Beneficial effects of black bean (Rhynchosia volubilis) on ocular surface damage induced by benzalkonium chloride in mouse model of dry eye

2017 ◽  
Author(s):  
A Kim Kyung ◽  
W Kang Suk ◽  
H Lee Chung ◽  
J Yang Sung ◽  
K Kang Tae ◽  
...  
Keyword(s):  
Mouse Model ◽  
Dry Eye ◽  
Ocular Surface ◽  
Benzalkonium Chloride ◽  
Surface Damage ◽  
Black Bean ◽  
Beneficial Effects

scholarly journals Successfully Improving Ocular Drug Delivery Using the Cationic Nanoemulsion, Novasorb

2012 ◽  
Vol 2012 ◽  
pp. 1-16 ◽  
Author(s):  
Frederic Lallemand ◽  
Philippe Daull ◽  
Simon Benita ◽  
Ronald Buggage ◽  
Jean-Sebastien Garrigue
Keyword(s):  
Clinical Trials ◽  
Dry Eye ◽  
Ocular Surface ◽  
Surface Damage ◽  
Symptomatic Treatment ◽  
Pharmacokinetic Studies ◽  
Beneficial Effects ◽  
Ophthalmic Delivery ◽  
Preservative Free ◽  
Selection Of

Topical ophthalmic delivery of active ingredients can be achieved using cationic nanoemulsions. In the last decade, Novagali Pharma has successfully developed and marketed Novasorb, an advanced pharmaceutical technology for the treatment of ophthalmic diseases. This paper describes the main steps in the development of cationic nanoemulsions from formulation to evaluation in clinical trials. A major challenge of the formulation work was the selection of a cationic agent with an acceptable safety profile that would ensure a sufficient ocular surface retention time. Then, toxicity and pharmacokinetic studies were performed showing that the cationic emulsions were safe and well tolerated. Even in the absence of an active ingredient, cationic emulsions were observed in preclinical studies to have an inherent benefit on the ocular surface. Moreover, clinical trials demonstrated the efficacy and safety of cationic emulsions loaded with cyclosporine A in patients with dry eye disease. Ongoing studies evaluating latanoprost emulsion in patients with ocular surface disease and glaucoma suggest that the beneficial effects on reducing ocular surface damage may also extend to this patient population. The culmination of these efforts has been the marketing of Cationorm, a preservative-free cationic emulsion indicated for the symptomatic treatment of dry eye.

scholarly journals Trehalose for Ocular Surface Health

Biomolecules ◽  
2020 ◽  
Vol 10 (5) ◽  
pp. 809
Author(s):  
Jarmo Laihia ◽  
Kai Kaarniranta
Keyword(s):  
Oxidative Stress ◽  
Clinical Trials ◽  
Animal Models ◽  
Dry Eye ◽  
Ocular Surface ◽  
Stress Protein ◽  
Life Forms ◽  
Beneficial Effects ◽  
Protein Clearance ◽  
Ocular Surface Health

Trehalose is a natural disaccharide synthesized in various life forms, but not found in vertebrates. An increasing body of evidence demonstrates exceptional bioprotective characteristics of trehalose. This review discusses the scientific findings on potential functions of trehalose in oxidative stress, protein clearance, and inflammation, with an emphasis on animal models and clinical trials in ophthalmology. The main objective is to help understand the beneficial effects of trehalose in clinical trials and practice, especially in patients suffering from ocular surface disease. The discussion is supplemented with an overview of patents for the use of trehalose in dry eye and with prospects for the 2020s.

scholarly journals In Vivo Confocal Microscopic Evaluation of Corneal Langerhans Cells in Dry Eye Patients§

2014 ◽  
Vol 8 (1) ◽  
pp. 51-59 ◽  
Author(s):  
Federica Machetta ◽  
Antonio M Fea ◽  
Alessandro G Actis ◽  
Ugo de Sanctis ◽  
Paola Dalmasso ◽  
...  
Keyword(s):  
Confocal Microscopy ◽  
Dry Eye ◽  
Ocular Surface ◽  
Tear Film ◽  
Surface Damage ◽  
Nerve Plexus ◽  
Sjogren Syndrome ◽  
Central Cornea ◽  
Eye Symptoms ◽  
Dry Eye Symptoms

