and complete response was recorded at the end of the protocol. Ten months later, he was presented at the referring veterinary practice with a non-bearing lameness of his left forelimb, and a transcondylar screw was placed following the suspicion of a fracture of the lateral humeral epicondyle. During surgery, a sample of bone was collected and submitted for histopathology. Histopathology and immunohistochemistry were consistent with a T-cell lymphoma. Total body CT scan revealed a monostotic aggressive lesion of the distal humerus with no evidence of infiltration into bone at any other sites, and no other signs of lymphoma relapse were seen elsewhere in the body. Based on these findings, secondary bone lymphoma was hypothesised.

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Hemophagocytic Lymphohistiocytosis as the Initial Presentation of Subcutaneous Panniculitis-Like T-Cell Lymphoma: A Rare Case Responding to Cyclosporine A and Steroids

Journal of Investigative Medicine High Impact Case Reports ◽

10.1177/2324709620981531 ◽

2020 ◽

Vol 8 ◽

pp. 232470962098153

Author(s):

Caitlin Sullivan ◽

Arya Loghmani ◽

Katharine Thomas ◽

Rachna Jetly-Shridhar ◽

Rajasree Pia Chowdry

Keyword(s):

T Cell ◽

Cyclosporine A ◽

Hemophagocytic Lymphohistiocytosis ◽

Cell Lymphoma ◽

Skin Lesions ◽

T Cell Lymphoma ◽

Cytotoxic T Cell ◽

Life Threatening ◽

History Of ◽

Rare Malignancy

Subcutaneous panniculitis-like T-cell lymphoma (SPTCL) is a rare peripheral cytotoxic T-cell lymphoma, clinically resembling panniculitis. Hemophagocytic lymphohistiocytosis (HLH) is a life-threatening syndrome of immune overactivation, triggered by underlying conditions. SPTCL presenting with HLH may represent a severe and rapidly progressive disease course. Currently, there is no standardized approach to treatment of HLH secondary to underlying SPTCL. A 34-year-old Asian male presented with a several months history of high fevers, weight loss, and nonpruritic purple discoloration of the skin. He had a skin biopsy showing atypical lymphohistiocytic panniculitis with dermal mucinosis and erythrophagocytosis consistent with SPTCL. The patient was initiated on treatment with dexamethasone and cyclosporine A. Almost immediate improvement of his skin lesions was noted and laboratory abnormalities trended toward baseline within 2 weeks. He noted complete symptom resolution after 3 months on therapy. SPTCL may be treated effectively with cyclosporine A and steroids to achieve rapid clinical and symptom management of this rare malignancy.

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Primary cutaneous CD8+ aggressive epidermotropic cytotoxic T‐cell lymphoma resembling pemphigus vulgaris

International Journal of Dermatology ◽

10.1111/ijd.15934 ◽

2021 ◽

Author(s):

Ty W. Gilkey ◽

Cory Pettit ◽

Abraham Korman ◽

Jose A. Plaza ◽

John Trinidad

Keyword(s):

T Cell ◽

Cell Lymphoma ◽

Pemphigus Vulgaris ◽

T Cell Lymphoma ◽

Cytotoxic T Cell

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Primary central nervous system gamma delta cytotoxic T-cell lymphoma

Journal of Clinical Neuroscience ◽

10.1016/j.jocn.2015.10.017 ◽

2016 ◽

Vol 26 ◽

pp. 138-140 ◽

Cited By ~ 4

Author(s):

Kelly L. Mooney ◽

Winward Choy ◽

Joslyn Woodard ◽

Rena R. Xian ◽

Taylor M. Deal ◽

...

Keyword(s):

Central Nervous System ◽

Nervous System ◽

T Cell ◽

Cell Lymphoma ◽

T Cell Lymphoma ◽

Cytotoxic T Cell ◽

Gamma Delta ◽

System Gamma

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Long-Term Remission After Matched Sibling Donor Hematopoietic Cell Transplantation in a Patient With Primary Cutaneous CD8+ Aggressive Epidermotropic Cytotoxic T-Cell Lymphoma

Cureus ◽

10.7759/cureus.15132 ◽

2021 ◽

Author(s):

Quinto Gesiotto ◽

Yumeng Zhang ◽

Ayesha Malik ◽

Lucia Seminario-Vidal ◽

Ernesto Ayala ◽

...

