scholarly journals Conservation of all three p53 family members and Mdm2 and Mdm4 in the cartilaginous fish

Cell Cycle ◽  
2011 ◽  
Vol 10 (24) ◽  
pp. 4272-4279 ◽  
Author(s):  
David P. Lane ◽  
Arumugam Madhumalar ◽  
Alison P. Lee ◽  
Boon-Hui Tay ◽  
Chandra Verma ◽  
...  
Keyword(s):  
Family Members ◽  
Cartilaginous Fish ◽  
P53 Family

Interactions of gut epithelial barrier, microbiome and p53 family members – what is their impact on liver cirrhosis?

2018 ◽  
Vol 56 (01) ◽  
pp. E2-E89 ◽  
Author(s):  
L Wächter ◽  
M Haderer ◽  
E Aschenbrenner ◽  
K Pollinger ◽  
S Schlosser ◽  
...  
Keyword(s):  
Liver Cirrhosis ◽  
Family Members ◽  
Epithelial Barrier ◽  
P53 Family

p53 Family Members: p63 and p73

2007 ◽  
pp. 187-198
Author(s):  
Elsa R. Flores ◽  
Tyler Jacks
Keyword(s):  
Family Members ◽  
P53 Family

scholarly journals Drosophila p53 isoforms have overlapping and distinct functions in germline genome integrity and oocyte quality control

eLife ◽  
2022 ◽  
Vol 11 ◽  
Author(s):  
Ananya Chakravarti ◽  
Heshani N Thirimanne ◽  
Savanna Brown ◽  
Brian R Calvi
Keyword(s):  
Quality Control ◽  
Family Members ◽  
P53 Gene ◽  
Genotoxic Stress ◽  
Oocyte Quality ◽  
Protein Isoforms ◽  
Dna Breaks ◽  
P53 Family ◽  
Dna Lesion ◽  
P53 Isoforms

p53 gene family members in humans and other organisms encode a large number of protein isoforms whose functions are largely undefined. Using Drosophila as a model, we find that a p53B isoform is expressed predominantly in the germline where it colocalizes with p53A into subnuclear bodies. It is only p53A, however, that mediates the apoptotic response to ionizing radiation in the germline and soma. In contrast, p53A and p53B are both required for the normal repair of meiotic DNA breaks, an activity that is more crucial when meiotic recombination is defective. We find that in oocytes with persistent DNA breaks p53A is also required to activate a meiotic pachytene checkpoint. Our findings indicate that Drosophila p53 isoforms have DNA lesion and cell type-specific functions, with parallels to the functions of mammalian p53 family members in the genotoxic stress response and oocyte quality control.

Differential regulation of transcription and induction of programmed cell death by human p53-family members p63 and p73

FEBS Letters ◽  
2002 ◽  
Vol 525 (1-3) ◽  
pp. 93-99 ◽  
Author(s):  
Sebastian Dietz ◽  
Karen Rother ◽  
Casimir Bamberger ◽  
Hartwig Schmale ◽  
Joachim Mössner ◽  
...  
Keyword(s):  
Cell Death ◽  
Programmed Cell Death ◽  
Family Members ◽  
Differential Regulation ◽  
Regulation Of Transcription ◽  
P53 Family

scholarly journals Gain and loss events in the evolution of the apolipoprotein family in vertebrata

2019 ◽  
Vol 19 (1) ◽  
Author(s):  
Jia-Qian Liu ◽  
Wen-Xing Li ◽  
Jun-Juan Zheng ◽  
Qing-Nan Tian ◽  
Jing-Fei Huang ◽  
...  
Keyword(s):  
Lipid Metabolism ◽  
Phylogenetic Trees ◽  
Family Members ◽  
Cartilaginous Fish ◽  
Broad Perspective ◽  
Evolutionary Progress ◽  
Genome Data ◽  
Evolutionary Scenario ◽  
Species Evolution ◽  
Gain And Loss