Purpose. To assess inflammatory involvement of cornea in dry eye by means of confocal microscopy, evaluating the presence and distribution of Langherans cells (LCs). Methods: 98 eyes of 49 subjects were enrolled: 18 subjects affected by Sjögren Syndrome Dry Eye (SSDE), 17 with Non-Sjögren Syndrome Dry Eye (NSSDE), 14 healthy volunteeers. Dry eye symptoms, tear film, ocular surface damage and corneal confocal microscopy were analized. Results: A significant increase of LCs density was observed at sub-basal nerve plexus (SSDE = 79 cells/mm2 and NDE = 22 cells/mm2; p = 0,0031) and sub-epithelial nerve plexus (SSDE = 38 cells/mm2 and NDE = 3 cells/mm2; p = 0,0169) in central cornea of SSDE group. An increased number of LCs from the center to the periphery of the cornea was observed, significant only in healthy volunteers group. In dry eye patients there was an increase in LCs density in both peripheral and central cornea with a significant difference between NDE (14,66 cells/mm2) and SSDE (56,66 cells/mm2) only in central cornea (p = 0,0028). In SSDE group, mean density of LCs in central cornea results also superior to NSSDE group (29,33 cells/mm2). There was no correlation between LCs density and dry eye symptoms, tear film deficiency and ocular surface damage. Conclusion: This study demonstrates the activation of an inflammatory and immunological reaction in cornea of NSSDE and SSDE patients. Confocal microscopy can be an important diagnostic tool in evaluation and follow-up of dry eye disease.

IN VITRO TOXICITY OF BENZALKONIUM CHLORIDE (BAC) TO OCULAR SURFACE CELLS AND PRESERVATIVE-INDUCED DRY EYE.

Cornea ◽  
2000 ◽  
Vol 19 (Supplement 2) ◽  
pp. S119
Author(s):  
M. De Saint Jean ◽  
C. Debbasch ◽  
F. Brignole ◽  
J M. Warnet ◽  
C. Baudouin
Keyword(s):  
Dry Eye ◽  
Ocular Surface ◽  
Benzalkonium Chloride ◽  
In Vitro Toxicity

scholarly journals Dose-dependent benzalkonium chloride toxicity imparts ocular surface epithelial changes with features of dry eye disease

2020 ◽  
Vol 18 (1) ◽  
pp. 158-169 ◽  
Author(s):  
Richard Zhang ◽  
Mijeong Park ◽  
Alexander Richardson ◽  
Nicodemus Tedla ◽  
Elvis Pandzic ◽  
...  
Keyword(s):  
Dry Eye ◽  
Ocular Surface ◽  
Benzalkonium Chloride ◽  
Dry Eye Disease ◽  
Eye Disease ◽  
Chloride Toxicity ◽  
Dose Dependent

scholarly journals Effect of a Novel Multi-Ingredient Formulation on Management of Dry Eye Discomfort in a Randomized, Double-Blind, Placebo-Controlled Human Clinical Study

2021 ◽  
Vol 5 (Supplement_2) ◽  
pp. 42-42
Author(s):  
Muralidhara Padigaru ◽  
Abhijeet Morde ◽  
Pranav Radkar ◽  
Prabhu Shankar Lakshmanan ◽  
Abhijeet Morde
Keyword(s):  
Dry Eye ◽  
Vitamin D3 ◽  
Ocular Surface ◽  
Test Group ◽  
Surface Damage ◽  
Controlled Study ◽  
Ocular Surface Disease Index ◽  
Double Blind ◽  
Health Technologies ◽  
Artificial Tear