Keyword(s):

T Cell ◽

Cell Transplantation ◽

Hematopoietic Cell Transplantation ◽

Cell Lymphoma ◽

Hematopoietic Cell ◽

T Cell Lymphoma ◽

Cytotoxic T Cell ◽

Sibling Donor ◽

Matched Sibling

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Enteropathy associated T-cell lymphoma

Srpski arhiv za celokupno lekarstvo ◽

10.2298/sarh0702080b ◽

2007 ◽

Vol 135 (1-2) ◽

pp. 80-84

Author(s):

Milena Bakrac ◽

Branka Bonaci-Nikolic ◽

Natasa Colovic ◽

Sanja Simic-Ogrizovic ◽

Miodrag Krstic ◽

...

Keyword(s):

T Cell ◽

Cell Lymphoma ◽

Previous History ◽

Lymph Node Biopsy ◽

Intestinal Wall ◽

T Cell Lymphoma ◽

The Third ◽

History Of ◽

Small Intestinal ◽

Mesenterial Lymph Node

Enteropathy associated T-cell lymphoma (EATCL) is a high grade, pleomorphic peripheral T-cell lymphoma with usually cytotoxic phenotype. This is a case report of three patients with EATCL. The first patient was 50 year-old woman with four year history of gluten sensitive enteropathy (GSE). Diagnosis of lymphoma was confirmed after the resection of the jejunum (small intestine obstruction). Pathohistological (PAS, Reticulin, Giemsa) and immunohistochemical (anti-LCA, anti-CD20, anti- CD45RO, anti-CD3) methods revealed the diagnosis of EATCL: CD45RO+, CD3+. After the third cycle of chemotherapy, the disease progressed with massive lung infiltration. Patient died due to complications of bone marrow aplasia. The second patient was 23 year-old woman with long earlier history of GSE. She presented with the acute renal failure. According to established diagnosis of tubulointerstitial nephritis, she was treated with pulse doses of steroid therapy. After temporary improvement, she had dissemination of the disease. On MRI, small intestinal wall was thickened, and abdominal lymph nodes were enlarged with extraluminal compression of common bile duct. Laparotomy with mesenterial lymph node biopsy and consecutive pathohistological and immunohistochemical analyses revealed the diagnosis of EATCL. The patient received chemotherapy, but she died with signs of pulmonary embolization. The third patient was 53 year-old woman without previous history of GSE. Diagnosis of EATCL was revealed after the resection of jejunum because of small intestinal obstruction. She received two cycles of chemotherapy, but she died with signs of disease progression. IgA antiendomysial antibodies were detected in the serum of all patients. The overall survival of patients was 7 months. The possibility of lymphoma rising in patients with clinical progression of GSE despite gluten free diet must be kept in mind.

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Subcutaneous panniculitis-like T cell lymphoma arising in association with chronic lymphocytic leukaemia

BMJ Case Reports ◽

10.1136/bcr-2021-243490 ◽

2021 ◽

Vol 14 (9) ◽

pp. e243490

Author(s):

Lakshmi Shree Kulumani Mahadevan ◽

Metin Ozdemirli

Keyword(s):

Risk Factors ◽

T Cell ◽

Cell Lymphoma ◽

Case Reports ◽

Lymphocytic Leukemia ◽

T Cell Lymphoma ◽

Cytotoxic T Cell ◽

Lupus Panniculitis ◽

Autoimmune Conditions ◽

Subcutaneous Adipose

Subcutaneous panniculitis-like T cell lymphoma (SPTCL) is a rare cutaneous T cell malignancy of cytotoxic T cell origin. It is frequently associated with autoimmune diseases. It is known to preferentially involve subcutaneous adipose tissue and histologically resembles lupus panniculitis. The aetiology and risk factors of SPTCL are unclear and there are limited studies available since this entity was initially described in 2001. There are even fewer case reports describing the association between SPTCL and chronic lymphocytic leukemia (CLL). In this article, we present a case of SPTCL arising during treatment for CLL. We conducted an extensive review of literature to delve into the possible risk factors for SPTCL development in association with CLL, including pre-existing haematological malignancies, autoimmune conditions, immunomodulation and immunosuppressive chemotherapy.

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