Abstract Background Various apolipoproteins widely distributed among vertebrata play key roles in lipid metabolism and have a direct correlation with human diseases as diagnostic markers. However, the evolutionary progress of apolipoproteins in species remains unclear. Nine human apolipoproteins and well-annotated genome data of 30 species were used to identify 210 apolipoprotein family members distributed among species from fish to humans. Our study focused on the evolution of nine exchangeable apolipoproteins (ApoA-I/II/IV/V, ApoC-I~IV and ApoE) from Chondrichthyes, Holostei, Teleostei, Amphibia, Sauria (including Aves), Prototheria, Marsupialia and Eutheria. Results In this study, we reported the overall distribution and the frequent gain and loss evolutionary events of apolipoprotein family members in vertebrata. Phylogenetic trees of orthologous apolipoproteins indicated evident divergence between species evolution and apolipoprotein phylogeny. Successive gain and loss events were found by evaluating the presence and absence of apolipoproteins in the context of species evolution. For example, only ApoA-I and ApoA-IV occurred in cartilaginous fish as ancient apolipoproteins. ApoA-II, ApoE, and ApoC-I/ApoC-II were found in Holostei, Coelacanthiformes, and Teleostei, respectively, but the latter three apolipoproteins were absent from Aves. ApoC-I was also absent from Cetartiodactyla. The apolipoprotein ApoC-III emerged in terrestrial animals, and ApoC-IV first arose in Eutheria. The results indicate that the order of the emergence of apolipoproteins is most likely ApoA-I/ApoA-IV, ApoE, ApoA-II, ApoC-I/ApoC-II, ApoA-V, ApoC-III, and ApoC-IV. Conclusions This study reveals not only the phylogeny of apolipoprotein family members in species from Chondrichthyes to Eutheria but also the occurrence and origin of new apolipoproteins. The broad perspective of gain and loss events and the evolutionary scenario of apolipoproteins across vertebrata provide a significant reference for the research of apolipoprotein function and related diseases.

scholarly journals δEF1 repressor controls selectively p53 family members during differentiation

Oncogene ◽  
2005 ◽  
Vol 24 (49) ◽  
pp. 7273-7280 ◽  
Author(s):  
Giulia Fontemaggi ◽  
Aymone Gurtner ◽  
Alexander Damalas ◽  
Antonio Costanzo ◽  
Yujiro Higashi ◽  
...  
Keyword(s):  
Family Members ◽  
P53 Family

scholarly journals Differences in the transactivation domains of p53 family members: a computational study

BMC Genomics ◽  
2010 ◽  
Vol 11 (Suppl 1) ◽  
pp. S5 ◽  
Author(s):  
Jagadeesh N Mavinahalli ◽  
Arumugam Madhumalar ◽  
Roger W Beuerman ◽  
David P Lane ◽  
Chandra Verma
Keyword(s):  
Computational Study ◽  
Family Members ◽  
P53 Family ◽  
Transactivation Domains

scholarly journals P53 Family Members Modulate the Expression of PRODH, but Not PRODH2, via Intronic p53 Response Elements

PLoS ONE ◽  
2013 ◽  
Vol 8 (7) ◽  
pp. e69152 ◽  
Author(s):  
Ivan Raimondi ◽  
Yari Ciribilli ◽  
Paola Monti ◽  
Alessandra Bisio ◽  
Loredano Pollegioni ◽  
...  
Keyword(s):  
Family Members ◽  
P53 Family ◽  
Response Elements ◽  
P53 Response

Cross Talk Between Oxidative Stress and p53 Family Members in Regulating Cancer

2021 ◽  
pp. 1-16
Author(s):  
Sumiran Kumar Gurung ◽  
Lokesh Nigam ◽  
Kunwar Somesh Vikramdeo ◽  
Neelima Mondal
Keyword(s):  
Oxidative Stress ◽  
Cross Talk ◽  
Family Members ◽  
P53 Family

scholarly journals p53 Family Members Regulate the Expression of the Apolipoprotein D Gene

2008 ◽  
Vol 284 (2) ◽  
pp. 872-883 ◽  
Author(s):  
Yasushi Sasaki ◽  
Hideaki Negishi ◽  
Ryota Koyama ◽  
Naoki Anbo ◽  
Kanae Ohori ◽  
...  
Keyword(s):  
Family Members ◽  
P53 Family ◽  
Apolipoprotein D
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