Interactions of gut epithelial barrier, microbiome and p53 family members – what is their impact on liver cirrhosis?

2018 ◽  
Vol 56 (01) ◽  
pp. E2-E89 ◽  
Author(s):  
L Wächter ◽  
M Haderer ◽  
E Aschenbrenner ◽  
K Pollinger ◽  
S Schlosser ◽  
...  
Keyword(s):  
Liver Cirrhosis ◽  
Family Members ◽  
Epithelial Barrier ◽  
P53 Family

scholarly journals Intestinal epithelial barrier function in liver cirrhosis: an extensive review of the literature

2013 ◽  
Vol 33 (10) ◽  
pp. 1457-1469 ◽  
Author(s):  
Kirsten E. Pijls ◽  
Daisy M. A. E. Jonkers ◽  
Elhaseen E. Elamin ◽  
Ad A. M. Masclee ◽  
Ger H. Koek
Keyword(s):  
Liver Cirrhosis ◽  
Barrier Function ◽  
Epithelial Barrier ◽  
Intestinal Epithelial ◽  
Extensive Review ◽  
Review Of The Literature ◽  
Intestinal Epithelial Barrier ◽  
Epithelial Barrier Function

scholarly journals Drosophila p53 isoforms have overlapping and distinct functions in germline genome integrity and oocyte quality control

eLife ◽  
2022 ◽  
Vol 11 ◽  
Author(s):  
Ananya Chakravarti ◽  
Heshani N Thirimanne ◽  
Savanna Brown ◽  
Brian R Calvi
Keyword(s):  
Quality Control ◽  
Family Members ◽  
P53 Gene ◽  
Genotoxic Stress ◽  
Oocyte Quality ◽  
Protein Isoforms ◽  
Dna Breaks ◽  
P53 Family ◽  
Dna Lesion ◽  
P53 Isoforms

p53 gene family members in humans and other organisms encode a large number of protein isoforms whose functions are largely undefined. Using Drosophila as a model, we find that a p53B isoform is expressed predominantly in the germline where it colocalizes with p53A into subnuclear bodies. It is only p53A, however, that mediates the apoptotic response to ionizing radiation in the germline and soma. In contrast, p53A and p53B are both required for the normal repair of meiotic DNA breaks, an activity that is more crucial when meiotic recombination is defective. We find that in oocytes with persistent DNA breaks p53A is also required to activate a meiotic pachytene checkpoint. Our findings indicate that Drosophila p53 isoforms have DNA lesion and cell type-specific functions, with parallels to the functions of mammalian p53 family members in the genotoxic stress response and oocyte quality control.

Differential regulation of transcription and induction of programmed cell death by human p53-family members p63 and p73

FEBS Letters ◽  
2002 ◽  
Vol 525 (1-3) ◽  
pp. 93-99 ◽  
Author(s):  
Sebastian Dietz ◽  
Karen Rother ◽  
Casimir Bamberger ◽  
Hartwig Schmale ◽  
Joachim Mössner ◽  
...  
Keyword(s):  
Cell Death ◽  
Programmed Cell Death ◽  
Family Members ◽  
Differential Regulation ◽  
Regulation Of Transcription ◽  
P53 Family

scholarly journals δEF1 repressor controls selectively p53 family members during differentiation

Oncogene ◽  
2005 ◽  
Vol 24 (49) ◽  
pp. 7273-7280 ◽  
Author(s):  
Giulia Fontemaggi ◽  
Aymone Gurtner ◽  
Alexander Damalas ◽  
Antonio Costanzo ◽  
Yujiro Higashi ◽  
...  
Keyword(s):  
Family Members ◽  
P53 Family

scholarly journals Differences in the transactivation domains of p53 family members: a computational study

BMC Genomics ◽  
2010 ◽  
Vol 11 (Suppl 1) ◽  
pp. S5 ◽  
Author(s):  
Jagadeesh N Mavinahalli ◽  
Arumugam Madhumalar ◽  
Roger W Beuerman ◽  
David P Lane ◽  
Chandra Verma
Keyword(s):  
Computational Study ◽  
Family Members ◽  
P53 Family ◽  
Transactivation Domains

scholarly journals Inhibition of cyclooxygenase-2 alleviates liver cirrhosis via improvement of the dysfunctional gut-liver axis in rats

2016 ◽  
Vol 310 (11) ◽  
pp. G962-G972 ◽  
Author(s):  
Jin-Hang Gao ◽  
Shi-Lei Wen ◽  
Huan Tong ◽  
Chun-Hui Wang ◽  
Wen-Juan Yang ◽  
...  
Keyword(s):  
Liver Cirrhosis ◽  
Cyclooxygenase 2 ◽  
T Cell Subsets ◽  
Epithelial Barrier ◽  
Signal Pathways ◽  
Intestinal Epithelial ◽  
Intestinal Epithelial Barrier ◽  
Epithelial Barrier Function ◽  
Cox 2 ◽  
E Cadherin

Inflammatory transport through the gut-liver axis may facilitate liver cirrhosis. Cyclooxygenase-2 (COX-2) has been considered as one of the important molecules that regulates intestinal epithelial barrier function. This study was aimed to test the hypothesis that inhibition of COX-2 by celecoxib might alleviate liver cirrhosis via reduction of intestinal inflammatory transport in thiacetamide (TAA) rat model. COX-2/prostaglandin E2 (PGE2)/EP-2/p-ERK integrated signal pathways regulated the expressions of intestinal zonula occludens-1 (ZO-1) and E-cadherin, which maintain the function of intestinal epithelial barrier. Celecoxib not only decreased the intestinal permeability to a 4-kDa FITC-dextran but also significantly increased expressions of ZO-1 and E-cadherin. When celecoxib greatly decreased intestinal levels of LPS, TNF-α, and IL-6, it significantly enhanced T cell subsets reduced by TAA. As a result, liver fibrosis induced by TAA was significantly alleviated in the celecoxib group. These data indicated that celecoxib improved the integrity of intestinal epithelial barrier, blocked inflammatory transport through the dysfunctional gut-liver axis, and ameliorated the progress of liver cirrhosis.

scholarly journals P53 Family Members Modulate the Expression of PRODH, but Not PRODH2, via Intronic p53 Response Elements

PLoS ONE ◽  
2013 ◽  
Vol 8 (7) ◽  
pp. e69152 ◽  
Author(s):  
Ivan Raimondi ◽  
Yari Ciribilli ◽  
Paola Monti ◽  
Alessandra Bisio ◽  
Loredano Pollegioni ◽  
...  
Keyword(s):  
Family Members ◽  
P53 Family ◽  
Response Elements ◽  
P53 Response

scholarly journals Conservation of all three p53 family members and Mdm2 and Mdm4 in the cartilaginous fish

Cell Cycle ◽  
2011 ◽  
Vol 10 (24) ◽  
pp. 4272-4279 ◽  
Author(s):  
David P. Lane ◽  
Arumugam Madhumalar ◽  
Alison P. Lee ◽  
Boon-Hui Tay ◽  
Chandra Verma ◽  
...  
Keyword(s):  
Family Members ◽  
Cartilaginous Fish ◽  
P53 Family

Cross Talk Between Oxidative Stress and p53 Family Members in Regulating Cancer

2021 ◽  
pp. 1-16
Author(s):  
Sumiran Kumar Gurung ◽  
Lokesh Nigam ◽  
Kunwar Somesh Vikramdeo ◽  
Neelima Mondal
Keyword(s):  
Oxidative Stress ◽  
Cross Talk ◽  
Family Members ◽  
P53 Family
Sign in / Sign up

Export Citation Format

Share Document