Abstract Objectives Dry eye is a chronic condition associated with insufficient tear production and faster tear evaporation and commonly accompanied by inflammation that may lead to ocular surface damage. We have developed a multi-ingredient formulation containing lutein, zeaxanthin, curcumin, and vitamin D3 to address conditions associated with dry eye. The objective of this study was to evaluate the efficacy and safety of our formulation in subjects with mild to moderate dry eye symptoms. Methods This was a randomized, double-blind, parallel, placebo-controlled study. Sixty subjects with mild to moderate DES were randomly assigned in a 1 : 1 ratio to the test or placebo groups. Subjects consumed one capsule of the test or placebo product every morning through the study duration of 56 days. The test product comprised 20 mg lutein, 4 mg zeaxanthin, 200 mg curcuminoids, and 600 IU vitamin D3 in form of a capsule. The placebo product contained soybean oil.  Changes in tear volume by Schirmer's test and severity of dry eye discomfort measured by Ocular Surface Disease Index (OSDI) score, changes in Standard Patient Evaluation of Eye Dryness (SPEED) questionnaire, tear film break up time (TBUT), corneal & conjunctival staining, tear osmolarity, Matrix Metalloproteinases (MMP)-9 levels in tear fluid, and artificial tear usage were evaluated. Results Thirty subjects in Test and 29 in Placebo group completed study. We observed statistically significant (P < 0.05) improvements in tear volume, TBUT, and a reduction in dry eye discomfort as measured by OSDI and SPEED scores from baseline to day 56 in the Test group. Mean corneal & conjunctival staining scores, tear osmolarity and tear MMP-9 levels also showed significant improvements (P < 0.05) when compared to Placebo on day 56. Artificial tear usage & frequency of usage were significantly reduced (P < 0.05) in test group as compared to Placebo. Products were well tolerated without any adverse events. Conclusions Our multi-ingredient formulation demonstrated significant improvement in dry eye conditions including eye hydration and moisture, tear stability and quality, and overall improvements in eye comfort. Funding Sources OmniActive Health Technologies

scholarly journals The effect of sinomenine eye drops on experimental mice dry eye

2020 ◽  
Author(s):  
Hui Li ◽  
Liang Yan ◽  
Peirong Lu
Keyword(s):  
Dry Eye ◽  
Ocular Surface ◽  
Clinical Signs ◽  
Surface Damage ◽  
Eye Drops ◽  
Scopolamine Hydrobromide ◽  
Investigation Methods ◽  
Tnf Α ◽  
Corneal Staining ◽  
Phosphate Buffered Saline

Abstract Background: To investigate the effect of topical sinomenine (SIN) on ocular surface damage in dry eye of experimental mice. Study Design: Laboratory Investigation. Methods: Experimental dry eye was created using scopolamine hydrobromide in female C57BL/6 mice. Eye drops consisting of 0.05%, or 0.1% SIN or phosphate-buffered saline (PBS) were applied to the dry eye of experimental mice. Tear product and corneal staining scores were measured at 7 and 14 days after treatment. Interleukin (IL)-1 β and tumour necrosis factor (TNF) -α levels in the SIN groups at 14 days after treatment were compared with those of other groups. Results: Mice treated with 0.05% or 0.1% SIN showed a significant improvement in tear product and corneal irregularity compared to the control and PBS-treated groups. A significant decrease in the levels of IL-1 β and TNF- α was observed in the 0.05% and 0.01% SIN-treated groups. Conclusions: Topical SIN eye drop application can effectively improve clinical signs and decrease inflammation in the ocular surface, and alleviate ocular surface damage in dry eye.

Ocular surface damage and tear lactoferrin in dry eye syndrome

2009 ◽  
Vol 72 (4) ◽  
pp. 433-437 ◽  
Author(s):  
Yukitaka Danjo ◽  
Mitsue Lee ◽  
Kohji Horimoto ◽  
Takashi Hamano
Keyword(s):  
Dry Eye ◽  
Ocular Surface ◽  
Surface Damage ◽  
Dry Eye Syndrome
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